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Buletin Penelitian Kesehatan
Buletin Penelitian Kesehatan (Bulletin of Health Research) merupakan salah satu jurnal yang dipublikasikan oleh Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), Kementerian Kesehatan Republik Indonesia. Buletin Penelitian Kesehatan diterbitkan 4 kali dalam setahun dan telah terakreditasi Lembaga Ilmu Pengetahuan Indonesia (Indonesian Institute of Sciences) dengan SK No. 387/AU/P2MI/04/2012.
Articles
705
Articles
ARAH KEBIJAKAN KESEHATAN MENTAL: TREN GLOBAL DAN NASIONAL SERTA TANTANGAN AKTUAL

Ridlo, Ilham Akhsanu ( Departemen Administrasi dan Kebijakan Kesehatan Fakultas Kesehatan Masyarakat Universitas Airlangga ) , Zein, Rizqy Amelia ( Department of Personality and Social Psychology, Faculty of Psychology Universitas Airlangga )

Buletin Penelitian Kesehatan Vol 46, No 1 (2018)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Globally, during the last three decades, mental health has played significant role in regards to the discourse of global health policy. Since two decades ago, WHO has firmly defined health as a rounded state of condition where an individual reaches “…not merely absence of the illness, but also achieves physical, mental and social well-being.” WHO’s definition of health implies a significant impact on global health policy – all member of states should adhere their health policy to this definition. The Global Burden of Disease study carried out by WHO in 2012 that mapped out the burden of disease around the world revealed an appalling fact namely worsened mental health condition. Years lost due to disability (YLD) study mentioned that 6 out to 20 diseases that were most responsible in causing disability were mental illnesses. Therefore, this article aimed to describe the mental illness prevalence in global and national level by reviewing several mental illness epidemiological studies. Additionally, this article highlighted some of important challenges that should be considered by healthcare service providers and policymakers in tackling mental health issues, which are treatment gap and mental health stigma.

CYTOKINE RESPONSE OF TNF-α AND IL-4 POST-STIMULATION rESAT-6-CFP-10 FUSION ANTIGEN

Pratiwi, Rahmah Indah

Buletin Penelitian Kesehatan Vol 46, No 1 (2018)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Introduction.Protective immunityof tuberculosis (TB) infection is highly dependent on the balance of Th1 and Th2 cytokines. TNF-α cytokines that produce by Th1 cell retain a latent status, and IL-4 that produce by Th2 aids in the production of antibodies. The recent development of the vaccine candidate shows that rESAT-6-CFP-10 fusion antigen is specific to induce protective immune responses. The objective of the study was to determine the immune response through the differences in levels of TNF-α and IL-4 post-stimulation of rESAT-6-CFP-10 fusion antigen. Method.This study used aquasi experimentaldesignin the laboratoryin vitrowith culturedPBMC ofpatients withnew casesof pulmonaryTB, latent TBandhealthy individuals. Examination ofTNF-α and IL-4 levels was done by ELISA. Results. The highest TNF-α mean levels were 866,05 in the latent TB group, compared to814,56 in active TB and 414,58 in healthy individuals, but were not significantly different. The highest IL-4 mean levels were 1,39 in the active TB group, compared to 0,88 in latent TB and 0,74 in healthy individuals, but were not significantly different. Conclusion. There were no significant differences in levels of TNF-α and IL-4 post-stimulation of rESAT-6-CFP-10 fusion antigens in all three groups

Riwayat Hipertensi Keluarga sebagai Faktor Dominan Hipertensi pada Remaja Kelas XI SMA Sejahtera 1 Depok Tahun 2017

Angesti, Annisa Nursita

Buletin Penelitian Kesehatan Vol 46, No 1 (2018)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Perubahan status gizi, pola makan dan gaya hidup pada remaja turut hipertensi remaja. Penelitian ini merupakan penelitian cross sectional untuk mengetahui faktor dominan hipertensi pada remaja di SMA Sejahtera 1 Depok tahun 2017. Data yang dikumpulkan meliputi tekanan darah, status gizi (IMT/U, lingkar pinggang, rasio lingkar pinggang dan panggul, persen lemak tubuh), asupan zat gizi (natrium, kalium, kalsium, lemak, konsumsi buah dan sayur), pola hidup (durasi tidur, stres, aktivitas fisik), dan karakteristik remaja (jenis kelamin dan riwayat hipertensi keluarga). Tekanan darah diukur menggunakan sfigmomanometer air raksa, status gizi dengan antropometri, asupan zat gizi dengan Semi Quantitative FFQ, pola hidup dan karakteristik dengan kuesioner. Hasil penelitian menunjukkan bahwa Sebanyak 42,4% remaja SMA Sejahtera 1 Depok mengalami hipertensi (≥95 persentil). Terdapat perbedaan IMT/U, lingkar pinggang dan riwayat hipertensi keluarga pada hipertensi. Faktor dominan yang paling berhubungan dengan hipertensi pada remaja di SMA Sejahtera 1 Depok tahun 2017 adalah riwayat hipertensi keluarga. Diperlukan edukasi tentang pentingnya riwayat hipertensi keluarga seperti kegiatan konseling genetik sebagai pencegahan hipertensi remaja.

EFEK KOMBINASI PEGAGAN, DAUN SALAM, ALANG-ALANG, DAN BIJI PALA TERHADAP FUNGSI KARDIOVASKULER PASIEN HIPERTENSI ESENSIAL DI RUMAH RISET JAMU HORTUS MEDICUS TAWANGMANGU

Nisa, Ulfatun, Dewi, Tyas Friska ( Balai Besar Penelitian Pengembangan Tanaman Obat dan Obat Tradisional )

Buletin Penelitian Kesehatan Vol 46, No 1 (2018)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Hipertensi merupakan penyakit yang berperan penting dalam terjadinya penyakit kardiovaskular. Pasien dengan penyakit kardiovaskuler sering menggunakan pengobatan herbal sebagai alternatif maupun komplementer. Penelitian ini bertujuan untuk mengetahui efek formula kombinasi herba pegagan, daun salam, akar alang-alang, dan biji pala terhadap fungsi kardiovaskuler pasien hipertensi esensial. Desain penelitian yang digunakan pada penelitian ini adalah quasi eksperimental pre dan post test design untuk menilai pengaruh penggunaan jamu pada fungsi kardiovaskular subjek. Subjek penelitian ini berjumlah 60 orang, diberi formula jamu yang diminum 2 kali setiap hari selama 56 hari. Pengukuran terhadap tekanan darah, heart rate, RPP, PP, dan MAP dilakukan setiap minggu. Data diolah dan dianalisis  dengan menggunakan program SPSS. Hasil yang didapat menunjukkan penurunan tekanan sistolik dari 147,16 ± 6,46 mmHg menjadi 132,25 ± 11, 21 mmHg dengan nilai p = 0,001%, tekanan diastolik menurun dari 92,16 ± 2,49 mmHg menjadi 77,83 ± 8,98 mmHg dengan nilai p = 0,001%, tekanan arteri rata-rata, heart rate, RPP, dan PP juga mengalami penurunan. Hal ini menunjukkan formula kombinasi herba pegagan, daun salam, akar alang-alang, dan biji pala dapat memperbaiki fungsi kardiovaskular dengan menurunkan tekanan sistolik, diastolik, tekanan arteri rata-rata, nilai PP dan RPP.

Front Matter vol 46 no 1 year 2018

Chandraleka, Happy

Buletin Penelitian Kesehatan Vol 46, No 1 (2018)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Determinants of asthma among productive age workers in Indonesia

Tana, Lusianawaty ( Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), Ministry of Health of Republic of Indonesia )

Buletin Penelitian Kesehatan Vol 46, No 1 (2018)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Determinants of asthma among productive age workers in Indonesia   *Center for Health Resources and Services Research and Development National Institute of Health Research and Development   Lusianawaty Tana E-mail: lusianawaty@yahoo.com   Asthma is one of the chronic respiratory diseases that often leads to decrease of productivity, loss of income and unemployment, as well as psychosocial and financial problems. The objective of the research was to identify the determinant of asthma of productive age  workers in Indonesia using National Health Research (Riskesdas 2013).   Samples criterias were 15-64 years old workers across the country. The data were analyzed by complex sample  with significance level  0.05 and 95% confidence intervals. Samples that met the criterias were  405.984 people. Determinants of asthma in interest of this research were the areas of residence, age, education, nutritional status, smoking, illumination sources, sex, occupation, ownership index, residence location, slum neighborhood, physical activity, and fuel type usage. (ORadj 1.1-2.1 p≤0.01). The proportion of asthma in eastern region of Indonesia and Java-Bali region was 2.05 and 1.75 higher than Sumatra region respectively. Less nutritional status had asthma proportion of 1.5 times higher than normal. It was concluded that the major determinants of asthma in productive age workers were the area of residence, age, education level, and nutritional status. Improving nutritional status and increasing knowledge about healthy lifestyle should be done as an effort to reduce the occurrence of asthma.   Key words:  workers, asthma, Indonesia, Riskesdas 2013

Faktor Determinan Penyakit Jantung Koroner pada Kelompok Umur 25-65 tahun di Kota Bogor

Pradono, Julianty ( Badan Litbang Kesehatan )

Buletin Penelitian Kesehatan Vol 46, No 1 (2018)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Background: Coronary Heart Disease (CHD) is the highest prevalence of Non Communicable disease (NCD) in general population. It affects the morbidity, disability, and mortality rate. The factors that are related to CHD can be controlled and the occurrence of CHD can be prevented. Aim of this study is to identify the determinant factors that are related to CHD on residents in Central Bogor village, Indonesia. Method: The data for this study is based on the baseline data of 2011-2012 NCD cohort study of Central Bogor village in Bogor city of West Java province. Diagnosis of CHD are based on the symptoms of CHD by interview and ECG examination. There are respondents, male and female, aged 25-65 years. Multivariate analysis had been done to describe the factors that influenced CHD. Results: The prevalence of CHD is 20,9 ± 0,41 percent in aged 25-65 years of Central Bogor population. Risk factors that are related to CHD are: stroke, 3.5 times (95% CI 2.0-5.9); hypertension, 1.6 times (95% CI 1.3-1.9); followed by IFG,  1.5 times (95% CI 1.1-1.9); diabetes mellitus, 1.2 times (95% CI: 0.8-1.6); emotional disorders, 1.4 times (95% CI: 1.2-1.7); LDL, 1.3 times (95% CI: 1.0-1.6); obese based on BMI, 1.2 times (95% CI: 1.0-1.5); compared to population with no risk factors. The proportion of CHD in female 1.9 times more than males and there are increasing with age. Conclusion: hypertension and hyperglycemia are the determinant factors of developing CHD. It is recommended develop a CHD risk guidebook to raise public awareness about CHD risk factors.    

Gambaran Kondisi Masyarakat pada Masa Surveilans Pasca-Transmission Assesment Survey (TAS)-2 Menuju Eliminasi Filariasis di Kabupaten Bangka Barat

suryaningtyas, nungki hapsari, arisanti, maya, Satriani, Ade Verientic, inzana, nur, santoso, santoso, suhardi, suhardi

Buletin Penelitian Kesehatan Vol 46, No 1 (2018)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Abstract Filariasis elimination program is a national priority with the main agenda conducting mass drug administration (MDA). West Bangka Regency is one of the districts that have implemented filariasis elimination program and has entered a stage stop MDA filariasis surveillance period. This study aims to describe the condition of the community during the post-TAS-2 surveillance in four villages in West Bangka Regency based on blood tests, knowledge, attitudes, behavior and society on filariasis based on blood tests, knowledge, attitudes, behavior, environment of filariasis. Data collected through interviews and examination of venous blood filtration to 150 people in four selected villages. Blood filtration test results obtained three positive respondents Brugia malayi microfilariae species and density of each patient amounted to 116 mf / ml, 245 mf / ml and 112 mf / ml. Respondents knowledge about the symptoms, modes of transmission, consequences and ways of preventing filariasis is still very low. The attitude of the respondents towards the prevention and eradication of filariasis in good categories. Treatment history most respondents ever get preventive treatment of filariasis, but only 2 percent ever taking medications to prevent filariasis five times. Behavior of respondents to safeguard oneself against mosquito bites by using mosquito nets have been conducted (73.3%) and mosquito (65.3%). Most respondents in the habit of going out at night (78.7%). Found swamp (23.3%) and reservoir host (cats) by 40.7 percent of respondents around the house. The presence of positive filariasis indicates the presence of filariasis. PSP of filariasis-related community still needs to be improved as prevention of filariasis. The presence of swamps can be carried out where potential filariasis vector vanishes. Cats as reservoirs found around the home can be a source of transmission of filariasis. Keywords : microfilariae, knowledge, attitude, practise, environment, West Bangka Abstrak Program eliminasi filariasis merupakan salah satu prioritas nasional dengan agenda utama melaksanakan kegiatan pemberian obat pencegahan secara masal (POPM) filariasis. Kabupaten Bangka Barat adalah salah satu kabupaten yang telah melaksanakan program eliminasi filariasis dan telah memasuki tahap surveilans periode stop POPM filariasis. Penelitian ini bertujuan untuk mengetahui gambaran kondisi masyarakat pada masa surveilans pasca TAS-2 di empat desa di Kabupaten Bangka Barat berdasarkan pemeriksaan darah, pengetahuan, sikap, perilaku dan lingkungan masyarakat tentang filariasis. Pengumpulan data dilakukan melalui wawancara dan pemeriksaan filtrasi darah vena terhadap 150 orang yang berada di empat desa terpilih. Hasil pemeriksaan filtrasi darah didapatkan tiga responden positif mikrofilaria dengan spesies Brugia malayi dan kepadatan masing-masing penderita sebesar 116 mf/ml, 245 mf/ml dan 112 mf/ml. Pengetahuan responden mengenai gejala, cara penularan, akibat yang ditimbulkan dan cara pencegahan filariasis masih sangat rendah. Sikap responden terhadap upaya pencegahan dan pemberantasan filariasis dalam kategori baik. Riwayat pengobatan sebagian besar responden pernah mendapatkan pengobatan pencegahan filariasis, akan tetapi hanya 2 persen yang pernah minum obat pencegahan filariasis sebanyak lima kali. Perilaku responden terhadap upaya perlindungan diri terhadap gigitan nyamuk telah dilakukan dengan menggunakan kelambu (73,3%) dan antinyamuk (65,3%). Sebagian besar responden mempunyai kebiasaan keluar rumah pada malam hari (78,7%). Ditemukan rawa (23,3%) dan hewan reservoir (kucing) sebesar 40,7 persen di sekitar rumah responden. Masih ditemukannya penderita positif filariasis mengindikasikan adanya penularan filariasis. PSP masyarakat terkait filariasis masih perlu ditingkatkan sebagai upaya preventif terhadap filariasis. Adanya keberadaan rawa dapat menjadikan tempat potensial perindukan vektor filariasis. Kucing sebagai reservoir yang ditemukan disekitar rumah dapat menjadi sumber penularan filariasis. Kata kunci: mikrofilaria, pengetahuan, sikap, perilaku, lingkungan, Bangka Barat

HUBUNGAN ANTARA KEPADATAN DAN TINGKAT INFEKSI SERKARIA Schistosoma japonicum PADA KEONG Oncomelania hupensis lindoensis DENGAN KASUS SCHISTOSOMIASIS DI DAERAH ENDEMIS SCHISTOSOMIASIS, SULAWESI TENGAH

Nurwidayati, Anis ( Balai Litbang P2B2 Donggala ) , Widjaja, Junus ( Balai Litbang P2B2 Donggala ) , Samarang, Samarang ( Balai Litbang P2B2 Donggala ) , Nurjana, Made Agus, Tolistiawaty, Intan ( Balai Litbang P2B2 Donggala ) , Sumolang, Phetisya Pamela Frederika ( Balai Litbang P2B2 Donggala )

Buletin Penelitian Kesehatan Vol 46, No 1 (2018)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Schistosomiasis in Indonesia is found only in theNapu and Bada Highlands, Poso District and Lindu Highlands, Sigi District, Central Sulawesi Province. Schistosomiasis in Indonesia is caused by Schistosoma japonicum and Oncomelania hupensis lindoensis is the intermediate snail. The mapping of snail focci areas in 2017 showed that there was a significant change in the spread of the snails focus. This paper aimed to describe the density and infection rate of cercariae S. japonicum on the snail in the endemic areas of schistosomiasis in Central Sulawesi Province. The mean O.hupensis lindoensis snail density in Napu ranged from 0.9 to 6.6/m2, with mean rates of cercariae infections ranging from 0.4% to 21.4%. The snail density average in Lindu ranging from 3/m2 to 69,1/m2, with 4.4%-72.9% of cercariae infections. In bada the snail density ranged from 0.1 to 4.9/m2, with mean rates of cercariae infections ranging from 0% to 14.9%. Bivariate analysis showed there was no correlation among snail density and cercariae infection rate with schistosomiasis case (p value> 0.05). Schistosomiasis di Indonesia hanya ditemukan di Propinsi Sulawesi Tengah, yaitu Dataran Tinggi Napu dan Dataran Tinggi Bada, Kabupaten Poso serta Dataran Tinggi Lindu, Kabupaten Sigi. Schistosomiasis di Indonesia disebabkan oleh Schistosoma japonicum dengan hospes perantara keong Oncomelania hupensis lindoensis. Pemetaan daerah fokus pada tahun 2017 menunjukkan bahwa  terdapat perubahan yang signifikan dalam penyebaran fokus keong. Tulisan ini bertujuan untuk menggambarkan kepadatan dan infection rate serkaria S.japonicum pada keong perantara schistosomiasis di wilayah endemis schistosomiasis di Provinsi Sulawesi Tengah. Rerata kepadatan keong O.hupensis lindoensis di Napu berkisar dari 0,9 – 6,6/m2, dengan rerata tingkat infeksi serkaria berkisar antara 0,4% sampai 21,4%, di Lindu kepadatan keong berkisar antara 3/m2 sampai 69,1/m2, dengan tingkat infeksi serkaria 4,4%-72,9%, dan di Bada kepadatan keong berkisar antara 0,1 – 4,9/m2, dengan rerata tingkat infeksi serkaria berkisar antara 0 % sampai 14,9%. Analisis bivariat menunjukkan tidak ada korelasi antara kepadatan keong dan tingkat infeksi serkaria dengan jumlah kasus schistosomiasis nilai p value > 0.05.

Back Matter vol 46 no 1 year 2018

Chandraleka, Happy

Buletin Penelitian Kesehatan Vol 46, No 1 (2018)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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