International Journal of Integrated Health Sciences
ISSN : 23021381     EISSN : 23384506
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Articles 8 Documents
Search results for , issue " VOL 4, NO 2, September (2016)" : 8 Documents clear
Chronic Rhinosinusitis Patient with Nasal Polyp Characteristics at Otorhinolaryngology-Head and Neck Surgery Outpatient Clinic, Dr. Hasan Sadikin General Hospital, Bandung

Riana, Dina, Dermawan, Arif, Wijana, Wijana, Saifuddin, Ongka Muhammad

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To evaluate chronic rhinosinusitis (CRS) with nasal polyp (NP) characteristics in patients with routine visits to the Otolaryngology-Head and Neck Surgery outpatient clinic of Dr. Hasan Sadikin General Hospital, Bandung.Methods: This descriptive retrospective cross-sectional study was conducted at the Rhinology-Allergy Outpatient Clinic, Departement of Otolaryngology-Head and Neck Surgery, Dr. Hasan Sadikin General Hospital, Bandung, in the period of January 2014 to December 2014. Data were obtained from medical records and the sampling method used was total sampling. A total of 100 CRS with NP patients were evaluated. Nasal endoscopy examinations were performed. Patients were classified based on age into 10–20 years, 21–31 years, 32–42 years, 43–53 years, and >54 years groups. Results: Chronic rhinosinusitis with NP incidences were mostly found in male patients compared to females. There were several CRS cases with NP risk factors, including smoking and allergy. Conclusions: In the study, CRS with NP patients may possibly have one or more risk factors. Smoking is the major risk factor from CRS with NP after allergy. Keywords: Nasal polyp, nasal endoscopy, rhinosinusitis, risk factor DOI: 10.15850/ijihs.v4n2.834

Response of Long-Term Memory to Molecular Changes of BDNF in Hippocampus in Various Intensities of Physical Activity

Lubis, Leonardo, Setiawan, Setiawan

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To analyze the physiological response of long-term memory (LTM) to the molecular changes of brain-derived neurotrophic factor (BDNF) in the hippocampus by the treatment of various intensities of physical activity. Methods: Subjects were 7–8 week old male Wistar rats weighed between 201–250 grams. This study was an experimental study with pre-(day-1) and post-(day-14) design. Molecular changes reflected by the changes in the expression of mRNA and protein of BDNF in the hippocampus. Treatment of physical activity on the subjects was running on the Animal Treadmill by grouping of the physical activity: light intensity at a speed of 10 m/min, moderate intensity at a speed of 20 m/min and heavy intensity at a speed of 30 m/min. The treatment’s duration was 30 minutes.Then, analysis of data on pre (day-1) and post (day-14) which were: LTM response based on travel time swimming test, the expression of mRNA (Ct) and protein (%) of BDNF in hippocampus based on RT-PCR and immunohistochemistry. Results: The results showed that moderate intensity group caused the better physiological and molecular responses than the other groups, as follows: travel time (0.6260 vs 0.7270 vs 0.9400 vs. 1.4000 seconds (p<0.05)), mRNA BDNF expression (17.2320 vs 18.8800 vs 19.7540 vs 20.7750 Ct (p<0.05)), and hippocampal BDNF protein expression. Conclusions: The study conclude that the moderate intensity is the best physical activity to improve LTM as showed by the BDNF mRNA expression as well as BDNF protein in hippocampus. Keywords: Intensity, long-term memory, brain-derived neurotrophic factor, hippocampus DOI: 10.15850/ijihs.v4n2.839

Handgrip Strength Prediction Formula Using Aneroid Sphygmomanometer in Elderly

Yahin, Akhmad, Moeliono, Marina Annette, Prananta, Marietta Shanti

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To examine the prediction formula used to measure handgrip strength using aneroid sphygmomanometer in elderly.Methods: This study was a cross-sectional study performed at the Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital from March to April 2015. Thirty five elderly subjects aged 60–74 years were included in the study. The subject handgrip strength was measured using an aneroid sphygmomanometer and a Jamar dynamometer. Results: All data were analyzed statistically using Pearson correlation test to examine the distributed data and Spearman test to examine the non distributed data. A significant correlation was found between hand width, age, and sex and the handgrip strength values using Jamar dynamometer (p<0.01) using multiple linear regression (p<0.01). A normality test using the Shapiro-Wilk test resulted normal residue with p value 0.000. The results showed that the regression analysis could be used to predict the handgrip strength using aneroid sphygmomanometer.Conclusions: Aneroid sphygmomanometer can be used to predict handgrip strength in elderly using conversion formula. Keywords: Aneroid sphygmomanometer, elderly, handgrip strength, Jamar dynamometer DOI: 10.15850/ijihs.v4n2.832

Rare Distal Anterior Choroidal Artery Aneurysm

Arifin, Muhammad Zafrullah, July, Julius, Ferry, Bilzardy, Faried, Ahmad

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To describe a rare patient with ruptur aneurysm case of distal anterior choroidal artery (AChA) and intraventricular hemorrhage. A 56-year old female came to our hospital with chief complaint sudden onset of severe headache and vomiting.Methods: Head computed tomography (CT)-scan and angiography on the lesion was performed at the Department of Radiology, Siloam Hospital, Tangerang, Indonesia.Results: Head CT-scan imaging revealed an intraventricular hemorrhage, primarily in the right lateral ventricle, with slight enlargement of both lateral, 3rd and 4th ventricles. Angiography examination revealed a round vascular lesion at the wall of the posterior cornu of the lateral ventricle and an occlusion of the M1 base segment of the left middle cerebral artery.Conclusions: The lesion, distal AChA aneurysm, at the posterior cornu was reached using an infratemporal lobe approach with the help of neuronavigation. Microsurgical clipping was successfully performed.Keywords: Aneurysm, distal anterior choroidal artery, neuronavigation DOI: 10.15850/ijihs.v4n2.837

Serum Selenium Concentration in Cervical Cancer Patients: Preliminary Study and Literature Review

Septiani, Leri, Hidayat, Yudi Mulyana, Mutakin, Mutakin, Abdulah, Rizky, Faried, Ahmad, Koyama, Hiroshi

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To analyze the role of selenium and glutathione peroxidase (GPx) in cervical cancer.Methods: Serum selenium concentrations and GPx activities of 19 women with cervical cancer along with their healthy counterparts (control group) were obtained. Selenium concentration were measured fluorometrically and GPx activities were measured spectrophotometrically based on the quantity of NADPH used in the reduction of glutathione. Results: The mean of serum selenium concentrations in cervical cancer group was significantly lower than that in the control group, 67.24±15 ng/mL and 77.05±12 ng/mL (p=0.03), respectively. The mean GPx activity in the cervical cancer group was also significantly lower than that in the control group, 128.18±38 ∆mmol NADPH/min/L and 148.9±23 ∆mmol NADPH/min/L (p=0.04), respectively. Multivariate analysis in the cervical cancer patients showed that the Fédération Internationale de Gynécologie et d’Obstétrique (FIGO) staging score (early vs. advanced) was inversely correlated with serum selenium concentration (p=0.027).Conclusions: Serum selenium concentration and GPx activity was significantly lower in the cervical cancer patients. Our results demonstrate that selenium and GPx activity may have an important role in the carcinogenesis of cervical cancer. Keywords: Cervical cancer, glutathione peroxidase activity, selenium DOI: 10.15850/ijihs.v4n2.833

Anterior Interhemispheric Approach for Olfactory Groove Meningioma

Hidayat, Imam, Sutiono, Agung Budi, Faried, Ahmad, Arifin, Muhammad Zafrullah

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To evaluate the surgical technique with bifrontal interhemispheric approach for total removal of tumor in olfactory groove meningioma (OGM). Methods: This study described a case of a 38-year-old woman with bilateral blindness, anosmia, and behaviour changes. Imaging studies show a tumor mass in midfrontal base. Surgery using a bifrontal interhemispheric approach was performed and total removal was achieved and postoperative computed tomography (CT) scan was performed to confirm the result. Histopathological findings established a diagnosis of meningioma.Results: A coronal skin incision behind the hairline was utilized. The scalp was elevated, taking care to reserve the vascularized pericranium medial to the linea temporalis of each side, and preserving the 2 supraorbital nerves. Eight burr holes were used, with the two initial holes made on each side of the orbitotemporal region, and the other four holes at the midline. A bifrontal craniotomy was performed. The tumor was first detached from its attachment with bipolar cautery and debulked. During this step, the main tumor feeder arteries from the anterior and posterior ethmoidal artery were interrupted, and the tumor devascularized. Total tumor removal through surgical intervention was achieved and confirmed by head CT-scan postoperatively.Conclusions: This case report supports the suitability of the bifrontal interhemispheric approach for OGM resection with additional radiation therapy.Keywords: Anterior interhemispheric approach, olfactory groove meningioma DOI: 10.15850/ijihs.v4n2.838

Comparison of VO2 Max Prediction Value, Physiological Response, and Borg Scale between 12-Minute and 3200-Meter Run Fitness Tests among Indonesian Army Soldiers

Abdillah, Maulidi, Prabowo, Tertianto, Prananta, Marietta Shanti

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To compare the VO2 max and physiological responses between 12-minute and 3200-meter run fitness tests.Methods: The subjects were 40 soldiers aged 18–21 years old of the Infantry Battalion 303/SSM of Cikajang, Garut, West Java, Indonesia. The 12-minute and 3200-meter run fitness tests were conducted with one week resting period. The measurement of the VO2 max prediction was based on each of the formulations and the measurement of physiological response included blood pressure, heart rate, respiratory rate, Borg scale and oxygen saturation before and after the tests. This study used a cross-sectional method while the data were analyzed statistically using t-test (p=0.05). Results: The results showed that the VO2 max prediction in 12-minute run fitness test was 52.046±2.980 mL/KgBB/min and the 3200-meter run test was 55.323±3.238 mL/KgBB/min. The value was statistically significant (p=0.008). There was no significant difference in the physiological response in both tests, except the SpO2 parameter after the tests (p=0.021). Conclusions: There is a significant difference in VO2 max prediction between 12 minutes and 3200 meter run test. No significant difference was found in the physiological response in both tests, except the SpO2 parameter. Keywords: 12-minute run fitness test, 3200-meter run fitness test, physiological response, soldiers, VO2 max DOI: 10.15850/ijihs.v4n2.836

Peripheral and Intracranial Compartment Serum Level of Selenium in Pediatric Patients with Intracranial Tumor in Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran–Dr. Hasan Sadikin Hospital, Bandung, Indonesia: a Preliminary Study and Literature Review

Faried, Ahmad, Saputra, Priandana Adya Eka, Sobana, Mirna, Arifin, Muhammad Zafrullah

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To determine the level of Selenium (Se) in peripheral and intracranial serum in pediatric patients with intracranial tumor. Selenium has chemopreventive potentials and acts as neuromodulator.Methods: This study was conducted on 13 pediatric patients with intracranial tumors who were treated in Dr. Hasan Sadikin Hospital, Bandung in the period of February 2014 to February 2015. Samples were taken from peripheral and intracranial serum. The results were analyzed with independent t-test and Pearson correlation test. Significance is defined as p≤0.05 with 95% confidence interval.Results: The results showed that the average Se concentration in peripheral serum was significantly higher than the Se concentration in intracranial serum (95.92±20.95 μg/L and 66.62±22.37 μg/L, respectively). After classifying the subjects into groups based on sex, age, tumor location, and grades, the difference between Se concentrations were still statistically significant (p≤0.05), with the exception of the supratentorial group (p=0.0053). Pearson correlation test showed very-low to medium strength correlations between peripheral and intracranial serum Se concentration in all groups (r=0.16–0.59, p>0.05).Conclusions: A significant difference is seen between the peripheral and intracranial serum Se concentration means in pediatric patients with intracranial tumors, with higher concentrations observed in the peripheral serum. Further studies are required to investigate the roles of Se in the management of pediatric patients with intracranial tumors.Keywords: Pediatric intracranial tumor patients, selenium concentration in peripheral and intracranial serum DOI: 10.15850/ijihs.v4n2.835

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