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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558393     EISSN : 2599056X     DOI : -
Core Subject : Education,
Folia Medica Indonesiana publishes articles in the field of medical science in particular and health sciences in general, as well as a variety of other fields related to those two disciplines. Most of the articles are research article, and others are articles on case reports and literature review. In their presentation in the journal, the articles have passed meticulous editing process by the editors and review process and by competent peer reviewers, with national and international reputation, making the articles presented in this journal qualified, updated, and informative.
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Articles 205 Documents
SUB-ACUTE STENT THROMBOSIS AND IN-STENT RESTENOSIS ASSOCIATED WITH ANTIPLATELETS CLOPIDOGREL RESISTANCE AND PROTEIN S DEFICIENCY Kurniawan, M Zakky; Pratanu, Iswanto
Folia Medica Indonesiana Vol 51, No 4 (2015): Oktober - December 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v51i4.2949

Abstract

Protein S deficiency and antiplatelets clopidogrel resistance may uncommonly be responsible for coronary artery thrombosis. Hereby we report a patient presented with coronary disease, who had undergone PCI. However, two days later the patient was found in-stent thrombosis. Primary PCI was performed later with good result, but after 4 months evaluation with treadmill test we found significant ST depression in related region. It was suspected the patient had in-stent re-stenosis incidence. Further hematologic investigation showed that this patient had antiplatelets clopidogrel resistance and protein S deficiency. Double antiplatelet with another kind of antiplatelets and anticoagulant had given in this case. However, the remaining consideration is the choice for reperfusion strategy.
MICROBIAL PATTERN AND ANTIBIOTIC SENSITIVITY TEST OF HOSPITALIZED CHILDREN Wiwin, John; Sri Rejeki, IGAA Putri
Folia Medica Indonesiana Vol 51, No 3 (2015): July - September 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v51i3.2837

Abstract

Infection often occurs in children with malignant hematology and causes morbidity and mortality in the children. Antibiotics given must be based on culture results and antibiotic sensitivity testing. This study was aimed to obtain the microbial pattern and sensitivity test in children hospitalized in the Hemato-Oncology Ward,  dr. Soetomo Hospital from September 2012 - February 2013. This was a descriptive study. Data were obtained from the  patients’ medical records  in Dr. Soetomo Hospital. There were 341 culture examinations (blood, urine, rectum swab, faecal, and others) from 88 patients (44 males and 44 females). Most of patients´ age was < 5 years (58%) and suffered from ALL (50%).There were microbial (83 of culture) and yeast (15 of culture) growth out of 98 cultures. Escherichia coli, Burkholderia cefacea, and Klebsiella oxytoca (Gram negative) dan CONS, Stapyloccocus aureus, and Stapylococcus sapropyticus (gram positive) were found in blood culture. S. aureus (gram positive) and E. coli, Klebsiella pneumoniae, and B. cefacea (gram negative) were found in urine culture. Only E. coli was found in rectal swab culture. CONS of gram positive cocci were mostly found in blood culture of children hospitalized in Hemato-Oncology Ward, Dr. Soetomo Hospital. E. coli was the mostly found gram negative rods. Gram positive cocci showed a high resistant to penicillin and co-trimoxazole. E. coli, mostly found in rectal swab and urine, has a high sensitivity to amikacin and meropenem, but highly resistant to  ampicillin and ampicillin sulbactam.
EFFECTIVENESS OF Betta splendens AS A BIOLOGICAL PREDATORY AGAINST Aedes aegypti LARVAE Permata, Saniya Hanum; Yotopranoto, Subagyo; Kusmartisnawati, Kusmartisnawati
Folia Medica Indonesiana Vol 51, No 4 (2015): Oktober - December 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v51i4.2857

Abstract

Dengue Hemorrhagic Fever (DHF) is caused by dengue virus and transmitted by Aedes aegypti mosquito. There are several fish species known to be used as a biological predator of Aedes aegypti larvae, such as Betta splendens. The purpose of this study was to examine Betta splendens as a biological predator of Aedes aegypti larvae. The larvae used were in the fourth stage. The Betta splendens consisted of four replicate groups, 3 and 6 months male age group, and 3 and 6 months female age group. The effectiveness rate of predation was only counted based on the speed of eating of 25 larvae in the aquarium containing 3 liters of water. Statistical test was performed with Annova with the parameters fish body weight and time to prey. The longest mean of preying time was found in 3 months aged male fish group (mean body weight = 1.474 grams), with a mean time of prey = 153.80 seconds. The shortest mean preying time was found ini 6 months aged female fish group (mean body weight = 2.566 grams), with a mean time of prey = 142.41 seconds. In conclusion, female 6 month-aged fish with highest mean body weight is most effective againts Aedes aegypti larvae. The body weight can affect the speed of preying, but body weight is only one of some variables that affect the speed and effectiveness beside gender and age of Betta splendens.
ANTIBODY ANTI-DENGUE PROFILE IN DENGUE HEMORRHAGIC FEVER PATIENTS AT DR. SOETOMO HOSPITAL, SURABAYA Waskito, Langgeng A; Notopuro, Paulus B; Endraswari, Pepy Dwi
Folia Medica Indonesiana Vol 51, No 3 (2015): July - September 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v51i3.2830

Abstract

Dengue hemorrhagic fever is one infectious diseases that have high case fatality rate in Indonesia. The aim of this study was to descibe the antibody anti-dengue profile in dengue hemorrhagic fever patients at Dr. Soetomo Hospital Surabaya. This study was epidemiological descriptive study to aims prevalence primary and secondary infection of dengue hemorrhagic fever and its clinical appearances. This study used 85 samples by taking medical record data of IgM and IgG anti-dengue serologic test from Internal Medicine Department, Dr. Soetomo Hospital, Surabaya, between January to December 2010. The data were collected and analyzed in diagrams and tables. Result of this study showed 25 (29,4%) patients had positive IgM serologic test, 14 (16,4%) patients had positive IgG serologic test and 46 (54,2%) patients had positive IgM and IgG serologic test. In primary infections, the history of fever was 3.8±1.2 days; platelet counts 58,6±21,4/ml and bleeding sign 37% of 25 patients. In secondary infections, the history of fever was 4.28±1.15 days; platelet count was 44,17±24,2/ml and bleeding sign 52% of 60 patients. In conclusion, patients with secondary infection have higher prevalence than primary infection. Then in secondary infection had more severe clinical appearance than primary infection.
THE USE OF HYDROXYETHYL STARCH 200/0,5 AS PLASMA SUBTITUTES IS SAFE IN HYPOVOLEMIC PATIENTS AS INDICATED IN CHANGES OF N-ACETYL--GLUCOSAMINIDASE AND CREATININ SERUM PARAMETERS Shinta, Dewi Wara; Khotib, Junaidi; Rahardjo, Eddy; Rahmadi, Mahardian; Suprapti, Budi
Folia Medica Indonesiana Vol 51, No 4 (2015): Oktober - December 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v51i4.2852

Abstract

Hydroxyethyl Starch (HES) is a compound that improves intravascular volume effectively and rapidly without causing tissue edema. However, HES also has renal safety profile which is still being debated. Based on clinical experience in Dr. Soetomo Hospital, the frequency of acute renal failure following HES 200/0.5 administration at a dose of less than 20 ml/kg (maximum dose) is very rare. The purpose of this study was to evaluate the effect of HES 200/0.5 at a dose of less than 20 ml/kg in patients undergoing surgery. N-acetyl-b-D-Glucosaminidase (NAG) per urine creatinine ratio and creatinine serum were used as main parameter to assess renal injury. This research was observational and prospective design in patients undergoing elective surgery at Gedung Bedah Pusat Terpadu, Dr. Soetomo Hospital, who requiring resuscitation therapy with HES 200/0.5 and met the inclusion and exclusion criteria. NAG was measured prior to surgery and 12 hours after administration of fluid therapy, while creatinine serum was observed before surgery and 48 hours after resuscitation. This study was conducted for three months, and obtained 50 subjects divided into 2 groups, crystalloid group and HES 200/0.5 group. Demographic and baseline characteristics did not differ between groups, except the total bleeding volume. Total bleeding in HES 200/0.5group was higher than crystalloid group (p <0.0001). The mean volume of fluid received in HES 200/0.5 group was 2042.0 ± 673.9 mL, higher when compared with that of crystalloid group (910.0 ± 592.0 ml). Doses of HES 200/0.5 received was 8.31 ± 4.86 ml/kg. Measurement of the of NAG/creatinine ratio and creatinine serum showed significant increase in both groups, but still within the normal range. In addition, the value of these two parameters did not differ between groups. In conclusion, HES 200/0.5 in a dose of less than 20 ml/kg is safe to use in patients who suffered from hypovolemic hemorrhage, without prior history of renal impairment.
RESISTANCE OF Escherichia coli FROM RECTAL SWAB CULTURE IN HEMATO-ONCOLOGY WARDS, DR. SOETOMO HOSPITAL, SURABAYA Rusanti, Rahmi; Sri Rejeki, IGAA Putri
Folia Medica Indonesiana Vol 51, No 3 (2015): July - September 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v51i3.2838

Abstract

Malignant hematology patients in the hospital are particularly susceptible to infection associated with endogenous microorganism originating from their own body. The most common etiology of infection is bacteria from gastrointestinal tract. Escherichia coli is a gram-negative facultative anaerobic bacteria, and part of the intestinal normal flora. However, E. coli is the most common cause of nosocomial infection. Resistance of E. coli to antibiotics has been widely reported. The aim of this study was to identify the development of antibiotic resistant properties of Escherichia coli from rectal swab of malignant hematology pediatric patients. A descriptive study of collected secondary data on sensitivity test results was done in the hematology-oncology pediatric ward, Dr. Soetomo Hospital from October 2012 to March 2013. There were 20 results of antibiotic susceptibility testing on positive Escherichia coli cultures from rectal swabs. The highest resistance levels were found towards cotrimoxazol, ampicillin sulbactam and cefotaxime. Escherichia coli with extended-spectrum b-lactamase (ESBL) was also found. Escherichia coli from rectal swabs of malignant hematology pediatric patients were shown to be resistant to cotrimoxazol, ampicillin sulbactam and ampicillin.
CHARACTERISTICS OF HELLP SYNDROME IN SEVERE PREECLAMPSIA PATIENTS IN DR. SOETOMO HOSPITAL SURABAYA P, Warih Angesti; Ernawati, Ernawati; Susanti, Dwi
Folia Medica Indonesiana Vol 51, No 4 (2015): Oktober - December 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v51i4.2858

Abstract

Hemolysis, elevated liver enzyme, and low platelet count syndrome (HELLPs) is complication following severe preeclampsia which is one of the three leading causes of maternal mortality in Indonesia. The purpose of this study was to understand the prevalence, characteristics, and post-partum outcome of HELLPs patients who deliver in Dr. Soetomo Hospital in July 2012-June 2013. This study was observational-descriptive, cross sectional study. The population observed was the severe preeclampsia patients who deliver in Dr. Soetomo Hospital and have complete medical data in July 2012-June 2013. study subject taken by total sampling. HELLPs follow the 7% of severe preeclampsia patients. The maternal average age of HELLPs group was 30.2 (19-43), while in non-HELLPs was 30.8 (17-46). Most HELLPs patients were in the first and second pregnancy. The average of gestational age at labor in HELLPs was 33-34 weeks. Both in HELLPs and non-HELLPs most performed Cesarean Section delivery. No post-partum maternal mortality found in HELLPs, but 25% had stillbirth. The average of birth weight in HELLPs was 1994.4 g. First minute Apgar score >7 was 33.3% in HELLPs group. In conclusion, Most HELLPs patients were in the first and second pregnancy, while non-HELLPs were in first pregnancy. The average of gestational age at labor was lower in HELLPs group. Neonates mortality were higher in HELLPs group. The average of birth weight was lower in HELLPs group. First minute Apgar score > 7 was higher in non-HELLP group.
PROFILE OF TYPE II DIABETES MELLITUS WITH CENTRAL OBESITY IN DR. SOETOMO HOSPITAL Munir, Misbakhul; Sutjahjo, Ari; Sustini, Florentina
Folia Medica Indonesiana Vol 51, No 3 (2015): July - September 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v51i3.2831

Abstract

Obesity, especially central obesity is often associated with insulin resistance and type 2 diabetes mellitus. Diabetes mellitus is a disease of the number six cause of death in Indonesia with the proportion of deaths by 5.8%. The purpose of this study was to identify central obesity in patients with type 2 diabetes mellitus in Poly Endocrine Dr. Soetomo Hospital, Surabaya. The study design was descriptive study. The sample was 100 type 2 diabetes mellitus patients taken with purposive sampling technique. The variable was central obesity and type 2 diabetes mellitus. The data obtained by interviewing patients and performing measurements on body weight, height and waist circumference. Data were analyzed by interpreting how the description of the variables studied and compared with other studies and theories. The results was the characteristics of patients most were female (66%), level of education was medium, unemployment, most of patient’s age was more than 50 years old, 43% for interval 51-60 years old, 43% were 1,50-1,59 meters in height and 28% were 50-59 kilograms and 28% were 60-69 kilograms in weight. According to Body Mass Index (BMI) measure that 54% the patients are normal in average 25,56 8,12 kg/m2. Measurement of waist circumference showed that 73.5% male and 81.8% female patients had central obesity. The conclusions, precentage of patients with type II diabetes mellitus who have central obesity were 81,82% female and 73, 53% male.
C-REACTIVE PROTEIN (CRP) AS A SUPPORTING MARKER OF ANTIBIOTIC EFFECTIVENESS ON CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS Olevianingrum, Melawati; Yulistiani, Yulistiani; Saharso, Darto; Zairina, Nun
Folia Medica Indonesiana Vol 51, No 3 (2015): July - September 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.093 KB) | DOI: 10.20473/fmi.v51i3.2821

Abstract

Infection of the central nervous system in pediatric patients have a high mortality as well as acute and chronic neurological sequelae. Signs of the disease are unclear, so cerebrospinal fluid (CSF) test is used as a gold standard for diagnosis, but the investigation has faced many obtacles. Empiric antibiotic therapy is the key factor in reducing morbidity and mortality. Microbiological culture result is obtained within 5-7 days. The effectiveness of empirical antibiotic use is questionable. Therefore, other investigations are conducted to determine the effectiveness of antibiotics by using one marker, the CRP. This study was to analyze CRP level in supporting antibiotic therapy effectiveness in pediatric patients with central nervous system (CNS) infections. A prospective cohort study was conducted to determine the relationship of CRP with other parameters, including clinical, microbiological and laboratory, in pediatric patients with central nervous system infections. Patients meeting blood samples criteria were taken before (H0), the third day (H3) and the fifth day (H5) after antibiotics administration. This study involved 10 patients with central nervous system infections (meningoencephalitis, encephalitis and encephalitis with cerebral edema). Six patients were male, with ages less than a year. Antibiotic treatment effectiveness was associated with improved condition of the patients' CRP level. It was 3.558 ±3.196 before (H0), 3.878±2.813 on the third day (H3) and 3.891±2.204 on the fifth day (H5) after antibiotic administration. Leukocyte levels were 13.680±1.660 before (H0), 17.832±7.213 on the third day (H5), and 10.546±3.671 on the fifth day (H5) after antibiotic administration. Pearson's correlation test analysis performed on CRP and WBC parameters showed H0 p=0.981, CRP and WBC H3 p=0.621, while CRP and WBC H5 obtained significance p=0.644. There was no significant correlation observed between CRP and WBC parameters before and after antibiotic administration. In conclusion, there was no correlation of CRP levels with clinical, laboratory and micobiological parameters in patients with central nervous system infections.
ETHANOL EXTRACT OF MANGOSTEEN PEEL REDUCES HISTOLOGICAL COUNT OF ALVEOLAR MACROPHAGE AND PULMONARY ALVEOLAR SPACE SIZE IN MALE WHITE RATS (Rattus norvegicus) EXPOSED TO CIGARETTE SMOKE Santoso, Anna Lewi
Folia Medica Indonesiana Vol 51, No 4 (2015): Oktober - December 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v51i4.2853

Abstract

This study aims to analyze histological alveolar macrophage cell number and width of pulmonary alveolar space white male rats given ethanol extract of mangosteen peel and then exposed to cigarette smoke. Smoking can reduce antioxidant and increases free radicals, so it is recommended increasing the antioxidants found in many mangosteen rind. This research was an experimental laboratory using the randomized post test-only control group design. White rats male were chosen randomly into 5 groups (K1, K2, P1, P2, P3). K1 (control-), only the Na-CMC 0.5%, K2 (control+) given Na-CMC 0.5% solution and smoke, P1, P2, P3 given the ethanol extract of mangosteen rind (50, 100, and 200mg/kg wt) and smoke. The data were tested normality and homogenity. Then they were analyzed with one-way Anova, LSD. Data that are not normally tested with Robust tests – (Brown-Forsythe) and Tamhane’s. Correlation test with Pearson and Spearman. Robust test results, the number of alveolar macrophages, value p=0.000 (p<a). Tamhane’s test results K1 significant with P1, P2, P3. P1 significant with P3. Spearman correlation test negative correlation between dose and the number of alveolar macrophage also negative correlation between dose and pulmonary alveolar space. Anova test results, the average variable width of the alveolar spaces, value p=0.000 (p<a). LSD test results are significant differences between the groups, except the group P1 to P2, P3 and P2 to P3. Conclusions of this study is the ethanol extract of mangosteen peel can reduce the number of alveolar macrophage cells and reduce the width of pulmonary alveolar space white male rats were exposed to cigarette smoke.

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