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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
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Articles 10 Documents
Search results for , issue " Vol 22 No 1, 2011" : 10 Documents clear
Characterization of physical properties of binary system of erythromycin stearate-sodium starch glycolate by compression force effect Setyawan, Dwi; Sumirtapura, Yeyet C; Soewandh, Sundani N; Tj, Daryono Hadi
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.09 KB) | DOI: 10.14499/indonesianjpharm0iss0pp43-49

Abstract

Characterizations  of  the  physical  properties  of  binary  system  of erythromycin stearate (ERS)-sodium starch glycolate(SSG) due to compression force, had been carried out. The solid state properties were evaluated by powder X-ray  diffraction  (PXRD),  scanning  electron  microscope  (SEM)  and  differential thermal  analysis  (DTA)  methods.  The  weight  fraction of  mixtures  ERS:  SSG (90:10),  (80:20)  and  (70:30)  were  compressed  using  hydraulic  press  and  flat plain  punches  with  a  diameter  of  13  mm.  The  compression  force  was  29.5  kN. Diffraction  peaks  at  2θ =  5.6;  10,6  and  25.6°  were  used  to  determine  the  full width at  half  maximum  (FWHM),  crystallite  size  and preferred orientation. Peak broadening  was  calculated  by  measuring  the  FWHM.  FWHM  values,  crystallite size  and  preferred  orientation  of  the  crystallites  were  calculated  by  WinPlotr program. The results of the  study showed that the FWHM value increased at all the crystal lattice as the fraction of SSG increased. The crystallite size and peak intensity  decreased  gradually  as  fraction  of  SSG  increased.  Scanning  Electron Microscope  (SEM)  analysis  indicated  that  SSG  was  dispersed  on  surface  and inside  of  the  tablet  of  ERS  at  all  combination.  The phase  diagram  of  binary system ERS and SSG showed a no interaction of ERS and SSG.Key words : characterization, physical properties, ERS, SSG, compression force
Determination of total phenol, condensed tannin and flavonoid contents and antioxidant activity of Uncaria gambirextracts Kassim, M. Jain; Hussin, M. Hazwan; Achmad, A.; Dahon, N. Hazwani; Suan, T. Kim; Hamdan, H. Safley
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.396 KB) | DOI: 10.14499/indonesianjpharm0iss0pp50-59

Abstract

Uncaria  gambir,  a  well  known  Southeast  Asia  plant  have  been  previously used as an alternative medicine for treatment such as diarrheal, sore throat and spongy  gums.  Due  to  its  useful  properties,  in  this  study  we  have  analysed  the total  phenol,  condensed  tannin,  flavonoid  content  and  antioxidant  activity  of Uncaria  gambir in  three  different  solvent  extracts.  Characterization  and quantification analysis using Fourier Transform Infrared (FTIR) spectroscopy and reverse  phase-high  performance  liquid  chromatography  (RP-HPLC)  has confirmed  that  the  major  chemical  constituents  of  Uncaria  gambir are  mainly catechins.  It  was  revealed  that  the  ethyl  acetate  gambir  extract  gives  the highest  catechin  content  and  antioxidant  activity  compared  with  other  solvent extracts.Key words: Uncaria gambir, antioxidant activity, condensed tannin, flavonoid 
Influence of drying methods to quality of meniran herb (Phyllanthus niruri LINN.) Rivai, Harrizul; Nurdin, Hazli; Suyani, Hamzar; Bakhtiar, Amri
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.019 KB) | DOI: 10.14499/indonesianjpharm0iss0pp73-76

Abstract

Effects of drying methods in obtaining the extractive, phenolic content and antioxidant activity in Phyllanthus niruri Linn. herbs have been investigated. The drying  methods  tested  were  air-drying  at  ambient  temperature,  oven-drying  at 40  °C,   oven-drying  at  60  °C,  and  fresh  samples  as  control.  Results  revealed that  drying  of  the  fresh  plant  caused  the  decrease  of  extractive  obtainability, phenolic  content  and  antioxidant  activity.  There  were  significant  differences among drying  methods (p < 0.05). Among the drying methods tested, the best result was by oven-drying at 40 °CKey words: Antioxidant, Phyllanthus niruri Linn., drying methods, phenolic compounds
Isolation and identification of kaempferol from jangkang (Homalocladium platycladum (F. Muell) Bailey) leaves and its antibacterial activity Nuria, Maulita Cut; ., Wahyono; Susidarti, Ratna Asmah
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.188 KB) | DOI: 10.14499/indonesianjpharm0iss0pp1-8

Abstract

Isolation and  identification  of  kaempferol  from  jangkang  (Homalocladium platycladum (F.  Muell)  Bailey)  leaves  and  its  activity  against  B.  subtilis ATCC 9466 dan S. typhi ATCC 1408 has been done. The dried ground leaves (300.04 gram)  were  macerated  with  petroleum  ether,  chloroform  and  methanol respectively.  The  methanol  extract  was  the  most  active  extract  against  both bacteria.  Further  separations  of  this  extract  using preparative  thin  layer chromatography  yielded  flavonoid  glycoside.  Its  aglicon  was  identified  as kaempferol  based  on  its  spectroscopic  data  (MS,  IR, and  UV-Vis)  and  UV spectrum  (densitometry).  This  compound  shows  iradical  zone  of  6.62  mm (Bacillus  subtilis)  and  6.27  mm  (Salmonella  typhi)  at  concentration  of  200 µg/disk.Key words : kaempferol, jangkang, glycoside, aglicon
The effect of the extract of pasak bumi roots (Eurycoma longifoliaJack.) on liver function Panjaitan, Ruqiah Ganda Putri; Manalu, Wasmen; Handharyani, Ekowati; ., Chairul
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.396 KB) | DOI: 10.14499/indonesianjpharm0iss0pp15-20

Abstract

The  aim  of  this  research  is  to  study  the  effects  of the  methanol  extract and  its  derived  fraction  (n-hexane,  chloroform,  ethyl  acetate,  and  methanolwater)  on  liver  function  of  male  rats.  The  treatment  groups  were  administered 500  mg/kg body weight of metanol extract and its derived fractions (n-hexane, chloroform,  ethyl  acetate,  n-butanol,  methanol-water)  of  E.  longifolia for  7 consecutive  days.  Positive  control  group  received  25  mg  silymarin/kg  body weight and negative control group received 2 mL aquadest/kg body weight daily for  7  consecutive  days.  Liver  function  was  monitored  by  measuring  alanine transaminase  (ALT),  aspartate  transaminase  (AST),  total  protein,  alkaline phosphatase  (ALP),  total  bilirubin,  direct  bilirubin,  and  indirect  bilirubin consentrations  in  the  serum.  Compared  with  control,  oral  administration  of methanol  extract  and  derived  fractions  of  methanol extract  of  E.  longifolia root had  no  significant  effects  on  liver  function  (p>0.05).  Methanol-water fraction gave similar results to silymarin.Key words: Eurycoma longfolia Jack.,liver function, biochemical blood Histopathologi
Synthesis and cytotoxicity test of LR-2 on breast cancer cell line T47D Ritmaleni, Ritmaleni; Anitasari, Dina; Susanti, Sinta; ., Sismindari
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.952 KB) | DOI: 10.14499/indonesianjpharm0iss0pp21-32

Abstract

LR-2  is  a  compound  analog  of  monastrol,  an  anticancer  agent,  which  has been succesfully synthesised through the application of Biginelli reaction and one of  LR  compound  series  that  synthesised  in  Faculty  of  Farmacy,  Universitas Gadjah  Mada.  This  reserach  was  aimed  to  synthesized the  LR-2  compound  and to investigate the cytotoxicity of LR-2 on breast cancer cell line. The reaction was carried out by using the one pot reaction method. In this reaction benzaldehyde, 2-indanone and thiourea were reacted together for 6hours in acid catalyst. The cytotoxicity  test  was  carried  by  using  breast  cancer  cell  line  the  MTT  assay method and the LC50 was ditermined by using the probit analysis with Miller and Tainter  method.  The  product  was  isolated  by  using  preparative  TLC  in  54  % yield. The structure was elucidated by spectroscopymethods (UV-Vis, H-NMR, IR and GC-MS).The LC50 is 159 µM.Keywords : LR-2, benzaldehyde, 2-indanone, thiourea, T47D 
Improvement of artemisinin content through mutation of in vitro shoot cultures of Artemisia cinamedicinal plant ., Aryanti
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.543 KB) | DOI: 10.14499/indonesianjpharm0iss0pp60-64

Abstract

Improvement of plant traits through mutation induction of herbal medicine of  shoots  Artemisia  cina  in  vitro  have  conducted  by  gamma  rays.  About  200  of A.cina shoots in vitro were cultured in Murashige & Skoog(MS) medium without phyto-hormone  were  irradiated  by  the  dose  of  10  Gy  at  Gamma  Chamber  in PATIR – BATAN. Irradiated shoot cultures were then multiplication and selected. The selected mutant lines have acclimatized and cultivated at distance of 0.5 x 1 m  at  Bogor  region.  21  of  mutant  lines  have  been  obtained  from  630  A.cina mutant  lines  from  field  cultivation.  The  morphological  observation  i.e.,  leaves area,  plants  high  and  percentage  of  flower  emerge  have  conducted  when  the plants  were  cultivated  in  the  field.  The  artemisinin  content  of  mutant  lines  and original plant have conducted by using  HPLC. The result  shown  that the mutant lines  had  higher  leaves  area  than  original  plant  and  some  of  mutant  lines  were shorter  than  original  plant.  The  percentage  of  emerge  flowers  were  reached 50.17%  to  be  A31.1  mutant  line.  The  improvement  of  plant  traits  by  gamma rays  was  showed  by  increasing  of  artemisinin  in  A.cina  mutant  lines.  The highest  artemisinin  content  to  be  A32a2,  A32c1  and  A36.2  were  found 21.03  mg/g, 19.99 and  15.79  mg/g  respectively  compared  to  the original  plant only 0.40 mg/g. The improvement of artemisinin  content of mutant line A32a2, A32c1 and A36.2 were 52.25; 48.97 and 38.48% respectively.Key word :mutation, shoots in vitro, artemisinin, Artemisia cina 
Analysis of P ® film-coated caplet quality control by implementing statistical process control method at PT. YF Puspita, Oktavia Eka; Fudholi, Achmad
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (848.845 KB) | DOI: 10.14499/indonesianjpharm0iss0pp33-42

Abstract

Manufacturing of film-coated caplet  dosage form is a multi-steps  process, including  weighing,  blending,  granulating,  drying,  compression,  coating,  and packaging.  Every  manufacturing  process  is  influenced  by  natural  variation  and assignable  variation  which  caused  the  process  operates  out-of  control  and interfering  consistency  and  attainment  of  output  quality  specification.  Based  on the above background a research was conducted upon manufacturing process of P® film  coated  caplet  at  PT.YF.  This  research  was  limited  for  core  caplet compression step and film coating step instead of entire production process. The purposes  of  this  research  were  analyzing  core  caplet  compression  process  and coating process and measuring process capabilityof those steps in meeting the pre-determined  quality  specifications.  Investigation  of  20  latest  consecutive batch  record  documents  within  2009  period  was  conducted  in  collecting quantitative data measurement of caplet quality characteristics including weight uniformity,  hardness,  friability,  disintegration,and  dissolution  of  drug  substance of  P® film  coated  caplet.  Those  data  were  analyzed  using control  chart  SPC method and process capabilitywas measured by Cpk index. The results showed that  from  caplet  core  compression  step  the  control  chart  of  caplet  weight uniformity  and   friability  indicates    statistically  in-control,  meanwhile  step  the control  chart  of  hardness;  disintegration  time  and  dissolution  of  Paracetamol  ; Ibuprophen indicates statistically out-of control. The result of film coating step of  P® film-coated  caplet  showed  that  the  control  chart  of weight  uniformity; hardness  and  Ibuprophen  dissolution  indicates    statistically  out-of  control, meanwhile  disintegration  time  and  Paracetamol  dissolution  was  statistically  in control.  The  process  capability  index,  Cpk.  of  core caplet  weight  uniformity: 1.375, and Paracetamol P® film-coated caplet dissolution: 1,841,Key  words  : Natural  variation,  assignable  variation,  Statistical  Process  Control,  P® filmcoated caplet
Potency of cinnamaldehyde of cinnamon oil as an antidiabetic compound ., Ngadiwiyana; ., Ismiyarto; Prasetya, Nor Basid A.; S., Purbowatiningrum R.
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (608.965 KB) | DOI: 10.14499/indonesianjpharm0iss0pp9-14

Abstract

Cafeic  and  cinnamic  compounds  have  been  reported  to give  an  excellent performance  as  α-glucosidase  inhibitor. Inhibition  of  α-glucosidase  in  the intestine of mammals are able to lower blood sugar  levels of the carbohydrates metabolism  so  it  can  reduce  postprandial  hyperglycemia  which  can  prevent chronic  complications  of  Diabetes  Mellitus  (DM). Based  on  cafeic  and  cinnamic structures in terms of organic chemistry and economic considerations, it can be offered  a  very  promising  alternative  to  provide  their  derivative  compounds  of cafeic  from  cinnamon  oil,  which  is  cinnamaldehyde.  Cinnamaldehyde  can  be isolated  from  cinnamon  oil  by  addition  of  sodium  bisulphite  to  provide  salt compounds  which  are  separated  easily  from  the  mixed system. The  aldehyde compound  can  be  obtained  by  acid  addition. Structure  elucidation  of cinnamaldehyde was done by mean of an infra red spectrophotometer and a gas chromatography-mass  spectroscopy. Activity  test  of  anti-diabetic  compounds was  carried  through  the  measurement  of  the  concentration  of  minimum resistance against α-glucosidase activity. Cinnamaldehyde which is isolated from cinnamon  oil  was  yellowish  oil  and  cinnamaldehyde’s yield  was  up  to  42.67%, and its purity was 99.8723%. Structure elucidation of cinnamaldehyde by mean of infra red spectrophotometer (FTIR) showed carbonyl vibration at 1676 cm-1, -C-H  aldehyde  at  2813.9  cm-1 and  2742.6  cm-1.  From  mass  spectra,  it  can  be known  that  cinnamaldehyde  had  M+ 132  with  m/z  of  main  fragmentation  were 131,  103,  77,  and  51.  Inhibition  activity  of  α-glucosidase  test  showed  that inhibitory concentration at 50 ppm of cinnamaldehyde was 93.29%, and IC50 to the α-glucosidase was 27.97 ppm.Key words :cinnamon oil, cinnamaldehyde, anti-diabetic 
Feasibility of transdermal transport of atenolol by combination of iontophoresis and oleic acid pretreatment Nugroho, Akhmad Kharis; Hakim, Arief Rahman; Laksitorini, Marlyn Dian; Rakhmatullah, Fajar; Masruriati, Eny
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (400.814 KB) | DOI: 10.14499/indonesianjpharm0iss0pp65-72

Abstract

Atenolol  has  a  low  oral  bioavailability  and  a  short  elimination  half-life. Therefore,  alternative  route  and  delivery  system  is  important.  Transdermal iontophoresis,  i.e.  a  systemic  drug  delivery  via  the  skin,  implementing  a  low intensity  of  electrical  current,  is  one  attractive  candidate.  This  study  evalu ated feasibility  of  atenolol  transdermal  transport  when  iontophoresis  is  applied  after enhancer  pretreatment.  There  were  4  formulas  prepared;  2  implemented iontophoresis  for  3  hours  (current  density:  0.25  mA/cm2)  while  the  others  did not  use  iontophoresis.  The  enhancer  was  oleic  acid  (5  or  10%  as  a  mixture  in propylene  glycol)  with  duration  of  pretreatment  of  one  hour.  Transport  was evaluated  in  the  diffusion  studies  across  the  fresh  rat  skin  in  a  static-vertical diffusion system. Data were analyzed based on the numeric convolution method to  obtain  simulated  Cp  profiles  as  well  as  AUC  of  Cp  profiles.  Based  on  the simulated Cp, the best transport was achieved in Formula 3, where iontophoresis is  performed  across  the  skin,  pretreated  with  5%  oleic  acid  for  one   hour.  The value  of  simulated  Cp  indicated  achievement  of  therapeutics  level  of  atenolol, suggesting the feasibility of the atenolol delivery by iontophoresis.Key words : atenolol, transdermal, iontophoresis, enhancer

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