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International Journal of Integrated Health Sciences
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Cervical stump fibroid

Mathew, Sherman David, Abraham, Betsy

International Journal of Integrated Health Sciences VOL 6, NO 2 September (2018)
Publisher : International Journal of Integrated Health Sciences

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Abstract

AbstractFibroids are common benign growths in uterus. Cervical fibroid are rare & represent about 5% of total cases.Case presentation: A 68 year old female with a history of lower abdominal pain & fullness was refereed from a local clinic to the department of radio-diagnosis for evaluation. Patient had been having a dull lower abdominal pain for about 5-6 months, which was increasing in severity .The patient gave history of subtotal hysterectomy about 12 years ago. On imaging studies (USG &CT), a large adnexal lesion was made out, suggesting the possibility of a cervical stump fibroid. The patient went through elective surgery & diagnose was later confirmed on context of histological findings.Conclusion: On literature review, few documented cases of stump fibroid after hysterectomy was seen. Though the incidences are very rare & preservation of the cervix with hysterectomy is satisfactory in most of the cases, there have been cases where complications have arisen from the cervical stump.  Future studies are further required to assess the benefits over the possible late complications of retaining the cervix at hysterectomy.

Osteoporosis Prevention Exercise Effects to Bone Density in Children with Thalasemia

Waluyojati, Andreas Arie Widiadiaksa, Prananta, Marietta Shanti, Moeliono, Marina Annette

International Journal of Integrated Health Sciences VOL 6, NO 2 September (2018)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective:Osteoporosis is defined as a complication generally found in children with thalassemia. Thalassemia patients may suffer from decreased bone mass caused by many factors, such assexual maturity, hormone deficiency, endocrine disorders, ineffective hematopoiesis due to enlarged bone marrow, iron toxicity inhibiting osteoblast, and liver diseases. In order to prevent decreased bone mineral density (BMD), osteoporosis prevention exercise (OPE) is regarded as suitable exercise to maintain BMD includingthe aspects of weight-bearing, loaded training, and low impact aerobic. Regular OPE can prevent decreasedBMD in normal people. This study aimed to discover OPE suitablity to children with thalassemia.     Methods: This study was conducted in the period of April–June 2017 by using quasi experimental and pretest-posttestdesigns. Eleven thalassemia patients who were the members of Yayasan Thalassaemia Indonesia/Indonesia Thalassemia Foundation and Perhimpunan Orangtua Penderita Thalasemia Indonesia/Indonesia Parent Association of Thalasemia Children, Bandung, Indonesia were enrolled in the study as the subjects. Sample calculation was carried out by using consecutive sampling method. The subjects were given OPE intervention 2 times per week during 12 weeks with 35 minutes of each exercise session. Due to analyze impacts of the intervention, BMD of spinal lumbarexamination was performedbefore and after practicing OPE by using stratos dosimetry. Collected data were analyzed statistically by using paired t and Wilcoxon tests with p value<0.05. Results: Bone mineral densityassessment was performed in each lumbar segment. After the intervention, BMD value of L1, L2, and L3 segments did not improve significantly while BMD value of L4segment showed significant improvement (p<0.05).Therefore, signficant improvement of Z-score in the spinal lumbar was found (p<0.05). Conclusions: Osteoporosis prevention exercise can improve BMD in children with thalassemia. The exercise can be performed to decline osteoporosis risk in children with thalassemia.  

Association of Ki-67 Expression and Response Neoadjuvant Chemotherapy on Invasive Breast Cancer Patient in Bandung

Rezano, Andri, Pan, Chen En, Istiqomah, Afrida Aizzatun, Zada, Almira

International Journal of Integrated Health Sciences VOL 6, NO 2 September (2018)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To compare the size of tumour before and after neoadjuvant chemotherapy between three Ki-67 expression categories and also to find out the predictive value of Ki-67 towards neoadjuvant chemotherapy outcome.  Methods: This study was a retrospective study by obtaining data from the 2015’s cohort of invasive breast cancer patient medical record from Dr. Hasan Sadikin General Hospital. Only female patient with Ki-67 expression level recorded and data from pre and post neoadjuvant chemotherapy were taken. Changes of the tumor size in terms of mm3were compared. The data obtained was analyzed using One-way ANOVA. A total of 25 patients were included in this study. The p value for the changes in mm3was p<0.05. Results: The study showed significant difference in changes of tumour size for Ki-67 level >20% compared to <14% (p=0.011) and 14-20% (p=0.018). Based on the result, neoadjuvant chemotherapy is proven to have similar effects on patient with Ki-67 expression of <14 and 14 - 20 but less effective on patient with Ki-67 expression of >20. Conclusions: The effect of neoadjuvant chemotherapy is dependent to Ki-67 expression and also showing potential as a predictive marker for neoadjuvant chemotherapy response

Infused Oyster Mushroom (Pleurotus ostreatus) Inhibits Glucose Absorption through Intestinal Mucosal Membrane in Wistar Rats

Ariyanto, Eko Fuji, Shahib, M. Nurhalim, Wargahadibrata, Abdullah Firmansah

International Journal of Integrated Health Sciences VOL 6, NO 2 September (2018)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: The objective of this study was to know the effect of infused oyster mushroom (Pleurotus ostreatus) on glucose absorption through intestinal mucosal membrane in Wistar rats.Methods: This study used experimental design. Subjects of this study were six Wistar rats which were randomly divided into two groups; three rats were used for the analysis of the most effective time for glucose absorption and the other three were used to evaluate the effect of infused oyster mushroom on glucose absorption. The intestine of subjects was connected to in situ perfusion machine. Control glucose solution (Ctr) or glucose solution containing 5% (Oys 5%), 10% (Oys 10%) or 20% (Oys 20%) infused oyster mushroom was added into the perfusion machine and flowed back and forth in the lumen of intestine. The glucose concentration was determined using deproteinization method followed by absorbance measurement. Student’s t test was performed to analyze the difference between groups.Results: The level of glucose absorbed through intestinal mucosal membrane in control glucose solution or glucose solution containing 5%, 10% or 20% infused oyster mushroom was 25.19 + 3.4 mg/dL, 16.27 + 0.86 mg/dL, 13.22 + 1.58 mg/dL and 10.03 + 1.25 mg/dL, respectively. Student’s t test showed significant difference between groups; Ctr and Oys 5% (p=0.03), Ctr and Oys 10% (p=0.02), and Ctr and Oys 20% (p=0.007).Conclusion: Infused oyster mushroom inhibited glucose absorption through intestinal mucosal membrane in Wistar rats.Keywords: Oyster mushroom (Pleurotus ostreatus), glucose absorption, intestine

The Effect of 3-Days Storage and Temperature On ADP-induced Platelet Aggregation

Puspita, Nanda Ayu, Suryawati, Suryawati

International Journal of Integrated Health Sciences VOL 6, NO 2 September (2018)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective:Previous studies have revealed that platelet functions start to deteriorate after 3 days of storage, platelet activity may have changed earlier as a response to the exposure to various conditions during storage. The aim of this study is to observe platelet functions during 3 days of platelet storage and to evaluate the effect of storage temperature towards platelet aggregation response.Material and Methods:Two conditions of platelet storage were used in our study, at room temperature and cold condition at 4°C to observe the temperature effect on platelet aggregation. The aggregation test was performed using a 96-wells plate platelet aggregation method.Results:On Day 1, the response of platelet aggregation reduced to 34.9 ± 10.6%, which was less than half of the aggregation of fresh platelet (100%). The aggregation on day 2 reduced modestly (26.8 ± 4.2%), in comparison with that seen on the first day. On day 3, platelet aggregation deteriorated significantly (6 ± 1.2%), which was comparable to the control group without the presence of platelet agonist (6.1 ± 1.4%).When platelets were stored at 4°C or at room temperature (22°C) platelet response to stimulation with ADP were different. The result showed that storing the blood at 4 ˚C or room temperature was not able to preserve platelet function, as the deterioration of platelet aggregation response over time was still taking place. Moreover, although the results was not statistically significant, our result indicated that cold storage might reduce platelet responsiveness toward ADP activationConclusion:This current study provides evidence of the deterioration of platelet function during first 3 days of platelet storage. Moreover, we found that storing platelets in 4°C showed no significant benefit in preserving the ADP-induced platelet aggregation capacity compared to that stored in 22°C.

Ethanol Extract of Stylissa carteri Induces Cell Death in Parental and Paclitaxel-Resistant Cervical Cancer Cells

Hardani, Isna Nisrina, Damara, Fachreza Aryo, Nugrahani, Annisa Dewi, Bashari, Muhammad Hasan

International Journal of Integrated Health Sciences VOL 6, NO 2 September (2018)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To evaluate the cytotoxic effects of ethanol extract of marine sponge Stylissa carteri in both parental and paclitaxel-resistant HeLa cervical cancer cells. Methods: This was experimental in-vitro study subjected ethanol extract Stylissa carteri obtained from Pramuka Island, Kepulauan Seribu National Park, Jakarta. Paclitaxel-resistant HeLa cells were treated with ethanol extract followed by microscopic observation and MTT assay. The IC50 and drug curves were analyzed using four-parametric logistic regression by SigmaPlot for Windows version 12.0. Results: Our data showed that ethanol extract of Stylissa carteri triggered cell death-associated morphological changes as well as inhibited cell viability. The IC50 was 1 ppm. Importantly, this ethanol extract of Stylissa carteri was also triggered cell death in paclitaxel-resistant HeLa cells. The IC50 was 4 ppm.  Conclusion: This study revealed that a potential cytotoxic activity of Stylissa carteri not only in parental HeLa cells but also in paclitaxel-resistant HeLa cells. This recommends for further study to discover a novel compound contained in marine sponge.

Cerebrospinal Fluid Characteristics in Tuberculous Meningitis with Hydrocephalus in Department of Neurosurgery, Dr. Hasan Sadikin General Hospital, Bandung in the Period of 2014–2016

Budiman, Astrid Tamara Maajid, Suryana, Nida, Faried, Ahmad, Parwati, Ida

International Journal of Integrated Health Sciences VOL 6, NO 2 September (2018)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objectives: To describe the cerebrospinal fluid (CSF) findings in tuberculous meningitis (TBM) with hydrocephalus as diagnostic criteria of TBM.Methods: The research design was descriptive cross sectional using retrospective method. The data were obtained from medical record of TBM with hydrocephalus patients treated in Department of Neurosurgery Dr. Hasan Sadikin General Hospital, Bandung from January 2014–September 2016.Results: Sixty one samples were included in the study. The patient characteristics such as age, gender, and CSF laboratory features: color and clarity, cells and differential count, protein and glucose were recorded. The majority of CSF macroscopic appearance was clear (88.5%) and colorless (88.5%). The median of CSF cell count was 25 cells/mm3 with lymphocyte predominance (median: 76%). Increased protein from normal value range was seen in CSF (median: 50 mg/dL), besides, the mean of CSF glucose in this study remained in its normal value range (mean: 58.9±26.68 mg/dL) with lower CSF to blood glucose ratio (mean: 0.41±0.27).Conclusion: Clear CSF and colorless appearance, lymphocyte pleocytosis, high protein, and low CSF glucose:blood glucose ratio remain as typical CSF of TBM patient characteristics in Department of Neurosurgery, Dr. Hasan Sadikin General Hospital, Bandung.Keywords: Cerebrospinal fluid, hydrocephalus, tuberculous meningitis

Pregnancy Rate after Intra Uterine Insemination with Presence or Absence of Leukocytospermia Prepared by Density Gradient Method

Widyastuti, Rini, Pangayoman, Julius, Riyanti, Aida, Lubis, Alkaustariyah, Syamsunarno, Mas Rizky Anggun Adipurna

International Journal of Integrated Health Sciences VOL 6, NO 2 September (2018)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Background: Increases leukocytes in the semen has been associated with increased reactive oxygen species (ROS) that reduces sperm quality.Objective: The aims of this study were to examine the association of different leukocyte concentrations to sperm recovery rate after prepared by density gradient method and pregnancy rate after Intra Uterine InseminationMaterial and method: Semen samples from 31 male partners of couples undergoing infertility investigations were analyzed for sperm concentration, motility and leucocytes concentration. Then divided in two group based on leucocytes concentration (category A: >0 to <1 × 10(6)/mL; category B: >1 x 10(6)/mL.  Sample processed using density-gradient centrifugation techniques. Results: We observed that there is a significantly difference in a number of sperm harvested and sperm motility after preparation. Interestingly, pregnancy rate after IUI, from non-leucocytospermia yielded the higher pregnancy rate (39%) compared to leukocytospermia (30%) (p <0.05, respectively). Conclusion: Seminal leukocytes (PMNL) concentration affect pregnancy rate after Intra Uterine Insemination.

Characteristics and Complications of Tuberculous Meningitis Patients with Hydrochepalus Undergone Fluid Diversion in Dr. Hasan Sadikin General Hospital, Bandung

Novalia, Adriani Lawrencia, Berbudi, Afiat, Faried, Ahmad, Nataprawira, Heda Melinda

International Journal of Integrated Health Sciences VOL 6, NO 1 March (2018)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To describe the clinical characteristics and complications observed in tuberculous meningitis (TBM) patients with hydrocephalus who had undergone fluid diversion management.Methods: This was a cross-sectional descriptive observational study involving 28 TBM patients with hydrocephalus aged 0–5 years who had undergone ventriculoperitoneal shunt or extraventricular drainage in the period of July 2011 to July 2016 in Dr. Hasan Sadikin General Hospital, Bandung. Age, gender, head circumferences, nutritional status, and classical characteristics such as sunset eye, frontal bossing, cracked pot sign, venectation as well as complications such as infection, phlebitis, and exposed shunt documented in the hospital medical records were analyzed.Result: The study discovered that infant group was predominant (21/28). Some of the patients had macrocephalus (7/28) and 18 had good nutrition status (18/28). There were 4 patients with frontal bossing characteristics (4/28) and almost none was found with others classic hydrocephalus characteristics. This study found no complication such as infection, phlebitis, and exposed shunt in TBM patients with hydrocephalus who had undergone fluid diversion therapy in Dr. Hasan Sadikin General Hospital, Bandung.Conclusion: One of the most dominan characteristics of TBM patients with hydrocephalus is frontal bossing. Tuberculous meningitis patients with hydrocephalus in our center did not show any fluid diversion-related complications such as infection, phlebitis, or exposed shunt.Keywords: Tuberculous meningitis, hydrocephalus, fluid diversion DOI: 10.15850/ijihs.v6n1.1048

Monocyte to Lymphocyte Ratio in Peripheral Blood of Tuberculous Meningitis with HIV Patients in Tertiary Hospital in West Java

Amalia, Ridha, Turbawaty, Dewi Kartika, Sugianli, Adhi Kristianto, Aminah, Siti

International Journal of Integrated Health Sciences VOL 6, NO 1 March (2018)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To describe peripheral blood monocyte to lymphocyte (ML) ratio in tuberculous meningitis (TBM) patients with human immunodeficiency virus (HIV) infection in Dr. Hasan Sadikin General Hospital Bandung as a tertiary hospital in West Java Province, Indonesia.Method: A cross-sectional study with retrospective data approach was done in Dr. Hasan Sadikin General Hospital, Bandung. Data were collected from TBM patients who were hospitalized in Dr. Hasan Sadikin General Hospital, Bandung in the period of 2014–2016. The sample size was determined using total sampling method. General data, clinical manifestation data, and laboratory finding data were collected. The ML ratio was collected and presented into three groups of percentile (25th, 25–75th and 75th) based on the pre-defined cut-off.Result: Six subjects (40%) had an ML ratio of ≤0.47 and 3 subjects had an ML ratio of ≥1.22 in TBM with HIV population. Among TBM with HIV-negative population, there were 16 subjects had ML ratio ≤0.47, and 19 subjects had ML ratio ≥1.22.Conclusion: The ML ratio in TBM with HIV infection has become additional tool for detecting the development of TBM with HIV-infected, as well as TBM with non-HIV-infected. Therefore, it could help directing the patients with clinical suspicious of TBM into the diagnosis algorithm and treatment of TBM, to have better outcome.Keywords: Human immunodeficiency virus infection,lymphocyte, monocyte, monocyte to lymphocyte ratio, tuberculous meningitis DOI: 10.15850/ijihs.v6n1.1140