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INDONESIA
STIFAR - Sekolah Tinggi Ilmu Farmasi
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Articles 3 Documents
Search results for , issue " Vol 4, No 2 (2009)" : 3 Documents clear
PENGARUH PEMBERIAN EKSTRAK ETANOL, FRAKSI AIR, DAN FRAKSI ETIL ASETAT BUNGA ROSELA (Hibiscus sabdariffa L.) TERHADAP KELARUTAN BATU GINJAL KALSIUM SECARA IN VITRO Ulfa, Ika Riyana; Wulansari, Endang Dwi; Wildan, Achmad
STIFAR - Sekolah Tinggi Ilmu Farmasi Vol 4, No 2 (2009)
Publisher : STIFAR - Sekolah Tinggi Ilmu Farmasi

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Abstract

Kidney stone is one of diseases that found more in Indonesia. Kidney stone is formed by foods contained many calcium compound. Kidney stone is one of kidney disfunction that often happens. Rosela flower (Hibiscus Sabdariffa L.) is one of plants that can be used to drop kidney stone. This research has aimed to know ethanol extract, water fraction and ethyl acetate fraction capability in dissolving kidney stone in vitro. Rosela flower was extracted by ethanol 70% in soxhlet. Ethanol extract obtained was fractionated by ethyl acetate and water, so it was obtained ethanol extract, water fraction, and ethyl acetate fraction. Identification of flavonoid content in rosela flower was done by thin layer chromatografi. Qualitative analysis of kidney stone was done by infra red spectrophotometer to know that there was calcium in kidney stone. Calcium kidney stone was submerged in extract ethanol, water fraction and ethyl acetate fraction for 6 hours, at temperature 37°C and at concentration 2, 4, 6, 8, and 10% v/v. Capability in dissolving at ethanol extract, water faction, and ethyl acetate fraction were measured by AAS method and was analyzed by anava one way with confidence level 95%. The result of research showed that 10 % of ethanol extract is the highest concentration to dissolve Ca in kidney stone followed by water fraction 84,15 ppm and ethyl acetat fraction 30,64 ppm. It was concluded that ethanol extract, water fraction and ethyl acetate fraction of rosela flower were capable to dissolve kidney stone. The Key word : Calcium kidney stone, Rosela flower, ethanol extract, water fraction and ethyl acetate fraction
UJI AKTIVITAS ANTIOKSIDAN DENGAN METODE LINOLEAT-TIOSIANAT SERTA PENENTUAN KADAR FENOLIK DAN FLAVONOID TOTAL EKSTRAK ETANOL DAUN KETAPANG (Terminalia catappa L.) Muryati, Sri; Yuniawati, Devi Ray; Mutiara, Erlita Verdia
STIFAR - Sekolah Tinggi Ilmu Farmasi Vol 4, No 2 (2009)
Publisher : STIFAR - Sekolah Tinggi Ilmu Farmasi

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Abstract

Antioxidant is a chemical compound that can prevent free radical reactions in the body. Ethanolic extract of ketapang leaves (Terminalia catappa L.) contain some phenolic compounds among others tannin, phenolic acids and flavonoid that can act as antioxidants. The aim of this research is to know the antioxidant activity of the ethanolic extract of ketapang leaves based on linoleanic-thiocyanic method. The determination of the total phenolic flavonoid content was done to know the effect of the total phenolic and flavonoid content against its antioxidant activity. The result of antioxidant activity test based on linoleanic-­thiocyanic method showed that the ethanolic extract of ketapang leaves had an antioxidant activity. The activity antioxidant was extract 1%, vitamin E 1%, extract 0.5% and extract 0.1 % respectively. The total phenolic content of the ethanolic extract of ketapang leaves 1% (0.4674%) > extract 0.5% (0.2209%) > extract 0.1% (0.0450%). The total flavonoid content of ethanolic extract of ketapang leaves 1% (0.2932%) > extract 0.5% (0.1419%) > extract 0.1% (0.0290%). Spearman rho correlation test showed that the phenolic compound and flavonoid greatly affects the antioxidant activity of the ethanolic extract of ketapang leaves.   Key words : antioxidant, linoleanic-thiocyanic method, total phenolic content, total flavonoid content, Terminalia catappa L.
Evaluasi Penggunaan Obat Demam Tifoid pada Pasien Anak Di Instalasi Rawat Inap RSUD Dr. H. Soewondo Kendal Periode Januari - Juni 2007 Haryanti, Sri; Dewi, Dian Ratna; Wirawan, Andaka
STIFAR - Sekolah Tinggi Ilmu Farmasi Vol 4, No 2 (2009)
Publisher : STIFAR - Sekolah Tinggi Ilmu Farmasi

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Abstract

Demam typoid atau tifus abdominalis merupakan penyakit infeksi akut usus halus yang disebabkan oleh kuman Salmonella typhi. Data Departemen Kesehatan RI tahun 2006 menyebutkan bahwa jumlah penderita demam tifoid menempati peringkat ketiga. Untuk menjamin efektivitas dan keamanan, pemberian obat harus dilakukan secara rasional, untuk menerapkan kerasionalan obat beberapa pustaka atau standar pelayanan medik dapat dijadikan pedoman dalam pemilihan obat, dosis, dan interval pemberian. Tujuan dari penelitian ini adalah untuk mengetahui pola penggunaan obat demam tifoid, kesesuaian penggunaan berdasarkan Standar Pelayanan Medik, dan evaluasi tentang rasionalitas penggunaan obat di RSUD Dr. H. Soewondo Kendal. Penelitian ini merupakan penelitian deskriptif non eksperimental dengan pengambilan data secara retrospektif pada pasien demam tifoid tanpa penyulit yang dirawat di Instalasi Rawat Inap RSUD Dr. H. Soewondo Kendal periode Januari- Juni 2007. Sampel dalam penelitian adalah pasien anak penderita demam tifoid dengan usia 0 - 14 tahun yang dirawat di Instalasi Rawat Inap dan pulang dalam keadaan baik. Teknik pengambilan sampel secara proporsional random sampling kemudian data dianalisis secara deskriptif Hasil penelitian menunjukkan bahwa pola penggunaan obat pada 167 pasien anak penderita demam tifoid adalah menggunakan obat- obatan golongan Antibiotik (100%) dimana sefotaksim merupakan antibiotika yang paling banyak digunakan, analgetik antipiretik (53,89%), kortikosteroid (38,32 %), Vitamin (8,98%), obat saluran cerna (12,57%), dan cairan elektrolit (100%). Penggunaan obat yang sesuai dengan Standar Pelayanan Medik di RSUD Dr. H. Soewondo Kendal sebanyak 154 kasus (92,22%), dan 13 kasus (7,78%) belum sesuai dengan Standar Pelayanan Medik. Evaluasi penggunaan obat demam tifoid yang sesuai dengan Standar Pelayanan Medik antara lain tepat penderita (100%), tepat obat (92,22%), tepat dosis (86,82%), dan kemungkinan terjadinya interaksi obat (0%).   Kata kunci : evaluasi obat, demam tifoid, pasien anak

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