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INDONESIA
Jurnal Ilmiah Farmasi
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
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Articles 4 Documents
Search results for , issue " Vol 11, No 1 (2015): Jurnal Ilmiah Farmasi" : 4 Documents clear
FORMULASI TABLET EKSTRAK KANGKUNG AIR (Ipomoea aquatica F.) DENGAN VARIASI KADAR AMILUM MANIHOT SEBAGAI BAHAN PENGHANCUR Khaidir, Sutrisna; Murrukmihadi, Mimiek; Kusuma, Aris Perdana
Jurnal Ilmiah Farmasi Vol 11, No 1 (2015): Jurnal Ilmiah Farmasi
Publisher : Jurnal Ilmiah Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol11.iss1.art1

Abstract

Ipomoea aquatica F. are plant that has a hypoglycemic effect. Ipomoea aquatica F. was  formulated into tablet dosage forms to produce benefits in terms of practicality and accuracy of therapeutic doses.Disintegrant has effect to release the active substance rate of the tablet so that drug effects can be felt by patients with diabetic immediatly. The purpose of this study was to determine disintegration time of Ipomoea aquatica F. extract tablets with various levels of amilum manihot and determine the best concentration of amilum manihot based on the evaluation of physical properties of tablets.Ipomoea aquatica F. extracts was obtained from the maceration using 96% ethanol, than concentrated by rotary evaporator. The extracts were tested qualitatively by TLC with petroleum eter: aceton: dietil amin mobile phase (10:4:1), the phase silica gel F254 with Rf value about 0,625.  Tablets were formulated with amilum manihot concentration variation of 10%, 15% and 20% by wet granulation method. Physical properties of granules were tested such as powder flow, angle of repose, porosity and compressibility index.Tablets were tested to know physical properties such as weight uniformity, sizeuniformity, hardness, friability and disintegration time.The results showed that variaton levels of amilum manihot decrease disintegration time. Variation of amilum manihot was affected in disintegration time, and the optimumt formula with was achieved by 15% amilum manihot. 
EVALUASI SIFAT FISIK DAN UJI IRITASI SEDIAAN SALEP MINYAK ATSIRI BUNGA CENGKEH DALAM BASIS LARUT AIR Pratimasari, Diah; Sugihartini, Nining; Yuwono, Tedjo
Jurnal Ilmiah Farmasi Vol 11, No 1 (2015): Jurnal Ilmiah Farmasi
Publisher : Jurnal Ilmiah Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol11.iss1.art2

Abstract

Essential oil of clove (Syzygium aromaticum) (MABC) with eugenol as its main active ingredient, has been studied as anti-inflammatory agent.  Its important to develop formulation in an advanced research. This study has been conducted to develop a topical dosage form (an ointment using a water-soluble base). The physical properties of water-soluble ointment preparation of MABC and the irritation properties at various concentrations of MABC have been evaluated. Ointment preparation MABC water-soluble base created using the mixing of the PEG 400 and PEG 4000 by a fusion method. Ointment made with a various concentration of MABC (5%, 10% and 15%). Ointment with each concentration were evaluated based on its physical properties such as pH, dispersiveness and adhesion. Ointment also tested its irritative properties on the skin, using test animals guinea pigs by Draize test method. Data from those experiments analyzed by ANOVA with T-test level of 95%. The results showed that the physical properties of water-soluble ointment base with MABC concentration of 5%, 10% and 15% reach the requirements of the pH and adhesion parameter, but not for its dispersiveness. Statistical analysis of each trial did not show any significant in difference. The experimental results against irritation test showed that the water-soluble ointment base concentration of 5%, 10% and 15% did not cause irritation to the skin of guinea pigs.  
Cytoprotective effect of tangeretin in hydrogen peroxyde-inducedoxydative stress on human umbilical vein endothelial cells (HUVECs) Jenie, Riris Istighfari; Setiawan, Irfan Muris; Jenie, Ikhlas Muhammad; Muflikhasari, Haruma Anggraini
Jurnal Ilmiah Farmasi Vol 11, No 1 (2015): Jurnal Ilmiah Farmasi
Publisher : Jurnal Ilmiah Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol11.iss1.art3

Abstract

Oxydative stress is known as a major trigger in cardiovascular dysfunction that leads to hypertension, atherosclerosis, and chronic heart failure. Polymethoxyflavone such as tangeretin and nobiletin has been reported to have biological activity including reducing cholesterol level and anti inflammation activity. The critical point that mediates atherosclerosis is the formation of stress oxidative which causes endothelial cells dysfunction.This study was conducted to explore the effect of tangeretin in protecting H2O2-induced oxidative stress on HUVEC. Cell viability was determined by using MTT assay. Cells were treated with different concentrations of tangeretin (12.5; 100; and 200 µM) for 24h before exposed to 600 µM H2O2 for 4h. Cells viability analyses showed that at low concentration (12.5 µM), tangeretin inhibited H2O2-induced cytotoxicity. Furthermore, it induced cells proliferation. However, at high concentration, it failed to protect HUVEC from H2O2-induced cytotoxicity and increased the cytotoxicity of H2O2. Based on this result, tangeretin in low concentration has a potential to reduce oxidative stress on HUVECs.  
KESESUAIAN RESEP DENGAN STANDAR PELAYANAN MEDIS DAN FORMULARIUM JAMKESMAS PADA PASIEN RAWAT JALAN JAMKESMAS Medisa, Dian; Danu, Sulanto Saleh; Rustamaji, Rustamaji
Jurnal Ilmiah Farmasi Vol 11, No 1 (2015): Jurnal Ilmiah Farmasi
Publisher : Jurnal Ilmiah Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol11.iss1.art4

Abstract

Health is rights of every human. In Indonesia, poor people had difficulty to access health services. Therefore government creates a program called “Jamkesmas” which based on DRGs (Diagnosis Related Groups) to improve quality of health services. Physicians should prescribe medicines according to the diagnosis and Jamkesmas formulary. The compliance between prescription with Standard Treatment Guidelines (STGs) and Jamkesmas formulary is a must. The aim of this research was to know the prescriptions compliance to STGs and Jamkesmas formulary. This research was observational study using prescriptions of Jamkesmas’s outpatients . Furthermore, qualitative data with in-depth interviews was used to further analysis. Quantitative data were calculated by using drug use indicators for the percentage of prescriptions compliance. The percentage of prescriptions compliance with STGs in each of 10 diseases in once of hospital in Daerah Istimewa Yogyakarta (Hospital X), started from 24.3% in CHF to 82% in DM diseases, whereas prescriptions compliance with Jamkesmas Formulary was started from 49% in vertigo to 96% in hypertension diseases. Average number of drugs per prescription was 2.7 and the most of drugs (85.7%) were prescribed by its generic names; 23.3% of prescriptions contained antibiotic and 22.0% contained of injectable drug. Percentage of drugs prescribed from essential medicines list was 76.7%. The prescriptions of 10 diseases were not fully compliance to Standard Treatment Guidelines and Jamkesmas formulary. 

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