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STIFAR - Sekolah Tinggi Ilmu Farmasi
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Articles 1 Documents
Search results for , issue " Proceeding 2013 : Pharmacy and Advanced Pharmaceutical Sciences" : 1 Documents clear
THE OPTIMIZATION OF AVICEL PH 101 AND MANNITOL IN Nigella sativa L. EXTRACT TROCHES BY SIMPLEX LATTICE DESIGN Siska Prima, Endang Dwi Wulansari, Endang Diyah Ikasari,
STIFAR - Sekolah Tinggi Ilmu Farmasi Proceeding 2013 : Pharmacy and Advanced Pharmaceutical Sciences
Publisher : STIFAR - Sekolah Tinggi Ilmu Farmasi

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Abstract

ABSTRACT Nigella sativa L. Is one of herbs that can be used as antibacterical against Steptococcus pyogenes. We did the optimization of the avicel PH 101 and mannitol in Nigella sativa L. Troches by simplex lattice design (SLD). The result showed that the optimum proportion formula was 0.1 part of avicel PH 101 : 0.9 part of mannitol, with flow rate 11.5034 g/sec, moisture content 2.83%, compressibility 6.34%, hardness 4.26 kg, and friability 0.45%. The granule flow rate, moisture content, compressibility, hardness of troches with avicel PH 101 were bigger than troches with mannitol. The troches with mannitol, while the interaction of both ingredients had the biggest hardness of troches. Key word : Nigella sativa, troches, optimization, simplex lattice design

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