Objective: This study aimed to verify the effect of oral siper-metrin exposure to decrease serum estradiol 17b levels and increased malondialdehyde (MDA) in the uterus level of female Wistar strain rats (Rattus norvegicus).Materials and Methods: The method of this study was true experimental post test only control group in vivo using 24 female rats, divided into 3 groups treated by administering a dose of 5, 10 and 20 mg/kg sipermetrin for 28 days and one control group. Then blood samples were taken from the heart for measurement of serum estradiol 17b levels by ELISA and uterine organs were taken for measurement of Malondialdehyde (MDA) with spectro-photometry method.Results: The results of the measurement of serum estradiol 17b and uterus malondialdehyde (MDA) levels of female Wistar strain rats (Rattus norvegicus) showed an opposite pattern, where there was a decline in serum estradiol 17b levels and an increase in uterus malondialdehyde (MDA) level. There was a significant difference (p=0.000

Objectives: To determine the effect of ovarian autotransplan-tation on decreasing FSH level in Wistarrats late menopause model.Materials and Methods: Experimental analytic research on 27 Wistar rats (Rattus novergicus) was divided into 3 groups. Group 1 (K1) or control. Group 2 (K2) performed bilateral oophorec-tomy without autotransplantation. Group 3 (K3) performed bilateral oophorectomy with autotransplantation. Measurements of FSH levels were performed on the first day, day 28 (four weeks after bilateral oophorectomy, during late menopause) and 56 day (four weeks after autotransplant). Measurement of FSH levels using ELISA. Data analysis used ANOVA and Post Hoc test.Results: The mean FSH level measured on day 56 at K1 = 63.400 ng/mL, at K2 = 78.416 ng/mL and K3 = 31.991 ng/mL. There were significant differences between K1 and K2 (p = 0,000), K1 and K3 (p = 0,000), and between K2 and K3 (p = 0,000).Conclusion: Ovarian autotransplantation decrease FSH levels in Wistar rats late menopause model.

Objectives: To know the characteristics of ovarian cancer patients with pleural and lung metastasis, and survival rates of ovarian cancer patients with pleural and lung metastasis in Dr. Soetomo Hospital Surabaya in 2014-2015.Materials & Methods: This was a descriptive observational study using secondary data from medical records in dr. Soetomo Hospital, Surabaya, Indonesia, in 2014 and 2015Results: Number of new patients of ovarian cancer in dr. Soe-tomo, Hospital, Surabaya in 2014 was 170 patients (14%) and 122 patients (12%) in 2015. Ovarian cancer patients most often came at the stage IIIC (33.38%) with the most histopathological type was epithelial ovarian cancer. There were 5 patients with ovarian cancer with pleural metastasis and 7 patients with lung metastasis. Pleural metastasis was 80% diagnosed at the time of ovarian cancer’s diagnosis, whereas 57.15% of lung metastasis were diag-nosed >12 months after the ovarian cancer’s diagnosis. Pleural metastasis was established by pleural fluid cytology, while lung metastasis with radiological features and/or biopsies. The most common feature of lung metastasis was nodal (71.42%). Ascites was found in 80% of ovarian cancer with pleural metastasis, but only 42.86% in lung metastasis. In 2 patients receiving NAC chemotherapy and continued by interval debulking, both had negative residues. Median survival rate in ovarian cancer with pleural metastasis was 7 months, whereas in lung metastasis was 12 months.Conclusions: Number of new patients of ovarian cancer in 2014-2015 in dr. Soetomo Hospital was on rising and was the second largest number of visits after cervical cancer. In 2014-2015, there were 5 patients with ovarian cancer and pleural metastasis and 7 patients with ovarian cancer patients and lung metastasis. Median survival rate in ovarian cancer with pleural metastasis was 7 months, whereas in lung metastasis it was 12 months.

Strategi Pemerintah dalam menurunkan AKI dan AKB salah satunya kelas ibu hamil. Tujuan penelitian ini mengetahui pengaruh keikutsertaan ibu di  kelas ibu hamil terhadap praktik IMD pada ibu bayi usia 6-8 bulan di wilayah kerja Puskesmas Sisir Kota Batu. Penelitian ini merupakan penelitian analitik dengan desain cohort retrospektif. Populasi terbagi menjadi dua, populasi terpapar yang mengikuti kelas ibu hamil saat hamil anak terakhir dan populasi tidak terpapar  ibu yang tidak mengikuti kelas ibu hamil. Besar sampel 32 responden. Analisis data dengan uji chi square. Hasil analisis bivariat usia (p value = 0,229), pendidikan (p value = 0,1790, paritas (p value = 0,011), pengetahuan (p value = 0,047), sikap (p value = 0,893), riwayat persalinan (p value = 0,021), informasi (p value = 0,472), penolong persalinan (p value = 0,017), tempat persalinan (p value = 0,003), keikutsertaan kelas ibu hamil (p value = 0,27), pengambil keputusan (p value = 0,137), penyuluhan saat hamil (0,16) Hasil analisis menunjukkan variabel yang signifikan adalah paritas (p=0,011), pengetahuan (p=0,047), penolong persalinan (p=0,017), tempat persalinan (0,003), riwayat persalinan (p=0,021), penyuluhan saat hamil (p=0,010). Kesimpulan penelitian ini tidak ada pengaruh keikutsertaan ibu di kelas ibu hamil terhadap praktik IMD, akan tetapi kelas ibu hamil berpengaruh terhadap pengetahuan dan sikap ibu. Pengetahuan berpengaruh terhadap praktik IMD.

Objectives: To identify the variants of genotype HPV that most often found in ICC at Dr Soetomo Hospital Surabaya.Materials and Methods: This was an explorative study with cross sectional approach. Specimens used were 30 formalin fix parrafin embedded from squamous cell carcinoma (SCC), adenocarcinoma (AD) dan adenosquamous carcinoma (AS) cervival cancer parients at Dr Soetomo Hospital Surabaya around Januari-Desember 2013, then used for DNA virus extraction and continued for PCR and HPV genotyping.Result : The result of HPV genotyping showed 10 positives from SCC, 6 positives and 4 negatives from AD, and 9 positives and 1 negative from AS. HPV infections in SCC were single infection by HPV 16, 18, 45, 56, and multiple infection by HPV 16+45, in AD were single infection by HPV 16,18, anad multiple infection by HPVhr+hr 68b+72 and HPVlr+hr  6+18+45, and in AS were single infection by HPVhr 16, 18, 45 and mutiple infection by HPV lr+hr 6+59.Conclusion : Infections HPV in ICC were single infection by HPV16, 18, 45, 56 and mutiple infection by HPV16+45, 68b+72, 6+18+45, 6+59. HPV 18 has highest prevalence in ICC patient from Dr Soetomo Hospital, followed by HPV16, 6, 45, 56, 59.

Objectives: This study aimed to analyze the influence of knowledge and regimentation of pregnant women consume tablets therapy adherence iron (Fe) and anemia in pregnant women in the South Regional Health Center Kediri.Materials and Methods: This study used observational analytic with cross sectional design. The population consisted of 63 third trimester pregnant women and samples taken were 34 third trimester pregnant women who have received 90 tablets of iron (Fe), with a simple random sampling technique. Data obtained from questionnaires, books Maternal and Child Health, and in-depth interviews. Data analysis was performed using ordinal regression and logistic regression.Results: There was an effect of knowledge of pregnant women on adherence to consume tablets of iron (Fe), there is no influence regimentation of therapy on adherence to consume tablets of iron (Fe), and no effect of compliance sufficient to consume tablets of iron (Fe) against anemia in pregnant women (p=0.012). Conclusion: The higher the level of knowledge possessed by pregnant women, pregnant women, the more it tends to stick to consume tablets of iron (Fe) during pregnancy. And no regimentation of therapeutic effect on adherence to consume tablets of iron (Fe) in pregnant women.

Objectives: to analyze the efforts of maternal health services that may affect maternal mortality rate.Materials and Methods: The study was conducted at the Health Office of East Java using secondary data from 38 districts/cities in East Java in 2015 that includes performance antenatal care K1 and K4, postnatal care, early detection of complications in pregnant women, natal in health workers and health facilities, management of complications by health workers and MMR. Data were analyzed with statistical method with spatial regression and illustrated with thematic maps by application ArcView statistics.Results: the highest MMR was in Bojonegoro district, Lumajang, Probolinggo, Bondowoso, Situbondo and Probolinggo city. Some districts/cities that have the highest maternal mortality has proximity of areas, namely the district Lumajang, Probolinggo, Bondowoso, Situbondo and Probolinggo city. Their proximity concluded an association condition and the causes of MMR between districts so they can be studied more in depth about the causes of MMR kind of social, cultural and geographical characteristics. The coverage maternal health services to all districts/cities in East Java province is not much difference.Conclusion: the maternal mortality rate in the district/city of East Java province in 2015 was not much affected by maternal health services so we need more research on other causes of MMR in districts/city of East Java Province.

Objectives: To study the characteristics of patient with uterine leiomyoma to be used as reference and evaluation.Materials and Methods: The data of this study taken by assess-ing patients’ medical record to be analyzed descriptively.Results: Of 145 patients, 69,7% were female who are older than forty years of age. Uterine leiomyoma often occur in patients of reproductive age (31%). Only 2.8% patient used oral contra-ceptive and 15.2% had menarche at the age of 12-13 years. The number of uterine leiomyoma was higher in female who had history of pregnancy less than or equal to two times (35.2%) and dominated by patients who had history of birth less than or equal to two times (37.2%). 63.4% patient never consume cigarette. Moreover, 29.7% of patients were overweight female. Unfortun-ately, there is no data about family history, exercise habit and history of tissue injury in the medical record.Conclusion: In this study, patients with uterine leiomyoma are dominantly female at age more than forty and at reproductive or perimenopause period with history of pregnancy and birth less than or equal to 2 times, never consume cigarette and overweight.

Objectives: This study aimed to compare the serum levels of soluble Endoglin (s-Eng) between early onset preeclampsia, late onset preeclampsia and normal pregnant women.Materials and Methods: This was an analytic observational study (Cross-Sectional) performed on 39 pregnant women with early-onset preeclampsia (EO-PE), late-onset preeclampsia (LO-PE), and normal pregnancy. The patients were consecutively chosen in Dr. Soetomo Hospital, Airlangga University Hospital and Dr. M. Soewandhi Hospital Surabaya in May-July 2016. The serum concentration of soluble Endoglin were collected by venous puncture taken from maternal circulation and measured by ELISA.Results: From this study, serum concentrations of soluble Endoglin was higher significantly on the early onset  preeclampsia compared with late onset preeclampsia and normal pregnancy (47,65 ± 40,17 vs 13,46 ± 9,48 vs 6,11 ± 1,45 ng/mL; p=0.000). Conclusion: This study shows angiogenic imbalance was more prominent compared in early-onset than late-onset preeclampsia. This may be because the placental dysfunction, placental ischemia, which produce excessive anti angiogenic factors, whic later causing endothelial dysfunction was more related to early onset preeclampsia.

Objectives: to identify factors affecting labor induction failure in Sungailiat General Hospital, District Bangka, Bangka Belitung.Materials and Methods: This is a case control retrospective analytic study. Population of this study was postterm delivering mother at delivery room Sungailiat General Hospital during July 1st, 2012 to July 1st, 2015. Sampling method conducted for case group was total sampling method with labor induction failure as a inclusion criteria, and no data for first trimester ultrasound, didn’t have a routine antenatal care history, and maternal complication as exclusion criterias as many as 78 samples. Whereas, control group was women whose underwent a success labor induction used random sampling method with 1:1 ratio. Data source was from medical records. Data analysis was chi square with 95% confidence interval.Results: From the 78 samples with labor induction, 19,2 % was ≥ 35 years old, 48,7% was primiparas, 62,8% with infant birth weight ≥ 3500 gram, and from 96 samples, 47,5% with ≥ 5 years pregnancy interval. Statistical analysis result showed factors that affecting induction failure were parity (P Value 0,014, odds ratio 2,970), baby’s weight (P Value 0,016, odds ratio 2,631), pregnancy interval (P Value 0,023, odds ratio 2,993), whereas mother’s age did not show significant effect (P Value 0,383, odds ratio 2,278).Conclusion: Parity has a 2,9 times risk to develop induction failure.