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Articles 6 Documents
Search results for , issue " Vol 51, No 1 (2019)" : 6 Documents clear
CRITICAL APPRAISAL OF NEUROPATHIC PAIN GUIDELINES IN ASIA Pinzon, Rizaldy Taslim; Sanyasi, Rosa De Lima Renita
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 1 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Introduction: Neuropathic pain is often difficult to treat, because it is resistant to many medications and/or because of the adverse effects associated with effective medications. Clinicians may be guided by a number of published guidelines and algorithms for the management of neuropathic pain. It is important for every clinicians to know the quality of guidelines.Objective: The aim of this study is to assess the quality of neuropathic pain guidelines in Asia using Appraisal of Guidelines for Research & Evaluation II (AGREE II) instrument.Method: The search were obtained to identify neuropathic pain guidelines in Asia. Each guideline were assessed using AGREE II instrument. There are 23 key items organized within 6 domains and each key items are rated on a 7-point scale. After calculating each domain, the result interpreted as a strongly recommended for use in practice, recommended for use with some modification, and not recommended for use in practice.Result and Discussion: There are 5 guidelines left: a guideline from Philippines, China, South Korea, Malaysia, and Middle East. There are no guideline scored 50% or more on all six domain, thus conclude that all five guidelines hadn’t achieved a satisfactory result. The highest score was obtained by domain 4 and the lowest score was obtained by domain 5 and domain 6.Conclusion: There is no neuropathic pain guidelines in Asia fulfill the satisfiying criteria according to AGREE II instrument.
Effects of resistant starch of mixed tubers snacks on glucose metabolism, leptin, visceral fat and body mass index in type 2 diabetes mellitus (T2DM) Hidayat, Jenny; Sunarti, .; Mustofa, .; Sadewa, Ahmad Hamim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 1 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract Resistant starch could lower blood glucose, decrease adipocyte in adipose tissue and affect satiety hormones such as leptin. Tubers and pumpkin have high content of resistant starch, but their effectiveness to type 2 diabetes mellitus (T2DM) has not been known clearly.  This research was conducted to determine the effectiveness of snack consumption made from tubers and pumpkins to BMI, visceral fat,glucose and leptin levels in the blood of T2DM patients and the correlation between the variables. The research method used was pre-post clinical trial with 16 T2DM subjects in treatment (RS) and control groups. Subjects in RS group consume snack twice daily for 4 weeks then after wash out for 4 weeks, the same subjects to be the subjects control. Paired T-test or Wilcoxon-test was used to analyze the differences between values before and after treatment in the group and between groups. Pearson test was used to analyze the correlation of BMI, visceral fat, glucose and leptin level. Result : The visceral fat was increase in RS group (P=0.04) after 4 weeks consuming snack but decrease in control group (P=0.04) without significant change of BMI. leptin level was decreased (P=0.00) in RS group. Blood glucose decreased significantly (P=0.01) and leptin level increased slightly in control group. Comparing the RS and control group at the end of study, the variation of visceral fat in the female groups (P=0.05) and leptin differed significantly (P=0.05). Visceral fat correlated with BMI in the RS  and control group. Conclusion : the mixed tubers and pumpkin snack decreased the leptin level but increased visceral fat. It might be caused by the resistant starch in snack, as they improve the sensitivity of insulin, decrease subcutan adipose tissue and increase the visceral fat. Subcutan adipose tissue secreted more leptin than visceral fat.
Urinary Tract Infection in Premature Rupture of Membrane (PROM): A University Hospital Based Study Pangastuti, Nuring; Rahman, Muhammad Nurhadi; Liligoly, Rivaldi D
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 1 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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ABSTRACT Introduction. Premature rupture of membrane (PROM) and preterm PROM (PPROM) are commonly related with poor maternal and perinatal outcomes. Urinary tract infection (UTI) has been known as one of its risk factors.Aim. To ascertain the frequency and pattern of urinary symptoms as well as the risk factors for UTI in PROM and preterm PROM (PPROM)Method. A retrospective study was conducted at Dr. Sardjito General Hospital, Yoyakarta, Indonesia. All pregnancy cases with the history of PROM/PPROM from January to December 2015 were included. The research subjects were obtained from medical records, using the format of basic data collection to identify the risk factors of UTI in pregnancyResults. One hundred cases of complicated pregnancy with either PROM or PPROM were obtained. The mean of maternal age, gestational age, and birth weight were 28 ± 5.99 years; 34.05 ± 4:28 weeks; 2170.79 ± 835.447 grams; respectively. Urinalysis were done in 58 patients. The prevalence of bacteriuria was 55.17%. Symptomatic vs asymptomatic bacteriuria showed statistically significant differences (p <0.001, OR = 0.409; CI = 0287-0584). In multivariate analysis using linear regression, maternal age, gestational age, and parity were not directly related to the occurrence of UTI (p = .367; p = .697; p = .385; respectively).Conclusion. It was revealed that the proportions of symptomatic bacteriuria in pregnancy were significantly higher than asymptomatic. There were no significant differences related to the prevalence of UTI in pregnancy complicated with PROM and PPROM.
Comparative Histochemical Study of the Kidney in Six Mammalian Species Oghoverere, Abiokuta Blessing; Igho, Odokuma Emmanuel
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 1 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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AbstractIntroductionComparative Anatomy describes the similarities and differences in the anatomy of different species, Comparative anatomical studies does not only provide evidence for evolution but indicates that various organisms originate from a common ancestor and assists scientists in classifying these organisms based on similar characteristics of their anatomical structure. Materials and Methods Approval was obtained from ethical committee of the Department of Human Anatomy and Cell Biology, Delta State University Abraka, reference number (DELSU/CHS/ANA/68/85). The animals were grouped into three based on their dietary patterns: Herbivores (Capra aegagrus &Bostourus), Carnivores (Canis lupus & Felis catus) and Omnivores (Rattus norvegicus &Sus scrofa), a renal tissue were obtained from each of the studied species and preserved in 10% formal saline for one week. The tissues were subsequently processed and stained using general and specific histochemical techniques.Observation    It was observed from this study all the mammalian kidneys consisted of similar histological features which explained that these studied mammals undergo the same evolutionary trend, adaptational changes and phylogenic relaionship that exist between the kidneys of the studied species. ConclusionDespite their differences in dietary patterns, the studied species have similar histological features with little observed variation. However, they have little differences in histochemical staining pattern for glycogen and glycoprotein but in reticulin they all stain intensely. This study has established a strong relationship in the histology of the kidney in six mammalian species.
Correlation between ratio of Nrf2/Keap1 and catalase gene expression in liver of hyperlipidemic rats after administration of 7-hydroxy-2-(4-hydroxy- 3-methoxyphenyl)-chromen-4-one Prasetyastuti, .; Rubi, Dianandha Septiana; Pramana, Abrory Agus Cahya; Sadewa, Ahmad Hamim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 1 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Hyperlipidemia results in excessive superoxide anion radicals that are the cause ofoxidative stress. Phytochemical compounds can reduce oxidative stress. The aim of thisstudy was to investigate the correlations between ratio of Nrf2/Keap1 and catalase geneexpression in livers of hyperlipidemic rats after administration of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one. Twenty-four Rattus norvegicus rats, aged 8 weeks andweighing an average of 200 g were randomly divided into 6 groups i.e. Group 1 wasnormal group (N), Group 2 was hyperlipidemic rats (HL), Group 3 was hyperlipidemicrats with simvastatin (HL+SV), and Groups 4-6 were hyperlipidemic rats with 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one doses 10 mg (HL+10), 30 mg (HL+30) or 90 mg/200 g BW (HL+90), respectively, administered orally by gavages. At the end ofthe study, the rats were euthanized and the livers were used to analyze the ratio of Nrf2/Keap 1 and catalase gene expression. Nrf2/Keap1 ratio and catalase gene expressionbetween groups were analyzed by Kruskal Wallis test. Spearman’s correlation test wasused to analyze the correlations between Nrf2/Keap1 ratio and catalase gene expression.The administration of 3 different doses of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one on hyperlipidemic rats increased catalase gene expression. There wasno correlation between ratio Nrf2/Keap1 and catalase gene expression. In conclusion,administration of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one can improvecatalase gene expression in hyperlipidemic rats. However, there is no correlation betweenthe ratio of Nrf2/Keap1 gene expression and the catalase gene expression.
The difference of nasal mucosal cytology features in gas station workers compared to non-gas station workers Rianto, Bambang Udji Djoko; Kurniawan, Linggawati; Sudarman, Kartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 1 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

 The pollutants contained in an outdoor air environment for example gasoline vapors can cause epithelial inflammation, metaplasia, and dysplasia. This study aimed to determine the difference in cytological nasal mucosa between gas station workers and non-gas station workers. This research used a cross-sectional design. There were 80 samples with inclusion criteria: aged 20-50 years, worked more than 3 months, consisting of 40 gas station workers (exposed group) and 40 non-gas station workers (unexposed group) who did not use nasal drops in the last ten days. The exclusion criteria of both groups were: 1) patients with acute rhinitis, 2) had nasal trauma, 3) had nasal surgery, 4) consume alcohol, 5) history of allergic rhinitis, and 6) refused to participate in the study. All samples performed brushing at 1/3 anterior nose inferior turbinate and cytology examination. The statistical analyses used X2 tests. From the exposed group we found 18 (45%) with inflammation, 17 samples (42.5%) with metaplasia, and 9 samples (22.5%) with dysplasia, while in the unexposed group there were 10 (20.5%) with inflammation, 4 (10.0%) with metaplasia and 2 (5.0%) dysplasia. There were statistically significant differences in nasal mucosal cytology, particularly metaplasia (p: 0.001; RP: 6.65; 95% CI: 1.78-27.01) and dysplasia (p: 0.023; RP: 5.52; 95% CI: 1.22-32.10) between both group samples. It can be concluded that there are statistically significant differences involving metaplasia and dysplasia in nasal mucosa cytology features of gas station workers compared to non-gas station workers.

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