cover
Filter by Year
Malang Neurology Journal
Published by Universitas Brawijaya
Malang Neurology Journal (MNJ) is a continuously published twice a year scientific journal which is using review by peer group system. MNJ accepts original research article, review, case report, and readers’ letters related to neurology.
Articles
58
Articles
COMPARISON EFFECT BETWEEN PEGAGAN (Centella asiatica) EXTRACT AND PRAMIPEXOLE TOWARD LOCOMOTOR ACTIVITIES, α - SYNUCLEIN, AND Nrf2 EXPRESSION IN ZEBRAFISH PARKINSON MODEL

Trisnawati, Ayu, Anasrulloh, Anasrulloh, Rianawati, Sri Budhi, Khotimah, Husnul, Ali, Mulyohadi, Susetya, Budi

Malang Neurology Journal Vol 5, No 1 (2019)
Publisher : Malang Neurology Journal

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Background: Parkinson disease is characterized with deposition of Lewy Bodies containing α–synuclein happened due to the effect of chronic neuroinflammation that causes the death of dopaminergic neurons through oxidative stress processes, so it involves the response of Nuclear factor erythroid 2-like 2 (Nrf2). Centella asiatica  (C.asiatica) contains antioxidant effect, inhibits the aggregation of α–synuclein and improves the locomotor on Parkinson-model animals so it needs to compare to the standard medication.Objective: To compare the C. asiatica extract and Pramipexole to the zebrafish Parkinson model by determining the locomotor activity, α–synuclein expression, and Nrf2.Methods: This study used six groups of zebrafish: negative control, rotenone rotenone [5 μg/L], pramipexole1, 2, 3 (rotenone + pramipexole [3,5] ng/mL, [7] ng/mL, [14] ng/mL), and C. asiatica(rotenone + C. asiatica [10] μg/mL). The observations of locomotor activity of day 0, 14, and 28 were continued to the α–synuclein immunohistochemical examination, and Nrf2 on the midbrain area.Results: There are significant differences in locomotor activity on day 28 among the C. asiatica group with rotenone (p<0,05), while there are no significant differences among the C. asiatica group with pramipexole [7] ng/mL and [14] ng/mL (p>0,05). α–synuclein expression of the C. asiatica group is the lowest and significantly different from all groups (p<0,05), while Nr2 had no significant differences (p>0,05).Conclusion: C. asiatica extract [10] μg/mL is equal to pramipexole [7] ng/mL and [14] ng/mL in improving locomotor activity, but C. asiatica extract holds excellence as it decreases α–synuclein expression better than pramipexole, while Nrf2 expression shows no differences.

ELECTRONEUROMYOGRAPHY EXAMINATION OF DIABETIC POLYNEUROPATHY PATIENTS

Nurlaela, Siti, Kurniawan, Shahdevi Nandar, Husna, Machlusil

Malang Neurology Journal Vol 5, No 1 (2019)
Publisher : Malang Neurology Journal

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Background: Diabetic polyneuropathy (DPN) is one of the chronic complications that occur in approximately 80% of diabetes mellitus (DM) patients. This condition is a results of metabolic, vascular, and immunological disorders.Objective: To determine the profile of electroneuromyography (ENMG) examination of DPN patients at neurology clinic of Saiful Anwar General Hospital.Methods: This cross-sectional observational descriptive study was carried out at Saiful Anwar General Hospital Malang from June 1, 2015 to December 31, 2015, with purposive sampling method. A total of 43 DM patients with symptoms of polyneuropathy fulfilling inclusion criteria and no exclusion criteria were examined for ENMG. ENMG examirnation were including distal latency, amplitude and nerve conduction velocity of 4 motoric nerves (median, ulnar, tibial, peroneal) & 3 sensory nerves (median, ulnar, sural), and F waves of ulnar, median and peroneal nerves of the left and right extremities.Results: Of the 43 patients evaluated in this study, the mean sensory sural nerve conduction velocity was 13.01 m/s. The majority type of nerve damage in diabetic polyneuropathy patients in this studywere mixed type (52.33% in the median nerve, 60.47% in the ulnar nerve, 72.10% in the tibial nerve, and 54.65% in the peroneal nerve in motor nerve studies and 80.23% in the median nerve and 88.37% in the peroneal nerve in the sensory nerve studies).Conclusion: The nerve damage that occurs in DPN patients at Saiful Anwar general Hospital is severe, with the majority being the axonal demyelinating type, especially in the sensory nerve fibers in the inferior extremities.

CLINICAL MANIFESTATIONS OF DELIRIUM IN ELDERLY

Inche Mat, Liyana Najwa, Sulaiman, Wan Aliaa Wan, Kee, Hoo Fan, Baharin, Muhammad Afwan Shamsul, Ghenesan, Surendran, Ishak, Siti Nabila, Abidin, Wan Fairuzlina Zainal, Daud, Nor Liyana Farhan, Yun, Tan Hong

Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Delirium is commonly encountered in the elderly. It is important to recognize and subsequently treat delirium early to prevent morbidity and mortality. The primary objective of this article review is to gather specific information about each clinical manifestation of delirium in elderly. Sieving through numerous literature and studies regarding the topic of Delirium in the elderly. Majority of the article source were from Medline and PubMed as subscribed by the institution where there are more than 27 million citations in the field of biomedical articles. The articles include articles that was published in Malaysia and also international article due to the limitation in Malaysia itself. The articles were retrieved from publications in the year 1992 up to the current year 2017. Clinical manifestation of delirium that had been reviewed include disordered thinking, euphoric, language impairment, illusion, reversal of sleep wake cycle, inattention, disoriented and memory deficit. Most of the information is about prevalence, clinical diagnosis, and pathophysiology of each of the clinical manifestation. Delirium in elderly is very complex and complicated which involve physical, emotion feelings not only for the patient but also for people in their surroundings. Many articles reviewed explain about each of the symptoms in further details in term on how they act and how they interact with people surrounding.

INTERPRETATION OF NERVE CONDUCTION STUDY IN POLYNEUROPATHY WITH MULTIBACILLARY LEPROSY TYPE 2 REACTION

Sari, Diane Tantia, Widasmara, Dhelya, Kurniawan, Shahdevi Nandar

Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Leprosy reaction contributes to disability due to peripheral nerve damage. Nerve conduction study (NCS) provides a profound physiological description of peripheral nerves. This study aims to report a case of polyneuropathy in leprosy with type 2 reactions (T2R) which is evaluated using NCS. A 33-year-old woman complain of painful bumps in her arms and legs, fever, swollen feet since 2 days ago, and history of leprosy. Dermatologic examination on the right superior palpebra, right and left arms and legs revealed multiple tenderness erythematous nodules; right claw hand; and both legs oedema. Slit skin smear revealed positive result. Histopathologic examination supported T2R description. The NCS examination concluded severe axonal demyelinating motoric sensoric polyneurophaty, with left worse. She was treated with MDT-MB, bed rest, orally methylprednisolone, vitamin B, paracetamol, ferrous sulfas, and topical olive oil. Clinical improvement was achieved after 2 weeks. The NCS is used to assess the nerve impuls conduction along the peripheral nerves. In this case, it was found that NCS could showed early neuropathy in nerves that were clinically undetectable. It can be concluded that the NCS examination is an important diagnostic modalities for early detection of neuropathy and confirmed the diagnosis of clinical neuropathy in leprosy.

COMPARISON OF INTUBATION QUALITY AND HAEMODYNAMIC RESPONSE IN ENDOTRACHEAL INTUBATION BETWEEN SUPERIOR LARINGEUS AND TRANSTRACHEAL BLOCK AND MUSCLE RELAXANTS

Primadita, Hanggia, Murti, Bhisma, Santosa, Sugeng Budi

Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Background. Endotracheal intubation stimulates various responses such as coughing and bucking, bronchial and laryngeal spasm and hemodynamic changes. Muscle relaxants facilitate easy intubation, but not suppressing hemodynamic response. Superior laryngeus and transtracheal block is presume to suppress hemodynamic changes while maintain intubation quality.Objective. To compare intubation quality and hemodynamic response from superior laryngeus and transtracheal block and muscle relaxants.Methods. Intubation quality is assessed using Helbo-Hansen Raulo and Trap Anderson. Blood Pressure, pulse and saturation were measured before and after intubation.Results. All intubation is acceptable in muscle relaxants group (100%), one unacceptable in block group (5.9%). After intubation hemodynamic in both groups were significantly different (p=<0.05) for systolics (148.35±26.33 vs 109.53±15.98), diastolics (94.88±20.18 vs 68.00±15.54), MAP (109.65±21.18 vs 79.94±16.94), and for pulse (101.71±16.34 vs 87.47±20.03), except for saturation (99.35±0.79 vs 99.35±0.99).Conclusion. Muscle relaxant and block deliver similar intubation quality, however block giving out better hemodynamic response stability.

COMPARISON OF ACUTE ISCHEMIC STROKE FUNCTIONAL OUTCOME IN SMOKERS AND NONSMOKERS MEASURED BY CANADIAN NEUROLOGICAL SCALE (CNS) AND NIHSS

Putri, Nila Novia, Islam, Mohamad Saiful, Subadi, Imam

Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Background. Stroke is the world’s second leading cause of death and main cause of disability. Smoking is a well-known risk factor of stroke. However, the correlation between smoking and stroke outcome is still remains a controversy.Objective. To analyze the differences of functional outcome between smokers and non-smokers in acute ischemic stroke patients.Methods. The design used in this study is retrospective cross-sectional. The functional outcomes of acute ischemic stroke were measured by Canadian Neurologic Scale (CNS) and NIHSS over a period of seven days after the onset of stroke. Differences of CNS and NIHSS were analyzed using Mann-Whitney U test.Results. Median of CNS in smokers and non-smokers were 9.0 and 11.0, respectively. Median of NIHSS in smokers and non-smokers were 4.0 and 2.0, respectively. There were no significant differences in the analysis of CNS score between smokers and non-smokers and NIHSS score analysis between smokers and non-smokers.Conclusion. Smoking is not correlated with the functional outcome in acute ischemic stroke patients measured by CNS and NIHSS.

PHYSICAL ACTIVITIES, SITTING TIME AND FRAILTY SYNDROME IN ELDERLY (A CROSS SECTIONAL STUDY AMONG ELDER PERSON BY FRIED CRITERIA)

Sunarti, Sri, Hariyanti, Tita, Chriswantara, Riz’q Threevisca

Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Background. Physical activity is being a protective factor of frailty syndrome. Sedentary life style is related to frailty, comorbidities and mortality. Sitting time is associated with greater risk of dying from all causes of mortality. The correlations between physical activities, sitting time and frailty have not been studied at Indonesia.Objective. To know the correlations between physical activities, sitting time and frailty syndrome among elder person in Malang.Methods. Survey method is used in this research among elders of >60 years old in Malang. Quistionnaire-based interview was asked to respondesn and frailty measurement based on Fried’s Criteria.Results. Physical activities measured with MET (Metabolic Rate) conversely related to frailty condition in elderly and sitting time correlate well with frailty.Conclusion. Physical activities and sitting time have strong correlation with frailty in Malang.

ATTENTION AND INTERNATIONAL HIV DEMENTIA SCALE (IHDS) DO NOT CORRELATE WITH CD4 COUNT IN HIV PATIENTS

Arofah, Annisa Nurul, Rianawati, Sri Budhi, Rasyid, Harun Al, Rahayu, Masruroh

Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Background. Despite it is common neurocognitive domain that affected in patient with Human Immunodeficiency Virus (HIV) infection, attention domain is not assessed using International HIV Dementia Scale (IHDS), a common screening test to diagnose HIV-associated cognitive disorder. Detection of attention deficit in HIV patient is important as it can maintain the capacity to adherence to antiretroviral therapy and essential to activity daily living. CD4 is one of the markers for severity of HIV infection. Objective. We aims to correlate between CD4 with IHDS and CD4 with attention performance test, such as forward digit span test (FWD), backward digit span test (BWD), and trail making test A test (TMA).Methods. This is an analytic study using cross sectional design. 20 respondents are collected for the study using purposive sampling. Data is collected using instrument IHDS, FWD, BWD, and TMA.Results. Using the correlation of Eta, Eta 2 of CD4 and IHDS, CD4 and FWD, CD4 and BWD, also CD4 and TMA are 0.025, 0.022, 0.022 and 0.011.Conclusion. We concluded that CD4 have no correlation with test for attention domain and IHDS.

THE ROLE OF TNF-α AND IL-6 CYTOKINE IN CHILDREN WITH STATUS EPILEPTICUS

Wibowo, Agung Prasetyo, Sujuti, Hidayat, Rahayu, Masruroh, Muid, Masdar, Kawuryan, Siti Lintang

Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Background. One of pediatric emergencies that has high mortality is status epilepticus (SE). Correlation between tumor necrosis factor (TNF)-α, interleukin (IL)-6, and SE had been reported but human study of it is limited. Objective. To compare TNF-α and IL-6 level in children with SE to those of children without SE and to find correlation between both cytokines.Methods. Cross-sectional study was conducted in dr.Saiful Anwar Hospital Malang with 48 children were enrolled in this study. All subjects were divided into three groups, including children who had SE; children who had seizure but not SE; and children who have no seizure. The levels of TNF-α and IL-6 serum were measured by ELISA.Results. TNF-α and IL-6 serum level were not significantly different between groups (p=0.920, p=0.829). We found interesting fact that the level of IL-6 in children with SE who have no disability was significantly higher than that of children who died or had disability (p=0.015). There was strong correlation between TNF-α and IL-6 in SE group (R 2 = 0.841 and p = 0.0001).Conclusion. IL-6 serum level was higher in SE children who have no disability and correlate with TNF-α serum level.

VACCINE FOR NEUROCYSTICERCOSIS: A PRESENT UPDATE

Wiwanitkit, Viroj

Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Show Abstract | Original Source | Check in Google Scholar |

Abstract

Cysticercosis is an important tropical parasitic worm infestation. This infection can result in cyst in any organs of human beings including to brain. The brain involvement of cysticercosis or neurocyticercosis is an important neurological infection that can cause serious neuruological problem. A good sanitation is the basic prevention for cysticercosis. Nevertheless, the hope is the use of vaccination. Here, the author briefly reviews and discusses on the present situation of neurocysticercosis vaccine.