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ALCHEMY
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Alchemy Journal of Chemistry ini diterbitkan oleh Jurusan Kimia Fakultas Sains dan Teknologi UIN Maulana Malik Ibrahim Malang secara berkala 2 kali setahun pada bulan Maret dan Oktober.
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Identifikasi Senyawa Kuersetin dari Fraksi Etil Asetat Ekstrak Daun Alpukat (Persea americana Mill.) Rustanti, Elly; Lathifah, Qurrotu A'yunin
ALCHEMY Vol 6, No 2 (2018): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v6i2.6768

Abstract

Avocado leaves (Persea americana Mill.) have many benefits in our health because the leaves contain many secondary metabolites. One of the secondary metabolites in avocado leaves is quercetin. Quercetin is the largest compound of the flavonols group in which percentage of quercetin and its glycosides is 60-75% of total flavonoids. The purpose of this study was to isolate quercetin compounds from ethyl acetate fraction of ethanol extract of avocado leaves and to determine the presence of quercetin compounds in the avocado leaves. The leaves were extracted by maceration using 95% ethanol and fractionated with ethyl acetate. Identification of quercetin compounds using liquid chromatography-mass spectrometry (LC-MS). The results of this study indicated that avocado leaf extract contained quercetin compounds with a retention time of 5.83 minutes with molecular weight m/z = 300.50-301.50 [M-H]+. Keywords: Avocado leaves, quercetin, LC-MS  Daun alpukat (Persea americana Mill.) banyak memiliki kegunaan dalam kesehatan karena mengandung banyak metabolit sekunder. Salah satu metabolit sekunder yang terkandung dalam daun alpukat adalah kuersetin. Kuersetin adalah senyawa kelompok flavonol terbesar yang mana kuersetin dan glikosidanya berada dalam jumlah sekitar 60-75% dari flavonoid. Tujuan dari penelitian ini adalah untuk mengisolasi senyawa kuersetin dari fraksi etil asetat dari ekstrak etanol daun alpukat dan untuk mengetahui adanya senyawa kuersetin dalam daun alpukat. Daun alpukat diekstraksi dengan metode maserasi menggunakan pelarut etanol 95% dan difraksinasi dengan etil asetat. Identifikasi senyawa kuersetin dengan menggunakan kromatografi cair-spektrometri massa (KC-SM). Hasil dari penelitian ini menunjukkan bahwa dalam ekstrak daun alpukat mengandung senyawa kuersetin dengan waktu retensi 5,83 menit dengan berat molekul m/z= 300,50-301,50 [M-H]+. Kata kunci: Daun alpukat, kuersetin, KC-SM
Pemisahan Senyawa Aktif Fraksi Petroleum Eter dan Etil Asetat Hasil Hidrolisis Ekstrak Etanol Hydrilla verticillata dari Ranu Grati Pasuruan Amalia, Suci; Fasya, Ahmad Ghanaim; Hasanah, Faiqotul; Yuliani, Dewi
ALCHEMY Vol 6, No 2 (2018): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v6i2.7014

Abstract

Hydrilla verticillata is one of water plants that has some bioactivities. The presence of secondary metabolites in H. verticillata is responsible for the bioactivity. The purpose of this study was to determine and separate bioactive compounds from fraction of petroleum ether (PE) and ethyl acetate (EA) as a result of hydrolysis of H. verticillata ethanol extract. H. verticillata was extracted by maceration method using ethanol solvent, hydrolyzed with hydrochloric acid and partitioned respectively with petroleum ether and ethyl acetate. Crude ethanol extract, PE and EA fraction were identified their secondary metabolites. The phytochemical test results showed H. verticillata ethanol extract containing alkaloid compounds, flavonoids, tannins, saponins, triterpenoids, and steroids. PE fraction contained steroids and terpenoids, while EA fraction contained flavonoids, steroids, and triterpenoids. Analytical thin layer chromatography analysis showed n-hexane : ethyl acetate (4: 1) eluent as the best mobile phase for separating steroids. The preparative thin layer chromatography analysis of H. verticillata fraction using n-hexane : ethyl acetate (8: 2) as mobile phase resulted in 17 and 14 spots of PE and EA fractions, respectively.Keywords: Hydrilla verticillata, thin layer chromatography, phytochemicals Hydrilla verticillata merupakan salah satu tanaman air yang banyak memiliki bioaktivitas. Adanya metabolit sekunder pada H. verticillata yang bertanggung jawab terhadap bioaktivitas ini. Tujuan penelitian ini adalah untuk mengetahui dan memisahkan senyawa aktif dari fraksi petroleum eter (PE) dan etil asetat (EA) hasil hidrolisis ekstrak etanol H. verticillata. Ekstrak diperoleh dengan metode maserasi menggunakan pelarut etanol, dihidrolisis dengan asam klorida dan dipartisi masing-masing dengan petroleum eter dan etil asetat. Ekstrak kasar etanol, fraksi PE dan EA diuji kandungan metabolit sekundernya. Hasil uji fitokimia menunjukkan ekstrak etanolH. verticillata mengandung senyawa alkaloid, flavonoid, tanin, saponin, triterpenoid, dan steroid. Fraksi PE mengandung steroid dan terpenoid, sedangkan fraksi EA mengandung flavonoid, steroid, dan triterpenoid. Hasil analisis KLTA menunjukkan eluen n-heksana : etil asetat (4:1) sebagai fasa gerak terbaik untuk memisahkan steroid.Hasil analisis KLTP fraksi H. verticillatamenggunakan perbandingan fasa gerak n-heksana : etil asetat (8:2) menghasilkan spot fraksi PE dan EA berturut-turut sebanyak 17 dan 14 spot.Kata Kunci: Hydrilla verticillata, kromatografi lapis tipis, uji fitokimia
Variasi Diameter Kolom dan Rasio Sampel-Silika pada Isolasi Steroid dan Triterpenoid Alga Merah Eucheuma cottonii dengan Kromatografi Kolom Basah Fasya, Ahmad Ghanaim; Tyas, Ariska Purwaning; Mubarokah, Fitroh Annasaul; NIngsih, Rachmawati; Madjid, Armeida D. R.
ALCHEMY Vol 6, No 2 (2018): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v6i2.7015

Abstract

Optimizing steroid and triterpenes isolation from red algae Eucheuma cottonii was done using column chromatography by varying of column diameter (1, 1.5 and 2 cm) and a ratio of sample : silica (1:50, 1:100, and 1:150). Active compound of E. cottonii was extracted by maceration with methanol. Then, the extract was hydrolyzed using HCl 2 N and partitioned with petroleum ether. The extract after partitioned was separated using wet column chromatography. The result of separation was monitored using analytical thin layer chromatography (Analytical TLC) and identified using FTIR. The best separation was aimed using diameter column 1 cm and a ratio of sample : silica 1:150. Based on FTIR analysis, the steroid from extract had a functional group –OH, –C–H, C=O, -C(CH3)2, and C-OH alcohol and the triterpenoid from extract had a functional group –OH, C–H, C=O, C=C, -C(CH3)2 and C-OH alcohol.Keywords: E. cottonii, column chromatography, steroid, triterpenoid, column size, sample : gel silica ratio  Optimasi isolasi senyawa steroid dan triterpenoid dalam alga merah Euchema cottonii telah dilakukan menggunakan kromatografi kolom dengan variasi diameter kolom (1; 1,5; dan 2 cm) dan rasio sampel : silika (1:50; 1:100; dan 1:150). Ekstraksi senyawa aktif pada E. cottonii dilakukan dengan maserasi menggunakan pelarut metanol. Ekstrak pekat metanol dihidrolisis menggunakan HCl 2 N dan dipartisi dengan petroleum eter. Hasil pemisahan dimonitoring menggunakan KLTA dan diidentifikasi menggunakan FTIR. Hasil penelitian menunjukkan pemisahan kromatografi kolom terbaik diperoleh dengan variasi diameter 1 cm dan variasi rasion sampel : silika 1:150. Hasil analisis senyawa steroid memberikan informasi gugus –OH, –C–H, C=O, -C(CH3)2, dan C-OH alkohol, sedangkan senyawa triterpenoid memberikan informasi gugus –OH, –C–H, C=O, C=C, -C(CH3)2 dan C-OH alkohol.Kata Kunci: E. cottonii, kromatografi kolom, steroid, triterpenoid, ukuran kolom, rasio sampel : silika gel
Terapi Infusa Pekat Buah Pare (Momordica charantia L.) terhadap Kadar Glukosa Darah dan SOD pada Ginjal Tikus DM Tipe 1 Hasanah, Nuraeni Uswatun; Hasanah, Hafidatul; Barroroh, Hummatul
ALCHEMY Vol 6, No 2 (2018): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v6i2.6762

Abstract

Bitter melon (Momordica charantia L.) is one of the Cucurbitaceae families which is useful as traditional antidiabetic medicine. Diabetes mellitus (DM) is an autoimmune disease indicated by increasing blood sugar levels. The aim of this study to determine the effect of concentrated infusions therapy of bitter melon fruit on blood glucose levels and SOD activity in three diabetic levels (low, medium, acute) in DM Type 1 of rat kidney. The doses of therapy used were 0.15, 0.30, 0.45, 0.60, 0.80 and 1 mL/200 g body weight (BW). Blood sugar level was measured using enzymatic (glucose oxidase) method and SOD activity using NBT (Nitroblue tetrazolium) test. The results showed that the concentrated infusions therapy of bitter melon fruit was able to decrease blood glucose levels and increase the SOD activity of DM 1 in the rat kidney. The average ability of the therapy to reduce DM in low, medium, and acute level was 87.21, 84.5 and 55,56%, respectively. In 0.3 mL/200 g Bw dose, concentrated infusions therapy of bitter melon fruit reduced blood sugar level to all diabetes levels. The average value of concentrated infusions therapy of bitter melon fruit in increasing SOD activity was 144.76%. Keywords:  Diabetes mellitus, infuse, SOD (superoxide dismutase), bitter melon fruit (Momordica charantia L.) Buah pare (Momordica charantia L.) merupakan salah satu keluarga Cucurbitaceae yang bermanfaat sebagai obat tradisional, salah satunya untuk antidiabetes. Diabetes mellitus (DM) merupakan salah satu penyakit autoimun yang ditandai dengan meningkatnya kadar gula darah (KGD). Penelitian ini bertujuan untuk mengetahui pengaruh terapi infusa pekat buah pare terhadap kadar glukosa darah dan SOD pada tiga tingkat diabetes yaitu ringan, sedang dan akut pada ginjal tikus DM tipe 1. Dosis yang digunakan yakni 0,15; 0,30; 0,45; 0,60; 0,80; dan 1 mL/200 g BB. KGD diiukur dengan metode enzimatik (glukosa oksidase) dan aktivitas SOD diukur dengan uji NBT (Nitroblue tetrazolium). Hasil penelitian menunjukkan terapi infusa pekat buah pare berpengaruh terhadap penurunan kadar glukosa darah dan peningkatan kadar SOD pada ginjal tikus DM 1. Kemampuan rata-rata terapi dalam menurunkan DM tingkat ringan, sedang, dan akut masing-masing sebesar 87,21; 84,5 dan 55,56%. Pada dosis 0,3 mL/200 g BB, terapi infusa pekat buah pare mampu menurunkan KGD terhadap seluruh tingkat DM. Kemampuan rata-rata infusa pekat buah pare dalam meningkatkan kadar SOD sebesar 144,76%. Kata Kunci: Diabetes mellitus, infusa, SOD (superoksida dismutase), buah pare (Momordica charantia L.)
Synthesis of Goethite (α-FeOOH) Pigment by Precipitation Method from Iron Lathe Waste Khoiroh, Lilik Miftahul; Nuraini, Elysia Dwi; Aini, Nur
ALCHEMY Vol 6, No 2 (2018): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v6i2.7106

Abstract

Lathe waste contains high iron content potential to be further processed into goethite pigment. The purpose of the research was to determine the effect of synthesis temperature on the structure, colour values, and morphology of goethite pigment. The synthesis was conducted with temperature variations of 60, 70, 80and 90°C. The XRD diffraction pattern shows that crystal structure of the product of all synthesis temperatures are goethite (α-Fe-OOH) with orthorhombic structure. The crystal size of the pigment ranges between 11.17 – 12.32 nm. Colour value analysis shows that product of 70°C synthesis temperature exhibits the highest lightness value about 40.5. Based on SEM-EDX imaging, the morphology of the samples is not uniform and forming agglomerates. Traces of impurities were detected, such as C and Na. Keywords: Iron lathe waste, goethite, temperature, precipitation

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