cover
Contact Name
Siti Rofida
Contact Email
-
Phone
6281234404440
Journal Mail Official
farmasains@umm.ac.id
Editorial Address
Jalan Bendungan Sutami 188 A Malang-65145
Location
Kota malang,
Jawa timur
INDONESIA
Jurnal Farmasains
ISSN : 20863373     EISSN : 2620987X     DOI : -
Core Subject : Health,
Farmasains is a scientific publication for widespread research and criticism topics in pharmacy science studies. Farmasains is published twice a year in April and November since June 2010 by Department of Pharmacy University of Muhammadiyah Malang. One volume of Farmasains is published in two year calendar.
Arjuna Subject : -
Articles 69 Documents
PERANAN MIKROBA ENDOFIT UNTUK PENGEMBANGAN OBAT ANTI KANKER Siti Rofida
Jurnal Farmasains Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : Jurnal Farmasains

Show Abstract | Original Source | Check in Google Scholar | Full PDF (2991.12 KB)

Abstract

Natural product that has developed as anticancer drugs are consists from secondary metabolites that has isolated from plant, ocean plant and microorganisms. To maintain its productivity, must be concerned to the cultivation of the medicinal plants. Medicinal plants need time to grow and producing secondary metabolites that would be isolated, so that the production of secondary metabolites compound from plant is very limited.             The plants that infected by endophytic fungi be able to grow faster than the normal plants. Endophytic fungi also have ability producing secondary metabolites compound that produced by the host plant. Taxol, podophyllotoxin and camptothecin are compounds that proved has anticancer activity. Endophytic fungi have also proved increasing the production of the compound.
STRUMA MULTI NODOSA NON TOKSIKA INTRATHORAKAL Apa pilihan approach operasinya? Haruskah dilakukan Median Sternotomy? Mochamad Aleq Sander; Fina CS
Jurnal Farmasains Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : Jurnal Farmasains

Show Abstract | Original Source | Check in Google Scholar | Full PDF (234.01 KB)

Abstract

Mochamad Aleq Sander, dr., M.Kes., SpB., FinaCSFakultas Kedokteran Universitas Muhammadiyah MalangJl. Bendungan Sutami 188A Malang 65145e-mail: aleq.sander@yahoo.comblog: bedahunmuh.wordpress.comAbstractIntrathoracal non toxic multi nodular struma is lumpy enlargement of thyroid glandwithout hypothyroidism that extend from cervical thyroid gland into thoracal cavity. Accordingto anatomy location of thyroid, their name were substernal, retrosternal, mediastinal,intrathoracal, plunging, anterior and posterior mediastinal, and aberrant mediastinal. Theorigin of blood supply of mediastinal struma was inferior thyroidea artery, especially casesfrom aorta, subclavia artery, internal mammary artery, or ima thyroidea artery. According toStudy got that seven patients with mediastinal struma had intrathoracal blood supply directly.Surgery could cervical approach and/or thoracotomy according to anatomic location andtype of intrathoracal struma.Keywords: intrathoracal strumaAbstrakStruma multi nodosa non toksika intratorakal adalah pembesaran kelenjar tiroid yang tampakberbenjol-benjol tanpa disertai tanda-tanda hipertiroidisme yang mengalami ekstensi kearahinferior dari kelenjar tiroid servikal hingga masuk ke dalam rongga thoraks. Jaringan tiroidyang berada di rongga toraks diberi nama sesuai tempat anatominya yaitu substernal, retrosternal,mediastinal, intrathorakal, plunging, anterior dan posterior mediastinum, serta mediastinumaberrant. Suplai darah untuk struma mediastinum biasanya dari arteri tiroidea inferior, padakasus tertentu suplai darah dapat berasal dari aorta, arteri subklavia, arteri mamaria interna,atau dari arteri tiroidea ima. Hasil penelitian didapatkan bahwa dari tujuh orang yang mengalamistruma mediastinum ternyata memiliki sumber perdarahan langsung dari intrathorakal. Tindakanoperasinya bisa melalui cervical approach dan/atau thoracotomy, hal ini tergantung dari lokasianatomis dan tipe struma intratorakal yang diderita oleh pasien.Kata kunci: struma intratorakal
Uji Potensi Perlekatan Bakteri Asam Laktat Isolat TLA-15 Dan TLA-20 Pada Sel Epitel Usus Tikus (Rattus norvegicus) Ernanin Dyah Wijayanti; Tri Ardyati
Jurnal Farmasains Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : Jurnal Farmasains

Show Abstract | Original Source | Check in Google Scholar | Full PDF (120.32 KB)

Abstract

In Vitro probiotic potential test that had been conducted before, which consist of probiotic bacteria test  resistance toward the gastro-intestinal track pH and the bile salt concentration shows that the strain bacteria TLA-15 and TLA-20 had potential as probiotic bacteria. An advance test are required to fullfill the requirement as the probiotic bacteria. So that, the objective of this research are to study the viability of lactic acid bacteria strain TLA-15 and TLA-20 at the Rattus norvegicus GI track. At the first step of this research was added 4 106 cell/ml lactic acid bacteria TLA-15 and TLA-20 given orally.
PENYEMBUHAN LUKA DECUBITUS PADA TIKUS PUTIH Moch. Agus Krisno Budiyanto
Jurnal Farmasains Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : Jurnal Farmasains

Show Abstract | Original Source | Check in Google Scholar | Full PDF (1570.601 KB)

Abstract

Chronic wounds are still problem is one of the most frequent among the community. Pressure ulcers (decubitus) are examples of types of chronic wounds in which the maintenance costs of the injury fairly expensive. The use of plants is an appropriate alternative for the treatment of decubitus chronic wounds. One among the many plants that are known efficacious drugs for the health of Aloe vera. With the various components contained therein, aloe vera is known to affect the decubitus chronic wound healing. This study is purely experimental posttest-only design approach. The sample uses a white rats strain wistar female, weight 150-250 gr and 2,5 to 3 months of age. The variable is the concentration of the extract of Aloe vera and scores healing pressure ulcers (decubitus) degree II in white rats. The data obtained using observation, then analyzed with the assumption test (Lilliefors test and the Barlett test), one way Anova test and different test real distance of Duncan with significansy values of 0,05. The results indicate that there is the influence of various concentrations of leaf extract of Aloe vera to diameter decubitus chronic wound healing in rats and the concentration of leaf extract of Aloe vera 100% to give a good effect on the diameter of decubitus chronic wound healing on white rats (á 0.05).
Studi Etnofarmasi Etnis Using Banyuwangi Indonesia Nailis Syifa; Apris Dwi Sihdianto; Adityo Herjuno; Alvan Febrian Salash
Jurnal Farmasains Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : Jurnal Farmasains

Show Abstract | Original Source | Check in Google Scholar | Full PDF (261.435 KB)

Abstract

Cultural studies about treatment methods and herbal plants in an ethnic important to understand in order to know the different methods of treatment and medicinal plants used from each ethnicity. In addition, this study is also useful to know the drugs from natural ingredients that have not been identified. In this study, as the object of research is ethnic Using, Kemiren village, District Glagah Banyuwangi. The method used in this study include interviews with local community and the people who play a role in traditional medicine in these ethnic. The results obtained information on 62 commonly used medicinal plants for traditional medicine. From 62 plants were then performed classification based on the bioactivity.
PROFIL PENDERITA KANKER PAYUDARA STADIUM LANJUT BAIK LOKAL MAUPUN METASTASIS JAUH DI RSUP HASAN SADIKIN BANDUNG Mochamad Aleq Sander
Jurnal Farmasains Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : Jurnal Farmasains

Show Abstract | Original Source | Check in Google Scholar | Full PDF (465.575 KB)

Abstract

Breast cancer represent one of the most second malignancy of the woman after cervix cancer. In Indonesia estimated ±100 new case per 100.000 population every year, meaning more or less 200.000 new case every year to all cancer type. While for the breast cancer ± 23.140 new case every year. If breast cancer found in early stage, it has high life expectancy, ranging from 85-95%. But actually 70-90% patient came to hospital after their disease were hard and advanced stage. Cancer medication at advanced stage was very difficult and its result very dissatisfactory. The aim of research is to know the epidemiology, clinical symptom, diagnosis, therapy, prognosis. Descriptive study with retrospective design. Total sampling was all outpatient in oncology deparment of Hasan Sadikin Hospital of Bandung with advanced stadium of breast cancer from January 2003 up to December 2008. 164 eligible respondens who had age below 35 yo 28 (17.1%) and above 35 yo 136 (82.9%). Average of menarche 11.77 yo. Location of right breast cancer 78 (47.6%), left 82 (50%), and both 4 (2.4%). A lot of stadium was T4bNoMx that is 18 (11%). Chest x-ray, laboratory, and USG were the most diagnostic procedure often used that is 19 (11.6%). The most common therapy was BE+VC+RM that is 17 (10.4%). The prognosis was healing 20 (12.2%),  not/not yet healed 30 (18.3%), not control 110 (67.1%), and who control in the other place 4 (2.4%). Conclusion was mostly diagnosis of breast cancer according to anatomy pathology, chest x-ray, laboratory, and ultrasonografi. A lot of breast cancer location was left side. Excision biopsy, and followed by radical mastectomy were the most therapy procedure. Therapy evaluation to assess the level of healing was difficult because most patient did not conduct the control after therapy.
PENGARUH IKLAN OBAT FLU DI TELEVISI TERHADAP PEMILIHAN OBAT SECARA SWAMEDIKASI PADA MASYARAKAT DI MALANG Hidajah Rachmawati
Jurnal Farmasains Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : Jurnal Farmasains

Show Abstract | Original Source | Check in Google Scholar | Full PDF (451.333 KB)

Abstract

Communications is process transfer of information signing the forwarding of message of someone to others, either through indirect and also direct that is media.Television as a mass media technically capable of informing public in numerous amount in the same time. One of television program offering various product to fulfill requirement and satisfaction of physical is commercial. Such commercial is influenza drug commercial, because met many people. This matter of tendency make people to do self-medication as solving of from problem of health which they recognize by self.             Data collecting uses purposive sampling method in 102 respondents . Instrument test is done by validity test and reliability testing . Data analysis tool used is correlation analysis,t-test and regression analysis. Based on the result of the research, correlation coefficient is 0.645 so r table is 0,195, means there is a relation between influenza drug commercial and self-medication drug of choice. Based on the test t, t calculation is 2,376 so t table is 1,980, means there is influenza drug commercial in television has significant effect to self-medication drug of choice with equation regression Y = 4.803 + 0.522 x, means if influenza drug commercial in television indicator increasing 1 so self-medication drug of choice increasing 0.522. Value Sig. Of 0.000 <0.05 then the correlation coefficient deduced influenza drug commercial to self medication ‘s drug of choice in people in Malang is significant.
REVITALISASI PENGGUNAAN OBAT GENERIK Nanang Yunarto
Jurnal Farmasains Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : Jurnal Farmasains

Show Abstract | Original Source | Check in Google Scholar | Full PDF (95.544 KB)

Abstract

The government through the Ministry of Health is very serious about revitalizing the use of generic drugs by issuing a policy that stipulated in the Regulation of the Minister of Health No. HK. 02.02/Menkes/068/1/2010 about duty to use generic drugs in government health care facilities. To maximize the use of generic drugs, it is very important to improve understanding and trust of society that generic drugs have the quality, safety and effectiveness are similar to branded drugs. Besides that, there is a lot of research and the study of generic drugs will increase the knowledge, so that health professionals, especially doctors do not hesitate to prescribe generic drugs. Quality used as a basis of reference to establish the truth of the eficacy and safety. For availability of certain products can be demonstrated in vitro. Studies of drug dissolution gave the same indication with drug bioavailability. Ideally, in vitro drug dissolution correlates bioavailability in vivo. From the research results of dissolution test generic drugs Amoxiciline 500 mg tablets, Isosorbit Dinitrat 5 mg tablets and Omeprazole capsules compared to branded drugs show no less generic drugs than branded drugs, dissolution test results even better generic drugs
SINTESIS N-3-CHLOROBENZOYLAMOXICILLIN DAN UJI AKTIVITAS ANTIBAKTERINYA TERHADAP Pseudomonas aeruginosa ATCC 27853 Ika T. D. Kusumowati Siswandono; Marcellino Rudyanto
Jurnal Farmasains Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : Jurnal Farmasains

Show Abstract | Original Source | Check in Google Scholar | Full PDF (122.029 KB)

Abstract

N-3-chlorobenzoylamoxicillin were prepared by reacting 3-chlorobenzoylchloride with amine group of amoxicillin (acylation reaction). The reaction is nucleophilic substitution reaction in which primary amine group of the amoxicillin, which was nucleophilic in nature, attack C=O groups of benzoyl chloride-derivatives which has positive charge. The results showed that percentages of N-3-chlorobenzoylamoxicillin were 75%, respectively. Rf value of the resulting compounds different from Rf value of the amoxicillin. The structures were identified by Infra Red Spectrophotometry and Nuclear Magnetic Resonance (1H-NMR) Spectrometry. The results of the spectral analysis showed that spectra of amoxicillin and N-3-chlorobenzoylamoxicillin had changed significantly. The resulting structure was well fitted to the expected compounds. Antibacterial activities of N-3-chlorobenzoylamoxicillin­ against Pseudomonas aeruginosa ATCC 27853 were tested using dilution method. Minimum Inhibition Concentration achieved in the research represented the lowest level that can inhibit bacterial growth adequately. Analysis of the Minimum Inhibition Concentration on Pseudomonas aeruginosa ATCC 27853 showed significant differences between amoxicillin and N-3-chlorobenzoylamoxicillin.
FORMULASI SUSPENSI DOKSISIKLIN MENGGUNAKAN SUSPENDING AGENT PULVIS GUMMI ARABICI: UJI STABILITAS FISIK DAN DAYA ANTIBAKTERI Nur Chasanah; Ika Trisharyanti DK; Peni Indrayudha
Jurnal Farmasains Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : Jurnal Farmasains

Show Abstract | Original Source | Check in Google Scholar | Full PDF (430.779 KB)

Abstract

Suspension is a dosage contain solid drug material with insoluble form and smooth. Doxycycline is an antibiotic which difficult dissolve in water. Stable doxycycline suspension during 2 week if it kept at space temperature, stable on the air but will change to be dark if it influence sunshine. The aim of the research to evaluate physical stability and ability antibacterial stability doxycycline suspension with PGA as suspending agent. Research category are: Independent variable : concentration of suspending agent (PGA), suspension holding time. Dependent variable: physical stability (sedimentation volume, viscosity, redispersibility, easy to pour, and particle size) and antibacterial of doxycycline suspension, and variabel control is temperature suspension making, create of suspension. Data collecting with measuring physical stability and ability antibacterial of doxycycline suspension. The result shows doxycycline suspension with suspending agent PGA had physical stability and antibacterial ability is good. Physical Stability test show  formula 1 rate PGA 5% is formula had physical stability better than formula 2 with rate PGA 7,5% and formula 3 withrate PGA 10%. stability ability test antibacterial show formula 2 is the  best in pursues Staphylococcus aureus.