Jurnal Respirasi
Published by Universitas Airlangga
ISSN : 24070831     EISSN : 26218372
Jurnal Respirasi is a National journal in accreditation process managed by Department of Pulmonology & Respiratory Medicine Faculty of Medicine Airlangga University - Dr. Soetomo General Hospital, Surabaya. Publish every January, May, September every year with each of 5 (five) complete texts in Indonesian.
Articles 46 Documents
Seorang Penderita Siliko Tuberkulosis dengan Penyulit Pneumotoraks Koesoemoprodjo, Winariani; Merinda, Vinodini
Jurnal Respirasi Vol 2, No 3 (2016): September 2016
Publisher : Universitas Airlangga

Show Abstract | Original Source | Check in Google Scholar | Full PDF (570.309 KB) | DOI: 10.20473/jr.v2-I.3.2016.76-81

Abstract

Background: Silicosis is a lung disease caused by the work because of respirable crystalline silica. Often occurs in workers mining gold, iron, tin, granite, sandstone, slate, foundries, cement, ceramics and glass. The risk of silicosis develop into lung tuberculosis (TB) is higher than patients without silicosis. Another complication of silicosis is secondary spontaneous pneumothorax. Case : A man, 45 years old with a history of work as a bricklayer for 5 years with complaints shortness of breath since three days before admitted to the hospital, chest pain in the right hemithorax, and had chronic cough. Patients is on ATD therapy. From radiographic there is collapse lung, it was shown collapse line on the right hemithorax, and fibroinfiltrat with multiple cavities on both hemithorax. Patients then got chest tube insertion and evaluation for 3 weeks, but the lung has not expanded. From thoracoscopy, there is fibrotic band on the pleural space with conclution right trapped lung. From forcep biopsy on visceral pleura showed a widened alveolar epithelial layer coated with a pile of inflammatory lymphocytes and dust pigments. From broncoscopy, there is chronic lung inflamation. Spectrophotometric analysis from BAL specimens results showed a silica content of 4.25 ppm SiO2 from left BAL an 14.34 ppm SiO2 on the right BAL. Furthurmore, this patient got pleurodesis using betadine agent and continue the ATD. Evaluation the lung is fully expanded. Conclusion : This case illustrates the secondary spontaneous pneumothorax as a complication of silicotuberkulosis. No drug has proven effective for silicosis. Treatment is aimed to the disease complications that occur, in this case is secondary spontaneous pneumothorax and lung TB. Prevention at workplaces that have a risk of silicosis is very important.
Pengaruh Jintan Hitam (Nigella Sativa) pada Konversi Sputum dan IFN- γ Penderita Tuberkulosis Paru yang Mendapat OAT Kategori I pada Akhir Minggu Kedua Fase Intensif Nurdin, Ahmad; Hasan, Helmia
Jurnal Respirasi Vol 1, No 3 (2015): September 2015
Publisher : Universitas Airlangga

Show Abstract | Original Source | Check in Google Scholar | Full PDF (273.473 KB) | DOI: 10.20473/jr.v1-I.3.2015.73-80

Abstract

Background: Primary resistance is the resistance that occurs in patients who have never received treatment OAT or had ever received  treatment OAT is less than 1 month. The incidence of primary MDR in Central Java in 2006 2.07%. Extrapulmonary TB about 15-20%  of all cases of TB, and TB lymphadenitis is the highest form (35% of all extrapulmonary TB). Patients with decreased immune systems  (SLE) can increase the incidence of TB. Research in Spain get 6x higher TB incidence in patients with SLE. Case: We present the case  of 19 year old woman SLE who received treatment for 11 months whose came with shortness of breath and chronic cough since 2 month  prior to admission. In physical examination we found right and left submandibula lymphonodi enlargement as solid, slightly mobile  nodule with diameter 3 cm. Chest X ray showed lung inflammation which suspicion of specific process and minimal left pleural effusion,  and concluded as pulmonary TB. FNAB confirmed lymphadenitis TB with granulomatous inflammation. One of AFB result is positive  and Gene Xpert is M.tb positive with rifampicin resistant that make this patient categorized as primary MDR TB with lymphadenitis  TB. This patient received Pirazinamid 1500 mg, Ethambutol 800 mg, Kanamicin 750 mg, Levofloxacin 750 mg, Ethionamide 500 mg,  Cicloserin 500 mg, and B6 100 mg. Conclusion: MDR TB in general occur in patients with a history of OAT previous TB (MDR TB  secondary). Primary MDR TB with lymphadenitis tb is a rare case, but can occur on the condition that decreases the immune system,  one of SLE. This involves multiple immune disorders caused by the use of long-term immunosuppressive therapy.  
Imunopatogenesis Asma Yudhawati, Resti; Krisdanti, Desak Putu Agung
Jurnal Respirasi Vol 3, No 1 (2017): Januari 2017
Publisher : Universitas Airlangga

Show Abstract | Original Source | Check in Google Scholar | Full PDF (604.766 KB) | DOI: 10.20473/jr.v3-I.1.2017.26-33

Abstract

Asthma is a chronic inflammatory disease of the airways characterized by recurrent wheezing, shortness of breath, chest tightness and cough especially at night and or early morning. Airflow resistance in asthma were caused by changes in the airways include bronchoconstriction, airway edema, hyperresponsiveness and airway remodeling. The inflammatory response in asthma patients varies among individuals, whether it can be immediate or late (slow-type) response. Different types of cells are known to play role in this process, especially mast cells, eosinophils, T lymphocytes, macrophages, neutrophils and epithelial cells. Degranulation of mast cells in the airways release inflammatory mediators and various metabolites that directly lead to smooth muscle hypersponsive resulting in airway obstruction. While eosinophil cells, mast cells and lymphocytes associated with slow-type responses, will release various mediators including leukotriene, prostaglandins and a number of proinflammatory cytokines. Type 2 immune response in the lower respiratory tract is a central immunologic process in asthma. This type 2 immune response is mediated by Th2 cells of CD4 + and IgE. The CD4 + Th2 cell is characterized by the large amount of transacting T-cell-specific transcription factor GATA-3 and the secretion of type 2 cytokines (IL-4, IL-5, IL-9 and IL-13). Excessive type 2 cytokines in the lower airway will trigger IgE-mediated hypersensitivity, epithelial cell activation, inflammatory cell inflation mediation into the airways, and cause remodeling responses in the epithelium and subepithelial matrices. This inflammatory cascade of type 2 cytokines is the pathological basis of the main symptoms of asthma.
Peranan Ultrasonografi Toraks dalam Menegakkan Diagnosis Beberapa Kelainan pada Paru Winaya, Erwin; Koesoemoprodjo, Winariani
Jurnal Respirasi Vol 1, No 1 (2015): Januari 2015
Publisher : Universitas Airlangga

Show Abstract | Original Source | Check in Google Scholar | Full PDF (733.611 KB) | DOI: 10.20473/jr.v1-I.1.2015.29-39

Abstract

Ultrasound is useful in the diagnosis of cases in the field of lung disease, such as pleural effusion, pneumothorax, consolidation, atelectasis, pulmonary edema, and others. The advantages of thoracic ultrasound is a low cost, radiation is small, easy to carry, short examination time and has a dynamic aspect that can be seen at the time of examination. Thoracic ultrasound is an inexpensive tool and can be used to assist in intervention, especially in cases of peripheral lung, pleura and chest wall diseases, such as thoracocentesis, chest tube installation and aspiration lung abscess. Ultrasound can also replace aspiration and biopsy with CT-scan guidance in cases involving the pleura, chest wall, and lung tumors that invade the pleura and chest wall. With the ultrasound portable and compact form, in the future is possible if the ultrasound will be a routine part of the examination as well as a stethoscope. However, ultrasound also has limitations which in patients with subcutaneous emphysema, peripheral edema and obesity, lung ultrasound is hard to do. Ultrasound examination is also highly dependent on the experience and ability of the ultrasound operator.
Seorang Wanita dengan Pneumokoniosis yang Mengalami Komplikasi Trapped Lung dan Dilakukan Dekortikasi Kusmiati, Tutik; Koesoemoprodjo, Winariani; Maulidiyah, Novita
Jurnal Respirasi Vol 3, No 3 (2017): September 2017
Publisher : Universitas Airlangga

Show Abstract | Original Source | Check in Google Scholar | Full PDF (1076.4 KB) | DOI: 10.20473/jr.v3-I.3.2017.74-80

Abstract

Background: Pneumoconiosis is an occupational lung disease caused by dust inhalation which deposit in lung parenchym and cause lung fibrosis. Trapped lung is impairment of compliance because of pleural inflammation. Case: We presented a diagnostic problem case of a woman, 37 years old who worked at coffee factory for 20 years as a coffee powder packer. Patient came in previous hospital with continous dispnea not relieved by rest or medication. She had been diagnosed with pneumothorax and already treated with chest tube for 2 weeks but there was no improvement. Patient was reffered to Dr. Soetomo hospital and treated with continous suction and chest physiotherapy for 2 months but there was no improvement. Patient then underwent thoracoscopy to find the cause of persistent collapsed lung. Thoracoscopy showed blackish leucoplaque pleural biopsy was done histopathological result showed pneumoconiosis. CT Scan showed fluidopneumothorax and severe lung restriction. The patient then underwent torachotomy and decortication which showed attachment of medial, inferior, and posterior lobe of left lung and organized pleural effusion. Post operation, the lung expanded completely and patient condition improved. Conclusion: Lung entrampment rarely become the complication of pneumoconiosis. Early diagnosis and appropriate treatment will avoid further complication.
Nilai Diagnostik Adenosine Deaminase (ADA) Cairan Pleura pada Penderita Efusi Pleura Tuberkulosi Amalia, Rizki Nur; Pradjoko, Isnu
Jurnal Respirasi Vol 2, No 2 (2016): Mei 2016
Publisher : Universitas Airlangga

Show Abstract | Original Source | Check in Google Scholar | Full PDF (181.968 KB) | DOI: 10.20473/jr.v2-I.2.2016.35-40

Abstract

Background: Tuberculosis pleural effusion is the most common extrapulmonary TB after lymphadenitis TB. Limited diagnostic methods make TB pleural effusion hard to diagnose. Adenosine deaminase ADA is an enzyme in purin catabolism process which catalyze adenosine into inosine and deoksiadenosine into deoksiinosin. This process is important in lymphoid cell differentiation. ADA is elevated in TB pleural effusion. Method: This study was a cross sectional analytic observational. Statistic analysis was using two independent samples T test. ROC curve was used to determine cut off value of ADA. Kappa test was used to determined the level of agreement of ADA cut off value. Results: Forty eight samples were included in this study, 18 samples with TB pleural effusion and 30 samples with non TB pleural effusion. There was significant difference between pleural fluid ADA in TB and non TB. Positivity of AFB sputum and MTB culture did not show any significant differences. Cut off ADA value for TB pleural effusion diagnosis was 39,19 with sensitivity 88,9% and spesificity 90%. Conclusion: Examination of ADA level in pleural fluid is a usefull tool to diagnose TB pleural effusion.
Perubahan Fungsi Paru Pada Usia Tua Hasan, Helmia; Maranatha, Rena Arusita
Jurnal Respirasi Vol 3, No 2 (2017): Mei 2017
Publisher : Universitas Airlangga

Show Abstract | Original Source | Check in Google Scholar | Full PDF (96.176 KB) | DOI: 10.20473/jr.v3-I.2.2017.52-57

Abstract

Aging causes many changes in biological processes characterized by progressive and widespread changes associated with increased susceptibility to various diseases. Aging is not a homogeneous process. In contrast, human organs aging at different rates are affected by several factors, including genetic factors, lifestyle, and environmental exposure. Healthy aging remains accompanied by some morphological and functional changes in the respiratory system. During the first two decades of life, the lungs undergo a phase of growth and maturation. Respiratory system achieves maximum function at the age of 20 years for women and 25 years for men. Throughout the rest of life, aging is associated with a progressive decline in pulmonary performance and function. The normal aging of the respiratory system is associated with structural and functional decline in the respiratory system, resulting in increased respiratory work compared to younger subjects and is associated with reduced reserves in cases of acute illness, such as heart failure, infection, or airway obstruction. Pulmonary function decreases slowly throughout life even in healthy people. Disabilities and diseases related to aging are a global problem due to the longevity of life expectancy. An increased proportion of the elderly population is a challenge for doctors because of the clinical complexity of the elderly. A better understanding of change can help diagnose and treat lung disease in the elderly population.
Kepositifan Induksi Sputum NaCl 3% dan Teknik Broncho Alveolar Lavage pada Pneumocystis Pneumonia Marhana, Isnin Anang; Puspitarini, Retna Dwi
Jurnal Respirasi Vol 2, No 3 (2016): September 2016
Publisher : Universitas Airlangga

Show Abstract | Original Source | Check in Google Scholar | Full PDF (113.621 KB) | DOI: 10.20473/jr.v2-I.3.2016.69-75

Abstract

Background: Pneumocystis pneumonia (PCP) is a major cause of morbidity and mortality in patients immunocompromised. The incidence of PCP in HIV are 0.3 cases per 100 person years with mortality 63.6%. The diagnosis of PCP experiencing difficulties because of the causative organism can not be cultured. Several attempts were carried out to obtain a representative sample sputum through induced sputum and bronchoalveolar lavage. This study compared the use of induced sputum and bronchoalveolar lavage (BAL) in the diagnosis of PCP. Methods: From September, 2015, to February, 2016, HIV-positive patients 21 to 65 years old were evaluated at UPIPI ward, Soetomo hospital with suspicion of PCP based on clinical and radiological findings. Sputum induction and BAL was done for Giemsa staining. Result: Thirteen subjects with a mean age of 40, with 11 male (84.6%). All subjects with chief complain shortness of breath and common complain cough with hard to expetorate. Most frequent risk factors was freesex. Mean of subjects received treatment cotrimoxazole is 3.5 days. Six subjects have been treated with ART. Mean of LDH serum was 554.62 ± 376.707 U/l. Interstitial infiltrate was the most frequent radiological pattern (76.9%). Most bronchoscopy examinations showed normal results (84.6%). Both Giemsa staining from induced sputum and BAL showed no positive results. Conclusion: All Giemsa staining from both induced sputum and BAL can not be compared due to no positive result.
Biomarker Pernapasan pada Penyakit Paru Maulidiyah, Novita; Amin, Muhammad
Jurnal Respirasi Vol 1, No 2 (2015): Mei 2015
Publisher : Universitas Airlangga

Show Abstract | Original Source | Check in Google Scholar | Full PDF (184.341 KB) | DOI: 10.20473/jr.v1-I.2.2015.67-71

Abstract

Breath analysis provides a convenient and simple alternative to traditional specimen testing in clinical laboratory diagnosis. As such, substantial research has been devoted to the analysis and identification of breath biomarkers. Development of new analytes enhances the desirability of breath analysis especially for patients who monitor daily biochemical parameters. Elucidating the physiologic significance of volatile substances in breath is essential for clinical use. This review describes the use of breath biomarkers in diagnosis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), lung cancer, as well as other pulmonary diseases. A number of breath biomarkers in lung pathophysiology will be described including nitric oxide (NO), carbon monoxide (CO), hydrogen peroxide (H2O2) and other hydrocarbons.
Peran Masker/Respirator dalam Pencegahan Dampak Kesehatan Paru Akibat Polusi Udara Faisal, Haruyuki Dewi; Susanto, Agus Dwi
Jurnal Respirasi Vol 3, No 1 (2017): Januari 2017
Publisher : Universitas Airlangga

Show Abstract | Original Source | Check in Google Scholar | Full PDF (556.344 KB) | DOI: 10.20473/jr.v3-I.1.2017.18-25

Abstract

Outdoor air pollution contributed harmful impact to public health. There are several respiratory disorders related to outdoor air pollution such as acute respiratory infection, lung cancer, asthma, chronic obstructive lung disease (COPD) and lung function disorder. Respirator is a personnel protective device which has role in the primary intervention step. Currently exist many types of respirators in industrial setting that have specific function to certain hazard exposure in work process. It is difficult to choose one type of respirator that can be implemented in population setting to protect against all air pollutant content. Therefore, it is relevant choosing one respirator type which has the ability to effectively filtrate one of air pollutant content that is the particulate matter. One respirator type, N95 mask has superiority in term of cost and technical use aspects for protecting particulate matter pollutant. Respirator usage effectivity in population setting is an important subject to find out more.