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INDONESIA
Jurnal Kardiologi Indonesia
ISSN : -     EISSN : 26204762     DOI : -
Core Subject : Health,
Indonesian Journal of Cardiology (IJC) is a peer-reviewed and open-access journal established by Indonesian Heart Association (IHA)/Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) [www.inaheart.org] on the year 1979. This journal is published to meet the needs of physicians and other health professionals for scientific articles in the cardiovascular field. All articles (research, case report, review article, and others) should be original and has never been published in any magazine/journal. Prior to publication, every manuscript will be subjected to double-blind review by peer-reviewers. We consider articles on all aspects of the cardiovascular system including clinical, translational, epidemiological, and basic studies.
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Articles 11 Documents
Search results for , issue " VOL. 28 NO. 4 September 2007" : 11 Documents clear
Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men Gunawan, Richard Indra; Kosasih, Adrianus; Lilyasari, Oktavia; Librantoro, dr; Joesoef, Andang H; Kaligis, RWM
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

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Background. Obesity is one of Cardiovascular risk factor. Obesity caused increase in heart mass due to cellular hypertrophic and metaplastic proses, independently of hemodynamic factors such as blood pressure. There were hyperleptinemia in obesity due to the selective Leptin resistency in central nervous system and peripheral organs. Study with cultured rat cardiomyocyte have shown hypertrophy and hyperplastic effect of Leptin to cardiomyocyte. Some clinical studies have shown correlation between circulating Leptin level with Left Ventricle Mass in hypertensive and insulin resistance men.Objective. This study aimed to elaborate the correlation between circulating Leptin level with Left Ventricle Mass in normotensive men.Methods. A cross sectional study was performed with normotensive men, which included 40 obese normotensive and 40 normoweight men. All patients underwent physical and laboratory assessment and examination of Left Ventricle with echocardiography. The circulating Leptin level were determined by ELISA method. The Leptin level were expressed as median (25th percentile; 75th percentile)Results. The circulating Leptin level were significantly different between the obese normotensive and the lean group. The Left Ventricle Mass in Obese increased, although have not fulfilled the criteria for Left Ventricle Hypertrophy. There were significant correlation between Left Ventricle Mass with BMI (r = 0,711; p<0,001) and waist circumference (r = 0,732; p<0,001). Respectively, there were significant correlation between Left Ventricle Mass Index with BMI (r = 0.541; p<0.001) and waist circumference (r = 0,558; p<0.001. There were significant correlation between circulating Leptin level with Left Ventricle Mass (r = 0,510; <0,001) and Left Ventricle Mass Index (r = 0,414; p<0,001) inobese  men.Conclusion. Circulating Leptin level is correlated with Left Ventricle Mass in normotensive men.
Factors Affecting Heart Rate Recovery After Symptom-limited Exercise Stress Testing Pakpahan, Henry AP; Priyana, Andria; Basha, Adnil; Radi, Basuni
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

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Background. Heart rate recovery (HRR) has been recognized as an independent predictor of mortality.Objective. To identify factors that may affect HRR in patient with unknown coronary artery disease (CAD).Methods. This cross sectional study was performed in National Cardiac Center Harapan Kita. We reviewed the chart of patients with unknown CAD who underwent symptom-limited exercise stress testing for medical check up between January – December 2006. Factors that may influence HRR were recorded including current medications, peak exercise heart rate (HR), HR after 3-minute recovery, and the ischemic response to exercise. HRR was defined as the change in HR from peak exercise to 3-minute recovery. We further categorized patients to normal or abnormal HRR by using mean HRR as cut off value. All factors related to HRR and normal/abnormal categories were analyzed.Results. There were 188 patients aged 48 + 11 years. HRR significantly influenced by male sex (p=0.003), hypertension (p=0.028), â-blocker (p=0.03), calcium channel blocker (p=0.008), aspirin (p<0.001), and provoked ischemia (p=0.005). Using mean HRR (57x) as cut off, patients were classified as having normal (HRR <57x) or abnormal (HRR>57x). On further analysis, there was significant association between age (p=0.003), male sex (p=0.02), hypertension (p=0.02), use of â-blocker (p=0.026) and aspirin (p<0.005).Conclusion. In patients with unknown CAD who underwent symptomlimited exercise stress testing, HRR was influenced by age, male sex, hypertension, the presence of provoked ischemia, use of â-blocker, calcium channel blocker, and aspirin.
Peran Lipopolisakarida Helicobacter pylori terhadap Aktivitas Neutrofil pada Penderita Infark Miokard Akut melalui Degradasi Kolagen Tipe IV Sargowo, Djanggan; Sumarno, dr; Muliartha, I Ketut Gede; Kamaruddin, Mudyawati
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

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Matrix metalloproteases (MMPs) are proteolytic enzymes that play a critical role in decreasing the stability of atherosclerotic plaque causing Acute Myocardial Infarction (AMI). In this process, degradation of type IV collagen as an important component of endothelial membrane is thought to be important. Several microorganisms and their products including Lipopolysaccharide (LPS) have been suggested to be able to activate MMPs. The aim of this study is to investigate the role of Helicobacter pylori LPS in type IV collagen degradation (in vitro). We used two stages in this study: MMP production stage and degradation of type IV collagen. MMP derived from the neutrophils of AMI and non- AMI patients that had been stimulated with LPS of Helicobacter pylori were used to digest type IV collagen. Analysis of type IV collagen degradation was performed with SDS-PAGE and Western blot. This study showed MMP isolated from neutrophil of AMI patients is an active MMP-9 at Molecular weight of 72 kDa. It can degrade type IV collagen at MW 78.6 kDa, 60 kDa, 50 kDa, 47.8 kDa and 43.8 kDa. Whereas MMP isolated from neutrophil of non-AMI have MW of 91.2 kDa and can only degrade collagen IVat merely 60 kDa. In conclusion, Helicobacter pylori LPS is able to induce n eutrophil of AMIpatients to produce an active MMP-9 at MW 72 kDa and the enzyme may play strategic role in the degradation of type IV collagen.
Left Ventricle Diastolic Function in Patients Underwent Chemotherapy with Doxorubicin Martha, Januar Wibawa; Soerianata, Sunarya; Soesanto, Amiliana M
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

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Background. Doxorubicin is one of the first-line chemoterapy against many form of neoplasm but the use is hampered by its cardiotoxic potentia lwith the end result of congestive  heart failure. It is imperative that specific monitoring scheme is applied to detect as early as possible the cardiac damage due to doxorubicin. There is large body of evidence that left ventricular diastolic dysfunction precede systolic dysfunction. Therefore, diastolic function may serve as am early monitoring parameter in patients receiving doxorubicin. This study is aimed to delineate the prevalence of diastolic dysfunction among patients receiving doxorubicin, to define the lowest cumulative dosage of doxorubicin that already cause diastolic dysfunction, and to describe the association between cumulative dosage of doxorubicin with grade of diastolic dysfunction.Methods. This study utilizes cross sectional design, conducted in Department of Cardiology and Vascular Medicine to 38 cancer patients receiving doxorubicin in Subdivision of Hematology-Oncology Department of Internal Medicine, Faculty of Medicine, Padjadjaran University. The study commenced from September 2006 until January 2007.Results. The prevalence of diastolic dysfunction among patients who received doxorubicin is 86,8%. The actual lowest cumulative dose of doxorubicin that already had diastolic dysfunction is 112 mg/m2 but the crossing point between correlation line and the occurrence of E/A ratio and Em/Am ratio of less than 1 is between 110-130 mg/m2. There is negative correlation between cumulative dose of doxorubicin and E/A ratio (r = -0,62) and Em/Am ratio (r = -0,69). Cumulative dose of doxorubicin among normal diastolic function, grade 1 diastolic dysfunction and grade 2 diastolic dysfunction are 101,4 + 3,9 mg/m2, 168,3 + 7,6 mg/m2 and 237,1 + 11 mg/m2, respectively (p < 0,01). There is positive correlation between cumulative dose of doxorubicin with grade of diastolic dysfunction (r = 0,7)Conclusions. The prevalence of diastolic dysfunction among patients who received doxorubicin is 86,8%. The lowest cumulative dose of doxorubicin that already had diastolic dysfunction is between 110-130 mg/m2. There is a strong positive correlation between cumulative dose of doxorubicin with grade of diastolic dysfunction.
Bedah Fontan dan Permasalahannya Rahajoe, Anna Ulfah
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

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Ketika bedah Fontan baru diperkenalkan pada tahun1970, para ahli menaruh harapan besar. Merekaberanggapan sirkulasi Fontan merupakan ide besar, yang mampu mengatasi berbagai variasi penyakit jantung bawaan (PJB) dengan fisiologi ventrikel tunggal. Tetapi 20 tahun kemudian, mulailah Fontan dkk mengenali kelemahan prosedur yang ia inisiasi. Dari evaluasi jangka panjang yang ia lakukan terbukti bahwa, meskipun pada bedah Fontan yang sempurna, dalam jangka panjang kapasitas fungsional pasen menurun, dan ini tak berkaitan dengan masalah lain kecuali sirkulasi Fontan. Beberapa penelitian jangka menengah dan jangka panjang lainnya juga menemukan berbagai masalah, misalnya disfungsi hati, gangguan koagulopati yang berakibat tromboemboli, protein loosing enteropathy (PLE)yang menimbulkan hipoalbuminemia dengan segalaakibatnya, aritmia, obstruksi pada jalur Fontan, fistulaarteriovenous pulmonal dan lain-lain. Semua masalahini tentu saja mengakibatkan berkurangnya kesintasanpasen-pasen tersebut.
Parasistol Isoritmis Yuniadi, Yoga
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

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Seorang wanita, 36 tahun mengeluh dada berdebar kuat.Perasaan itu timbul tidak menentu dan dapatberlangsung berjam-jam. Timbul tidak menentu. Tidakada riwayat pingsan maupun nyeri dada. Pemeriksaankoroner angiografi pernah dilakukan satu tahun yanglalu di rumah sakit lain, dengan hasil normal.Pemeriksaan fisik dalam batas normal. Ekokardiografitidak memperlihatkan kelainan struktur jantung.Rekaman EKG saat tidak terdapat keluhan ditunjukkanpada gambar 1A. Sedangkan gambar 1B adalahrekaman pada waktu timbul keluhan.Rekaman EKG pada saat timbul keluhan setidaknyamengarah pada tiga buah diagnosis diferensial, yaitu (1)terjadinya suatu konduksi aberan, (2) adanya jarastambahan (berkas Kent), dan (3) suatu parasistol.
Fibrilasi Atrium Pada Penyakit Hipertiroidisme Patogenesis dan Tatalaksana Firdaus, Isman
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

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Fibrilasi atrium (atrial fibrilation, AF) merupakanaritmia jantung yang paling sering terjadi pada pasenusia diatas 65 tahun. Prevalensi semakin tinggi denganbertambahnya usia, dan merupakan penyebab utamaterjadinya stroke. AF sering timbul sebagai manifestasihipertiroidisme, dan menjadi predisposisi terbentuknyatrombus dan emboli. AF dan disritmia supraventrikularlainnya yang disebabkan oleh hipertiroidisme,menambah angka kematian penyakit vaskular. Padasepuluh hingga limabelas persen pasen denganhipertiroidisme akan berlanjut menjadi AF, dan insidenini semakin tinggi bila disertai penyakit jantung
Penyakit Jantung Koroner pada “Chronic Kidney Disease” Dewayani, Retna
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

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Pada populasi normal, proses aterosklerosis terjadiselama puluhan tahun. Tetapi pada pasen-pasen usiamuda dengan gagal ginjal kronik (Chronic KidneyDisease, CKD), telah ditemukan kelainan vaskularsebelum terjadi penyakit ginjal stadium lanjut (end stagerenal disease, ESRD). Komplikasi kardiovaskular inikemudian menjadi penyebab kematian utama padapasen CKD. Maka timbullah pertanyaan: apakahpasien uremi mengalami percepatan aterosklerosis?Penelitian epidemiologi klinik melaporkan angkamortalitas penyakit kardiovaskular meningkat 20 kalilebih banyak pada pasen dialisis, dibanding populasinormal; karena keterlibatan faktor risiko tradisional(Framingham Risk Factors) dan faktor risiko terkaituremia.
Ablasi Frekuensi Radio Pada Fibrilasi Atrium Paroksismal Yuniadi, Yoga; Rahadyan, Adhantoro; Munawar, Muhammad
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

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Fibrilasi atrium (Atrial Fibrilation, AF) merupakanaritmia yang paling sering ditemukan dalam praktekklinis, meliputi sepertiga dari perawatan gangguanirama jantung. Diperkirakan prevalensi AF 0,4%hingga 1% dari populasi umum, yang meningkatdengan bertambahnya umur. Selama 20 tahun terakhir, terjadi 66% peningkatan angka perawatan rumah sakit oleh karena AF yang berkaitan dengan faktor umur dan prevalensi penyakit jantung kronis. AF juga dapat terjadi pada pasien tanpa penyakit jantung struktural (lone AF). Berdasarkan studi pada populasi, kejadian lone AF berkisar antara 12 hingga 30% dari seluruh kasus AF. AF meningkatkan risiko stroke 4 – 5 kali pada seluruh kelompok umur. Secara keseluruhan AF bertanggung jawab terhadap 15% kasus stroke diAmerika Serikat. Prinsip tatalaksana AF meliputi rate control, rhythm control, dan pencegahan tromboemboli. Beberapa studi besar, seperti PIAF, RACE, STAF dan AFFIRM memperlihatkan bahwa rate control tidak inferior terhadap rhythm control. Walaupun demikian, para ahli tetap beranggapan bahwa, konversi dan mempertahankan irama sinus lebih baik dalam hal peningkatan kualitas hidup, pengurangan risiko stroke Ablasi Frekuensi RadioPada Fibrilasi Atrium Paroksism dan gagal jantung, serta peningkatan survival
Tatalaksana Medis Protein-Losing Enteropathy Pasca Bedah Total Cavo Pulmonary Connection Hidayat, Syarief; Rahajoe, Anna Ulfah; Iskandarsyah, Kurniawan
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

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Sebelum bedah Fontan diperkenalkan, penyakitjantung bawaan (PJB) kompleks yang tidak idealuntuk reparasi biventrikular dilakukan bedahpaliatif pulmonary artery banding (PAB) atausystemic-to-pulmonary shunt. PAB adalah upayauntuk memperkecil lumen arteri pulmonalsehingga alirannya berkurang, dengan memasangikatan melingkari arteri pulmonal cabang utama.Sedangkan bedah systemic-to-pulmonary shuntadalah memasang saluran penghubung antaracabang cranial aorta ke arteri pulmonal. Tetapiharapan hidup pasen-pasen ini hanya berlangsungdua hingga tiga dekade saja.

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