Media Pharmaceutica Indonesiana
Published by Universitas Surabaya
ISSN : 25276208     EISSN : 25279017
Media Pharmaceutica Indonesiana (MPI) is a journal focusing on pharmaceutical aspects. MPI is dedicated to update and support the development of information and knowledge on pharmaceutical fields. This journal is published twice a year (June and December).
Articles
46
Articles
Sintesis Senyawa Turunan Amoksilin Dan Uji Aktivitas Antibakterinya Terhadap Bakteri Salmonella typhi

Siddiq, Hadi Barru Hakam Fajar, Rashati, Dewi, Nurmalasari, Dewi Riskha

Media Pharmaceutica Indonesiana (MPI) Vol 2 No 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

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Abstract

The synthesis of amoxicillin derivate has been done by reacting amoxicillin with 4-t-butylbenzoil chloride. The product was characterized by organoleptic test, melting point determination, TLC, UV/Vis Spectrophotometry, and FTIR Spectrophotometry. Antibacterial activity of amoxicillin derivative against Salmonella typhi were tested using dilution method. Result showed that the product has characteristic as follow: light yellow powder, bitter bite, melting point of 132 °C, Rf value of 0.86, pH value of 7.7, maximum wavelength (uv) of 286 nm. Moreover, FTIR spectra of amoxicillin derivate exhibited peaks at 3271 cm-1 (-NH amine), 2962 cm-1 (-CH aromatic), 1633 cm-1 (-C=O ketone), and other. Antibacterial test showed that amoxicillin derivate was unable to form a clear zone around the disc paper. Amoxicillin derivate cannot be used for the treatment of Salmonella typhi.

Analisis Kadar Merkuri dan Hidrokuinon dalam Kosmetik Krim Pemutih yang Dijual di Online Shop

Puspitasari, Adela

Media Pharmaceutica Indonesiana (MPI) Vol 2 No 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

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Abstract

Mercury and hydroquinone are chemicals that are often added in cosmetic skin whitening. Both of these chemicals inhibit the formation of melanin, a pigment to protect skin against the dangers of ultraviolet rays that can cause negative effects on the skin. The long-term use of mercury and hydroquinone cause various toxic effects such as kidney, nerve, and brain disorders as well as blood cancer and liver cancer. The purpose of this study was to analyze mercury and hydroquinone in whitening creams sold in online shops. Each analysis was carried out using the Atomic Absorption Spectrophotometer (AAS) and UV-Vis Spectrophotometer. The results showed that of the 15 samples tested, 4 samples contained mercury and hydroquinone, while 11 other samples only contained hydroquinone. From this study it can be concluded that the fifteen samples of whitening cream tested were not safe and did not meet the requirements of the Regulation of the Head of the Republic of Indonesia Drug and Food Control Agency No. 18 of 2015 concerning Technical Material Requirements for Cosmetics.

Hubungan Antar Faktor Penyebab Human Error Terhadap Jumlah Penyimpangan Produk Blister Di PT. XXX

Irfiani, Nurliya, Pradana, Aditya Trias, Winantari, Agnes Nuniek

Media Pharmaceutica Indonesiana (MPI) Vol 2 No 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

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Abstract

Human error is the main cause of blister product quality deviation at PT. XXX, which lead by personnel factor and work method. The research intends to analyze the relationship between personnel qualification level (blister production team), number of blister product and production length (Z blister machine), with blister product deviation at PT. XXX (2015-2017). The research was a descriptive-observational study (retrospective) by linier regression analysis using 2 variables and multi variable. The t-test analysis result between personnel qualification level and blister product deviation, p=0.041 (p<0.05) showed a significant relationship between those variables. The t-test analysis result between number of blister product and blister product deviation, p=0.164 (p>0.05) showed that there is no significant relationship between those variables. The result of t-test between production length (Z blister machine) and blister product deviation, p=0.542 (p>0.05) showed that there is no significant relationship between those variables. The F-test analysis result showed a significant relationship between personnel qualification level (blister production team), number of blister product and production length (Z blister machine) with blister product deviation (p=0,000; p<0.05).

Cost-Effectiveness Analysis Kloramfenikol Dan Seftriakson Untuk Pengobatan Demam Tifoid Pada Pasien Dewasa Di Rumah Sakit Sanglah Denpasar

Lorensia, Amelia, de Queljoe, Doddy, Swari Santi, Made Dwike

Media Pharmaceutica Indonesiana (MPI) Vol 2 No 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

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Abstract

The number of typhoid fever patient in Indonesia is still high. Typhoid fever can be treated by antibiotic therapy such as chloramphenicol and ceftriaxone. The purpose of this study was to compare the cost-effectiveness of chloramphenicol and ceftriaxone which was given to adult patients who were diagnosed with typhoid fever in Sanglah Denpasar Hospital. A comparative study between two alternatives was conducted using the hospital perspective. Retrospective method was used to collect data from patient medical records, who was diagnosed and hospitalized in Sanglah Denpasar Hospital during January 2017 until July 2018. The cost analysis was perform using cost-effectiveness grid and cost-effectiveness ratio (ACER) methods. Cost-effectiveness grid showed that dominant of ceftriaxone for patient with typhoid fever. ACER analysis for ceftriaxone was IDR 2,097,170.88 with effectivenes (length of stay) 4.27 days, and was IDR 2,097,170.88 with effectiveness (the time of reaching normal temperature) 2.42 days. ACER analysis for chloramphenicol was IDR 2,555,464.22        with effectivenes (length of stay) 10.22 days, and was IDR 2,555,464.22 with effectiveness (the time of reaching normal temperature) 3.44 days. ACER analysis showed lower degree of ceftriaxone and higher effectiveness based on length of stay and the time of reaching normal temperature. The conclusion of this study is that ceftriaxone is more cost-effective than chloramphenicol.

Induction of Flowering and Fruiting in Plantlets of Tomato (Lycopersicon esculentum Mill.)

savitri, wina dian, Florentinus W.N. Nurtyandi, Florentinus W.N., Hardjo, Popy Hartatie

Media Pharmaceutica Indonesiana (MPI) Vol 2 No 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

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Abstract

Tomato (Lycopersicon esculentum Mill.) is used as vegetable or fruit by people around the world. The effective and efficient propagation of tomato is needed due to the high demand, while its availability is not enough to meet the consumer demand. In vitro flowering and fruiting is useful in order to produce high quality hybrid seeds. Also, this can be produced in all seasons. Beside, this technique is beneficial to improve genetic diversity in tomato. In addition, tomato has natures that make it compatible as a plant model. This experiment intended to find the best combination of plant growth regulators or plant retardants  to induce flower and fruit from tomato plantlets. The results will be beneficial to overcome self-fertilization in tomato, as well as to promote higher genetic biodiversity in tomato. To do so, some plant growth regulators (6-Benzylaminopurine (BAP), Indoleacetic acid (IAA), and Gibberellin (GA3)) and retardants (Ancymidol and Paclobutrazol) were used to find the best combination in inducing in vitro flowering and fruiting. The results showed that 1 mg.L-1 BAP was the best candidate plant growth regulator to produce the in vitro flowers and fruits from the treated plantlets.

Metabolite Profiling Bagian Akar, Batang, Daun, dan Biji Helianthus annuus L. Menggunakan Instrumen UPLC-MS

Maslakhah, Fitrotun Nasikhatul, Mutiah, Roihatul, Hakim, Abdul, Aprinda, Risma, Suryadinata, Arief

Media Pharmaceutica Indonesiana (MPI) Vol 2 No 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

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Abstract

Sunflower (Helianthus annuus L.) is one of the plants that can be used for herbal medicine as antimalaria and antioxidant. To control the quality of plant as raw material of herbal medicine, we need to analyze the metabolites or chemical compounds found in the plant. One of the techniques for this purpose is the metabolite profiling. Chemical compounds in the plants are obtained from different metabolic processes in each plant organs. The purpose of this study was to obtain the metabolite profile data, to identify the marker and major  compound of roots, stems, leaves and seeds of sunflower using UPLC-MS. Each plant organ was extracted using 96% ethanol by the Ultrasound Assisted Extraction (UAE) method. Each extracts were then analyzed using the UPLC-MS instrument. The interpretation of the UPLC-MS chromatograms were then classified using multivariate Principal Component Analysis (PCA) to determine the grouping effects and characteristic compounds in each organ. Based on the research, it is known that metabolite profiles of roots, stems, leaves and seeds of sunflower were different and the concentration of major compounds in each part are 5.9490%; 5.5558%; 8.6758%; and 9.2150%,  respectively.

Uji Aktivitas Antioksidan Ekstrak Etanol Kayu Secang (Caesalpinia sappan) Menggunakan Metode DPPH, ABTS, dan FRAP

Setiawan, Finna, Yunita, Oeke, Kurniawan, Ade

Media Pharmaceutica Indonesiana (MPI) Vol 2 No 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

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Abstract

ABSTRAK: Perbedaan letak geografis suatu tanaman dapat menyebabkan perbedaan pada kandu–ngan kimianya. Kandungan kimia yang berbeda dapat menyebabkan perbedaan aktivitas farmakologitanaman, salah satunya adalah aktivitas antioksidan. Pada penelitian sebelumnya telah dilakukan berbagaipengujian antioksidan terhadap secang yang berasal dari beberapa lokasi baik di luar nege–ri maupun Indonesia. Oleh karena itu pada penelitian ini dilakukan pengujian aktivitas antioksidanekstrak etanol kayu secang (Caesalpinia sappan) yang berasal dari B2P2TOOT Tawangmangu. Metodeekstraksi yang digunakan dalam penelitian ini adalah soxhletasi dengan pelarut etanol 80%. Skri–ning fitokimia dilakukan untuk mengetahui kandungan kimia yang terdapat dalam ekstrak etanolkayu secang. Ekstrak tersebut menunjukkan hasil positif pada golongan glikosida flavonoid, flavonoidbebas, alkaloid, dan polifenol. Pengujian aktivitas antioksidan menggunakan metode peredaman radikalbebas DPPH, ABTS, dan FRAP. Trolox digunakan sebagai standar pembanding untuk menunjukkanaktivitas antioksidan. Hasil pengujian aktivitas ekstrak etanol kayu secang dan trolox menunjukkannilai IC50 masing-masing sebagai berikut: 101,47 dan 76,15 ppm (DPPH); 26,70 dan 19,38 ppm(ABTS); 11,37 dan 11,04 ppm (FRAP). Hal ini menunjukkan bahwa ekstrak etanol kayu secang memilikidaya antioksidan yang kuat. Polifenol dan flavonoid diduga memiliki peranan penting pada aktivitasantioksidan kayu secang.

Aktivitas Inhibisi Enzim Alfa-glukosidase dari Ekstrak Rimpang Bangle (Zingiber cassumunar Roxb.) secara In vitro

Yuniarto, Ari, Selifiana, Nita

Media Pharmaceutica Indonesiana (MPI) Vol 2 No 1 (2018): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

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Abstract

Diabetes mellitus merupakan penyakit kelainan metabolik yang ditandai dengan kondisi hiperglikemia.Salah satu obat yang dapat digunakan untuk menangani diabetes mellitus, khususnya untuk diabetesmellitus tipe II adalah akarbosa. Akarbosa dapat digunakan pada pasien dengan kadar gula post-prandialyang tinggi. Akarbosa bekerja dengan mekanisme menghambat aktivitas enzim alfa-glukosidase di dalamusus. Penghambatan yang terjadi pada enzim alfa-glukosidase menyebabkan penundaan absorpsi dan digestiglukosa. Maka, kenaikan kadar gula post-prandial dapat dicegah. Namun, penggunaan obat sintetik antidiabetesseperti akarbosa dalam jangka waktu panjang dapat memberikan beberapa efek samping, khususnyagangguan pada sistem saluran pencernaan. Oleh karena itu, penggunaan obat bahan alam sebagai terapialternatif dapat dipertimbangkan untuk digunakan. Salah satu tanaman di Indonesia yang memiliki potensisecara empiris sebagai antidiabetes adalah bangle (Zingiber cassumunar). Penelitian ini bertujuan untuk mengujiaktivitas penghambatan terhadap enzim alfa-glukosidase dari ekstrak etanol rimpang bangle. Hasil IC50yang didapatkan dari uji aktivitas penghambatan enzim alfa-glukosidase adalah 98,31 μg/ml. IC50 akarbosasebagai pembanding adalah 36,17 μg/ml. Berdasarkan hasil penelitian yang didapatkan, dapat disimpulkanbahwa ekstrak etanol rimpang bangle memiliki potensi yang sangat baik untuk dikembangkan dan dipertimbangkanlebih lanjut sebagai kandidat obat antidiabetes, khususnya untuk mengobati diabetes mellitus tipe II.

Efektivitas Antibiotik Golongan Sefalosporin Generasi Ke-3 Dibandingkan Fluroquinolon Terhadap Pasien Infeksi Saluran Kemih di RS PKU Muhammadiyah Yogyakarta

Baso, F F, Perwitasari, D A, Risdiana, I

Media Pharmaceutica Indonesiana (MPI) Vol 2 No 1 (2018): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

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Abstract

Salah satu penyakit infeksi yang banyak dijumpai di rumah sakit adalah infeksi salurankemih. Pemilihan antibiotik yang tidak tepat dapat menyebabkan pertumbuhan resistensi dan multipelresistensi mikroba terhadap antibiotik yang berdampak pada meningkatnya morbiditas, mortalitas,dan biaya kesehatan. Penelitian ini bertujuan untuk mengevaluasi efektivitas dan perbandinganlama rawat inap antibiotik golongan sefalosporin generasi ke-3 dan fluoroquinolon di instalasi rawatinap RS PKU Muhammadiyah Yogyakarta. Penelitian ini menggunakan rancangan kohort retrospektifpada pasien ISK periode Januari 2015 – Desember 2017. Semua data pasien yang memenuhi kriteriainklusi diambil dari catatan rekam medis pasien. Berdasarkan hasil penelitian, sebanyak 66 pasienISK, 90,9% didominasi oleh perempuan dan 53% didominasi oleh kelompok berumur >60 tahun.Kedua golongan antibiotik tidak menunjukkan perbedaan bermakna terhadap luaran terapi muntah(p=0,178), nyeri pinggang (p=1,000), nyeri berkemih (p=0,587), dan lama rawat inap (p=0,364). Sedangkankedua golongan antibiotik menunjukkan perbedaan bermakna terhadap luaran terapi suhubadan (p=0,001) dan lekosit urin (p=0,001). Antibiotik golongan fluoroquinolon memiliki rata-ratalama rawat inap lebih cepat 5,42 hari dibandingkan golongan sefalosporin generasi ke-3. Efektivitasantara kedua kelompok menunjukkan perbedaan yang bermakna (p<0,05) terhadap suhu badan danlekosit urin, namun kedua kelompok tidak menunjukkan perbedaan yang bermakna (p>0,05) terhadapluaran terapi muntah, nyeri pinggang, nyeri berkemih, dan lama rawat inap.

Studi Farmakokinetika Teofilina Setelah Pemberian Oral Dosis Tunggal Tablet Teofilina dan Aminofilina Lepas Kendali pada Subyek Normal

Parfati, Nani, Chandra, Jenny, Sia, Tan Kiauw, Queljoe, Doddy de, Kardjito, Thomas

Media Pharmaceutica Indonesiana (MPI) Vol 2 No 1 (2018): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

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Abstract

Telah dilakukan penelitian untuk mempelajari farmakokinetika dari teofilina setelahpemberian oral dosis tunggal tablet teofilina dan aminofilina lepas kendali pada subyek normal. Ta–blet teofilina (dosis 300 mg) dan aminofilina (dosis 350 mg) lepas kendali diberikan dalam bentukoral dosis tunggal, pada pria normal (20-30 tahun, 50-75 kg), tidak merokok, dengan fungsi paruparu,hati, ginjal dan jantung normal. Kadar teofilina serum ditentukan dengan metode FlourescencePolarization Immunoassay (FPIA). Parameter farmakokinetika yang diamati meliputi: t maks, Cpmaks, AUC, tetapan laju absorpsi (Ka) dan eliminasi (K) serta t ½ eliminasi. Hasil penelitian menunjukkanbahwa profil kurva kadar teofilina serum terhadap waktu untuk tablet teofilina (AUC=97,56μg/ml jam, Cp maks=5,83 μg/ml, Ka=0,209 jam-1, t maks=4 jam, K=0,080 jam-1, dan t½=8,87 jam)dan aminofilina (AUC=121,93 μg/ml jam, Cp maks=6,70 μg/ml, Ka=0,239 jam-1, t maks=6,8 jam,K=0,061 jam-1, dan t½=11,51 jam) lepas kendali sesuai dengan profil farmakokinetika sediaan lepaskendali pada umumnya.