International Journal of Integrated Health Sciences
ISSN : 23021381     EISSN : 23384506
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Articles 8 Documents
Search results for , issue " VOL 1, NO 1, July (2013)" : 8 Documents clear
Histological Description of Meningeal and Periosteal Dural Layers at the Porus of Internal Acoustic Canal in the Vestibular Schwannoma

Sutiono, Agung Budi, Arifin, Muhammad Zafrullah, Faried, Ahmad, Ohira, Takayuki

International Journal of Integrated Health Sciences VOL 1, NO 1, July (2013)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To study the transformation point of meningeal and periosteal dural at the porus of internal acoustic canal (IAC) in order to verify the different thickness of meningeal and periosteal dura in vestibular schwannomas (VS). Methods: Three IAC cadaver specimens and ten samples of VS patients from porus were obtained and analyzed. Samples were stained by using Masson trichrome technique after cutting in 6 micron of thickness. The samples were then observed under light microscopes to understand the meninges pattern in the IAC. Results: The meningeal dura is becoming thin at the porus and disappears at the meatal portion to form epineurium. However, the periosteal dura is lining continuously to the fundus. In VS, the meningeal dura becomes thick and forms a pseudo-capsule in the middle of meatus, known as perineurium. The residual nerve filament was compressed by the tumor parenchyma. Between the tumor and nerve interface, three or more perineureal layers are seen. The perineurium in the cisternal portion was consistently loose and forms the tumor and arachnoid nerve interface. Almost all the nerve filaments are displaced to the tumor periphery near the pseudocapsule. In contrast, the periosteal dural of VS is becoming thin and disappear nearby the middle of meatal portion. This changing site establishes “meningo-periosteal ring” of VS because of the encircling nearby the porus. Conclusions: In IAC, the meningeal dural becomes thin. The periosteal dura is lining continuously to the fundus. In VS, the meningeal dura becomes thick, joins perineurium and forms pesudocapsule near the porus, but the periosteal dura disappeared. This changing point is called meningo-periosteal ring.     Keywords: Meningeal,  periosteal, porus, vestibular schwannomasDOI: 10.15850/ijihs.v1n1.104

Effect of Overground Walking and Treadmill Exercise on Walking Speed and Walking Ability in Elderly

Novy, Theresia Chandra Tania, Vitriana, Vitriana, Sastradimaja, Sunaryo Barki, Defi, Irma Ruslina

International Journal of Integrated Health Sciences VOL 1, NO 1, July (2013)
Publisher : International Journal of Integrated Health Sciences

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Objective: To compare the effect of overground walking and treadmill exercise on walking speed and ability in elderly from week to week.  Methods: This study was conducted in 6 weeks to 18 elderly at Panti Wreda Karitas and Nazareth Bandung (September–December 2011). They were divided into two groups; overground walking exercise group and treadmill group. Walking speed and ability was measured using 10 meter walk test and 6 minute walk test consecutively. Results: Both group walking speed was improved after 1 and 2 weeks exercise (p=0.019 and p=0.050), consecutively. Walking ability in the overground and treadmill group was improved after 1 and  3 weeks  exercise (p=0.019 and p=0.009), consecutively. Overground walking group showed greater improvement in walking speed and ability after 3 weeks exercise (p=0.008 and p=0.017) consecutively. Conclusions: Three weeks overground walking exercise improves walking speed and ability better  than treadmill exercise.    Keywords: Elderly, overground walking exercise, treadmill exercise, walking ability, walking speed DOI: 10.15850/ijihs.v1n1.105

Integrating Basic Sciences into Global Health by Implementing the Translational Research

Shahib, Muhamad Nurhalim, Dhyanawati, Diah, Rofaani, Elrade

International Journal of Integrated Health Sciences VOL 1, NO 1, July (2013)
Publisher : International Journal of Integrated Health Sciences

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An emphasize on herbal medicine in cancer therapy is also included as an example of translational research implementation. A translational research in Faculty of Medicine, Universitas Padjajaran, has been conducted to develop a novel genomic approach (herbal genomic) on herbal crude extracts. This study focuses on the effects of the extracts on specific gene expressions. In this aspect, the concept of molecular targets is slightly different from pharmaceutical approaches  that aim to find compounds that interact with a specific molecule or macromolecule with known function. In this research strategy, the herbal genomic approaches involve screening of herbal extracts that affect particular gene expression related to cell responses rather than a single proteins. The determination of herbal concentration is based on differential gene expression before and after treatment which is analyzed by real time PCR. The results are being compared to the existing small molecule (active molecule) on the gene expressions. All these academic activities require biomedical research workforce to implement the translational research which, in the Faculty of Medicine, Universitas Padjadjaran, is fulfilled by involving the postgraduate students. New crude extract formulation plus specific gene expression profile is a concept required for developing chemotherapeutic agent in Indonesia. Hopefully, this review can support increased cooperation between hospital and academic institutions in implementing translational research in Indonesia.    DOI: 10.15850/ijihs.v1n1.86

Preliminary Study: Glycemic Index of Brown and White Rice Variant IR64 in Healthy Adult Men

Idril, Nur Irika, Diana, Aly, Wargahadibrata, Abdullah Firmansyah

International Journal of Integrated Health Sciences VOL 1, NO 1, July (2013)
Publisher : International Journal of Integrated Health Sciences

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Objective: To measure the glycemic index of brown and white rice in healthy adult men. Methods: The study was conducted in April 2010 at Universitas Padjadjaran, Jatinangor. Subjects of 21 healthy male students were randomly divided into 3 groups, which were given white bread (WB), white rice (WR) and brown rice (BR). Results: The results show that the highest and lowest average values of the blood glucose response was in the WR group at 30 minutes (126.9 mg/dL) and at 120 minutes (87.4 mg/dL), respectively. The glycemic index of brown rice (97.28) was lower compared to the white rice (99.26). Conclusions: Both WR and BR are classified as high glycemic index food. The higher glycemic index of brown rice, compared to the index found in other literatures, may be caused by differences in variant and/or production process. This study suggested the importance of evaluation of local products before promoting it to the community.     Keywords: Blood glucose level, brown rice, glycemic index DOI: 10.15850/ijihs.v1n1.106

Strategy for the Use of Erythropoetin Alpha to Maintain Hemoglobin Level in Breast Cancer Patient Treated with Anthracycline-base of Adjuvant Chemotherapy

Achmad, Dimyati, Hariady, Yusuf Hariady, Isakh, Benny, Abdurrahman, Maman, Faried, Ahmad

International Journal of Integrated Health Sciences VOL 1, NO 1, July (2013)
Publisher : International Journal of Integrated Health Sciences

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Objective: To evaluate the value of erythropoietin alpha (epoetin) administration, as an alternative treatment of anemia in the operable breast cancer patients.Methods: This is a multicenter phase III randomized clinical trial to evaluate the value of epoetin administration among anemic breast cancer patients who are undergoing anthracyclin-based adjuvant chemotherapy. Sixty four patients were incuded in this trial with initial hemoglobin (Hb) level of 10–12 g/dL. The patients were randomly distributed into two groups: one group received aministration of 40,000 IU epoetin/week for six times a week after operation and the other did not.  In the third week after the operation, both groups were started on a 6 cycles of adjuvant chemotherapy with three weeks intervals. Hb levels were evaluated during every chemotherapy cycle. Results: The Hb levels in the epoetin group were always above 10 g/dL up until the end of the sixth chemotherapy cycle or until the twenty first week post operation without blood transfusion. Conclusions: The administration of epoetin 3 weeks prior and 3 weeks after the first cycles of chemotherapy, maintains a sufficient/normal Hb level in breast cancer patients receiving anthracycline-based chemotherapy.Keywords: Anthracyclin-based chemotherapy, breast cancer, erythropoietin alpha DOI: 10.15850/ijihs.v1n1.102

Chlamydial Infection Prevalence in Human Immunodeficiency Virus Patients

Teja, Feilicia Henrica, Rowawi, Rasmia Rowawi, Soedarwoto, Asmaja, Puspitosari, Diah, Rasianti, Rini, Rahmatdinata, Rahmatdinata, Djadjakusumah, Tony

International Journal of Integrated Health Sciences VOL 1, NO 1, July (2013)
Publisher : International Journal of Integrated Health Sciences

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Objective: To determine the prevalence of chlamydial infection in male urethra and female cervix of HIV-positive patients based on PCR assay in Teratai Clinic, Dr. Hasan Sadikin General Hospital Bandung. Methods: A cross sectional observational study with consecutive sampling method, which was conducted in Teratai Clinic during the month of July 2012. All participants underwent history taking, physical examination, and PCR assay for C. trachomatis. Swab samples were obtained from male urethra and female endocervix. Results: Eighty one HIV-positive patients, consisted of 48 males and 33 females were included in this study. The PCR examination for C. trachomatis was positive in 14 of 81 subjects (17.3%), with 10 (20.8%) urethral chlamydial infection in 48 males and four (12.1%) cervical chlamydial infection in 33 females. Conclusions: The study concluded that the prevalence of chlamydial infection in male urethra and female cervix of HIV-positive patients were 20.8% and 12.1%, respectively. Identifying chlamydial infection based on PCR testing should be considered for routine screening test in HIV-positive patients.    Keywords: Chlamydia trachomatis, HIV, prevalence, PCR DOI: 10.15850/ijihs.v1n1.107

Akt–the Mammalian Target of Rapamycin (mTOR) Pathway Inhibition Increases Cervical Cancer Cell Chemosensitivity to Active Form of Irinotecan (SN-38)

Septiani, Leri, Hidayat, Yudi Mulyana, Effendi, Yusuf Sulaeman, Djuwantono, Tono, Luftimas, Dimas Erlangga, Faried, Ahmad

International Journal of Integrated Health Sciences VOL 1, NO 1, July (2013)
Publisher : International Journal of Integrated Health Sciences

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Objective: To investigate the molecular pathway of the cytotoxic effect of SN-38 in human cervical cancer cell lines.Methods: Two human cervical cancer cell lines were treated with various concentrations of irinotecan for 24–72 hours and the sensitivity was analysed using the MTT assay. Apoptosis was further observed through microscopic examinations. The protein expression was determined using Western blot analysis.  Results: CaSki cells demonstrated the highest sensitivity to SN-38, whereas HeLa cells showed the lowest. In cervical cancer cells, SN-38 induced apoptosis through an intrinsic- and extrinsic-pathways. In addition, we showed that SN-38 downregulated the phosphorylation of Akt-mTOR pathways in CaSki cells, but not in HeLa cells. Interestingly, in HeLa cells, which were more suggestive of a resistant phenotype, pre-treatment with LY294002 and rapamycin inhibited activation of Akt-mTOR signaling and significantly enhanced the sensitivity of HeLa cells to SN-38. Conclusions: Irinotecan exerts its anti-neoplastic effects on cervical cancer cells by inducing apoptosis through caspase-cascade. Inhibition of Akt-mTOR, LY294002 and rapamycin, which is targeted to Akt-mTOR pathways, may sensitize irinotecan-resistant cervical cancer cells.Keywords: Akt-mTOR pathways anti-neoplastic drugs, cervix cancer cells, LY294002, rapamycin DOI: 10.15850/ijihs.v1n1.103

Nephropathy and Encephalopathy in an Indonesian Patient with Dengue Viral Infection

Rachmadi, Dedi, Anggara, Mohamad Yanuar

International Journal of Integrated Health Sciences VOL 1, NO 1, July (2013)
Publisher : International Journal of Integrated Health Sciences

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Objective: To describe unusual manifestation of dengue virus infection that has been increasing in number and elucidate the indirect effect of dengue infection on the central nervous system which may explain the occurence of dengue encephalopathy. Methods: A case report of 6-year-old boy who was admitted with a history of fever for three days, accompanied with decreased consciousness, hypertension, and edema is presented. Laboratory examination showed hemoconcentration, thrombocytopenia, with positive anti dengue Immunoglobulin G (IgG) and IgM, microscopic glomerular hematuria, and proteinuria as well as normal creatinine serum level. He was treated with supportive treatment. Results: After six days, the consciousness was improved and blood pressure was normal.  Proteinuia was alleviated by Day 11 and completely negative on Day 19.  Microscopic glomerular hematuria was negative after 6 months.Conclusions: Recognition of unusual dengue manifestations is important in early diagnosis and effective treatment of the disease.Keywords: Dengue virus infection, encephalopathy, nephropathy DOI: 10.15850/ijihs.v1n1.108

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