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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
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Articles 14 Documents
Search results for , issue " Vol 22 No 3, 2011" : 14 Documents clear
Influence of learning and growth toward internal business processes: case studies on Departement of Hospital Pharmacy in DIY ., Satibi; Fudholi, Achmad; Kusnanto, Hari; ., Jogiyanto
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.147 KB) | DOI: 10.14499/indonesianjpharm0iss0pp238-250

Abstract

Hospital Pharmacy have revenue contribution to the Hospital reached 40-60%,  thus  becoming  one  of  the  hospital  revenue  center.  However  hospital pharmacy  services  in  Indonesia  are  still  many  shortcomings,  is  considering several  constraints  such  as  the  ability  of  pharmaceutical  workers,  the  limited ability  of  hospital  management,  hospital  management policies,  and  limited knowledge of the relevant parties of hospital pharmacy services. Such conditions must be efforts to change with the development of learning and growth factors, because  these  factors  (human  capital,  organizational  capital  and  information capital)  and  that  effective  management  is  a  source  of  sustainable  competitive advantage. The research objective is to determine the relationship and influence of learning and growth to the internal business processes in Hospital Pharmacy. Kind  of  research  is  non-experimental  research  is  associative.  Research  tool includes a questionnaire indicators of learning andgrowth, and internal business processes.  The  subjects  was  the  head  of  hospital  pharmacy  in  the  hospital region  of  Daerah  Istimewa  Yogyakarta  (DIY).  Sample  size  was  35  hospital.  In addition  to  sending  questionnaires,  random  interviews  will  be  conducted  on several  hospital  pharmacies  to  enrich  the  results  of  the  survey  questionnaire. The  data  was  analyzed  by  correlation  and  linear  regression  to  determine  the relationship  and  influence  the  learning  and  growth  factors  to  the  internal business  processes  in  hospital  pharmacy.  Results  obtained  from  statistical calculations  with  95%  confidence  show  that  there  is a  strong  relationship between  the  organizational  culture  against  internal business  processes  with  r value of 0.981 with a contribution of 96.20% of theorganizational capital of the sustainability  of  the  internal  business  processes  in  Hospital  pharmacy  in Yogyakarta  Special  Region.  There  is  not  significant relationship  between  the human  capital  against  internal  business  processes.   There  is  not  significant relationship between the information capital against internal business processesKey words:learning and growth, internal business processes, the hospital pharmacy 
Liquisolid ibuprofen tablets Hadisoewignyo, Lannie; hadi, Evania; Wibowo, Nehru
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.538 KB) | DOI: 10.14499/indonesianjpharm0iss0pp197-203

Abstract

Ibuprofen  is  an  antiinflamatory  drugs  with  poor  solubility  in  water  but good  permeability  in  the  gastrointestinal  tract.  Liquisolid  tablet  is  the  one method of increasing solubility and dissolution rate of ibuprofen. The aims of this study  was  to  determine  the  effect  of  glycerine  and  propylene  glicol  as  non volatile  solvent  and  PVP  K-30   as  hydrophilic  polymer  on the  dissolution  rate of liquisolid  ibuprofen  tablets.  In  this  research,  there  are  7  formulas  of  liquisolid ibuprofen  tablets  were  made.  The  ratio of  ibuprofenin  glycerine  is 1  : 3  and of propilene glicol is 5:1 with various concentration of PVP K-30 (5, 10, and 15%). Formula I was made as a control so there was no addition of non volatile solvent and hydrophilic polymer. Based on the results, liquisolid ibuprofen tablets using glycerine  or  propylene  glycol  as  a  non  volatile  solvent  and  PVP  K-30  as  a hydrophilic  polymer  can  increase  the  dissolution  rate  constant  of  liquisolidibuprofen  tablets  comparedthat  of  ibuprofen  conventional  tablets  (non liquisolid).  The  addition  of  PVP  K-30  as  a  hydrophilic  polymer  can  increase  the dissolution  rate  constants  liquisolid  ibuprofen  tablets  until  a   concentration  of more  than  10%  because  the  polymer  will  swell  and  form  a  viscous  layer  that inhibits the disintegration so that the percent release decrease.Key words:Ibuprofen, liquisolid, non volatile solvent, hydrophilic polymer.
Antibacterial invitroand antidiarrhea invivoeffects of the infusion of sago roots (Metroxylon sagu) Bakhriansyah, Mohammad; Febria, Aswin; Rahmah, Defiyanti
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.044 KB) | DOI: 10.14499/indonesianjpharm0iss0pp158-165

Abstract

Fresh  root  of  sago  (Metroxylon  sagu)  traditionally  has  been  used  as  an antidiarrhea  in  South  Kalimantan  community.  However,  there  is  no  scientific data  yet  to  support  it.  The  aims  of  this  study  were  to  investigate  the antibacterial effect of the infusion of sago root on Salmonella typhi(S. typhi) as one  of  bacteria  causing  diarrhea in  vitro and  to  find  out  its  effects  as  anti diarrhea  in  male  mice  induced  by  castor  oil in  vivo. This  experimental  study measured the inhibitory zone in S. typhiculture and to count the frequency and duration  of  diarrhea.  It  used  3  concentrations,  i.e  10%;  20%  and  40%  of  the infusion of sago root. Chloramphenicol and aquadest were used as positive and negative  control  groups  respectively  in in  vitro study,  whereas  in  in  vivo one loperamide was positive control group. Chloramphenicol was used since it is an antibiotic  standard  for  eradicating S.  thypi, whereas  Loperamide  is  anti peristaltic  agent  from  declining  the  frequency  and  duration  of  diarrhea.  The infusion  inhibited  radical  zone  of  S.  typhi culture  by  7.8;  9.8  and  10  mm, decreased  the  frequency  of  diarrhea  24.23%;  40.54%  and  16.22%  and decreased  the  duration  of  diarrhea  26.69%;  52.92%  and  10.27%  at concentration  10%,  20%  and  40%,  respectively. As  conclusion  the  infusion  of sago  root  has  the  potency  as  anti  bacteria  and  decrease  the  frequency  and duration of diarrhea. The best concentration of the infusion of sago root is 20%.Key words: Metroxylon sagu, Mice, Anti diarrhea, Anti bacteria
Mucous dilution activity of non soluble ethylacetate fraction syrup of hibiscus flowers (Hibiscus rosa-sinensis L.) at cow intestinein vitro Murrukmihadi, Mimiek; Wahyuono, Subagus; ., Marchaban; Martono, Sudibyo
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.07 KB) | DOI: 10.14499/indonesianjpharm0iss0pp251-256

Abstract

Previous  study  indicated  that  ethylacetate  insoluble  fraction  of  ethanol extract  of  Hibiscus  flowers  (Hibiscus  rosa-sinensis L.)  were  able  to  dilute intestine cattle mucous in vitrothat was often associated with mucolytic activity.In  this  study,  syrup  preparation  of  various  concentrations  of  these  fractions (1.20,  1.60  and  2.00%)  was  tested  for  its  ability  to  dilute  of  mucous.  Each  of syrup  concentrations  was  mixed  with  20%  buffer  Phosphate  (pH,  7)  at  equalproportion (1:1 v/v), the resulting mixtures were tested for their ability to dilute mucous  in  vitro. Mucous  dilution  was  observed  by  flow  time  recorded in  the viscosimeter.  The  study  showed  that  all  syrup  concentrations  (1.20,  1.60, 2.00%) exhibited mucous dilution effect compared tonegative control and syrup concentration  at  2.00%  was  comparable  to  positive  control  acetylsistein  0.1% (p<0.05). Therefore, there was a possibility that thispreparation could be used as mucolytic.Keywords: Hibiscus rosa-sinensisL., viscosity, mucous dilution, mucolytic
Formulation of nanoparticles from short chain chitosan as gene delivery system and transfection against T47D cell line Winarti, Lina; Martien, Ronny; ., Sismindari
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.858 KB) | DOI: 10.14499/indonesianjpharm0iss0pp204-211

Abstract

Recently numerous prototype DNA-based biopharmaceuticals can be used to  control  disease  progression  by  induction  and  inhibitin  the  overexpression  of genes.  Since  there  are  poor  cellular  uptake  and  rapid  in  vivo  degradation  of DNA-based  therapeutics  therefore  the  use  of  delivery  systems  to  facilitate cellular internalization and preserve their activity is necessary. Cationic polymers commonly used as carriers to delivery gene because of easy to form complexes and  higher  stability  compared  to  that  lipoplexs.  Chitosan,  a  cationic,  are polymer most widely used in gene delivery systems because of the low toxicity, and biocompatible. The aim of this study was to formulate nanoparticles of short chain  chitosan-pEGFP-C1  and  short  chain  chitosan/TPP-pEGFP-C1  by coaservation  complex  method.  Stability  test  of  the  formula  was  performed  by incubating the nanoparticles complex with DNase I and Artificial Intestinal Fluid. Cytotoxicity  and transfection  studies  were  evaluated  against  T47D  cell line.  The diameter  of  Chitosan-pEGFP-C1  and  chitosan/TPP-pEGFP-C1  nanoparticles  were on the range of 56–282.8 nm. The zeta potential wasdetermined to be +14.03 - +16.6  mV.  Stability  studies  showed  that  chitosan-pEGFP-C1  and  chitosan/TPPpEGFP-C1  nanoparticles  were  stable,  undegradable  by  DNase  I  and  artificial intestinal fluid. Cytotoxic Assay of Chitosan-pEGFP-C1 and  chitosan/TPP-pEGFPC1  nanoparticles  (pH  4.0)  showed  that  the  viability  of cell  was  >  90%  for  all formulas.  EGFP-C1  plasmid  gene  delivered  by  chitosan  nanoparticles  can  be expressed  in  T47D  cell  culture.  According  to  these  results  chitosan  and chitosan/TPP  nanoparticles  had  potentially  to  be  used  as  a  non-viral  vector system delivery for gene therapy.Key words:Chitosan, Nanoparticles, Plasmid EGFP-C1, Cell culture T47D 
Gonadotropin inhibitory hormone (GnIH) prevents the ‘priming’ effect of estradiol-17β Sari, Ika Puspita; Jacobi, Jessica; Rao, Alexandra; Clarke, Iain
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.017 KB) | DOI: 10.14499/indonesianjpharm0iss0pp166-173

Abstract

GnIH  inhibits  GnRH-stimulated  gonadotropin  secretion  in  the  sheep  by action on the pituitary gonadotropes. Estradiol-17β(E2) also acts at the level of the  pituitary  gonadotrope  to  exert  negative  and  positive  feedback  effects  on gonadotropin secretion. The positive effect facilitates the estrogen-induced surge in  gonadotropin  releasing  hormone  (GnRH)  and  LH.  This  study  was  undertaken to  determine  whether  this  ‘priming’  effect  of  E2  is  prevented  by  GnIH.  Cultured pituitary  cells  were  treated  with  GnRH  or  vehicle  every  4  h  for  24  h  with  and without  GnIH  and  E2 treatment.  GnRH  stimulated  (LH)  and  follicle  stimulating hormone  (FSH)  secretion  was  increased  by  E2 treatment.  The  effect  of  E2  was overcomes  by  the  inhibitory  effect  of  GnIH.  We  conclude  that  GnIH  may counteract the priming effect of E2 on pituitary gonadotropes.Key words:Gonadotropin, gonadotrope, gonadotropin inhibitoryhormone, estradiol
Dead time determination and its influence to retention index in GC system using polar capillary column Idroes, Rinaldi; Oesman, Frida
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.696 KB) | DOI: 10.14499/indonesianjpharm0iss0pp257-264

Abstract

In this research for the determination of dead timeused a method that is mathematically calculated as iteration and linearization of the polar capillarry column  in  Gas  Chromatography  (GC)  type  DN-Wax,  by  injecting  the  homologous series  of  n-alkanes  (n-pentane  up  to  n-decane)  on  GC  system.  The  dead  time values  obtained  are  then  used  to  determine  the  Kovats  Retention  Index (Retention  Index,  RI).  The  results indicated that the  retention index  had  values of  systematic  error  those  are  more  accurate  than  the  retention  time  (tR), corrected retention time (tR) and retention factor(k), but the retention index shows  the  value  of  random  error  slightly  larger  than  with  other  retention parameters. In this study  the average values obtained by the iteration method, the  dead  time  was  3.52  minutes  with  a  correlation  coefficient  of  0.9998.Retention  index  values  obtained  are  at  the  confidence  level  92.11%-97.06% with the systematic errors 2.04%-7.89%, while the linearization method showed the average value of the dead time 3.3 minutes witha correlation coefficient of 0.9992,  but  the  value  of  retention  index  values  obtained  show  that  the systematic error is very large.Key words:Dead time, Retention Index, Homologous Series, GC
Response to antiretroviral therapy undergone by HIV/AIDS patients Yasin, Nanang Munif; Maranty, Hesaji; Ningsih, Wahyu Roossi
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.023 KB) | DOI: 10.14499/indonesianjpharm0iss0pp212-222

Abstract

HIV/AIDS,  with  new  cases  thereof  coming  up  year  after  year,  is  a  fastgrowing  disease.  In  order  to  inhibit  HIV  replication,  ARV  is  administered  to HIV/AIDS  patients  throughout  his  life-time.  Continuous  monitoring  for  the detection of its desired result ought to be conducted. This study is aimed to find out  the  response  of  the  ARV  therapy  undergone  by  the  HIV/AIDS  patients hospitalized  in  a  teaching  hospital  in  Yogyakarta.  Descriptive  non-experimental design  was  used  for  the  study.  The  data  were  obtained  retrospectively  from medical records of 71 patients who met the inclusion and exclusion criteria. The data  were  analyzed  descriptively.The  research  findings  indicated  that  of  the first-line  ARV  therapy,  zidovudine+lamivudine+nevirapine  (AZT+3TC+NVP)  was mostly  used  (61.97%).  It  was  found  that  all  of  the  ARV  types  used  were  in accordance  with  the  National  Therapy  Antiretroviral Guidelines  (2007)  from Health  Ministry  Department,  Indonesia.  As  observed  further,  61  (92.80%),  40 (85.00%), and 20 (85.00%) patients had their CD4 increased; 66 (72.72%), 44 (75.00%), 24 (79.17%) had gained weight; and 71 (100%), 55 (100%), and 31 (96.77%) had survived the disease after 6, 12, and 24 months undergoing ARV therapy.  However,  the  increase  in  CD4 after  six-month  therapy  was  not  always attended  by  the  increase  in  weight.  To  conclude,  this  phenomenon  indicated good immune and clinical responses.Key words: HIV/AIDS, antiretroviral, therapy response, CD4count, hospital 
Effect of Indonesian medicinal plants essential oils on Streptococcus mutansbiofilm Hertiani, Triana; Pratiwi, Sylvia Utami Tanjung; Irianto, Irami Duma Kencana; Adityaningrum, Dian; Pranoto, Budi
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.812 KB) | DOI: 10.14499/indonesianjpharm0iss0pp174-181

Abstract

Essential  oil’s  component  such  as  menthol  and  eucalyptol  were  already used as dental plaque inhibitors. In searching of potential dental plaque inhibitor from natural products, a study to explore the potency of essential oils extracted from  several  Indonesian  medicinal  plants  against  planktonic  growth  and  biofilm adherence  of  S.  mutans was  performed.  A  total  of  14  essential  oils  from  some selected Indonesian medicinal plants were extractedby steam-hydro distillation. Antibacterial assay was performed against S. mutansby micro dilution technique on  nutrient  broth  media.  Biofilm  formation  inhibition  assay  was  conducted  on  a flexible  U-bottom  96-wells  PVC  micro  plate  by  using BHI  enriched  with  sucrose 2%  at  36.6  °C  for  18-24  h.  After  staining  with  1%  crystal  violet,  the  optical density  was  read  at  595  nm.  A  mouthwash  commercial  product  containing essential  oil  component  was  used  as  a  positive  control.  Result  showed  that  the essential oils of  C. sintoc exhibited the highest biofilm formation inhibition (IC50 =  0.005%),  and  Z.  officinale showed  the  highest  biofilm  degradation  with  EC50 value  of  0.013%.  Both  were  active  against  bacterial planktonic  growth  but  C. sintocshowed lower MIC90 value (0.6%) in comparison to Z. officinale(0.06%). Meantime,  C.  citratus was  showed  promising  antibacterial  and  antibiofilmactivities with MIC90 value of 0.06%, MBC 0.6%, IC50 0.008% and EC50 0.026%. It is concluded that the essential oils of C. citratus, Z. officinaleand C. sintocare potential to be developed as dental plaque inhibitors.Key words: essential oils, antibacterial, biofilm, Streptococcus mutans
Drug-related problems and clinical risk factors relationship in hepatic cirrhosis patients Lorensia, Amelia; ., Widyati; Hubeis, Aziz; Bagijo, Hary
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (190.249 KB) | DOI: 10.14499/indonesianjpharm0iss0pp223-228

Abstract

Diffusion  processes  in  hepatic  cirrhosis  is  characterized  with  fibrosis  and structural changed. Patients with cirrhosis are at risk to get problems because of the  effects  of  the  drugs  used  have  drug-related  problems  (DRPs),  due  to changes  in  heart  function  that  affects  many  aspects of  drug  pharmacokinetics. Therefore,  treatment  of  patient  with  hepatic  cirrhosis  should  consider  the  drug and  dose  adjustment  so  that  subsequent  problems  could  be  avoided.  The research  method  was  prospective  and  descriptive,  with  a  purposive  sampling technique.  Patients’s  treatment  were  monitoring  and analyzed.  Significance  of 0000  means  that  p  (0000)  <0.05,  then  the  Pearson  correlation  test  results  are H1a, ie there was a relationship between the numberof DRPs events by the total number of clinical risk factors of DRPs in patientswith cirrhosis. Therefore from this relationship could be expected to know the possible risk of DRPs in patients. The  increasing  number  of  clinical  risk  factors  DRPs in  patients  with  cirrhosis, indicate  thatthe  patient  should  receive  a  more  stringent  monitoring  of  the provision of therapy because the risk of experiencing DRPs more.Key words: cirrhosis, drug related problems (DRPs), clinical risk factors of DRPs

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