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Contact Name
Prof. Dr. dr. Taufiqurrachman Nasihun, M.Kes., Sp.And
Contact Email
-
Phone
 024-6583584
Journal Mail Official
sainsmedika@unissula.ac.id
Editorial Address
Fakultas Kedokteran Universitas Islam Sultan Agung
Location
Kota semarang,
Jawa tengah
INDONESIA
Sainsmedika
ISSN : 20851545     EISSN : 2339093X     DOI : -
Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.
Articles 144 Documents
Dengue Virus Detection in Egg of Aedes Species from DHF Endemicity Areas (Case Study at Semarang Municipality Mashoedi, Imam Djamaluddin; Qathrunnada Djam’an, Qathrunnada; Yusuf, Iwang
Sains Medika Vol 1, No 1 (2009): Januari-Juni 2009
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Original Source | Check in Google Scholar

Abstract

Background: Dengue infection is a serious public health problem in Indonesia, even the efforts to eradicatethe vector of Dengue virus have not been successfull. Recently, the number of Dengue cases has becomeincrease. The continuing spread requires more intensive control measure for Dengue vector. There has been ashift—older age tends to be more susceptible to Dengue than before. The municipality of Semarang is includedin the high endemic areas. Only few was studied about Dengue virus isolated from Aedes species. The studywas conducted to prove the existence of Dengue virus in the egg of Aedes species.Design and Method: This study was analytic descriptive with Cross Sectional Design. Dengue virus and eggs ofAedes species were the independent variable and dependent variable respectively. The eggs of Aedes speciesobtained from the areas with the high and low endemicity. The epidemiological study was carried out inSemarang Municipality for two months, between May 2007-July 2007. Dengue virus was detected byImmununohistochemistry (IHC) test in Parasitological Laboratory of Medical Faculty of Gajah Mada University.Result: The IHC test was positive indicated by brown colour for all samples.Conclusion: The result proved the existence of Dengue virus in eggs of Aedes species, (Sains Medika, 1 (1) : 1-8).
The Difference in Clinical Reasoning Competence between Pre-Clinical Students and Clinical Students on Pediatric Tropical Disease Cases Pujiati, Pujiati Abbas
Sains Medika Vol 6, No 1 (2015): January-June 2015
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (491.948 KB) | DOI: 10.26532/sainsmed.v6i1.341

Abstract

Introduction: Clinical reasoning is a thinking process happened when various informations gathered from clinical cases were given or met by medical students, and used for formulating diagnosis and solving patients problems. Experiences and material inputs are important factors affecting clinical reasoning. Various theories explained that students on pre-clinical and clinical rotation level are still on the novice stage, so it is possible to have similar stage on clinical reasoning. On the other hand, it was reported that there are differences in clinical reasoning on different academic stages. Objective: knowing the differences of clinical reasoning on preclinical students and clinical students.Method: observational study with cross sectional design. Respondents of this study were 120 students from medicine faculty of Sultan Agung Semarang University, comprised of: 60 preclinical students whom have been underwent tropical disease modul batch 2011 and 60 clinical rotation students on pediatric stage. Respondents answered 20 items questions in Script Concordance Test (SCT) form on pediatric tropical disease cases. SCT items were prepared by pediatricians, structures and contents were reviewed by medical education experts and concordanced by 10 experts of pediatric unit. Value differences between 2 groups were statistically analyzed using Mann Whitney U on SPSS 16.0, with acceptable error accepted level if p<0.05. Result: non parametric result test by Mann-whitney showed that mean score of SCT on preclinical group were lower (8,57;+ 1,81) than on clinical rotation students 11,49 (+ 1,98) p = 0,000. Conclusion: clinical reasoning competence measured by SCT is higher on clinical rotation students compared to pre clinical students.
Effect of Ginger Juice Water on Blood Glucose Levels and Histopathology of Pancreatic Beta Cells Experimental Studies on Alloxan Induced Wistar Male Rats Djama’an, Qatthrunnada; Goenarwo, Edijanti; Mashoedi, Imam
Sains Medika Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (144.211 KB) | DOI: 10.26532/sainsmed.v4i2.373

Abstract

Background: Hyperglycemia is one of the signs of diabetes mellitus, the disease is still being suffered by the people of Indonesia. Oral antidiabetic drugs mostly give unwanted side effects, then the experts developed a system of traditional medicine for diabetes mellitus. The research aimed to determine the effect of ginger juice on blood glucose levels and histopathological of pancreatic beta cells in male wistar rats induced by alloxan.Design and methods: An experimental study with a post-test only control group design, the study subjects white male wistar rats. Rats were divided into 5 groups, each group consisted of 5 rats, the group I was the control group (no treatment), group II is diabetic group (negative control), group III is Ginger + diabetes group, diabetes group is a group IV + Ginger + glibenclamide at a dose of each half, the group is the group of diabetic + V Glibenklamid.Results: The mean blood glucose levels were highest 172.02 ± 21.40 mg / dl is the K II. Lowest mean glucose levels were 112.72 ± 14.49 mg / dl for KV. Score the highest rates of pancreatic beta cell damage that is at the K II, while the lowest in the K V. Conclusion: Ginger Juice effect on blood glucose levels alloxan-induced rats. Ginger juice histopathologic effect on pancreatic beta cells alloxan-induced rats (Sains Medika, 4(2):165-173).
Hyperexpression of TNF-Stimulated 6 (TSG-6) of HumanTracheal Aspirate and Bronchial Alveolar Lavage from Heavy-Smoker and Lung TB Trihadi, Djoko
Sains Medika Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (310.373 KB) | DOI: 10.26532/sainsmed.v3i1.406

Abstract

Background: TSG-6, an inflamation-associated protein, forms covalent complexes with heavy-chains from TNF. These protein potentiating the antiplasmin activity of this serine protease inhibitor. The aim of study was to determine and show that TSG-6 are present in Bronchoalveolar Lavage (BAL) from patients with lung TB and heavy smoker.Design and Methods: Experiments conducted in vitro with purified components revealed that TSG-6 had immunodetection in the Human Tracheal Aspirates (HTA) and BAL of heavy smoker and Lung Tuberculosis.Results: Immunoprecipitation revealed that TSG-6 accounts in airways hyperresponsiveness for significant proportion of BAL and HTA, but not in control (p < 0,01). TSG-6 relevant protease inhibitor in airway secretion. In primary cultures of differentiated human airway epithelial, which suggest that TSG-6 may be induced by TNF. Our results suggest that TSG-6 may play an important protective role in bronchial epithellium buy increasing the antiprotese screen on the airway lumen. The present study identifies a novel function of TSG-6 by a distinct mechanism system regulated, enhancement of anti TK activity, and provides a rational for this activity within the context of inflamed airways. These findings correlate with the observed increases in protein expressions in human HTA and BAL.Conclusions: TSG-6 are hyper-expressed in airway epithelial cells in cultures of smoker and lung TB. The interactions of TSG-6 with other molecules are also potentially important to the pathophysiologic aspects of inflammatory airways diseases that remain to be elucidated (Sains Medika, 3(1):31-40).
Effect of Tempeh Flour Supplementation During Pregnancy In Wistar Rats With Limited Diet Wibowo, Joko Wahyu
Sains Medika Vol 5, No 1 (2013): January-June 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (255.8 KB) | DOI: 10.26532/sainsmed.v5i1.364

Abstract

Free radicals are formed in the body as a by-product of an aerobic respiration. During pregnancy, the increase in free radicals potentially causes structural and functional damages to fetus. Tempeh is originally from Indonesia having various nutrition inclding vitamin, mineral and isoflaphon serving as antioxidhant having potential to reduce and improve DNA damage. This study was aimed to investigate the effect of tempeh flour suplementation during pregnancy on Glutathione peroxides (GPx) and Malondetaldehyde (MDA) as an indicator of lipid peroxide in the offspings. In this experimental study, 20 pregnant female wistar rats were devided into four groups of 5 rats each to receive one of the following treatment :10 g standard diet/rat/d, 10 g/rat/d of standard diet and tempeh flour 1. g//d, 10 g/d of standard diet and tempeh flour 2g/d, standard diet of 10 g/d and 1g of egg/d. And aquades ad libitum. During nursing period (until 1 month) the rats were fed 10 g/100gBB/d normal diet, after weining they were supplemented with a diet of high in saturated fat for 4 weeks for each group. The Mean of litter size was 1: 9.33 with mean of BW 4.93 g, group II:6.17 with BW of 5.32, group III: 5.17 with BW of 5.33, group IV: 6.33 with BW: 5.01. Means of GPx for the four groups were 22.38 U/mg, 28.94 U/mg, 38.59 U/mg, 16.98 U/mg respectively. The mean of MDA for the four groups were 11.07 nmol/mg, 9.89 nmol/mg, 10.06 nmol/mg and 12.25 nmol/mg respectively. There was a significant difference in GPx and MDA (p=0.00). In conclusion tempeh flour had an effect on the level of GPx and MDA in rats with limited diet during pregnancy.
Effect of Pb-acetate on Testicle Weight and Volume of Mice Isradji, Israhnanto
Sains Medika Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (159.514 KB) | DOI: 10.26532/sainsmed.v3i2.397

Abstract

Background: The human effort to meet the needs of human life is almost always cause pollution in the environment of his life. One of the pollutants that harm human beings are lead (Pb = plumbum), Pb is one of the heavy metals that are harmful to health. Pb may also affect the reproductive organs. The purpose of this study to determine the effect of Pb-acetate on mouse testis weight and volumeDesign and Method: Eighty male mice placed in individual cages according to the group. Food and drink provided ad libitum. The treatment of male mice given for 6 weeks. Treatment with 0.2 ml distilled water to PI, P II were given a solution of 400 ppm Pb acetate total of 0.2 ml, P III was given a solution of 1000 ppm Pb acetate as many as 0.2 ml, and P IV were given a solution of 2000 ppm Pb acetate total of 0,2 ml by using a gastric sonde, every morning once a day for 42 days. At week 7, mice were surgery to take the testis. Testicular volume was measured and weighed. Data were analyzed by ANOVA, hypothesis is accepted when p<0.05, to know the difference between the effect of treatment used the least smallest difference test.Result: The weight of the testes treated with Pb-acetate 0 ppm, 400 ppm 1000 ppm and 2000 ppm consecutive is 0.237, 0.237, 0.227 and 0.217 g, Volume testes treated with Pb acetate concentrations of 0 ppm, 400 ppm 1000 ppm and 2000 ppm consecutive is 0.278, 0.273, 0.255 and 0.263 cm3, respectively testicular volume Anova test results obtained by the probability of 0.189 (> 0.05), testis weight obtained by ANOVA test probability of 0.216 (> 0.05), mean Pb -acetate had no effect on testis weight and volume.Conclusion: Pb-acetate had no effect on testis weight and volume (Sains Medika, 3(2):150-156).
The Relationship between Total Blood Cholesterol Level and VO2 max in 6-Minute Walk Test An Analitical Observational Study in Students of Medical Faculty UNISSULA aged 19 to 21 years Innash, Rahmaan; Rosdiana, Ika
Sains Medika Vol 5, No 1 (2013): January-June 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (244.396 KB) | DOI: 10.26532/sainsmed.v5i1.355

Abstract

The increase in total cholesterol level is a risk factor for coronary heart diseases leading to decrease in fitness. VO2 max is the biggest advocate for heart and lung fitness. There have been few studies conducted on relationship between total cholesterol level and VO2 max. The purpose of the study was to determine the relationship between total colesterol level and VO2 max through the 6-minute walk test. In this Analytical observational study with the population of medical faculty students of 2009, 2010, 2011 included 51 persons aged 19-21 years. Total cholesterol level was measured by specthrophotometer from blood. VO2 max analyzed by the 6-minute walk test. The study resulted in mean VO2 max of 24.48 ml/kg/min, mean of total blood cholesterol of 164.16 mg/dl. Pearson correlation test showed there was a significant correlation between total blood cholesterol level and VO2 max (p < 0.05), with negative correlation r = -0.281. An increase in the blood levels of total cholesterol will decrease physical fitness (VO2 max).
Efficacy Assessment of Lemon Peel Aromatherpy Againts Airborne Bacteria Experimental Study in ICU Room of Sultan Agung Islamic Hospital Semarang Sari, Merin Awu; Masfiyah, Masfiyah; Chodidjah, Chodidjah
Sains Medika Vol 4, No 1 (2012): Januari-Juni 2012
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (140.925 KB) | DOI: 10.26532/sainsmed.v4i1.388

Abstract

Background: Healthcare associated infections (HAI) are infections acquired in health care centers such as hospital, clinic or other health care sites due to microorganisms. Research conducted by WHO showed 3-10% of all patients treated in hospitals were victims of HAI and 90% were mainly caused by bacteria, the rest by viruses, fungi or protozoa. Lemon peel aromatherapy is one of the essential oils from plants having antimicrobial activity and are beneficial to health reducing bacterial growth by inhibiting the function of cell membranes. This study aimed at evaluating the efficacy of lemon peel aromatheraphy againts airborne bacteria.Design and Method: This experimental study used post test only control groups design. The number of airborne bacteria colonies obtained from ICU room of Sultan Agung Islamic Hospital Semarang treated with lemon peel aromatherapy at the concentration of 100 % and the control group (-).The data were analyzed for normality using Shapiro Wilk followed by independent T-test Result: independent inT-test Independent showed a significant differences in the number of bacterial colonies between the treated groups receiving 100% concentration of lemon peel aromatherapy and control group (-) (p < 0.045).Conclusion: Aromatherapy extracts of lemon peel has effect on reducing the number of airborne bacteria in the ICU of Sultan Agung Islamic Hospital Semarang (Sains Medika, 4(1):71-77).
Customer’s Perspective in Performance Assessment of Pharmacy Instillation of RSUD X with Balanced Scorecard Sulistyaningrum, Indriyati Hadi; Satibi, Satibi; Andayani, Tri Murti
Sains Medika Vol 5, No 2 (2013): July-December 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (361.504 KB) | DOI: 10.26532/sainsmed.v5i2.346

Abstract

Balanced Scorecard performance measurement (financial perspective, customer perspective, internal business perspective, and learning and growth perspective) offers a more thorough and comprehensive evaluation in a public organization such as a hospital. The object of this study was the Department of Pharmacy of RSUD X. This study was descriptive non-experimental. The data were obtained retrospectively and prospectively. The qualitative data were obtained through questionnaires. The quantitative data were obtained through direct observation, surveys. From the research using the Balanced Scorecard data gathering, it has been found that: performance customer perspective showed that the average patient satisfaction was 88% of patients. They were satisfied with the service of the Department of Pharmacy, and the average growth of customers has increased by 10% each month. In conclusions, the working performance of the department of pharmacy was included in “good criteria”, with some suggestions and improvements that need to be taken into consideration.
Therapeutic Drug Monitoring (TDM) in The Use of Aspirin as Antirheumatoid Drugs Miladiyah, Isnatin
Sains Medika Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (305.137 KB) | DOI: 10.26532/sainsmed.v4i2.378

Abstract

Therapeutic drug monitoring (TDM) is used in drug therapy for selected drugs with narrow therapeutic index, or a broad range of kinetics variation, or drugs with strong correlation between plasma concentration and clinical effects or toxicity. Aspirin is one of the widely used old generation drugs, with a broad range of activity spectrum: analgesic, antipyretic, anti‐inflammatory, and antiplatelet. As anti‐inflammatory drug, aspirin directed as therapy for many of chronic inflammation, such as rheumatoid arthritis. As an antirheumatic agent, aspirin shows a wide variation in the pharmacokinetic of aspirin metabolism, and has a narrow therapeutic index because it effectives at concentration of 10‐30 mg/dl, but at more than 40 mg/dl intoxication occurs (metabolic acidosis, hyperpnea, and death). Those are why aspirin use as antirheumatic agent need therapeutic drug monitoring, so that doctors can guarantee that plasma aspirin concentration is in the therapeutic range, to achieve optimilization of therapy with minimal side effects. This article reveals about use of aspirin as antirheumatoid drugs and why therapeutic drug monitoring is needed in aspirin use (Sains Medika, 4(2):210‐226).

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