International Journal of Integrated Health Sciences
ISSN : 23021381     EISSN : 23384506
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Articles 167 Documents
Eicosapentaenoic Acid as Adjuvant for Cachexia in Cancer’s Patients

Hadi, Soeseno, Kurniawan, Cynthia, Budiono, Jansen

International Journal of Integrated Health Sciences VOL 3, NO 1, March (2015)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Cachexia is a frequent problem in cancer patients associated with mortality and morbidity since it causes death, reduced therapy effectiveness, as well as decreased quality of life. Cachexia emerges from interactions of several factors, namely metabolic effect of cancer cells, factors released by cancer cells, cytokines release from host cell in response to tumors, and side effects of therapies. Combination of these factors contributes to anorexia, decreased body fat and muscle, and weight loss. Unfortunately, there is no gold standard for treatment of cachexia. Several studies found that eicosapentaenoic acid (EPA) might improve cancer cachexia. It has potential blocking effects on several cachexia underlying factors. It may reverse weight loss, increase lean body mass, and improve the efficacy of therapy and the quality of life. The objective of this literature review is to describe and give basic understanding of EPA as adjuvant for cancer cachexia. Keywords: Cachexia, cancer, EPADOI: 10.15850/ijihs.v3n1.399

Prediction of Jamar Grip Strength Value Using Modified Aneroid Spyhgmomanometer Cuff Method

Pujianita, Lusia, Prabowo, Tertianto, Prananta, Marietta Shanti

International Journal of Integrated Health Sciences VOL 5, NO 1, March (2017)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To examine the prediction of Jamar grip strength value by using aneroid sphygmomanometer cuff method in adults.Methods: This study involved 120 subjects, aged 20–59 years old. The grip strength of subjects were measured using Jamar dynamometer and aneroid sphygmomanometer cuff method. Spearman analysis was used to evaluate the correlation between variables and grip strength. Forward stepwise was used to analyze the regression of Jamar dynamometer using aneroid sphygmomanometer cuff method. Results: There was a weak correlation (r<0.4) between grip strength with age and BMI, moderate correlation (r = 0.4–0.6) for grip circumference, and also strong correlation r= (0.6–0.8) for sex, hand length, and hand width. Jamar grip strength value can be predicted using spyghmomanometer with the formula of (0.1157 x Sphygmomanometer grip strength value) – (5.696 x sex) + (0.0824 x age) (female =1, male= 0).Conclusions: Grip strength correlates with physiological variables. The variables to predict Jamar grip strength using sphygmomanometer are sex and age. Regression analysis shows that spyhgmomanometer can be used as an alternative to measure grip strength and has a valid value to predict the Jamar grip strength value. Keywords: Adult, grip strength, Jamar dynamometer, sphygmomanometer, prediction formula DOI: 10.15850/ijihs.v5n1.958

Effectiveness in Dynamic Balance: a Comparison between Foot Muscle Strengthening Using Elastic Band and without Elastic Band in Children Aged 8–12 with Flexible Flatfeet

Listyorini, Indri, Shanti, Marietta, Prabowo, Tertianto

International Journal of Integrated Health Sciences VOL 3, NO 1, March (2015)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To compare the effects of foot muscle strengthening exercises with and without elastic band to the dynamic balance function in children aged 8–12 years with flexible flatfeet.Methods: Forty-one children (aged 8–12 years) with flexible flatfeet and dynamic balance problem were randomly allocated into either the intervention or control group. Both groups received thrice weekly training for 6 weeks. The foot strengthening exercise regimens consisted of pronation, supination, short foot, and tiptoeing using elastic band for the intervention group and without elastic band for the control group. Star Excursion Balance Test (SEBT) was tested before and after 6 weeks of training. Results: A statistically significant difference of normalized SEBT scores was found for both groups in both legs (p=0.00, p<0.05). The intervention group was significantly better than the control group for both right and left legs (p=0.00, p<0.05). Conclusions: Foot muscle strengthening either with or without elastic band improves dynamic balance in children aged 8–12 years with flexible flatfeet. Exercise given with elastic band significantly shows better improvement in the dynamic balance compared to without elastic band.Keywords: Flexible flatfeet, strengthening exercises, elastic band, dynamic balance, star excursion balance test DOI: 10.15850/ijihs.v3n1.404

Relationship between Physical Activity, Anthropometry, and Forced Expiratory Volume in One Second with 6-Minute Walk Distance in Elderly

Sukarya, Irna Purnamasari, Vitriana, Vitriana, Prabowo, Tertianto

International Journal of Integrated Health Sciences VOL 5, NO 1, March (2017)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To examine the correlation between physical activity using the Global Physical Activity Questionnaire (GPAQ), anthropometry (body mass index/BMI), and forced expiratory volume in one second (FEV1) value with six-minute walk distance in healthy community-dwelling elderly.Methods: A cross-sectional design study with consecutive sampling was conducted. This study included sixty nine participants (30 males and 39 females), aged ≥60 years who lives at Batununggal region in Bandung, Indonesia. The data was analyzed statistically by using normality, correlation, and multiple regresion tests. Results: The results showed that there was a correlation between six-minute walk distance and BMI in females (p=0.006), and FEV1 value in males (p=0.010). No significant correlation was found between GPAQ value and six-minute walk distance in females (p=0.4074) and in males (p=0.0926). Conclusions: There was a correlation between anthropometry and FEV1 value with six-minute walk distance in healthy elderly. There was no significant correlation between physical activity and six-minute walk distance. Keywords: Anthropometric measurement, FEV1, physical activity, six-minute walk distance DOI: 10.15850/ijihs.v5n1.963

Discharge against Medical Advice in Pediatric Intensive Care Unit and Subsequent Events

Somasetia, Dadang Hudaya, Isman, Susanto, Wonoputri, Nathania

International Journal of Integrated Health Sciences VOL 3, NO 1, March (2015)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: The occurence of discharge against medical advice (DAMA) has impacted globally. Decisions of DAMA in pediatric patients are not made by the patients, but pose life-threatening consequences, especially for children treated in Pediatrics Intensive Care Unit (PICU). The present study aimed to identify the occurence of DAMA and subsequent events to the DAMA patients after treated in PICU of Dr. Hasan Sadikin General Hospital Bandung, Indonesia.Methods: A retrospective study from medical records of DAMA patients from PICU of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, between April 2011 and April 2012. Results: A total of 195 children aged 1–5 years were admitted. Of this number, 12 (6.2%) were DAMA. Financial problems were the most common reason for DAMA, followed by parents’ perception about their child’s terminal condition. The majority of parents were laborer. Last parents’ education level was mostly elementary school. Most patients who DAMA from PICU died in less than 24 hours.Conclusions: A considerable number of DAMA was found in our PICU. High mortality occured after patients asked for DAMA from PICU.Keywords: Discharge against medical advice (DAMA), pediatric, pediatrics intensive care unit (PICU) DOI: 10.15850/ijihs.v3n1.400

Robotic Surgery for Giant Presacral Dumbbell-Shape Schwannoma

Yudoyono, Farid, Arifin, Muhammad Zafrullah, Dahlan, Rully Hanafi, Ompusunggu, Sevline Estethia, Ah, Shin Dong, Seong, Yi, Yoon, Ha, Heum, Yoon Do, Nyun, Kim Keung

International Journal of Integrated Health Sciences VOL 3, NO 1, March (2015)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To demonstrate the feasibility of using da Vinci robotic surgical system to perform spinal surgery.Methods: Magnetic resonance imaging (MRI) of a 29-year-old female patient complaining right pelvic pain for 1 month revealed a 17x8x10 cm non-homogeneous dumbbell shape encapsulated mass with cystic change located in the pelvic cavity and caused an anterior displacement of urinary bladder and colon.Results: There was no systemic complication and pain decrease 24 hours after surgery and  during 2 years of follow up. The patient started a diet 6 hours after the surgery and was discharged 72 hours after the surgery. The pathological diagnosis of the tumor was schwannoma. Conclusions: Giant dumbbell shape presacral schwannomas are rare tumours and their surgical treatment is challenging because of the complex anatomy of the presacral. Clinical application of da Vinci robotic surgical system in the spinal surgical field is currently confined to the treatment of some specific diseases or procedures. However, robotic surgery is expected to play a practical future role as it is minimally invasive. The advent of robotic technology will prove to be a boon to the neurosurgeon.Keywords: da Vinci robotic surgical system, presacral, schwannoma DOI: 10.15850/ijihs.v3n1.407

Sapodilla (Manilkara zapota) Broth as an Alternative Media for Candida albicans

Ying, Chen Chui, Kuswardinah, Ine, Setiawati, Elsa Pudji

International Journal of Integrated Health Sciences VOL 5, NO 1, March (2017)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To determine whether sapodilla can be used to grow Candida albicans. Among all the high galactose and arabinose content fruits, the sapodilla was chosen because it is available year round and can get easily in market. Other than that, it also contains vitamins, calcium and phosphorus which are very useful for fungi growth.Methods: This study used an experimental study as a method of research. The researcher culture Candida albicans on the experimental sapodilla media and identifies the morphology of the fungi by using Gram staining method. The experiment will be replicated two times to get accurate result. The procedure of this experiment constitute of sapodilla media preparation, sapodilla media observation, organism preparation, planting and incubation, observation of fungal colonies and identification of the fungi.Results: In 0%, there was no fungal growth at all. In 5%, there was mild density of fungal colonies. In 10%, there was moderate density of fungal colonies and in 15% the fungal grew with very dense colonies.Conclusions: Sapodilla (Manilkara zapota) broth can be used as an alternative media for Candida albicans.Keywords: Alternative media, Candida albicans, Sapodilla brothDOI: 10.15850/ijihs.v5n1.965

Ultrasound Guided Fine Needle Aspiration Biopsy in Renal Tumors

Tjahjodjati, Tjahjodjati, Pitoyo, Joko

International Journal of Integrated Health Sciences VOL 3, NO 1, March (2015)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To assess the sensitivity and specificity of ultrasound guided fine needle aspiration biopsy (FNAB) in renal tumors.Methods: A diagnostic study was performed on 23 patients with renal tumors who visited the Urology Division, Department of Surgery, Dr. Hasan Sadikin General Hospital from January 2011 to August 2012. First time ultrasound guided was performed to the patients before nephrectomy. Renal tissues that were obtained from both procedures were examined histopathologically, and the result from nephrectomy was used as the gold standard. Analysis was conducted by measuring the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the ultrasound guided FNAB. Results: The results showed that the sensitivity value of ultrasound guided FNAB was 85.71%, with 50% specificity, 94.74% PPV and 25% NPV. From 23 patients, only 2 patients had hematoma. Conclusions: Ultrasound guided FNAB is sufficiently sensitive with a fair specificity for diagnosing renal tumors and is safe for patients.Keywords: Renal tumor, sensitivity, specificity, ultasound guided FNAB DOI: 10.15850/ijihs.v3n1.401

Morphological Changes of Cisplatin-resistant Human Breast Cancer MCF-7 Cell Line

Puspita, Nanda Ayu, Bedford, Amy

International Journal of Integrated Health Sciences VOL 5, NO 1, March (2017)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To evaluate morphological changes of breast cancer cell line MCF-7 following the development of acquired resistance towards cisplatin. Resistance towards anticancer agents still plays an important role in the breast cancer chemotherapy failure.Methods: The cisplatin resistant subline MCF-7/CisR was developed in-vitro by cultivating the parental cell line cisplatin-sensitive MCF-7 with raising concentration of cisplatin (from 0.01 to 2.3 µM) for four months. The cell morphology was observed by giemsa staining. Results: The resistance was shown by the increase of IC50 by 9 folds on MCF-7/CisR compared to the initial IC50 value of MCF-7. The change in cisplatin cytotoxic potency on the resistant cell line was accompanied by the morphological modification, including the enlargement of cell size, the increase of nucleus and cytoplasm ratio, and the increase of the number of microvesicular and cytoplasmic granules.Conclusions: This result has supported the underlying mechanism of cisplatin resistance, including the ability of the cells to decrease intracellular cisplatin concentration and repair DNA damage effects. Keywords: Drug resistance, human breast cancer, cisplatin, MCF-7 DOI: 10.15850/ijihs.v5n1.960

Normal Pressure Hydrocephalus Following Myodil Myelography

Akar, Ezgi, Akmil, Mehmet Ufuk

International Journal of Integrated Health Sciences VOL 3, NO 1, March (2015)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: Fat-saturated contrast agent-enhanced myelography was used for the purpose of diagnosing most spinal lesions from the beginning of the 19th century until the end of the 20th century. Myodil was among the agents used for many years for this purpose.Methods: A rare long-term complication of myodil myelography is presented with a cerebrospinal fluid (CSF) absorption disorder occurring years after myelography that caused a secondary normal pressure hydrocephalus.Results: A case of normal pressure hydrocephalus with a slowly developing clinical picture that emerged years after a ventriculoperitoneal shunt for a myodil myelography 25 years ago due to suspicion of lumbar spinal stenosis was treated. Conclusions: Many acute and chronic complications of fat-saturated contrast agents were reported. Because of these complications and with the technological developments in due course, these agents are replaced by computerized tomography (CT), magnetic resonance imaging (MRI), or hydrophilic contrast agents.Keywords: Normal pressure hydrocephalus, myelography, myodil DOI: 10.15850/ijihs.v3n1.406

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