Berkala Ilmu Kesehatan Kulit dan Kelamin
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Penatalaksanaan Kandidiasis Mukokutan pada Bayi

Kusumaputra, Bagus Haryo, Zulkarnain, Iskandar

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Original Source | Check in Google Scholar | | DOI: 10.20473/bikkk.V26.2.2014.1-7

Abstract

Latar belakang: Bayi memiliki risiko lebih tinggi terhadap cedera kulit, absorbsi kulit, dan infeksi kulit. Kandidiasis mukokutan pada bayi dapat berupainfeksi yang paling umum seperti kandidiasis oral dan ruam popok, sampai berupa infeksi serius yang berpotensi menjadi infeksi sistemik, seperti kandidiasis kongenital dan dermatitis fungal invasif. Infeksi mukokutan pada bayi prematur dapat menjadi permulaan infeksi sistemik sehingga membutuhkan perhatian khusus.Tujuan: Memberikan pengetahuan mengenai kandidiasis mukokutan pada bayi yang meliputi etiopatogenesis dan manifestasi klinis, sehingga diharapkan dapat memberikan pengobatan yang lebih baik. Telaah kepustakaan: Lokasi utama kontak dengan kandida pada bayi baru lahir yang tersering adalah mukokutan, termasuk saluran pencernaan, pernapasan, dan kulit. Faktor predisposisi kandidiasis meliputi faktor mekanik, nutrisi, perubahan fisiologis, penyakit sistemik, dan faktor iatrogenik. Diagnosis kandidiasis mukokutan berdasarkan pemeriksaan klinis ditunjang dengan pemeriksaan mikroskop langsung dan kultur. Pengobatan kandidiasis mukokutan pada bayi meliputi pengobatan topikal dan sistemik. Golongan antijamur topikal yang digunakan pada kandidiasis antara lain imidazol dan poliene, sedangkan pengobatan antijamur sistemik meliputi flukonazol dan amfoterisin B. Simpulan: Pengobatan kandidiasis mukokutan pada bayi sebagian besar menggunakan obat topikal. Pengobatan sistemik digunakan bila terapi topikal gagal atau pada infeksi kandida yang terdapat gejala sistemik.Kata kunci: kandidiasis mukokutan, bayi, tatalaksana.

Retrospective Study of Skin Prick Test in Atopic Dermatitis Patients at DermatoVenereology Outpatient Clinic of Dr. Soetomo General Hospital Surabaya During 2007-2012

Natallya, Fransiska Rismauli, Barakbah, Jusuf

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Original Source | Check in Google Scholar | | DOI: 10.20473/bikkk.V27.1.2015.9-16

Abstract

Background: Atopic dermatitis (AD) gives impact on quality of life of patients because of  frequent exacerbation. Various factors play a role in pathogenesis of AD. Trigger factors of exacerbation especially due to enviroment including irritant and allergen agents. Identifying and avoiding trigger factors are important in management of AD. Skin prick test (SPT) is one method to detect the presence of Ig E spesific to certain allergens (food allergens, aeroallergens). Purpose: To describe the characteristic of AD patients, and evaluate the result of SPT and their clinical relevance. Methods: This research was a retrospective study of AD patients who underwent SPT  during 2007-2012. Results: Nineteen of 57 patients (33,3%) had positive SPT to one or more allergens, and 36 patients (63,1%) had negative result. One patient (1,8%) showed false positive result and 1 patient (1,8%) showed false negative result. The most common allergens were house dust in 8 patients (42%) and crab in 6 patients (31,6%). Clinical relevance was found in 11 patients (58%), and 8 patients (42%) had no clinical relevance. Compared with SPT–negative patients, SPT–positive patients showed more severe symptom and clinical manifestation. Conclusions: In this study, the allergens could be detected in 19 patients (33,3%) by SPT, mostly to house dust (42%) and crab (21,6%). Clinical relevance was found in 11 patients (58%). SPT is recomended to perform in management of AD in order to detect enviromental allergen because it has significant clinical relevance. Key words: atopic dermatitis, skin prick test, allergens.

Retrospective Study: Oral Medications for Atopic Dermatitis

Widia, Yuri, Hutomo, Marsoedi

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Original Source | Check in Google Scholar | | DOI: 10.20473/bikkk.V27.2.2015.130-136

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by recurrent itch. The prevalence of AD in children is 10-20%, while in adults is as many as 1-3%. Several factors are proposed to play role in the pathogenesis of AD as well as genetics, immunological, and environmental factors. There are recent advances in the management of the AD but still not fully satisfactory. Purpose: To evaluate oral medications for AD to improve patients care in the future. Methods: Retrospective study performed in Allergy Immunology Division of Dermatology and Venereology Outpatient Clinic Dr. Soetomo th stGeneral Hospital within January 1 2009 until December 31 2011. Data was collected from medical records. Results: There were 11.7% AD patients who received oral treatment. The most antihistamine given was mebhydrolin napadisilat in 51.5% of patients. The most corticosteroids given was dexamethasone in 33.6% patients. Dexamethasone was given in tapering off in 7.9% patients. The most oral antibiotics given was erythromycin in 4.8% patients and cloxacillin in 0.3% patients. Conclusions: Oral medications mostly used in AD was antihistamine. Some patients were also given corticosteroids. Antibiotics were used if secondary bacterial infection was assessed.Key words: atopic dermatitis, retrospective study, oral medications.

Cara Penularan HIV & AIDS Di Unit Perawatan Intermediate Penyakit Infeksi (UPIPI) RSUD Dr. Soetomo Surabaya

Astindari, Astindari, Lumintang, Hans

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Original Source | Check in Google Scholar | | DOI: 10.20473/bikkk.V26.1.2014.1-5

Abstract

Latar belakang: Kasus HIV & AIDS makin lama makin meningkat. Sejak pertama kali dilaporkan pada tahun 1987 sampai 2009, di Indonesia tercatat 3.492 orang meninggal dunia karena penyakit ini. Cara penularan HIV & AIDS di Indonesia selalu mengalami perubahan. Awalnya cara penularan terjadi melalui hubungan heteroseksual. Kemudian peningkatan jumlah pengguna narkoba suntik (penasun) di Indonesia menyebabkan cara penularan HIV & AIDS juga mengalami perubahan karena penularan bisa terjadi melalui penggunaan jarum suntik bersama di kalangan para penasun. Saat ini cara penularan HIV & AIDS kembali lagi, terutama melalui hubungan heteroseksual. Perubahan cara penularan HIV & AIDS dari kelompok penasun ke heteroseksual mempengaruhi strategi pencegahan penularan HIV & AIDS di Indonesia, khususnya di RSUD Dr. Soetomo Surabaya. Tujuan: Mengevaluasi cara penularan HIV & AIDS di UPIPI RSUD Dr. Soetomo Surabaya tahun 2006-2010. Metode: Penelitian deskriptif, retrospektif tentang cara penularan HIV & AIDS di UPIPI RSUD Dr. Soetomo Surabaya tahun 2006 – 2010. Hasil: Kasus baru HIV & AIDS di UPIPI RSUD Dr. Soetomo Surabaya tahun 2006-2010 didapatkan 3.090 kasus, dengan perbandingan pasien laki-laki lebih banyak dari pasien perempuan. Cara penularan tertinggi melalui hubungan seksual yaitu 63,5%, cara penularan berikutnya melalui penasun 24,8%, penasun + seksual 6,3%, dan perinatal 3,2%. Cara penularan melalui heteroseksual makin meningkat dari tahun 2006 sebanyak 186 orang (47,1%) menjadi 509 orang (71,9%) pada tahun 2010. Simpulan: Cara penularan HIV & AIDS di UPIPI RSUD Dr. Soetomo mengalami perubahan, yang semula terbanyak melalui penasun pada tahun 2005 berubah melalui heteroseksual pada tahun 2010. Hal itu akan mempengaruhi strategi upaya pencegahan penyakit tersebut. Kata kunci: studi retrospektif, HIV & AIDS, penularan, heteroseksual, IDUs, penasun, perinatal.

Urticaria and Angioedema: Retrospective Study

Wirantari, Nadia, Prakoeswa, Cita Rosita Sigit

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Original Source | Check in Google Scholar | | DOI: 10.20473/bikkk.V26.3.2014.1-7

Abstract

Background: Urticaria is a common disorder that often presents with angioedema. Angioedema which may lead to laryngeal involvement, asphyxiation, and urticaria lasting more than 72 hours, are indications of hospitalization. Purpose: To describe the distribution, duration of hospitalization, trigger factor, clinical form, diagnostic, and therapeutic approach in urticaria and angioedema patients in Dermaro-venerelogy Departement Dr. Soetomo General Hospital during year 2011-2013. Methods: Retrospective study using medical records of new patients with urticaria and/ or angioedema in Dermatovenereology Ward st thduring 1 January 2011 until 31 December 2013. Basic data, anamnesis, physical examination, diagnostic, and therapeutic approach are recorded. Results: There were 42 new patients with urticaria and/or angioedema (2.3% of all Dermatoveneorology inward patients), with mean length of stay 4-6 days (57.1%), chief complaint of itch, hives, and swelling (42.8%), lesions occur for less than 6 weeks (92.9%), for the first time (54.8%), with episodes of less than 72 hours (45.3%). Urtica and angioedema were the most often clinical findings (38.1%), complete blood count and urinalysis were routinely examined (100% and 97.6% respectively). Treatment combination of corticosteroid and antihistamin H1 was the most commonly prescribed (64.0%). Conclusion: Urticaria along with angioedema was the most common condition in inward patients, thus combination therapy of antihistamin H1 and corticosteroid were most often needed.Key words: urticaria, angioedema, retrospective study.

Eosinophil and Eosinophil Cationic Protein Level Raising in Dermatitis Due to Food Patients

Umborowati, Menul Ayu, Sawitri, Sawitri, Hoetomo, Marsoedi

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Original Source | Check in Google Scholar | | DOI: 10.20473/bikkk.V27.2.2015.90-96

Abstract

Background: Food allergy prevalence worldwide has been increase. Skin is secondary most often target organ in food allergy reaction. Food allergy affects 35% atopic dermatitis (AD) patients. Diagnosis of food allergy  is still challenge because signs are not specific. Previous researches showed eosinophil and eosinophil cationic protein (ECP) role in food allergy reaction on gastrointestinal tract, but none on dermatitis due to food. Purpose: To evaluate eosinophil and serum ECP in dermatitis due to food. Method: This is a descriptive observational cross sectional study, with dermatitis due to food patients in Dermatovenereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya as subjects. Subjects has been collected trough consecutive sampling during 3 months, then data were analysized descriptively Results: Serum ECP level of dermatitis due to food patients were above normal range in all subjects, with mean level 108.5 µg/L, lowest level 33.011 µg/L and higher level 284.849 µg/L. Mean eosinophil of dermatitis due to food patients just arise above normal limit (0.413µg/L). AD patients were 48.4% among all subjects. Mean serum ECP level of AD patients was higher (121.703 µg/L) than non-AD (96.123 µg/L). Conclusions: Eosinophil and ECP seems have role in dermatitis due to food pathogenesis. Serum ECP examination can be benefits to monitor dermatitis due to food severity.Key words: dermatitis due to food, eosinophil, serum eosinophil cationic protein.

Retrospective Study: Characteristic of Herpes Zoster Patients

Ayuningati, Lia Kinasih, Indramaya, Diah Mira

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Original Source | Check in Google Scholar | | DOI: 10.20473/bikkk.V27.3.2015.211-217

Abstract

Background: Herpes zoster (HZ) is a disease caused by the Varicella-zoster virus (VZV) that localized, primarily affects adults with characteristics of radicular pain, unilateral, and group of vesicles distributed according to dermatomes, innervated by a sensory nerve ganglion. Several risk factors for HZ is older populationand cellular immune dysfunction. Purpose: To evaluate general overview of HZ patients, hence better management can be provided. Methods: Retrospective study of newly diagnosed HZ patientsin Kemuning ward Dr. Soetomo General Hospital Surabaya during 2010-2013. Results: This study showed most commonly affected women (55.9%), themost common age was45-64 years old (40.7%)and the most common location was HZ thoracalis (31.4%). Conclusion: HZ is a common disease, which most commonly occured illness in elderlywith predisposing factors, that can determine the course of the disease, so we need proper management and education.Key words: herpes zoster, retrospective.

Perbedaan antara Uji Transformasi Limfosit dengan Uji Tempel Obat pada Pasien Erupsi Obat

Karina, Dhita, Rahmadewi, Rahmadewi, Pohan, Saut Sahat

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Original Source | Check in Google Scholar | | DOI: 10.20473/bikkk.V26.1.2014.1-6

Abstract

SurabayaABSTRAKLatar belakang:Diagnosis erupsi obatseringditegakkan berdasarkan anamnesis dan pemeriksaanklinis sajasehingga sulit untuk mengetahui obat penyebabnya. Pemeriksaan penunjang diperlukan untukdiagnosis yang lebih pastidan mengetahui penyebabnya. Uji Tempel Obat (UTO) adalah prosedur in vivoyang sering digunakan di praktek sehari-hari dan sensitivitasnya sebesar 30-50%. Uji Transformasi Limfosit (UTL) adalah suatu pemeriksaan laboratorium dengan prosedur invitroyangsensitivitasnya dilaporkan 70-90% dalam mendiagnosis erupsi obat. Tujuan:Menganalisis perbedaan antara hasil UTO dan UTL pada pasienerupsi obat.Metode:Penelitian cross sectionaldilakukan terhadapduapuluh dua pasien dengan riwayat erupsi obat di Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya. DilakukanUTO pada punggung pasiendanpengambilandarah venapasien untuk pemeriksaan UTL. Hasil:Dari duapuluh duapasiendidapatkan hasil positif UTO pada tujuhpasiendan negatifpada lima belaspasien, sedangkan hasil positif UTL pada dua puluh pasien dan negatif pada duapasien.Simpulan:Terdapatperbedaan yang signifikan antara UTO dan UTLpada pasien erupsi obat. Kesesuaian dua pemeriksaan ini sebesar 40,9%,yang berarti UTL dapat dilakukan bila hasil UTO negatif atau meragukan.

Profil Uji Tempel pada Pasien Dermatitis Kontak

Noviandini, Anggraeni, Prakoeswa, Cita Rosita Sigit

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Original Source | Check in Google Scholar | | DOI: 10.20473/bikkk.V26.2.2014.1-7

Abstract

Latar belakang: Prevalensi Dermatitis Kontak (DK) di Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya semakin meningkat dalam 10 tahun terakhir. Identifikasi penyebab dengan uji tempel penting untuk memberikan penatalaksanaan yang tepat pada pasien tersebut. Sampai saat ini penelitian mengenai prevalensi dan insidensi DK di Indonesia masih terbatas. Tujuan: Menentukan prevalensi dan interpretasi hasil uji tempel positif terhadap alergen yang dicurigai. Metode: Penelitian retrospektif tentang uji tempel menggunakan The European Baseline Series of Contact Allergens yang telah dilakukan terhadap 42 pasien. Interpretasinya dicatat dan dievaluasi berdasarkan pemeriksaan klinis pasien. Hasil: Dari 42 pasien yang dilakukan uji tempel, 27 pasien (64,3%) menunjukkan hasil positif dengan satu atau lebih alergen tes. Alergen terbanyak adalah p-phenylenediamine (40,5%), fragrance mix I (16,7%), formaldehyde (14,3%). Dermatitis wajah dilaporkan pada 81,5% pasien, 97,6% terdiagnosis Dermatitis Kontak Alergika (DKA). Prevalensi tertinggi pada wanita, usia muda, dan mayoritas pelajar. Simpulan: Profil DK di URJ Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya berbeda dengan daerah lain di Indonesia, karena perbedaan pola hidup menyebabkan paparan lingkungan terhadap alergen berbeda pada tiap area. Katakunci: uji tempel, dermatitis kontak, retrospektif.

Correlation of Expression p16 on Genital Wart Lesions with Various Degrees of Cervical Dysplasia

Rahmawati, Asri, Damayanti, Damayanti, SP, Cita Rosita, Lumintang, Hans

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Original Source | Check in Google Scholar | | DOI: 10.20473/bikkk.V26.3.2014.1-7

Abstract

Introduction: Infection of Human Papillomavirus (HPV) can cause condylomata acuminata. High-risk HPV types have proteins E6 and E7 called “oncoprotein” for its role in the occurrence of cancer. E7 protein causing no active bond pRb and E2F is regulated by CDK inhibitors, such as p16INK4a . Overexpression p16INK4a could be obtained from pre cancerous lesions. Pap smear, the standard screening method, is performed to detect early malignancy of the cervix, but have low sensitivity. The presence of tumor markers, p16INK4 ,will help early detection of malignancy. Purpose: To evaluate the profile of p16INK4a expression in condylomata acuminata lesions with various degrees of cervical dysplasia. Methods: Discriptive, observational, cross seetional study by performed p16INK4a immunohistochemical examination in lesions condylomata acuminata and cytologic examination on cervical biopsy. Results: Results of cervical cytology (pap smear) from 18 samples showed Low-grade Squamous Intraepithelial Lesions (LSIL) in 10 patients (55.6%) and Negative for Intraepithelial Lesion or Malignancy (NILM) in 8 patients (44.4%). Immunohistochemical examination obtained p16INK4a expression with score of 1 (sporadic) in 8 patients (44.4%), with score of 2 (focal) in 7 patients (38.9%) and with score of 3 (diffuse) in 3 patients (16.7%).  From 3 patients with diffuse expression of p16INK4a , 2 patients (66,6%) showed LSIL from cytology cervix and 1 patient (33,3%) revealed NILM. Spearman correlation test results showed no significant correlation between p16INK4a expression in cervical dysplasia with p = 0.24 (p> 0,05). Conclusion: There were three samples of diffuse, with most of Low-grade Squamous Intraepithelial Lesions (LSIL) in cervical dysplasia, it indicates there is a potential of p16INK4a as a marker of malignancy in condylomata acuminata. Key words : condylomata acuminata, p16INK4a , cervical dysplasia.

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