International Journal of Integrated Health Sciences
ISSN : 23021381     EISSN : 23384506
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Articles 167 Documents
Morphometric Analysis of the Corpus, Spinal Canal and Torg Ratio Using Midsagittal Cervical Vertebrae Computed Tomography Scan: Indonesian Population

Dahlan, Rully Hanafi, Saputra, Priandana Adya Eka, Farid Yudoyono, Farid, Ompusunggu, Sevline Esthetia, Arifin, Muhammad Zafrullah, Sutiono, Agung Budi, Faried, Ahmad

International Journal of Integrated Health Sciences VOL 2, NO 1, July (2014)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To determine the normal ranges of cervical spinal canal morphometry in Indonesian population and to compare the acquired data collected from other populationsMethods: Computed tomography measurements on the diameter of midsagital spinal canal and corpus of cervical vertebrae and its Torg ratio from the lower cervical (C3-C7) canal from 24 normal Indonesian adults were performed at the Radiology Department of Dr. Hasan Sadikin General Hospital. Patients who had cervical spine disorders and those under 20 years old were exluded.  We used computed tomography scan midsagittal view to measure the aforementioned parameters.    Results: The average diameter for the cervical spinal canals for the Indonesian population is comparable with those of other Asian populations such as Hongkong and India, albeit with smaller Torg ratio.     Conclusions: This study reports the normal radiological anatomy of the midsagital spinal canal and corpus of cervical vertebrae as well as Torg ratio from the lower cervical vertebrae among Indonesian population. The measurements result of this study shows that, although slightly smaller, the measurement results for those parameters are identical with other Asian populations.    Keywords: Corpus cervical vertebrae, midsagittal cervical spinal canal, Torg ratio DOI: 10.15850/ijihs.v2n1.285

Comparison between Two-Layer Density Gradient and Three-Layer Density Gradient Technique for Sperm Preparation at Aster Fertility Clinic, Dr. Hasan Sadikin General Hospital

Astarto, Nanang Winarto, Tjahyadi, Dian, Jatnikasari, Sintya

International Journal of Integrated Health Sciences VOL 2, NO 1, July (2014)
Publisher : International Journal of Integrated Health Sciences

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Objective: To compare the efficacy of sperm preparation techniques modified by two layer density gradient technique (80%, 40%).     Methods: Sperm preparation was performed by two- and three-layer density gradient technique by centrifugation at 500 rpm for 20 minutes using SpermGrad (Vitrolife, Sweden).    Results: The average concentration of total sperm preparation by two-layer density gradient was 23.19 million with a standard deviation of 11.9 million while the result of three-layer density gradient preparation obtained a mean total sperm concentration of 19.64 million with a standard deviation of 10.033 million. The mean total concentration of sperm in three-layer was lower than two-layer density gradient with p <0.001.Conclusions: This study concludes that there was a significant difference between the concentration of sperm prepared using two-layer and three-layers density gradient technique.Keywords: Density gradient, spermatozoa DOI: 10.15850/ijihs.v2n1.286

Multimodal Analgesic Effect on Proinflammatory and Anti-inflammatory Cytokines Serum

Ahmad, Muhammad Ramli, Bisri, Tatang

International Journal of Integrated Health Sciences VOL 2, NO 1, July (2014)
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Abstract

Objective: To investigate the effect of combination epidural bupivacaine and intravenous parecoxib analgesia on  immune response in patients who underwent open reduction and internal fixation of the lower limb under epidural anesthesia.  Methods: This research was conducted using the randomized, placebo-controlled double blind trial method on 52 patients who were randomly divided into 2 groups: the Parecoxib group which received 40 mg intravenous parecoxib for 30 minutes before incision and the control group which received an equal volume of 0.9% normal saline. Both groups received epidural anesthesia and postoperative epidural 0.125% bupivacaine analgesia continously. Venous blood samples were obtained before parecoxib administration, 2 and 24 hours after the surgery. The data were analyzed using Mann Whitney U and Independent t tests (p<0.05).     Results: There was a significant difference between the two groups (p<0.05) in IL-1β, IL-6, IL-10 levels and proinflammatory to anti-inflammatory ratio, 2 hours after surgery.    Conclusions: Multimodal analgesic combination of 40 mg IV parecoxib and 0.125% bupivacaine epidural analgesia have the effect to alter and stabilize the  systemic immune response.    Keywords: Cytokines, epidural analgesia, interleukins, immune response, parecoxib, tissue damage DOI: 10.15850/ijihs.v2n1.272

Cardiovascular Disorders in Adolescents with Chest Pain

Rahayuningsih, Sri Endah, Budi, Rahmat, Garna, Herry

International Journal of Integrated Health Sciences VOL 2, NO 1, July (2014)
Publisher : International Journal of Integrated Health Sciences

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Objective: To detect cardiovascular abnormalities in adolescents with chest pain.     Methods: In this cross sectional study, the subjects were 25 adolescents with chest pain who came to the Cardiac Center of Dr. Hasan Sadikin General Hospital, Bandung during the period of January 2008 to January 2011. The presence of established cardiovascular disorders were based on history, physical examination, electrocardiography and echocardiography    Results: It was found that 13/25 adolescents with chest pain had cardiovascular abnormalities. Of the 25 teens that came with chest pain, most of which showed normal electrocardiographic results, only 9/25 of those with dysrhythmias experienced sinus tachycardia and 8 had a first degree AV block. Echocardiography examination showed only four patients with abnormal cardiac anatomy.  No correlation between nutritional status and chest pain, and cardiovascular abnormalities and chest pain (p = 0.206 and p = 0.632, respectively). There was a positive correlation between sex and cardiovascular abnormalities in adolescents with chest pain (p = 0.007).Chest pain is a prevalent problem that is usually benign and that it frequently signals underlying cardiac disease.Conclusions: Cardiovascular abnormalities in adolescents with symptoms of chest pain are found in some cases. There is no correlation between female and male adolescents with chest pain  and  cardiovascular abnormalities.Keywords: Adolescents, cardiovascular, chest painDOI: 10.15850/ijihs.v2n1.287

Correlation between Protein-with-Molecular-Weight-53 (p53), Burkit Cell Lymphoma 2 (Bcl2), and Fas Ligand (FasL) and Vascular-Cell-Adhesion-Molecule-1 (VCAM-1) mRNA Expression Levels in a Pathogenesis Study of Preeclampsia

Teguh, Mintareja, Karkata, Made Kornia, Wirakusumah, Firman Fuad, Mose, Johanes Cornelius, Satari, Mieke Hemiawati, Septiani, Leri

International Journal of Integrated Health Sciences VOL 2, NO 1, July (2014)
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Objective: To determine the role of protein-with-molecular-weight-53 (p53), burkit cell lymphoma 2 (Bcl2),  Fas ligand (FasL) mRNA, and vascular cell adhesion molecule 1 (VCAM-1), known as the apoptosis-related molecular pathway, in preeclamptic patients.     Methods: Observation on the correlation between the mRNA levels of p53, Bcl2 and FasL and VCAM-1 in 31 subjects at 28-42 weeks gestational age was performed in this study using the real time reverse transcriptase-polymerase chain reaction (RT-PCR).    Results: The results showed that p53 mRNA increased (>1.2350 ng/μL) in the preeclampsia group compared to the normal pregnancy group (p=0.010), Bcl2 mRNA was lower (≤0.9271 ng/μL) in the preeclampsia group than the control group (p=0.041). There was also a tendency of increased FasL mRNA expression (>0.5509 ng/μL) in the preeclampsia group compared to the normal pregnancy group (p=0.300). The level of VCAM-1 elevated (>890.08 ng/mL) in the preeclampsia group compared to the normal pregnancy group (p=0.001). In preeclampsia, the correlation between the Bcl2/p53 ratio and VCAM-1 was r=0.541 (p=0.002), whereas the correlation in normal pregnancy was r=0.099 (p=0.595).     Conclusions: There are correlations between the mRNA expression levels of p53 and Bcl2 as an intrinsic pathway of apoptosis along with the VCAM-1 levels in the incidence of preeclampsia. However, no correlation is found between FasL mRNA expression and the incidence of preeclampsia.Keywords: Bcl2, FasL, p53, Preeclampsia, VCAM-1DOI: 10.15850/ijihs.v2n1.273

Mycoplasma Genitalium Infection Prevalence in Patients with Human Immunodeficiency Virus

Rasianti, Rini, Dharmadji, Hartati, Miliawati, Risa, Puspitosari, Diah, Teja, Feilicia Henrica, Rowawi, Rasmia, Rahmatdinata, Rahmatdinata, Djajakusumah, Tony

International Journal of Integrated Health Sciences VOL 2, NO 1, July (2014)
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Objective: To determine the prevalence of Mycoplasma genitalium (M. genitalium) infection in HIV positive patients by PCR examination in Teratai Clinic of Dr. Hasan Sadikin General Hospital, Bandung in order to reduce sexually transmitted diseases, especially M. genitalium infection in HIV positive patients.Methods: This study was a cross-sectional study with consecutive sampling methods. Eighty one HIV positive patients attending the Teratai Clinic of Dr. Hasan Sadikin General Hospital, Bandung were recruited to be the subjects of this study. All subjects underwent history taking, physical examination, and PCR examination for M. genitalium. Specimens were taken from cervical smear in females and first void urine in male.Results: The prevalence of M. genitalium based on the PCR examination in HIV positive patients attended to Teratai Clinic Dr. Hasan Sadikin General Hospital Bandung was 9%. Conclusions: Mycoplasmal infection identification based on PCR examination should be considered for routine screening test to reduce the incidence of sexually transmitted diseases in HIV positive patients.Keywords: Human immunodeficiency virus, Mycoplama genitalium, polymerase chain reaction DOI: 10.15850/ijihs.v2n1.274

Osteoporosis Risk and Body Mass Index Comparison among Urban and Rural Menopausal Women

Tarawan, Vita Muniarti, Adnantami, Putri Fatima, Adnantama, Putra Habibie, Adnantama, Putra Haqiqie

International Journal of Integrated Health Sciences VOL 3, NO 1, March (2015)
Publisher : International Journal of Integrated Health Sciences

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Objective: To compare osteoporosis risk factors between urban and rural menopausal women. Methods: This study applied the causal-comparative analysis to compare osteoporosis risk factors between urban and rural menopausal women. The subjects included in this study were 40 urban and 40 rural menopausal women who were randomly recruited. The respondents’ bone mass density was measured using densitometry. This study also examined several aspects, including the respondents’ nutritional status (body mass index calculation) and physical fitness (VO2 max). The correlation between osteoporosis risk and either nutritional status or physical fitness among urban and rural menopausal women were tested using Chi square correlation analysis. Results: This study examined several aspects, including age (years) 58.7±6.1 (urban) and 58.3±6.5 (rural), p=0.815, body mass index (kg/m2) 23.7±3.7 (urban) and 22.7±3.6 (rural), p=0.221, VO2 max (average) 27 (67.5%) (urban) and 25 (62.5%) (rural), p=0.624. The respondents diagnosed as suffering from osteoporosis were statistically measured for the: nutritional status (body mass index) (under) urban 0%, rural (p=0.789) 2.5%, body mass index 7.5% urban, rural (p=0.571) 2.5%, physical fitness condition (VO2 max) (average) urban 7.5%, rural (p=0.850) 5%, VO2 max (poor) urban 7.5%, rural (p=0.880) 5%. Body mass index and bone mass density calculation results described that the nutritional status of urban and rural menopausal women: normal 12 (30%) vs (32.5%), osteopenia 8 (20%) vs (15%), osteoporosis 3 (7.5%) vs (2.5), p=0.571. Conclusions: This study shows that there is no significant difference between osteoporosis risk and nutritional status and physical fitness in urban and rural menopausal women.Keywords: Nutritional status, osteoporosis level, physical fitness DOI: 10.15850/ijihs.v3n1.402

Chronic Rhinosinusitis Patient with Nasal Polyp Characteristics at Otorhinolaryngology-Head and Neck Surgery Outpatient Clinic, Dr. Hasan Sadikin General Hospital, Bandung

Riana, Dina, Dermawan, Arif, Wijana, Wijana, Saifuddin, Ongka Muhammad

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
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Objective: To evaluate chronic rhinosinusitis (CRS) with nasal polyp (NP) characteristics in patients with routine visits to the Otolaryngology-Head and Neck Surgery outpatient clinic of Dr. Hasan Sadikin General Hospital, Bandung.Methods: This descriptive retrospective cross-sectional study was conducted at the Rhinology-Allergy Outpatient Clinic, Departement of Otolaryngology-Head and Neck Surgery, Dr. Hasan Sadikin General Hospital, Bandung, in the period of January 2014 to December 2014. Data were obtained from medical records and the sampling method used was total sampling. A total of 100 CRS with NP patients were evaluated. Nasal endoscopy examinations were performed. Patients were classified based on age into 10–20 years, 21–31 years, 32–42 years, 43–53 years, and >54 years groups. Results: Chronic rhinosinusitis with NP incidences were mostly found in male patients compared to females. There were several CRS cases with NP risk factors, including smoking and allergy. Conclusions: In the study, CRS with NP patients may possibly have one or more risk factors. Smoking is the major risk factor from CRS with NP after allergy. Keywords: Nasal polyp, nasal endoscopy, rhinosinusitis, risk factor DOI: 10.15850/ijihs.v4n2.834

Comparison of Estimated Glomerular Filtration Rate Mean Value of HARUS 15-30-60, HADI, and ASIAN Fomula Accuracy in Diabetes Mellitus Type 2

Rachmayati, Sylvia, Parwati, Ida, Martakusumah, Abdul Hadi, Soelaeman, Rachmat, Sekarwana, Nanan

International Journal of Integrated Health Sciences VOL 3, NO 1, March (2015)
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Objective: To compare the accuracy of HARUS 15-30-60, HADI, and Asian Formulas (Chinese-equation (Ch-E), Japanese-equation (Jp-E), and Thai- equation (Th-E)) for estimated glomerular filtration rate (eGFR).Methods: The Kidney Dialysis Outcome Quality Initiative (KDOQI) has published a guideline to measure renal function, which is based on glomerular filtration rate (GFR). This procedure is complicated and expensive, therefore an estimated GFR (eGFR) has been proposed. The modification of diet in renal disease (MDRD) study prediction equation is the most frequently eGFR used. This method still have a weakness in accuracy, so the chronic kidney disease epidemiology collaboration (CKD-EPI) formula is developed. Since CKD-EPI is not practical for daily use, the MDRD is published for Asian population that includes Ch-E, Jp-E, and Th-E. In Indonesia, the MDRD formula has not been validated using any gold standard, therefore 2 new formulas have been developed, i.e. HARUS 15-30-60 and HADI formulas. In this study, we analyzed 102 medical records of Diabetes Mellitus Type 2 (DMT2) patients who visited Dr. Hasan Sadikin General Hospital, Bandung during the period of 2012 to 2013. We analyzed the data using HARUS 15-30-60, HADI, Asian formulas, and then compared them to CKD-EPI to see the accuracy. Statistical analysis used was paired t-test in SPSS-17 program.Results: The accuracy of the different formulas are as follows: HADI (p=0.173), HARUS 15-30-60 (p=0.060), Ch-E (p=0.001), Th-E (p=0.000), and Jp-E (p=0.000).Conclusions: HADI is the most accurate formula, followed by HARUS Formula, Ch-E, and Th-E and Jp-E, respectively.Keywords: Chinese-equation, HADI and HARUS 15-30-60 formulas, Japanese-equation, and Thai-equation DOI: 10.15850/ijihs.v3n1.403

Response of Long-Term Memory to Molecular Changes of BDNF in Hippocampus in Various Intensities of Physical Activity

Lubis, Leonardo, Setiawan, Setiawan

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
Publisher : International Journal of Integrated Health Sciences

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Objective: To analyze the physiological response of long-term memory (LTM) to the molecular changes of brain-derived neurotrophic factor (BDNF) in the hippocampus by the treatment of various intensities of physical activity. Methods: Subjects were 7–8 week old male Wistar rats weighed between 201–250 grams. This study was an experimental study with pre-(day-1) and post-(day-14) design. Molecular changes reflected by the changes in the expression of mRNA and protein of BDNF in the hippocampus. Treatment of physical activity on the subjects was running on the Animal Treadmill by grouping of the physical activity: light intensity at a speed of 10 m/min, moderate intensity at a speed of 20 m/min and heavy intensity at a speed of 30 m/min. The treatment’s duration was 30 minutes.Then, analysis of data on pre (day-1) and post (day-14) which were: LTM response based on travel time swimming test, the expression of mRNA (Ct) and protein (%) of BDNF in hippocampus based on RT-PCR and immunohistochemistry. Results: The results showed that moderate intensity group caused the better physiological and molecular responses than the other groups, as follows: travel time (0.6260 vs 0.7270 vs 0.9400 vs. 1.4000 seconds (p<0.05)), mRNA BDNF expression (17.2320 vs 18.8800 vs 19.7540 vs 20.7750 Ct (p<0.05)), and hippocampal BDNF protein expression. Conclusions: The study conclude that the moderate intensity is the best physical activity to improve LTM as showed by the BDNF mRNA expression as well as BDNF protein in hippocampus. Keywords: Intensity, long-term memory, brain-derived neurotrophic factor, hippocampus DOI: 10.15850/ijihs.v4n2.839

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