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Articles 12 Documents
Search results for , issue " Vol 40, No 02 (2008)" : 12 Documents clear
The Effecct of cisplatin on male white mice testicular tissue Dick Moch. Rizal, Dick Moch. Rizal
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Universitas Gadjah Mada

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Background: Cisplatin is a potent anticancer drug. In the therapy of various kinds of tumours. such as testicular, ovarian, bladder and lung cancer, cisplatin is used. It has cytotoxic and antimitotic effect on cell and tissue. Some studies reported the negative effect of cisplatin on male reproductive system.Objective: To know the effect of cisplatin on testicular tissue of male white miceMethods: Ten male white mice of DDI strain, 2 months old, 28.8-33.0 grams were classified into control group (5 mice) and treatment group (5 mice). The animal models were given standard feeding LPPOM, while those the control group were given CMC-Na 0.5% orally for 7 days. Cisplatin was given to the treatment group intravenously in the dose of 3 mg/kgBW for 7 days. At the end of the experiment, the animal model was killed by decapitation and the testicle was taken out. The testicle was placed in 10% formalin solution and processed for histology preparation with hematoxilin (Meyer) eosinand analyzed under binocular microscope.Results: All mice in the treatment group showed mild to severely damaged testis. There were serious spermatogenic and Sertoli cell disruption in severely damage testis.Conclusion: Intravenous injection of 3 mg/kgBW cisplatin for 7 days had deleterious effects on testicular tissue of male white mice, resulting in mild to severe damage.Key words: cisplatin - spermatogenesis - tubulus seminiferous - testicular damage
Natural Killer (NK) cells and severity of dengue infection among children hospitalized in Dr. Sardjito Hospital Ida Savitri Laksanawati, Umi S. Intansari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Universitas Gadjah Mada

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Background: Dengue infection isONE OF the most frequent infectious diseases in Indonesia. The manifestation of dengue infections varies from asymptomatic to live-threatening, dengue shock syndrome. It is hypothesized that immune responses contribute to immunopathogenesis of severe dengue infection. Natural killer INK) cells are innate lymphocytes which play a crucial role in anti-pathogen host defense and are particularly important in mediating resistance to viral infections. However, only a few studies of NK cells have been conducted in vivo, especially in Indonesia.ObJectives: The objectives of this study were to find the correlation between the number of NK cells with severity of the disease, and to find out the profile of NK cells absolute numbers in acute and convalescent dengue infection patients among children hospitalized n Dr. Sardjito hospitalMethods: An observational prospective study was conducted. Clinical and laboratory data were followed from the day of admission until the day of discharge. The severity of the disease was graded according to the WHO criteria for Dengue Hemorrhagic Fever IDHF). The absolute number of NK cells was measured by flow cytometer using monoclonal antibody anti-CD3, anti-CD16 + 56, and anti-CD45, with dual platform method. Student t-test was used to find out the difference of NK cell absolute number between acute and convalescent phases. The correlation between NK cells and the severity of the disease was analyzed using Spearman correlation test.Results: NK cell absolute number tended to be lower in acute compared to convalescent phase, but the difference was not statistically significant. There was an inverse correlation between the NK cell absolute number and the severity of dengue infection Ir=-O.322; p=O.017).Conclusion: Absolute number of NK cells were decreased during acute phase of dengue infection, and the decrease was more pronounced in severe than in mild dengue infection.Key words: NK cells absolute number - mild and severe dengue infection - acute and convalescent phases
Evaluation of substrate metabolism in critically ill pediatric patients Antonius H Pudjiadi, Nurnaningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Critically ill pediatric patients are characterized by a hypermetabolic state, a catabolic response, and a decreased capacity to utilize substrate. Metabolic state of critically ill pediatric patients can be detected by analyzing substrate utilization.Objective: To determine the metabolic state of critically ill pediatric patients using PRISM III Score, blood glucose level, and urinary nitrogen excretion.Methods: A cross sectional study was conducted in Pediatric Intensive Care Unit (PICU) of Cipto Mangunkusumo Hospital Jakarta between May and September 2006. All admitted PICU patients, except those with renal or hepatic failure, burns, diabetic ketoacidosis and died in the first 24 hours, were included. PRISM III Scores were measured in the first 24-hours of admission. Blood glucose level was observed at random within the first hour of hospitalization, while urinary nitrogen excretion was measured using urine collected in the second 24-hours of admission.Results: Fifteen cases were eligible for this study. Their age ranged between 1 to 96 months. The median (01 ;03) for PRISM III Scores, random blood glucose, and urinary nitrogen excretion were 6.0 (3.0;11.0), 123.0 (100.0;227.0), and 279.4 (124.3;408.4) mg/dL, respectively. There were no significant correlations between PRISM III Scores and random blood glucose (r=0.40;p=0.14), and between PRISM III Scores and urinary nitrogen excretion (r = -0.27;p = 0.33). There was significant correlation between random blood glucose and urinary nitrogen excretion (r=0.56;p=0.03).Conclusion: Critically ill pediatric patients had a catabolic state that had no association with PRISM III Scores. Random blood glucose level within the first hour of admission predicted the increasing protein catabolism.Key words: critically ill pediatric patients - blood glucose level - urinary nitrogen excretion - PRISM III Score.
Psychosocial stress and bacterial vaginosis in adult women Ova Emilia, Ova Emilia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Objectlve:The purpose of this study was to assess the association of bacterial vaginosis with psychosocial stress with in adult women.Methods: A cross sectional design was used. Adult women (n = 320) aged 15 to 44 years were recruited at routine health care visits. Assessments were conducted on clinical symptoms, and an extensive selfreport interview.Results: Psychosocial stress was associated with overall prevalence of bacterial vaginosis (ratio prevalence, 1.22; 95% CI, 1.13-1.34). Factors that may influence the association were age, frequency of douching, frequency of vaginal intercourse and use of hormonal contraceptive. The association was not changed appreciably by the control for behavioral and demographic characteristics.Conclusion: Increased psychosocial stress is associated with greater bacterial vaginosis prevalence independent of other risk factors.Key words: bacterial vaginosis - stress - immune functioning
Diagnostic test of mammography in a palpable mass of the breast Bambang Udji Djoko Rianto, Rosalia Sri Sulistijawati Henry Kusumo Husodoputro
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Background: Breast cancer is the most common cancer in Indonesia after cervical cancer. The diagnosis of breast cancer is based on triple diagnostics, clinical diagnostic, mammograph, and fine needle aspiration biopsy (FNAB). Mammograph is a non-invasive radiologic imaging to demonstrate microcalcification as an early sign of breast cancer.Objective: The aim of this study was to measure the validity of mammograph in a palpable mass of the breast.Methods: Study design for this study was a diagnostic test that compared mammograph with histopatology result as the gold standard. Study was performed between March 2006 and September 2007 in Sardjito General Hospital, Yogyakarta. There were 79 palpable masses of the breast that were included as the subjects of this study. They were mammographed and examined histopatologically. Descriptive analysis with McNemar non parametric test with 2x2 table was performed by a computer software program to calculate sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positivelikelihood ratio (positive LR) and negative likelihood ratio (negative LR). .Results: Sensitivity, specificity, PPV, NPV, positive LR and negative LR of mammograph in diagnosing a breast palpable mass were 87.18%,87.50%,87.18%,87,50%,7, and 0.146, respectively Conclusion: Mammograph had a high validity in diagnosing breast palpable masses.Key words: breast palpable mass - mammograph - diagnostic test - validity.
The combination effect of triamcinolone acetonide and tamoxifen citrate on fibroblast populated collagen lattice contractions Yohanes Widodo Wirohadidjojo, Agung Pranoto Satiti RetnoPudjiati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Universitas Gadjah Mada

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Background: Keloid is caused by fibroblast hyperproliferation stimulated by transforming growth factor-IH ITGF-131 I, and it is usually treated with triamcinolone acetonide (TAl, which has the ability to inhibit TGF131 synthesis. However, the clinical results is still unsatisfied. Another drug that may inhibit keloid fibroblast TGF-131 synthesis is tamoxifen citrate (TCI, but the effect of the combination on keloid fibroblast activities has never been published.Objective: To find out the effect of combined triamcinolone acetonide and tamoxifen citrate on fibroblast keloid activities in vitro.Methods: It was a parallel post-test only study. The third passage keloid fibroblasts were isolated from a patient with keloid, cultivated in collagen lattice, and treated with several combinations of 5, 10, and 20 pM TA and 10, and 20 pM TC. Lattice contractions were measured based on digital image using scion image.Results: Among TA groups, the best inhibition of lattice contraction was found among 20 pM treated group and among TC groups. The best inhibition of lattice contraction was found among 20 pM TC. The best combination was found in the combination of 20 pM TA plus 20 pM TC.Conclusion: The result indicated that a combination of triamcinolone acetonide and tamoxifen citrate had a significant role in suppressing fibroblast activity, better than triamcinolone acetonid or tamoxifen citrate alone.Key words: tamoxifen - triamcinolone - collagen lattice - keloid fibroblast.
The combination effect of triamcinolone acetonide and tamoxifen citrate on fibroblast populated collagen lattice contractions Pranoto, Agung; Pudjiati, Satiti Retno; Wirohadidjojo, Yohanes Widodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Keloid is caused by fibroblast hyperproliferation stimulated by transforming growth factor-IH ITGF-131 I, and it is usually treated with triamcinolone acetonide (TAl, which has the ability to inhibit TGF131 synthesis. However, the clinical results is still unsatisfied. Another drug that may inhibit keloid fibroblast TGF-131 synthesis is tamoxifen citrate (TCI, but the effect of the combination on keloid fibroblast activities has never been published.Objective: To find out the effect of combined triamcinolone acetonide and tamoxifen citrate on fibroblast keloid activities in vitro.Methods: It was a parallel post-test only study. The third passage keloid fibroblasts were isolated from a patient with keloid, cultivated in collagen lattice, and treated with several combinations of 5, 10, and 20 pM TA and 10, and 20 pM TC. Lattice contractions were measured based on digital image using scion image.Results: Among TA groups, the best inhibition of lattice contraction was found among 20 pM treated group and among TC groups. The best inhibition of lattice contraction was found among 20 pM TC. The best combination was found in the combination of 20 pM TA plus 20 pM TC.Conclusion: The result indicated that a combination of triamcinolone acetonide and tamoxifen citrate had a significant role in suppressing fibroblast activity, better than triamcinolone acetonid or tamoxifen citrate alone.Key words: tamoxifen - triamcinolone - collagen lattice - keloid fibroblast.
Psychosocial stress and bacterial vaginosis in adult women Ova Emilia, Ova Emilia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Objectlve:The purpose of this study was to assess the association of bacterial vaginosis with psychosocial stress with in adult women.Methods: A cross sectional design was used. Adult women (n = 320) aged 15 to 44 years were recruited at routine health care visits. Assessments were conducted on clinical symptoms, and an extensive selfreport interview.Results: Psychosocial stress was associated with overall prevalence of bacterial vaginosis (ratio prevalence, 1.22; 95% CI, 1.13-1.34). Factors that may influence the association were age, frequency of douching, frequency of vaginal intercourse and use of hormonal contraceptive. The association was not changed appreciably by the control for behavioral and demographic characteristics.Conclusion: Increased psychosocial stress is associated with greater bacterial vaginosis prevalence independent of other risk factors.Key words: bacterial vaginosis - stress - immune functioning
Diagnostic test of mammography in a palpable mass of the breast Bambang Udji Djoko Rianto, Rosalia Sri Sulistijawati Henry Kusumo Husodoputro
Journal of the Medical Sciences (Berkala ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Breast cancer is the most common cancer in Indonesia after cervical cancer. The diagnosis of breast cancer is based on triple diagnostics, clinical diagnostic, mammograph, and fine needle aspiration biopsy (FNAB). Mammograph is a non-invasive radiologic imaging to demonstrate microcalcification as an early sign of breast cancer.Objective: The aim of this study was to measure the validity of mammograph in a palpable mass of the breast.Methods: Study design for this study was a diagnostic test that compared mammograph with histopatology result as the gold standard. Study was performed between March 2006 and September 2007 in Sardjito General Hospital, Yogyakarta. There were 79 palpable masses of the breast that were included as the subjects of this study. They were mammographed and examined histopatologically. Descriptive analysis with McNemar non parametric test with 2x2 table was performed by a computer software program to calculate sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positivelikelihood ratio (positive LR) and negative likelihood ratio (negative LR). .Results: Sensitivity, specificity, PPV, NPV, positive LR and negative LR of mammograph in diagnosing a breast palpable mass were 87.18%,87.50%,87.18%,87,50%,7, and 0.146, respectively Conclusion: Mammograph had a high validity in diagnosing breast palpable masses.Key words: breast palpable mass - mammograph - diagnostic test - validity.
The effect of combination of triamcinolone acetonide and methotrexate on keloidfibroblast activity in dermis equivalent Yustin E. S, Endra; Waskito, Fajar; Wirohadidjojo, Yohanes Widodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Triamcinolone acetonid (TA) intralesion has been a standard treatment for keloids for manyyears, due to its effect in inhibiting collagen synthesis and fibroblast proliferation. However, until now theclinical result is unsatisfactory. Keloid flattening is slow and sometimes adverse reactions may occur.Methotrexate (MTX) is a chemotherapeutic agent having an antiproliferating effect which act as an antifolicacid. Because of this effect, MTX is potential to be used in combination with TA for the treatment inkeloid. Fibroblast populated collagen lattice (FPCL) was a dermal equivalent usually used for fibroblastactivity measurement.Objective: To understand the inhibition of fibroblast keloid activities of MTX in vitro on FPCL contraction,compared to TA and MTX plus TA.Methods: This research used simple parallel multigroups experimental study design, and conducted on thirdpassage keloid fibroblast culture, which was isolated from one patient. Fibroblast was cultivated in collagentype 1 from rat tail (FPCL). Keloid fibroblasts was classified into 16 groups, and treated with 5, 10, 20mM TA, 1.75, 3.5, 7 mM MTX, combination of TA and MTX, and a control negative. FPCL contractionindicating activities of fibroblast was measured using Scion Image software. Mean of FPCL contractionwas analyzed using one way analysis of variance (ANOVA).Results: All treatments could inhibit FPCL contraction until day 2 (p<0.05). The highest inhibition of FPCLwas found in combination of TA 20 mM + MTX 7 mM (p<0.05). The treatment that could inhibit FPCLcontraction until day 3 was only group MTX 3.5 mM + TA 20 mM. This result indicated that a combinationof TA and MTX was stronger in inhibiting keloid fibroblast activities compared with TA and MTX alone.Key words: keloid fibroblast - growth factors - triamcinolone acetonid - methotrexate - FPCL contraction

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