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Congenital Heart Disease among Down Syndrome Children at Dr. Hasan Sadikin General Hospital from 2008 to 2013

Rajamany, Thyviyaa, Kuswiyanto, Rahmat Budi, Lubis, Leonardo

Althea Medical Journal Vol 5, No 1 (2018)
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Abstract

Background: Children with Down syndrome are more prone to congenital heart disease due to the consequences of trisomy chromosomal 21 on gene expression. The aim of this study was to determine the pattern of congenital heart disease in children with Down syndrome. Methods: This was a retrospective study of reviewed children with Down syndrome from January 2008 to January 2013 at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. This study was conducted from August until October 2014. Patients under the age of 15 years and diagnosed having congenital heart disease from 2008 to 2013 were enrolled in this study by using the total sampling method. Incomplete medical records and children who had not performed an echocardiogram were excluded. Sex, age at diagnosis for congenital heart disease, nutritional status and other comorbidities were also examined.Results: Congenital heart disease occurred in 28 children with Down Syndrome. Patent ductus arteriosus (PDA) was the most common and found in 11 patients followed by a combination of congenital heart diseases in 5 patients. Other 3 patients had Atrioventricular septal defect (AVSD), and Tetralogy of fallot (TOF) was found in 3 patients, 2 patients had Atrial septal defect (ASD) and 1 patient had miscellaneous cardiac defect.Conclusions: The most common CHD in Down syndrome is PDA.

Demographic and Risk Factors of Intracerebral Hemorrhage Stroke Patients in Dr. Hasan Sadikin General Hospital Bandung in 2007–2016

Lofissa, Sabrina Putri, Ong, Paulus Anam, Atik, Nur

Althea Medical Journal Vol 5, No 1 (2018)
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Abstract

Background: Intracerebral hemorrhage stroke is a type of stroke which is considered to have a higher mortality risk than ischemic stroke. Preventive programs are needed to minimize stroke cases by reducing the risk factors. This study aimed to identify the demographic and risk factors of intracerebral hemorrhage stroke patients in Dr. Hasan Sadikin General Hospital Bandung in 2007–2016. Methods: This was a descriptive cross sectional study. Data were obtained from Dr. Hasan Sadikin General Hospital medical resume January 2007- December 2016 by total sampling.  Subjects of this study were intracerebral hemorrhage stroke patients hospitalized in Dr. Hasan Sadikin General Hospital. The period of study was from August 2016 until May 2017. Variables included in this study were gender, occupation, education level, age; risk factors such as hypertension, dyslipidemia, diabetes mellitus, hyperuricemia, and kidney disease. The collected data were presented in percentage.Results: The highest demographic prevalence in 10 years was in female, non-occupational person, elementary school graduate, and frequently found in the 50-59 age group. The highest risk factor was hypertension, but it slightly decreased from 78.8% in 2007-2008 to 55.3% in 2015-2016, followed by dyslipidemia, diabetes mellitus, hyperuricemia which increased in 2007-2008 and 2015-2016. (Dyslipidemia: from 8.1% to 23.8%; Hyperuricemia: from 2.5% to11.2%; Diabetes Mellitus: from 6.6% to 8.9%).Conclusions: The demographic of intracerebral hemorrhage stroke shows a high prevalence found in females, older age, non-occupational persons, and elementary school graduates. Among the risk factors, hypertension is most likely to happen in ten years. 

Characteristics of Liposarcoma Patients: 5-Year Data

Rahmah, Miftahur, Afiati, Afiati, Sugiri, Unwati

Althea Medical Journal Vol 5, No 1 (2018)
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Abstract

Background: Liposarcoma is the second highest soft tissue sarcoma in adults with prevalence of 15% to 25%. If the size of liposarcoma is very large, it may cause abdominal pain, weight loss, gastrointestinal bleeding, even kidney failure. Therefore, for early detection of liposarcoma, the characteristics of liposarcoma should be investigated. This study aimed to determine liposarcoma characteristics based on age, sex, location and histopathologic type according to WHO (World Health Organization) Classification of Tumors 2013.Methods: A descriptive study was conducted from August to October 2015 at the Department of Anatomic Pathology, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Data was obtained from database of patients with liposarcoma at the Department of Anatomic Pathology in the period of January 2010 to December 2014. The collected data was presented in the form of figures and tables.Results: Out of 102 cases, the percentage of liposarcoma was highest between the age of 50 and 59 years (31.37%), followed by the age of 40–49 years (28.43%). The percentage were slightly higher in males (54.9%) compared to females with a ratio of 1.22:1. Femur (23.52%), intraabdomen (22.55%) and retroperitoneum (11.76%) were the most common locations affected. The most common histopathologic subtype was myxoid liposarcoma (52.95%) exceeding a half of the total cases.Conclusions: Liposarcoma most likely occurs in the age range of 40–60 years, the percentage is slightly higher in males, and abdomen and lower extremities are the most common location affected. Myxoid liposarcoma is the most common subtype. 

Cognitive and Functional Outcome among Hospitalized Intracerebral Haemorrhage Patients in West Java’s Top Referral Hospital

Setyawan, Ilham Bagas, Ong, Paulus Anam, Arifin, M. Zafrullah

Althea Medical Journal Vol 5, No 1 (2018)
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Abstract

Background: Stroke is the highest cause of disability in adults. Disability and cognitive function impairment cause dependency and decreasing quality of life. The objectives of this study was to describe the outcome of functional and cognitive function among intracerebral haemorrhage patients admitted to Dr. Hasan Sadikin General Hospital Bandung in 2013.Methods: This study was a quantitative descriptive study, conducted from October 2016 to August 2017. Data were collected retrospectively with total sampling method from medical records of intracerebral haemorrhage patients admitted to Dr. Hasan Sadikin General Hospital in 2013 assessed with the Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) and Barthel Index. Patients with incomplete medical records , severe aphasia, severe sensoric-motoric impairment, and decreased consciousness were excluded in this study. Data were analyzed using Microsoft Office Excel 2010 and presented in percentage.Results: Out of the 26 subjects, 11 were men and 15 women , who were in the age range of 45–54 years (42.3%), with low education level (61.5%), and unemployed (61.5%) had the highest prevalence on subjects studied. Hypertension was the most common risk factor (78%). Most subjects had cognitive function impairment (69.2%) with delayed memory function as the most common impairment domain found (84.6%), followed by visuospatial/executive function (69.2%). Most subjects had a high score of dependence according to the Barthel test (61.5%).Conclusions: Two third of intracerebral haemorrhage patients have cognitive function impairment and functional dependence. Memory function is the most common impaired cognitive functional domain. 

Knowledge, Attitude, and Behavior Level of Women of Reproductive Age toward Calcium Intake

Dewi, Kartika Ratna, Hidayat, Eva M., Rachmawati, Anita

Althea Medical Journal Vol 5, No 1 (2018)
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Abstract

Background: Women have a higher risk of developing osteoporosis compared to men. Calcium intake is one of the determinant factor which can be modified to prevent osteoporosis. Knowledge, attitude and behaviour are important factors to fulfill the needs of calcium intake. This study aimed to describe  knowledge, attitude, and behavior toward calcium intake of woman of reproductive age.Methods: This descriptive study recruited 100 women (aged 20–30 years) in Jatinangor, West Java and was conducted from September to November 2014. Knowledge and attitude measurements used a validated questionnaire consisting of 10 and 9 closed questions respectively. Behavioral aspect was assessed using semi-quantitative Food Frequency Questionnaire (FFQ). Knowledge was classified as high, moderate, and low based on questionnaire scoring results, >75%, 60–75%, and <60% respectively. Attitude was categorized in two: positive and negative. Behaviour category used Recommended Dietary Allowances (RDA) as the cut-off point. If the  daily calcium intake is below the RDA it is categorized less and if the daily calcium intake equals to or exceeds the RDA it is categorized sufficient. The collected data were presented in frequency tabulation and percentage.Results: The majority of subjects  showed low to moderate level of knowledge toward calcium intake, 66% of subjects showed negative attitude towards calcium intake, and  98% showed calcium intake below the RDA. Conclusions: Subjects of this study have low to moderate level of knowledge, negative attitude toward calcium intake, and low level of behavior toward calcium intake.

Characteristics of Functional Constipation among Kindergarten Students in Kecamatan Jatinangor, West Java, Indonesia

Giovanni, Livia, Ermaya, Yudith Setiati, Hafsah, Tisnasari

Althea Medical Journal Vol 5, No 1 (2018)
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Abstract

Background: Functional constipation can occur in children and affect their quality of life, but there is still lack of awareness and inability to provide proper management. Therefore, early detection is important. The aim of this study was to identify the prevalence of functional constipation among kindergarten students and its risks.Methods: A quantitative descriptive study was conducted from April to May 2017 on kindergarten students in Kecamatan Jatinangor, West Java, Indonesia by using questionnaires for their parents. In total, 149 parents joined the study.  The questionnaire was made based on the Rome IV Criteria with additional questions for the student’s characteristics comprised of sex, prematurity, allergy, family history of constipation, dietary fiber consumption, and parents’ education level. Descriptive analyses were conducted.Results: The prevalence of functional constipation among the students was 8.7% with the most frequent complaints were retentive posturing (76.9%), hard stool consistency (38.5%), and history of obstructing toilet by stool (38.5%). Characteristics of children with functional constipation were prematurity (15.4%), history of allergy (15.4%), low dietary fiber intake (from fruits, 69.2%, vegetables 84.6%, seeds 100%), and non-university educated parents (father 76.9%, mother 84.6%).Conclusions: Constipation among kindergarten students in Jatinangor is 8.7%, while the most apparent characteristics in constipated children is low dietary fiber intake. 

Superior Vena Cava Syndrome and Multiple Venous Thrombosis in a Patient with B Cell Lymphoma

Kocak, Mehmet Zahid, Aktas, Gulali, Erkus, Edip, Atak, Burcin, Duman, Tuba, Savli, Haluk

Althea Medical Journal Vol 5, No 1 (2018)
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Abstract

Background: Superior vena cava syndrome (SVCS) develops due to external mechanical pressure of superior vena cava (SVC) by a mass lesion or by an enlarged lymph node, tumor invasion of the vessel wall, or venous thrombosis resulting in intraluminal obstruction. Approximately 3,9% of lymphomas are complicated with SVCS. This rate reaches to 7% in diffuse large B cell lymphoma. The objective of this article was to describe a case report of  a young woman with a diffuse large B cell lymphoma, complicated with pericardial-pleural effusion and SVCS. Methods: A 25 year old woman referred to the Internal Medicine Clinic of Abant Izzet Baysal University Hospital with complaints of bloating in the neck and both arms. She had chest pain, dyspnea, cough, and epigastric discomfort for 10 days. A thoracic magnetic resonance imaging (MRI) test and pathological assessment were carried out.Results: A mediastinal mass 64x112x82 mm in size, displaced the heart and main mediastinal structures to posterior, was detected by thoracic magnetic resonance imaging (MRI) test. The result of the pathological assessment of the biopsy specimen revealed large B cell lymphoma, stained strongly and diffusely with CD20 and bcl-2. She was referred to the hematology unit and doing well after a chemotherapy.Conclusions: Diagnosis of SVCS requires high level of clinical suspicion, detailed and complete physical examination. Moreover,  SVCS should be kept in mind in the differential diagnosis of patients  presented with edema in the neck and upper extremities. 

Correlation Between Radiographic Grading of Osteoarthritis, Pain Severity and Functional Status in Knee Osteoarthritis Patients

Khairina, Annisa Dwi, Moeliono, Marina A., Rahmadi, Andri Reza

Althea Medical Journal Vol 5, No 1 (2018)
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Abstract

Background: Osteoarthritis is a joint degenerative disease characterized with structural changes of joint. The structural changes can be assessed with radiological assessment. Major clinical manifestations may include pain, inflammation, and stiffness, resulting in limitations for performing daily activities. The purpose of this study was to determine the correlation between radiographic grading of osteoarthritis, pain severity, and lower extremities functional status in patients with knee osteoarthritis.Methods: The study involved 29 patients with knee osteoarthritis in Dr. Hasan Sadikin General Hospital, Bandung and Bandung District General Hospital during the period of August to October 2014 using the cross sectional method. This study used NRS (Numeric Rating Scale) for pain severity assessment, Kellgren-Lawrence criteria for radiographic grading of osteoarthritis, and Modified Lower Extremity Funcional Scale for functional status assessment. The data were analyzed using statistical analysis tools. If the data were normally distributed, the correlation test will be carried out  by using the Pearson correlation test and if the data were not normally distributed then the Spearman’s Correlation test will be used.Results: Correlation coefficient between severity of pain and functional status is r= -0,439 with p value= 0.17 (p<0.05). There was no significant correlation between radiographic grading of osteoarthritis and functional status (p > 0.05).Conclusions: The severity of pain correlates with the functional status of patients with osteoarthritis of the knee, while radiographic grading of osteoarthritis does not correlate with functional status. Keywords: 

Perception of Universitas Padjadjaran Students towards Psychotic Disorders

Rusly, Renzavaldy, Pandia, Veranita, Sunjaya, Deni Kurniadi

Althea Medical Journal Vol 5, No 1 (2018)
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Abstract

Background: Psychotic disorders have a very high incidence in Indonesia and arethe first rank in terms of the global burden of disability. Students are the frontline in the face of society. The formation of stigma and discrimination  is rooted from  bad perceptions. The aim of this study was to determine and measure Universitas Padjadjaran students’ perceptions towards psychotic disorders and find out why these perceptions can be shaped. Methods: The design of study was a sequential explanatory mixed method research. The population of this study is glittering Universitas Padjadjaran students who were in Jatinangor between batches 2011 to 2013. Samples were taken using cluster and stratified random sampling. Quantitative data retrieval was collected by using a self-administered questionnaire. Next, there would be focused group discussions and in-depth interviews which discussed the results of the quantitative data collection then interpreted them qualitatively. Result: The percentage of students at Universitas Padjadjaran with perception of psychotic disorders in good category was 19.04%, 80.96% unfavorable category, and bad 0% (n=126). Besides various relevant opinion found why these perceptions were formed, such as a lack of education on students towards psychotic disorders, the existence of stigma based on life experience of psychotic patients, the lack of social media and physical campaign towards the psychotic disorders.Conclusions: The perception of Universitas Padjadjaran students towards psychotic disorders is still relatively unfavorable, therefore literation towards psychotic disorders should be provided through education, campaigns, social media utilization by psychiatrists and the government.

Early Detection of Suspected Systemic Lupus Erythematosus in Community-Dwellings in West Java Indonesia

Ghassani, Nadia Gita, Hamijoyo, Laniyati, Hadi, Soeseno

Althea Medical Journal Vol 4, No 3 (2017)
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Abstract

Background: Prevalence of systemic lupus erythematosus (SLE) has been known in almost all countries around the world.  Contrary to this, in Indonesia, neither a national epidemiologic study on SLE nor any direct study on SLE in the general population has been conducted. Early detection of SLE is needed as a first step to determine prevalence of SLE in Indonesia as well as to prevent further complications. This study aimed to obtain the prevalence of suspected SLE in community-dwellings.Methods: This study was conducted in the period September to November 2015 and used the descriptive cross-sectional method. The respondents were people who were at least 18 years old and lived in selected blocks in three different villages in Jatinangor, West Java. Data were obtained from secondary sources of a previous SLE screening study that was incorporated in a study on “Epidemiology of hypertension and albuminuria in Jatinangor” in 2014, using the multistage sampling method. Suspected SLE was based on the Liang screening questionnaire. The collected data were presented in tables.Results: There were 72 respondents (8%) suspected to have SLE. Most of the cases were female (Odds ratio:1.47) and 51–60 years old.  The most clinical manifestation was painful swollen joints >3 months.Conclusions: The existence of suspected SLE cases in Jatinangor’s population, as an example of Indonesian population should be a concern so that examinations could be carried out to make sure that  respondents with SLE can be provided  prompt interventions  to prevent further complications.