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Dr. dr. Hardian
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Program Studi Kedokteran, Fakultas Kedokteran, Universitas Diponegoro, Jalan Prof. Soedarto, Kampus Undip Tembalang, Semarang
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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : 25408844     EISSN : -     DOI : -
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Articles 1,171 Documents
UJI DIAGNOSTIK TES SEROLOGI WIDAL DIBANDINGKAN DENGAN KULTUR DARAH SEBAGAI BAKU EMAS UNTUK DIAGNOSIS DEMAM TIFOID PADA ANAK DI RSUP Dr. KARIADI SEMARANG Rachman, A. Fatmawati; Arkhaesi, Nahwa; Hardian, Hardian
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Background: Typhoid fever is a health problem in developing countries. Diagnosis by blood culture as the gold standard of Salmonella enterica. A more rapid, simple, and cheaper diagnostic method are needed.Widal serological test is a test that meets these criteria and still widely used.. This study was aim to determain the accuration of Widal serological test.Methods: Data used in this study is patients suspected of suffering from typhoid fever in the Paediatric ward RSUP Dr .Kariadi Semarang in March to June 2011. Study subjects totaled 49 children aged 24-178 months. Blood cultures compared with the Widal serological test, determine the cut- off point and then assess the diagnostic Widal.Results: At 1:80 titer obtained sensitivity values, specificity, positive expected value, negative expected value, and accuracy of Salmonella thypi sequentially Salmonela thypi O (97.737%, 10.00%, 40.00%, 75.00% and 36.734 %). Salmonella thyipi H (89.474%,16.667%, 40.476%, 71.429% and 44.898%). Salmonella parathypi AO (94.737%, 13.333%, 40.909%, 80.00% and 44.898%). Salmonella parathypi (100.00%, 3.33%, 39.583%, 100.00% and 40.816%). Salmonella parathypi BO (100%, 10.00%, 41.304%, 100.00%, and 44.898). Salmonella parathypi BH (73.684%, 10.667%, 35.897%, 50.00% and 38.776%).Conclusion: The accuration of Widal serological test for diagnosing typhoid fever in children was low.Keyword:Typhoid fever, Salmonella thypi, widal serological test, blood culture
PENGARUH PEMBERIAN LARUTAN EKSTRAK JERUK NIPIS (Citrus aurantifolia) TERHADAP PEMBENTUKAN PLAK GIGI Ambarwati, Fitarosana Enda; Utami, Devi Farida; Pramono, Dodik
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Latar belakang: Plak yang menempel pada gigi menyediakan nutrisi bagi bakteri untuk tumbuh, menyebabkan kolonisasi bakteri, serta menyediakan suasana asam yang akan berkontak dengan permukaan gigi, sehingga menyebabkan enamel larut dan menimbulkan karies. Pencegahan terbentuknya plak dapat dilakukan secara kimiawi. Penelitian ini digunakan larutan ekstrak jeruk nipis (Citrus aurantifolia) sebagai obat kumur karena terdapat berbagai fitokemikal yang mampu menghambat pembentukan plak dengan cara menurunkan pembentukan pelikel, menurunkan viskositas dan meningkatkan kecepatan aliran saliva, serta menurunkan jumlah bakteri pembentuk plak. Penelitian bertujuan untuk mengetahui pengaruh pemberian larutan ekstrak jeruk nipis terhadap pembentukan plak gigi.Metode: Penelitian uji klinis dilakukan dengan rancangan Randomised Controlled Trial. Sampel penelitian ini adalah santri pondok pesantren Qosim Al- Hadi, Mijen, Semarang, sebanyak 54 santri dibagi dua kelompok secara acak yaitu kelompok kontrol dan kelompok perlakuan. Kelompok perlakuan diberikan larutan ekstrak jeruk nipis dengan konsentrasi 65%. Skor plak gigi diukur menggunakan metode Sillness&Loe sebelum dan sesudah intervensi. Analisis data diolah program komputer dengan uji t tidak berpasangan dan taraf signifikansi diterima bila p<0,05Hasil: Uji Wilcoxon menghasilkan nilai signifikansi p <0,05 dan pada uji Independent t-test terdapat perbedaan bermakna (p<0,05) pada kelompok perlakuan (65%) dibandingkan dengan kelompok kontrol. Hasil penelitian ini menunjukkan bahwa skor plak setelah intervensi kelompok P (median=0,75) lebih rendah dari K (median=1,25).Simpulan: Pemberian larutan ekstrak jeruk nipis 65% dapat menghambat pembentukan plak gigi dan terdapat perbedaan rerata skor plak yang bermakna antara kelompok kontrol dan kelompok perlakuan, dimana skor plak pada kelompok perlakuan lebih rendah daripada kelompok kontrol.Kata kunci: larutan ekstrak jeruk nipis, pembentukan plak gigi
PENGARUH FORMALIN PERORAL DOSIS BERTINGKAT SELAMA 12 MINGGU TERHADAP GAMBARAN HISTOPATOLOGIS GASTER TIKUS WISTAR Katerina, Sherly; Suharto, Gatot; Margawati, Ani
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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ABSTRACTBackground: formalin is a substance generally used for human body preservation, as well as the industrial and pathology anatomy examination substance. Formalin is currently applied as food preservation, despite its danger for health. Based on the investigation and laboratory test conducted by Balai Besar Pengawasan Obat dan Makanan (BPOM) in Jakarta, there were some products found with formalin addition such as salted fish, noodle, and tofu.Aim: To prove the effect of gradually per oral dosage of formalin to the change of histopathological image of wistar rat gaster.Method: This research was conducted using laboratory experiment with post test only control group design. There were 20 wistar rats which had fulfilled the inclusion and exclusion criteria and then adapted for seven days. After completed the adaptation period, the samples were divided by simple random sampling into 4 groups. K is control group without per oral formalin dosage. P1, P2, and P3 are case groups with per oral formalin dosage of 50mg/kgW/day, 100mg/kgW/day, and 200mg/kgW/day respectively. After 12 weeks, all samples’ gasters were taken and they underwent histopathologic examination. Data were described on table, images and computer program.Results: The highest rate of gastric cell damage is on group P3. By Kruskal Wallis test there was a significant difference (p=0.000). Post Man Whitney Test found significant differences in K-P1 (p=0,008), K-P2 (p=0,008), K-P3 (p=0,008), P1-P2 (p=0,010), P1-P3 (p=0,008), whereas on P2-P3 there was no significant different found (p=0,456).Conclusion: Gradual per oral formalin dose for 12 weeks caused histopathological changes on wistar rat’s gaster. The changes showed including epithelial desquamation, epithelial erosion and epithelial ulceration.Key Words: gradual dose of formalin, histopathological image of gaster
FAKTOR RISIKO PENDERITA MELASMA Oktarina, Prananingrum Dwi; Muslimin, Muslimin
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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ABSTRACTBackground Melasma is one of the common skin problems, which caused color disturbances in the skin and decrease in confidence of the patients, a generally symmetrical macular hyperpigmentation. Certaint etiology of melasma as yet known, but there are some risk factors that are considered to play a role in its pathogenesis, include: sunlight, hormones, drugs, genetics, cosmetics, past illness history, age, and occupation.Objectives To determine the role of magnitude from each risk factor on the incidence of melasma and baseline frequency distribution of the patients.Methods This is an observational analytic study with case-control design, which was conducted from March-June 2012. Cases were patients with melasma who have been or are being treated in Dermatovenerology clinic of RSUD Semarang. Contraception acceptors in Obstetry-Gynecology clinic and staff / employees of RSUD Semarang who do not suffer from melasma, were included as control. Data taken from filling out the questionnaire by respondents, including sunlight, hormones (hormonal contraceptive use and pregnancy), drugs, genetic (family history), cosmetics, past illness history, age, occupation, gender and latest educational status. Data were analyzed to determine the relationships and significance of the risk by using a 2x2 table. Data analysis using SPSS 16.0 program, including Chi-Square test with significance p <0.050; 95% confidence interval; OR> 1 with a confidence interval does not include the value of 1.Results There are 43 respondents with melasma as cases and 43 non-melasma respondents as control. Variables which are statistically proven have a meaningful relationship and as a risk factor are the exposure to sunlight (p = 0.004, OR = 12.727; 95% CI = 1.550 to 104.515) and the use of cosmetics (p = 0.000, OR = 7.515; CI 95% = 2.890 to 19.543).Conclusion The variables which are proven to be risk factors for melasma are the exposure to sunlight and the use of cosmetics.Key words: Melasma, risk factors
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KETERLAMBATAN BEROBAT PADA PASIEN PATAH TULANG YANG MENGGUNAKAN SISTEM PEMBIAYAAN JAMKESMAS (Studi Kasus di RS dr. Kariadi Semarang) Sari, Ayu Puspita; Priambodo, Agus; Pramono, Dodik; Yudhanto, Eka; Budijitno, Selamat
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Background : Delayed treatments made bone fracture cases more difficult and required more intensive treatments. The Jamkesmas program was created to give the poor and the needy easy access to get health services.Aims : To analyze factors related to the delayed treatment on bone fracture patients who used Jamkesmas payment method in dr. Kariadi Hospital in Semarang.Methods : The type of this research is observational analysis with cross sectional design. The research was held from May 2012 until June 2012, at the Surgery in-patient installation of dr. Kariadi Hospital in Semarang. Interviews were conducted to patients by using questionnaires. Chi Square and Fischer exact test were used for the statistical test.Results : There are 90% of patients who do not have delayed treatment (< 72 hours) and 10% who have delayed treatment (> 72 hours). Most patients have low level of education (72%), sufficient level of knowledge about bone fracture (55,1%), good level of knowledge about Jamkesmas (69%), have good attitude toward bone fracture (96,6%), and have medical behaviors in searching for initial treatment of bone fracture (82,8%). Most of health facilities are affordable (96,9%). There is a significance between patient behaviors in searching for initial treatment of bone fracture (p<0.05) with the delayed treatment on patients who use Jamkesmas. There is no significance between the level of education (p>0.05), level of bone fracture knowledge (p>0.05), level of Jamkesmas knowledge (p>0.05), the affordable health facilities (p>0.05) and attitude toward bone fracture (p>0.05) with the delayed treatment on patients who used Jamkesmas.Conclusion : The patient behaviors in searching for initial treatment of bone fracture has a significant relationship with the delayed treatment on bone fracture patients who used Jamkesmas.Key words: delayed treatment, bone fracture, Jamkesmas
PENGARUH PEMBERIAN JUS NONI ( Morinda Citrifolia L) DOSIS BERTINGKAT TERHADAPPRODUKSI NITRIC OXIDE(NO) MAKROFAG PERITONEUM PADA TIKUS GALUR WISTARYANG DIBERI PAPARAN ASAPROKOK Soesilo, Novitasari; Ismail, Akhmad; Susilaningsih, Neni
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Latar Belakang : Asap Rokok mengandung radikal bebas (tar,H2O2,NO)2.Kandungan radikal bebas yang tinggi pada rokok dapat memacu pembentukan NO oleh makrofag peritoneum jauh lebih banyak. Sehingga diperlukan antioksidan eksogen.Buah Noni (Morinda citrifolia L) mengandung antioksidan alami yang mampu menangkal radikal bebas.Tujuan : Membuktikan ada pengaruhpemberian jus Noni terhadap produksi Nitric Oxide (NO) makrofag peritoneum pada tikus galur Wistar yang diberi paparan asap rokok.Metode : Penelitian ini dilakukan pada tikus Wistar jantan. Semua Wistar diberi paparan asap rokok dalam selama 30 hari. Hewan coba dibagi dalam 4 kelompok, tiap kelompok terdiri dari 5 tikus. Kontrol tanpa jus Nonil,kelompok perlakuan 1 diberi jus Noni 1 ml,kelompok perlakuan 2 diberi 2 ml, kelompok perlakuan 3 diberi 4 ml. Pemberian jus Noni pada menit ke 30 setelah pemaparan asap rokok. Semua Wistar diterminasi pada hari ke 31.Pengukuran variabel berupa produksi NO (Nitric Oxide) makrofag peritoneum yang diukur dengan ELISA reader.Hasil: Uji ANOVA didapatkan perbedaan kadar NO antara kelompok kontrol dan kelompok perlakuan(p=0.000). Post Hoc Test didapatkan perbedaan bermakna kadar NO makrofag peritoneum antara kontrol dengan kelompok perlakuan 2 dan 3 (p=0.036 dan p=0.001).Tidak terdapat perbedaan antara kontrol dengan kelompok perlakuan 1 secara statistik (p=0.271). Antara kelompok perlakuan 1 dengan kelompok perlakuan 2 dan 3 juga terdapat perbedaan yang bermakna (p=0.003 dan p=0.000).Tetapi antara kelompok perlakuan 2 dan 3 tidak terdapat perbedaan bermakna(p=0.075).Kesimpulan: Jus Noni mempengaruhi kadar NO makrofag peritoneum pada tikus galur Wistar yang diberi paparan asap rokok.Kata Kunci: Rokok, radikal bebas,Nitric Oxide,Morinda citrifolia L,antioksidan,makrofag
PERBEDAAN DERAJAT DIFERENSIASI ADENOKARSINOMA KOLOREKTAL PADA GOLONGAN USIA MUDA, BAYA, DAN TUA DI RSUP DR.KARIADI SEMARANG Ratnasari, Dian; Mughni, Abdul; Yudhanto, Eko; Budijitno, Selamat
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Background : Nowadays, colorectal cancer was more oftenly found on patient in younger age which had worse prognosis than in older patient. Adenocarcinoma was a type of colorectal cancer which was oftenly found. Differentiation degree was a factor influenced colorectal cancer prognosis. The purpose of this study was to show that there was difference in differentiation degree of Adenocarcinoma colorectal between young, middle, and old age.Method : It was an observational analytic retrospective studies with cross sectional method. Patient’s medical records with diagnosis adenocarcinoma colorectal from Kariadi Hospital Semarang were classified into three groups, young age (≤40 years old), middle age(41-60 years old), and old age(>60 years old). Then, differentiation degree were noted . It was analyzed by chi-square test.Result : Analysis between age and differentiation degree shows that there is a significant difference with p=0,01. It also shows that the younger patient they are found the most in moderate-poorly differentiation degree, and the least they are found in well differentiation degree.Conclusion : There is a significant difference in differentiation degree of adenocarcinoma colorectal between young, middle, and old age in Dr Kariadi Hospital Semarang.Keyword: differentiation degree, adenocarcinoma colorectal, age
Prediktor Kejadian Kejang Pascaoperasi Bedah Epilepsi Lobus Temporal Niantiarno, Fajar Herbowo; Arifin, Muhammad Thohar; Hardian, Hardian
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Latar Belakang : Perubahan status kejang pascaoperasi bedah epilepsi lobus temporal (ELT) merupakan indikator terhadap berhasilnya tindakan operasi. Karakteristik klinis pasien (usia saat operasi, usia onset epilepsi, lama epilepsi, jenis kelamin, frekuensi kejang tiap bulan, aura) dan hasil evaluasi pre opersasi (gambaran semiologi, rekaman elektroensefalogram (EEG) serta gambaran magnetic resonance imaging (MRI) diduga sebagai faktor risiko yang berpengaruh terhadap status bebas kejang pascaoperasi.Metode : Jenis penelitian adalah observasional analitik dengan rancangan kasus kelola. Pengambilan sampel dengan consecutive sampling. Subjek adalah pasien pascaoperasi ELT sebanyak 20 pasien yang tidak bebas kejang sebagai kasus dan 41 pasien yang bebas kejang sebagai kontrol. Variabel merupakan karakteristik klinis dan hasil evaluasi preoperasi didapatkan dari data rekam medis. Data dianalisis menggunakan uji Mann-Whitney,uji t-tidak berpasangan dan uji Chi-square.Hasil : Faktor risiko terhadap status bebas kejang pascaoperasi ELT adalah usia onset epilepsi ≤ 10 tahun (OR:3,4;95%CI:1,0 s/d 10,9), aura non ELT (OR:23,4;95%CI:2,5 s/d 219,2) dan tidak ada gambaran fokus epilepsi pada MRI (OR:4,1;95%CI:1,6 s/d 10,9). Variabel lama menderita lebih dari sama dengan 10 tahun (OR:2,3), frekuensi kejang per bulan lebih dari empat kali (OR:2,3) dan automatisasi positif (OR:1,5) belum dapat disimpulkan sebagai faktor risiko.Kesimpulan : Usia onset epilepsi yang kurang dari sepuluh tahun, aura non ELT serta tidak adanya gambaran fokus epilepsi pada MRI merupakan faktor risiko terhadap status bebas kejang pascaoperasi bedah ELT.Kata Kunci : Epilepsi lobus temporal, status bebas kejang pascaoperasi bedah ELT.
HUBUNGAN USIA, JENIS KELAMIN DAN STATUS NUTRISI DENGAN KEJADIAN ANEMIA PADA PASIEN TUBERKULOSIS Martina, Adinda Devi; Kholis, Fathur Nur
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Background: One – third of the populations in the world are being infected by tuberculosis. In 2010, Indonesia was proven to be the 4th country in terms of the amount of people that are being infected by tuberculosis. Actually TB is a chronic disease that leads to anemia. Anemia itself can cause the extension of patients’ length of stay in hospital and also has a major impact to the patient’s quality of life. Anemia that impacted to tuberculosis’ patients is a result of bad nutrition consumed by the patient, therefore it is presumed that the serum albumin concentration, which is used as a parameter of the nutrition, is also a risk factor of anemia in tuberculosis.Goal: To find out whether gender, age, and nutritional state are related to anemia in tuberculosis.Method: This study was an observational study with cross sectional design. The subjects were 73 medical records of tuberculosis patients. The data consisted of identity, age, gender, and laboratory test that included hemoglobin and serumalbumin concentration as the parameter of nutritional state. The statistic test used was Chi Square test.Result: Age could not be concluded related to anemia in tuberculosis (RP=1,0; CI 95 %=0,6-1,5). Gender could not be concluded related to anemia in tuberculosis (RP=0,8; CI 95%=0,6-1). The nutritional state could be concludedrelated to anemia in tuberculosis (RP=1,3; CI 95%=1,09 – 1,7).Conclusion: According to the analysis of the research; age and gender can not be concluded related to anemia in tuberculosis. Nutritional state is related to anemia in tuberculosis. Keywords: tuberculosis, anemia, age, gender, nutritional state, serum albumin concentration.
Hubungan Akses Media Massa dengan Pengetahuan Kesehatan Reproduksi pada Remaja ( Studi Kasus di SMK Kristen Gergaji) Donggori, Ratna Indriana; Margawati, Ani
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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ABSTRACTBackground Knowledge of reproductive health is an important things for teenager but in a reality there are many teenagers who do not know about good reproductive health where that information can be obtained from various source and one of them is mass media.Aim To analyze the relationship of mass media access with knowledge of reproductive health in adolescent and to analyze the relationship between kind of mass media with knowledge of reproductive health.Methods Observational study with simple random sampling or simple randomization for 11th grade student of Christian Vacational High School who met the inclusion criteria and not included in an exclusion criteria and obtained the required sample by fourty five respondents. Respondents were given quetionnaires and fill out by themselves under supervision of researchers. Analysis data used chi-square with degrees of significance under 0,05.Result This results prove that there is a significant relationship between mass media access to knowledge of reproductive heatlh on adolescent (p=0,110) and have a significant relationship between kind of mass media to knowledge of reproductive health on adolescent (p=0,002).Conclusion There is not relationship between mass media access with knowledge of reproductive health and there is a relationship between variety of mass media with knowledge of reproductive health.Keyword mass media access, knowledge of reproductive health, kind of mass media.

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