cover
Filter by Year
Majalah Obstetri & Ginekologi
Published by Universitas Airlangga
Articles
83
Articles
Sambiloto (AS201-01) is better than standard antimalarial drug (DHP) in reducing Toll-Like Receptor 2 (TLR2) on placenta malaria model

Hamidah, Masyitah, Widyawaruyanti, Aty, Widjiati, Widjiati, Prasetyo, Budi

Majalah Obstetri & Ginekologi Vol 26, No 2 (2018): August
Publisher : Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Objectives: To compare the TLR2 expression in the placenta between treated by sambiloto EA-96 fraction tablet (AS201-01) and dihydroartemisinin-piperaquine phosphate (DHP)Materials and Methods: Experimental study using 24 pregnant mice. All sample divided into 4 groups with randomization are uninfected group, Plasmodium infected group and given placebo, sambiloto (AS201-01) and DHP. Then performed surgery and placental sampling were staining with adopting in tunnel assay method to measure the TLR2 expression of placental.Results: The expression of TLR2 in uninfected group has the lowest rate compared to other groups. The infected and placebo treated group has the highest TLR2 expression campared with sambiloto and DHP. The sambiloto group has not differ signi-ficantly with the group uninfected and lower than DHP.Conclusion: Tablet of sambiloto EA-96 fraction (AS201-01) decreased TLR2 expession better than with DHP tablet.

The effect of sambiloto tablet (AS201-01) on placental Chondroitin Sulfate A (CSA) expression of pregnant mice infected by Plasmodium berghei

Wahdi, Nasrul, Widjiati, Widjiati, Widyawaruyanti, Aty, Prasetyo, Budi

Majalah Obstetri & Ginekologi Vol 26, No 2 (2018): August
Publisher : Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Objectives: To determine the effect of Sambiloto tablet (AS201-01) in reducing the placental Chondroitin Sulfate A (CSA) Expression of pregnant mice infected Plasmodiumberghei.Materials and Methods: Experimental study using 24 pregnant mice were divided into 4 groups with randomization. Uninfected group, the placebo group, the Sambiloto tablet (AS201-01) group and the DHP tablet (as a standart drug) group. The last three groups, were infected with P. bergheion day 9th of pregnancy, and the treatment was started at day 11th of pregnancy, and samples were terminated at day 15th of pregnancy by surgery. Placental sampling were stained with Tunnel assay to measure placental CSA antibodies.Results: The placental Chondroitin Sulfate A (CSA) expression. Uninfected group compared to Sambiloto tablet (AS201-01) groups was not significantly different (p>0.05), uninfected group compared with the other treatment groups differ meaningfully (p<0.05). Placebo group compared with all groups significantly different (p<0.05). Sambiloto tablet (AS201-01) group compared to uninfected group (p>0.05) was not significantly different, with another group was significantly different (p<0.05). DHP tablet group compared to all the groups was significantly different (p<0.05).Conclusion: Placental Chondroitin Sulfate A (CSA)expression of mice infected by Plasmodium berghei treated with Sambiloto tablet (AS201-01) lower than DHP tablet. 

Combination of palonosetron-dexamethasone is more effective than ondansetron-dexamethasone as single cisplatin antiemetic chemotherapy

Putra, Agung Sunarko, Suhatno, Suhatno

Majalah Obstetri & Ginekologi Vol 26, No 2 (2018): August
Publisher : Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Objective: To know the efficacy differences between two groups of drug combination ondansetron-dexamethasone (A) and ondan-setron-dexamethasone (B) to prevent emetic rsponses after chemotherapy cisplatin administration (CINV).Materials and Methods: A prospective double blind randomized clinical trial study held in Dr. Soetomo General Hospital involving 66 subjects, devide into two groups randomly 33 patients each. One group receive palonosetron-dexamethasone combination therapy compare to ondansetron-dexamethasone combination as standart therapy in gynecologic oncology Dr. Soetomo Hospital in a control group as cisplatin chemotharapy CINV prophylaxis. The research was conducted from June till October 2014 in the Dr. Soetomo General Hospital-Surabaya. Assessment and measurement of the response of nausea and frequency of vomiting according Gralla scale, changes in plasma density and electrolyte serum (Na, K, and Cl) as a result of dehydration caused by nausea and vomiting, as well as counting the onset of nausea and vomiting occur.Results: There was significant differences between the results of the combination therapy compared ondansetron-dexamethasone to palonosetron-dexamethasone for nausea and vomiting (p=0,001). 31 subjects suffers nausea in ondansetron group, while 9 subjects suffers nausea in palonosetron group. Vomiting occurs in 17 subjects from ondansetron group, and only 1 subject from palono-setron group during study. Changes in plasma density significant in palonosetron group, and natrium in ondansetron group. For K and Cl not significantly difference in both groups before and after cisplatin chemotherapy administration.Conclusion: Palonosetron-dexamethasone combination is super-ior as cisplatin CINV prophylaxis in response to nausea and vomiting frequency, and also give longer protection compare to ondansetron-dexamethasone significantly. The plasma density and electrolyte serum changes are varied in numbers and also influenced by many factors including physical status and nutrition, also intake of each patients.

Postplacental insertion of IUCD Cu T 380A at transcesarean section does not influence bleeding and infection at puerperial period

Utami, Menik, Winardi, Baksono

Majalah Obstetri & Ginekologi Vol 26, No 2 (2018): August
Publisher : Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Objective: To determine the difference of the puerperial bleeding and puerperial infection women who had intrauterine contraceptive device (IUCD) T380A insertion at caesarean section compare with women who had caesarean section without IUCD insertion.Materials and Methods: This study was an observasional analytic prospective cohort. Participants allocated to 2 groups : IUCD inserted during cesarean and cesarean with no device inserted. Subject research monitoring at 10 and 40 day of puerperial period.Results: Puerperial bleeding of group with IUCD insertion is 99,309+32,845 ml and group without IUCD is 88,010+30,824 ml, with the analysis test got p=0,085 (p>0,05) means no difference between two groups.Level hemoglobin at post cesarean section (day-0), 10 and 40 day, proportion increasing severity of anemia and duration of lochia rubra were analized and got p>0,05, no difference between two groups. Duration of puerperial bleeding period, median group with IUCD 40 days (25-50) and group without IUCD 30 days (26-45), with analized test got p<0,05. Duration of puerperial bleeding were significantly difference. Proportion of clinical sign puerperial infection 3 (6,4%) of group with IUCD and 2 (4,1%) of group without IUCD, with analized test got p=0,614 (p>0,05), no difference between two groups. Level of leucocyte at post cesarean section (day-0), 10 and 40 day, the difference both two groups was not significant (p>0,05). In this research the difference puerperial bleeding and proportion puerperial infection between two groups (women who had IUCD T380A insertion at caesarean section compare with women who had caesarean section without IUCD insertion) was no significant.Conclusion: Insertion IUCD Cu T 380A postplacental at caesarean section is safety.

Increased Brain Derived Neurothropic Factor in the cerebrum and cerebellum of Rattus norvegicus newborn with exposure to Mozarts music in default sequence compared with the reversed sequence and without exposure during gestation

Hidayati, Agustina, Joewono, Hermanto Tri, Widjiati, Widjiati

Majalah Obstetri & Ginekologi Vol 26, No 2 (2018): August
Publisher : Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Objectives: To analyze the differences in the expression of Brain Derived Neurothropic Factor (BDNF) in Rattus norvegicus cerebrum and cerebellum of newborn between those exposed to Mozarts music composition in default sequence, reverse sequence, and without exposure in the womb.Materials and Methods: Analytical laboratory experimental study with randomized post test only control group design using animal models Rattus norvegicus. The animal models were divided into three groups: control group without any exposure, the treatment groups with exposure to Mozarts music in default sequence and another group in reverse sequence since day 10 of gestation. We used a comparison test in the analysis of BDNF expression.Results: We found significant difference in BDNF expression with p value 0.004 (mean 8.98±1.31 default sequence group, 5.58±3.08 reverse sequence group, 6.80±1.95 control) in the cerebrum. We found significant difference of BDNF expression with p value 0.003 (mean 9.48±1.41 default sequence group, 6.02±3.25 reverse sequence group, 7.14±2.54 control) in the cerebellum. In cerebrum dan cerebellum we found significant difference between standard Mozart??s music and control (cere-brum p=0.018, cerebellum p=0.001), and we found significant difference between standard Mozart??s music and reverse Mozart??s music (cerebrum p=0.001, cerebellum p=0.008) and no significant difference in reverse Mozart and control (cerebrum p=0.264, cerebellum p=0.490)Conclusion: Sequence in Mozart??s music is very important in increase expression of BDNF.

Apoptosis index of cerebrum and cerebellum neuronal cells in Rattus norvegicus neonates born from mothers treated with 50% food restriction during gestation

Hapsari, Andita, Joewono, Hermanto Tri, Widjiati, Widjiati

Majalah Obstetri & Ginekologi Vol 26, No 2 (2018): August
Publisher : Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Objective: To analyze the difference of neuronal apoptotic index on Rattus norvegicus offspring in cerebrum and cerebellum between food restriction 50% group and control.Materials and Methods: An analytical experimental study with single blind randomized post test only control group using animals subjects Rattus norvegicus. This study was conducted at animal laboratory, Veterinary Faculty, Universitas Airlangga. Animal subjects were divided into food restriction 50% group and control. The apoptotic index was analyzed using comparison test, with significancy p<0.05.Results: There was significant difference of neuronal apoptotic index on Rattus norvegicus offspring between FR 50% group and control in cerebrum with p= 0.002 (mean 6,12±3,51 in FR 50% group, 2,81±2,16 in control group), and cerebellum with p= 0.026 (mean 5,56±3,03 in FR group, 3,43±2,58 in control group).Conclusions: Food restriction 50% during gestation has signifi-cant influence on neuronal apoptotic index in cerebrum and cerebellum of Rattus norvegicus offspring.

Role of family structure and parenting style in adolescent pregnancy in Surabaya, Indonesia

Anifah, Fulatul, Dasuki, Djaswadi, K, Herlin Fitriana, Triratnawati, Atik

Majalah Obstetri & Ginekologi Vol 26, No 2 (2018): August
Publisher : Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Objectives: To explore the relationship of family structure and parenting style with adolescent pregnancy in SurabayaMaterials and Methods: This research uses mix methods approach with case-control design and case study. Data were collected by questionnaire and in-dept interview guidelines. This study involved 46 adolescent (23 cases and 23 control) by purpossive sampling and 6 adolescents as main participants. Quantitative data were analyzed on univariable, bivariable with chi square and multivariable with multiple logistic regression with p=0,05 and CI 95%. Qualitative data were analyzed by in-depth interviewResults: Family stucture were not statistically significant (OR 10.53; CI 0.657-168.93), but socially meaningful. There is not statistically significant between parenting style with adolescent pregnancy (OR 1.191; CI 0.373-3.806). Other factors that have a significant relationship with adolescent pregnancy is education of responden (OR 559.76; CI 3.608-23026.4). There is no statis-tically significant in education father, education mother, employment status and where they living. Parenting style can be influenced by communication between parents and adolescent.Conclusions: Risk of adolescent pregnancy on people who have low education. Adolescents from extended family and single parent have a role to the incidence of teenage pregnancy.

Knowledge of pregnant women about anemia is related with adherence to iron tablets

Winardi, Baksono, Grahardika Andani, Elga Caecaria

Majalah Obstetri & Ginekologi Vol 26, No 1 (2018): April
Publisher : Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Objectives: to identify association between knowledge of pregnant women about anemia and the adherence to consume iron tablets in BPM Titik Suharti, Surabaya, IndonesiaMaterials and Methods: Observational analysis cross sectional study. Population consisted of 55 trimester pregnant women in BPM Titik Suharti, Surabaya, in March-April 2017. Samples were recruited using consecutive sampling. The number of sample was 35 respondents. Data were analyzed using chi-square test.Results: This research showed that all of the less knowledgeable women on anemia (100.00%) were non-adherent to consume iron tablets, almost all moderately knowledgeable women (92.9%) were adherent, and all of the fully knowledgeable women (100.00%) were adherent. Fisher exact test in significance level of 0.05 revealed p value equal to 0.0001, indicating association between knowledge about anemia and adherence to consume iron tablets at BPM Titik Suharti, Surabaya, Indonesia.Conclusion: There is an association between knowledge of pregnant women about anemia with adherence to iron tablets.

Nitric oxide (NO) level of the follicular fluid in endometriosis patients

Hadi, Cahyono, Dasuki, Djaswadi, Sadewa, Ahmad Hamim, Astuti, Indwiani, Prasetyo, Awal

Majalah Obstetri & Ginekologi Vol 26, No 1 (2018): April
Publisher : Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Objectives: To ascertain the nitric oxide (NO) level of the follicular fluid of endometriosis sufferers compared with that of the non-endometriosis patients.Materials and Methods: Follicular fluid was taken from 64 women, but only 54 continued with further laboratory test. Women with endometriosis had their follicular fluid taken during laparoscopy, while the follicular fluid from non-endometriosis women was taken during tubectomy. Nitric Oxide level was analyzed using the PCR-RFLP method. Data were analyzed using software STATA Intercooled Version 11.Results: NO level in endometriosis is higher than that in non-endometriosis and has a significant relationship with all the variables (age, parity, dysmenorrhea, dyspareunia, types of endometriosis, and grade of endometriosis).Conclusion: The NO level in endometriosis is higher than that in non-endometriosis. The distribution of the polymorphism of allele GG is greater than that in non-endometriosis. The existence of polymorphism GG caused a higher eNOS, increasing NO level, causing a decrease in fertility which derived from the degenera-tive oocyte.

Effect of prenatal Mozart composition on Brain Derived Neurotrophic Factor expression in cerebrum and cerebellum of Rattus norvegicus offspring from Food Restriction 50 model

Permatasari, Yulia Putri, Widjiati, Widjiati, Joewono, Hermanto Tri

Majalah Obstetri & Ginekologi Vol 26, No 1 (2018): April
Publisher : Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Objectives: To analyze the difference of BDNF expression on Rattus norvegicus offspring FR50 model in cerebrum and cerebellum between Mozart composition stimulation group and control.Materials and Methods: An analytical experimental study with single blind randomized post test only control group using animal subjects Rattus norvegicus FR50 model. This study was conducted at animal laboratory, Faculty of Veterinary Medicine, Airlangga University. Animal subjects were divided into Mozart music stimulation group and control. The BDNF expression was analyzed using comparison test, with significancy p<0,05.Results: There was no difference of BDNF expression on Rattus norvegicus offspring FR50 model between Mozart music stimu-lation group and control in cerebrum with p=0.495 (mean Mozart group 6.89+2.52 vs control 6.22+1.99), and cerebellum with p=0.146 (mean Mozart group 7.41+2.67 vs control 5.73+2.45).Conclusions: There was no difference of BDNF expression between Mozart composition stimulation group and control in the cerebrum and cerebellum of Rattus norvegicus offspring FR50 model.