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INDONESIA
Indonesian Journal of Tropical and Infectious Disease
Published by Universitas Airlangga
ISSN : 20851103     EISSN : 23560991     DOI : -
This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and elimination. The journal is intended for scientists, clinicians, and professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists in academia, industry, clinical practice, public health, and pharmacy, as well as from specialists in economics, social sciences and other disciplines.
Articles 7 Documents
Search results for , issue " VOL 6, NO 5 (2017)" : 7 Documents clear
INTEGRATING THE ROLES OF STAKEHOLDERS IN PREVENTING THE HIV/AIDS TRANSMISSION IN EAST JAVA, INDONESIA Koesbardiati, Toetik; Kinasih, Sri Endah; Mas’udah, Siti
Indonesian Journal of Tropical and Infectious Disease VOL 6, NO 5 (2017)
Publisher : Institute of Topical Disease

Show Abstract | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v6i5.4792

Abstract

HIV/AIDS prevention is very important and absolutely necessary. HIV transmission is now entering a fairly alarming level, in which people with HIV/AIDS in certain subpopulations are emerging. Special steps and resources are thus needed to cope with the condition. There are some phenomena potentially encourage HIV transmissions, such as the increasingly common free sex, homosexuality, the use of unsafe and unsterile syringes in narcotics consumption, commercial sex workers and various high-risk sexual activities. One of the crucial concerns that arises when sending prostitutes back to their hometowns without any coordinated and holistic mechanism is that the prostitutes may cause the spreading of HIV/AIDS in their hometowns. The research objective is to provide the material (input) how the prostitutes themselves may cause the spreading of HIV/AIDS. The research employed descriptive method with a qualitative approach. The results showed that the implementation and the role division in the closure have been highly coordinated and holistic. The leading sector in the role division is the Social Welfare epartment of the Government in Surabaya. In terms of health aspects for the former prostitutes sent back to their hometowns, there has been no policies related to medical screening designed to identify the disease early. Screening is very important for early diagnosis during the post-closure phase. The screening mechanism is that the Provincial Health Department has to optimize the monitoring, coordination, cooperation, agreements and partnerships with stakeholders such as the Local Health Department and the National/Provincial/Distric AIDS Commission, NGOs that are concerned with the problems of HIV-AIDS, international organizations, professional organizations, community leaders, religious leaders and universities.
IJTID FRONT MATTER IJTID, Editor
Indonesian Journal of Tropical and Infectious Disease VOL 6, NO 5 (2017)
Publisher : Institute of Topical Disease

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Abstract

AN EVALUATION STUDY OF ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA) USING RECOMBINANT PROTEIN GRA1 FOR DETECTION OF IgG ANTIBODIES AGAINTS TOXOPLASMA GONDII INFECTIONS Muflikhah, Nina Difla; Artama, Wayan Tunas
Indonesian Journal of Tropical and Infectious Disease VOL 6, NO 5 (2017)
Publisher : Institute of Topical Disease

Show Abstract | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v6i5.5903

Abstract

Toxoplasmosis is an infectious disease caused by Toxoplasma gondii, an intracellular protozoan parasite that live inside the cells of the reticulo endothelial and parenchymal cells of human and animals (mammals and birds). Some cases of toxoplasmosis usually have no symptoms, but in any cases caused severe symptoms, such as hydrocephalus, microcephalus, intracranial calcification, retinal damage, brain abscess, mental retardation, lymphadenopathy, and others. Its severe symptoms usually showed a long time after first exposure, except symptoms showed by congenital transmission caused by infected mother. Early diagnosis is important to prevent the illness but methods for toxoplasmosis screening are still too expensive for developing country. Enzyme-linked immunosorbent assay (ELISA) allow the testing of a large number samples within short time frame and based on antibody or antigen detection. This study aimed to know the sensitivity and specificity of recombinat protein GRA1 as antigen using ELISA methods. We tested the sensitivity and spesificity of GRA1 protein as antigen in ELISA methods to diagnose toxoplasmosis and compared with ELISA Kit Commercial. Reliable laboratory testing is important to detect Toxoplasma gondii infection, and focused to improving the low cost and easy-to-use diagnostic instrument. Seventy sera collected and tested using both indirect ELISA, commercial ELISA kit and GRA1 protein coated as antigen. Fourty eight and fifty one samples showed positive IgG antibody result of ELISA-GRA1 and ELISA kit. Negative sample tested by ELISA-GRA1 was 22 samples and 19 sample tested by ELISA Kit. The sensitivity and specificity of GRA1-based on ELISA were 100% and 86.36%, positive prediction value (ppv) was 94.11%. These data indicate that the recombinant protein GRA1 is a highly immunogenic protein in human toxoplasmosis and become a promising marker for the screening of toxoplasmosis.
IJTID BACK MATTER IJTID, Editor
Indonesian Journal of Tropical and Infectious Disease VOL 6, NO 5 (2017)
Publisher : Institute of Topical Disease

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Abstract

RELATIONSHIP BETWEEN GROWTH RATE AND DIFFERENT TYPES OF INFECTION IN CHILDREN UNDER 5 YEARS ON WEST PAPUA Pratomo, Fransiskus Aryo
Indonesian Journal of Tropical and Infectious Disease VOL 6, NO 5 (2017)
Publisher : Institute of Topical Disease

Show Abstract | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v6i5.5180

Abstract

Malnutrition is still a significant problem in the world and in Indonesia. Among the factors underlying it, the role of growth faltering is often underestimated. Considering infection as a factor that affects growth and that Indonesia is endemic to various different infectious diseases, to understand its role, a study on infants is conducted using using longitudinal study design in the Sumuri District, Bintuni Bay Regency, West Papua Province. A total of 138 children aged 6 months to 5 years is followed for 6 months in February to August 2014. Weight gain data and frequency of infection is collected, with the infections divided into four category of disease: upper respiratory tract infection, skin infection, gastroenteritis, and malaria. These data are gathered by Puskesmas daily and monthly records followed by home visit. This study found that the prevalence of malnutrition for the area covered by Puskesmas Tanah Merah is 15.9% for moderate malnutrition and 2.9% for severe malnutrition, with the mean SD value in the beginning of the study -1.15 and at the end of study -1.12, with the difference of SD value calculated as weight gain. Total incidence of infections and mean duration of each infection is then compiled and calculated with weight gain data using linear regression method statistical test to understand the difference of role of each infection to weight gain. The result of the study shows that gastroenteritis has a significant negative effect to weight gain and upper respiratory tract infection has a negative effect to weight gain on children in the villages handled by Puskesmas Tanah Merah West Papua.
NO ASSOCIATION OF RECURRENT RESPIRATORY PAPILLOMATOSIS AGGRESSIVENESS AND HUMAN PAPILLOMAVIRUS TYPE 6 AND 11 Perdana, Rizka Fathoni; Herawati, Sri; Suroso, Bakti; Aksono, Eduardus Bimo
Indonesian Journal of Tropical and Infectious Disease VOL 6, NO 5 (2017)
Publisher : Institute of Topical Disease

Show Abstract | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v6i5.3705

Abstract

Recurrent Respiratory Papillomatosis (RRP) is the most common benign neoplasm of the larynx among children as a result of HPV infection mainly type 6 and 11. RRP is still considered as serious problem since papilloma in the airway can cause hoarseness and obstruction which later described as aggressive and non aggressive types. Patients underwent multiple surgeries to keep airway patency and in order to communicate vocally. Previous studies reported that HPV-11 was associated with a more aggressive disease course. This study aim is to determine the association of RRP aggressiveness with HPV-6 and 11. Papilloma specimens were taken from patients who underwent surgical treatment of RRP patients and subjected HPV typing. All 17 patients with completed data and epidemiologic questionaires were defined for their staging to disease severity. Informations in the database were analyzed to identity statistically significant relationship with HPV type and knowing the HPV type is to predict the disease course. 17 patients RRP (12 males and 5 females) with age at onset 3,15 + 2,28 years and age at diagnosis 3,81 + 2,51 years. Surgery was performed 2,71 ± 1,16 times per year and 9 patients treated more than 3 surgeries per year. 10 patients had distal papilloma and 11 patients had tracheotomy. Agrressive disease was show found in 14 patients among 17 patients. HPV-11 was detected in 10 patients, HPV-6 was detected in 7 patients. According to the statisitcal analysis (Chi square test), there is no relationship between HPV type and disease aggressiveness. HPV-6 and 11 are not the only cause that affect the aggressiveness of Recurrent Respiratory Papillomatosis.
ANTIMICROBIAL ACTIVITY OF PINEAPPLE (ANANAS COMOSUS L. MERR) EXTRACT AGAINST MULTIDRUG-RESISTANT OF PSEUDOMONAS AERUGINOSA: AN IN VITRO STUDY Zharfan, Rahmat Sayyid; Purwono, Priyo Budi; Mustika, Arifa
Indonesian Journal of Tropical and Infectious Disease VOL 6, NO 5 (2017)
Publisher : Institute of Topical Disease

Show Abstract | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v6i5.4159

Abstract

Pseudomonas aeruginosa is the main cause of nosocomial infection which is responsible for 10% of hospital-acquired infection. Pseudomonas aeruginosa tends to mutate and displays potential for development of antibiotic resistance. Approximately, 10% of global bacterial isolates are found as Multidrug-resistant Pseudomonas aeruginosa. Pseudomonas aeruginosa have a quite tremendous severity index, especially on pneumonia and urinary tract infections, even sepsis, which 50% mortality rate. Pineapple (Ananas comosus L. Merr) has antimicrobial properties. The active antimicrobial compounds in Ananas comosus L. Merr include saponin and bromelain. This research aims to find the potency of antimicrobial effect of pineapple (Ananas comosus L. Merr) extract towards Multidrug-resistant Pseudomonas aeruginosa. Multidrug-resistant Pseudomonas aeruginosa specimen is obtained from patient’s pus in orthopaedic department, Dr Soetomo Public Hospital, Surabaya. Multidrug-resistant Pseudomonas aeruginosa specimen is resistant to all antibiotic agents except cefoperazone-sulbactam. This research is conducted by measuring the Minimum Inhibitory Concentration (MIC) through dilution test with Mueller-Hinton broth medium. Pineapple extract (Ananas comosus L. Merr.) is dissolved in aquadest, then poured into test tube at varying concentrations (6 g/ml; 3 g/ml; 1.5 g/ml; 0.75 g/ml, 0.375 g/ml; and 0.1875 g/ml). After 24 hours’ incubation, samples are plated onto nutrient agar plate, to determine the Minimum Bactericidal Concentration (MBC). The extract of pineapple (Ananas comosus L. Merr) has antimicrobial activities against Multidrug-resistant Pseudomonas aeruginosa. Minimum Inhibitory Concentration (MIC) could not be determined, because turbidity changes were not seen. The Minimum Bactericidal Concentration (MBC) of pineapple extract (Ananas comosus L. Merr) to Multidrug-resistant Pseudomonas aeruginosa is 0.75 g/ml. Further study of in vivo is needed.

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