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Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
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Search results for , issue "Vol 11, No 1 (2019)" : 8 Documents clear
Formulasi Sediaan Tablet Kunyah Kompleks Inklusi Dimenhidrinat–β-Siklodekstrin dengan Metode Pengeringan Semprot (Chewable Tablet from Inclusion Complexes of Dimenhydrinate– β-Cyclodextrine using Spray Drying Method) Faizatun, Faizatun; Joenoes, Luvita; Nafisa, Safira
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2039.211 KB) | DOI: 10.35617/jfi.v11i1.593

Abstract

Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality.
Efek Antihipertensi Ekstrak Etanol Daun Sembung (Blumea balsamifera) pada Model Hewan Uji Induksi Epinefrin Sutjiatmo, Afifah Bambang; Bintussolihah, Falna; Vikasari, Suci Nar
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1160.17 KB) | DOI: 10.35617/jfi.v11i1.592

Abstract

Hypertension is a non-communicable disease that has a high prevalence. Blumea balsamifera(Asteraceae) is one of the plants that has traditionally been used to treat high blood pressure. The aim of this study is to evaluate antihypertensive effect of ethanol extract of Blumea balsamiferaleaves on animal models induced epinephrine. The extract was made in 50% ethanol. Extraction was done using a set of Soxhlet tools. The antihypertensive effect test was carried out on male Wistar rats using epinephrine 0.25 mg/kg bwas inductor and blood pressure was measured indirectly through the tail using Kent Scientific's CODA system. The dose of extract was 8.75; 17.5 and 35 mg/kg bw, while propranolol at dose dose 1.8 mg/kg bw was used as comparator. The parameters were diastolic and systolic blood pressure. The results showed that the ethanol extract at doses of 8.75; 17.5 and 35mg/kg bw can prevent the increase in diastolic and systolic blood pressure in animals model induced epinephrine when compared to controls (p <0.05), where the best results is shown by the ethanol extract at dose of 17.5 mg/kg bw. The ability of the ethanol extract is equivalent to propranolol (p> 0.05). It can be concluded that Blumea balsamiferaleaves can be developed and have the potential to be antihypertensive.
PHYSICAL ACTIVITY AND VITAMIN D LEVEL IN ASTHMA AND NON-ASTHMA AKTIVITAS FISIK DAN KADAR VITAMIN D PADA PASIEN ASMA DAN NON-ASMA Lorensia, Amelia; Suryadinata, Rivan Virlando; Saputra, Rifaldi
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i1.591

Abstract

Worsen asthma symptoms is associated with low vitamin D levels that increases asthma attacks risk. Physical activity is one factor that affects vitamin D levels in the blood. This study aimed to identify relationship physical activities effects with vitamin d levels on asthma and non-asthma patients. The study was conducted in March-June 2018. The subjects were asthma patients and non-asthma adults and didn’t have other comorbidities. Data analysis used pearson test to determine physical activity effect with vitamin D levels. There were significant differences in vitamin D levels (P <0.000) and physical activity (P <0.000) in asthma and non asthma respondents. The results of the correlation test between vitamin D levels and physical activity in Approximate Significance value was 0.965, which means there were very strong relationships between vitamin levels and physical activity on the respondents of asthma and non asthma. So, the asthma patients with sufficient physical activity will have normal vitamin D levels to improve control of asthma symptoms. Worsen asthma symptoms is associated with low vitamin D levels that increases asthma attacks risk. Physical activity is one factor that affects vitamin D levels in the blood. This study aimed to identify relationship physical activities effects with vitamin d levels on asthma and non-asthma patients. The study was conducted in March-June 2018. The subjects were asthma patients and non-asthma adults and didn’t have other comorbidities. Data analysis used pearson test to determine physical activity effect with vitamin D levels. There were significant differences in vitamin D levels (P <0.000) and physical activity (P <0.000) in asthma and non asthma respondents. The results of the correlation test between vitamin D levels and physical activity in Approximate Significance value was 0.965, which means there were very strong relationships between vitamin levels and physical activity on the respondents of asthma and non asthma. So, the asthma patients with sufficient physical activity will have normal vitamin D levels to improve control of asthma symptoms.
PENGARUH PEMBERIAN PATIENT INFORMATION LEAFLET (PIL) DAN SMS MOTIVASI TERHADAP PENGETAHUAN DAN KEPATUHAN PASIEN DM DENGAN DISLIPIDEMIA Dania, Haafizah; Saputri, Ginanjar Zukhruf; Faridah, Imaniar Noor
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1389.016 KB) | DOI: 10.35617/jfi.v11i1.590

Abstract

Diabetes mellitus(DM) and dyslipidemia are high prevalence diseases which also as one of risk factors for coronary heart disease. Knowledge and adherence are important factors in the treatment of DM-dyslipidemia either to control blood glucose and cholesterol or to prevent from complications. Education is one of the ways to increase knowledge and adherence. The aim of this research is to determine the impact of intervention (Patient Information Leaflet (PIL) and motivation messages by SMS) to knowledge and adherence of DM-dyslipidemia patients in PKU Muhammadiyah Yogyakarta Hospital. This research is a quasi experimental study with analytical quantitative. The data taken from February 2016 to April 2017 at PKU Muhammadiyah Yogyakarta Hospital. Inclusion criterias in this research are patient with age more than 18 years old, with diagnosed by DM-dyslipidemia, using 1 or more of DM and dyslipidemia medicine, not deaf, and cooperative. Interventions that given to the patients are Patient Information Leaflet (PIL) and motivation messages by SMS which routinely given in a week after first we met. Knowledge is assessed using questionnaire and adherence is assesed using pill count method. The data that need analyzed are characteristic patients and the impact of intervention using Wilcoxon and paired t-test. The result of intervention in 56 patients showed the increasing number of patient that have good knowledge after intervention, from 58,9% to 71,4%, otherwise it not differ significantly (p 0.071). Other than that, the adherence also increased that showed from the patients who have adhere category after intervention, from 58,93% to 91.07% and it differ significantly with p 0.001 (p<0.05). Diabetes mellitus(DM) and dyslipidemia are high prevalence diseases which also as one of risk factors for coronary heart disease. Knowledge and adherence are important factors in the treatment of DM-dyslipidemia either to control blood glucose and cholesterol or to prevent from complications. Education is one of the ways to increase knowledge and adherence. The aim of this research is to determine the impact of intervention (Patient Information Leaflet (PIL) and motivation messages by SMS) to knowledge and adherence of DM-dyslipidemia patients in PKU Muhammadiyah Yogyakarta Hospital. This research is a quasi experimental study with analytical quantitative. The data taken from February 2016 to April 2017 at PKU Muhammadiyah Yogyakarta Hospital. Inclusion criterias in this research are patient with age more than 18 years old, with diagnosed by DM-dyslipidemia, using 1 or more of DM and dyslipidemia medicine, not deaf, and cooperative. Interventions that given to the patients are Patient Information Leaflet (PIL) and motivation messages by SMS which routinely given in a week after first we met. Knowledge is assessed using questionnaire and adherence is assesed using pill count method. The data that need analyzed are characteristic patients and the impact of intervention using Wilcoxon and paired t-test. The result of intervention in 56 patients showed the increasing number of patient that have good knowledge after intervention, from 58,9% to 71,4%, otherwise it not differ significantly (p 0.071). Other than that, the adherence also increased that showed from the patients who have adhere category after intervention, from 58,93% to 91.07% and it differ significantly with p 0.001 (p<0.05). Diabetes mellitus(DM) and dyslipidemia are high prevalence diseases which also as one of risk factors for coronary heart disease. Knowledge and adherence are important factors in the treatment of DM-dyslipidemia either to control blood glucose and cholesterol or to prevent from complications. Education is one of the ways to increase knowledge and adherence. The aim of this research is to determine the impact of intervention (Patient Information Leaflet (PIL) and motivation messages by SMS) to knowledge and adherence of DM-dyslipidemia patients in PKU Muhammadiyah Yogyakarta Hospital. This research is a quasi experimental study with analytical quantitative. The data taken from February 2016 to April 2017 at PKU Muhammadiyah Yogyakarta Hospital. Inclusion criterias in this research are patient with age more than 18 years old, with diagnosed by DM-dyslipidemia, using 1 or more of DM and dyslipidemia medicine, not deaf, and cooperative. Interventions that given to the patients are Patient Information Leaflet (PIL) and motivation messages by SMS which routinely given in a week after first we met. Knowledge is assessed using questionnaire and adherence is assesed using pill count method. The data that need analyzed are characteristic patients and the impact of intervention using Wilcoxon and paired t-test. The result of intervention in 56 patients showed the increasing number of patient that have good knowledge after intervention, from 58,9% to 71,4%, otherwise it not differ significantly (p 0.071). Other than that, the adherence also increased that showed from the patients who have adhere category after intervention, from 58,93% to 91.07% and it differ significantly with p 0.001 (p<0.05).
Polimorfisme Gen Sitokrom P450 2A6 Alel *1, *4, *7 dan *9 pada Subyek Uji Perokok Suku Thionghoa Indonesia Patramurti, Christine; Candaya, Evan Julian; Kiatarto, Stella Felina; Karut, Agnes Kurniati
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1789.796 KB) | DOI: 10.35617/jfi.v11i1.589

Abstract

The CYP2A6 gene, encodes the CYP2A6 enzyme, has a highly polymorphism. These ezyme have played a role in nicotine metabolism, one of the active compounds in cigarettes that causes of cigarette dependence. The active form of the CYP2A6 gene allele is * 1 allele and some inactive forms of the CYP2A6 gene allele are * 4, * 7 and * 9 alleles. The inactive alleles would reduce the activity of the CYP2A6 enzyme. The genotypes of CY2A6 gene (CYP2A6* 1, * 4, * 7 and * 9) among Chinese Indonesian smokers were determined by allele-specific polymerase chain reaction (PCR) followed by electrophoresis method. The cigarette dependence was analyzed using the Fagerstrom Test for Nicotine Dependence (FTND) method.This study showed that there are CYP2A6 polymorphism genes among 30 smokers who participate in these study. The frequencies of the genotypes of CYP2A6 alleles were CYP2A6 *1/*1 (46.7%), CYP2A6 *1/*4 (16.7%), CYP2A6 *1/*7 (3.3%), CYP2A6 *1/*9 ( 10%), CYP2A6 *1/*4/*7 (6.7%), CYP2A6 *1/*4/*9 (10.0%), CYP2A6 *1/*7/*9 (3.3% ) and CYP2A6 *4/*7/* 9 (3.3%). The presence of inactive alleles can reduce the activity of the CYP2A6 enzyme in metabolizing nicotine, which can reduce the effects of cigarette dependence. The CYP2A6 gene, encodes the CYP2A6 enzyme, has a highly polymorphism. These ezyme have played a role in nicotine metabolism, one of the active compounds in cigarettes that causes of cigarette dependence. The active form of the CYP2A6 gene allele is * 1 allele and some inactive forms of the CYP2A6 gene allele are * 4, * 7 and * 9 alleles. The inactive alleles would reduce the activity of the CYP2A6 enzyme. The genotypes of CY2A6 gene (CYP2A6* 1, * 4, * 7 and * 9) among Chinese Indonesian smokers were determined by allele-specific polymerase chain reaction (PCR) followed by electrophoresis method. The cigarette dependence was analyzed using the Fagerstrom Test for Nicotine Dependence (FTND) method.This study showed that there are CYP2A6 polymorphism genes among 30 smokers who participate in these study. The frequencies of the genotypes of CYP2A6 alleles were CYP2A6 *1/*1 (46.7%), CYP2A6 *1/*4 (16.7%), CYP2A6 *1/*7 (3.3%), CYP2A6 *1/*9 ( 10%), CYP2A6 *1/*4/*7 (6.7%), CYP2A6 *1/*4/*9 (10.0%), CYP2A6 *1/*7/*9 (3.3% ) and CYP2A6 *4/*7/* 9 (3.3%). The presence of inactive alleles can reduce the activity of the CYP2A6 enzyme in metabolizing nicotine, which can reduce the effects of cigarette dependence. The CYP2A6 gene, encodes the CYP2A6 enzyme, has a highly polymorphism. These ezyme have played a role in nicotine metabolism, one of the active compounds in cigarettes that causes of cigarette dependence. The active form of the CYP2A6 gene allele is * 1 allele and some inactive forms of the CYP2A6 gene allele are * 4, * 7 and * 9 alleles. The inactive alleles would reduce the activity of the CYP2A6 enzyme. The genotypes of CY2A6 gene (CYP2A6* 1, * 4, * 7 and * 9) among Chinese Indonesian smokers were determined by allele-specific polymerase chain reaction (PCR) followed by electrophoresis method. The cigarette dependence was analyzed using the Fagerstrom Test for Nicotine Dependence (FTND) method.This study showed that there are CYP2A6 polymorphism genes among 30 smokers who participate in these study. The frequencies of the genotypes of CYP2A6 alleles were CYP2A6 *1/*1 (46.7%), CYP2A6 *1/*4 (16.7%), CYP2A6 *1/*7 (3.3%), CYP2A6 *1/*9 ( 10%), CYP2A6 *1/*4/*7 (6.7%), CYP2A6 *1/*4/*9 (10.0%), CYP2A6 *1/*7/*9 (3.3% ) and CYP2A6 *4/*7/* 9 (3.3%). The presence of inactive alleles can reduce the activity of the CYP2A6 enzyme in metabolizing nicotine, which can reduce the effects of cigarette dependence.
PHYSICAL ACTIVITY AND VITAMIN D LEVEL IN ASTHMA AND NON-ASTHMA AKTIVITAS FISIK DAN KADAR VITAMIN D PADA PASIEN ASMA DAN NON-ASMA Lorensia, Amelia; Suryadinata, Rivan Virlando; Saputra, Rifaldi
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i1.591

Abstract

Worsen asthma symptoms is associated with low vitamin D levels that increases asthma attacks risk. Physical activity is one factor that affects vitamin D levels in the blood. This study aimed to identify relationship physical activities effects with vitamin d levels on asthma and non-asthma patients. The study was conducted in March-June 2018. The subjects were asthma patients and non-asthma adults and didn’t have other comorbidities. Data analysis used pearson test to determine physical activity effect with vitamin D levels. There were significant differences in vitamin D levels (P &lt;0.000) and physical activity (P &lt;0.000) in asthma and non asthma respondents. The results of the correlation test between vitamin D levels and physical activity in Approximate Significance value was 0.965, which means there were very strong relationships between vitamin levels and physical activity on the respondents of asthma and non asthma. So, the asthma patients with sufficient physical activity will have normal vitamin D levels to improve control of asthma symptoms. Worsen asthma symptoms is associated with low vitamin D levels that increases asthma attacks risk. Physical activity is one factor that affects vitamin D levels in the blood. This study aimed to identify relationship physical activities effects with vitamin d levels on asthma and non-asthma patients. The study was conducted in March-June 2018. The subjects were asthma patients and non-asthma adults and didn’t have other comorbidities. Data analysis used pearson test to determine physical activity effect with vitamin D levels. There were significant differences in vitamin D levels (P &lt;0.000) and physical activity (P &lt;0.000) in asthma and non asthma respondents. The results of the correlation test between vitamin D levels and physical activity in Approximate Significance value was 0.965, which means there were very strong relationships between vitamin levels and physical activity on the respondents of asthma and non asthma. So, the asthma patients with sufficient physical activity will have normal vitamin D levels to improve control of asthma symptoms.
Formulasi Sediaan Tablet Kunyah Kompleks Inklusi Dimenhidrinat–β-Siklodekstrin dengan Metode Pengeringan Semprot (Chewable Tablet from Inclusion Complexes of Dimenhydrinate– β-Cyclodextrine using Spray Drying Method) Faizatun, Faizatun; Joenoes, Luvita; Nafisa, Safira
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i1.593

Abstract

Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality.
Polimorfisme Gen Sitokrom P450 2A6 Alel *1, *4, *7 dan *9 pada Subyek Uji Perokok Suku Thionghoa Indonesia Patramurti, Christine; Candaya, Evan Julian; Kiatarto, Stella Felina; Karut, Agnes Kurniati
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i1.589

Abstract

The CYP2A6 gene, encodes the CYP2A6 enzyme, has a highly polymorphism. These ezyme have played a role in nicotine metabolism, one of the active compounds in cigarettes that causes of cigarette dependence. The active form of the CYP2A6 gene allele is * 1 allele and some inactive forms of the CYP2A6 gene allele are * 4, * 7 and * 9 alleles. The inactive alleles would reduce the activity of the CYP2A6 enzyme. The genotypes of CY2A6 gene (CYP2A6* 1, * 4, * 7 and * 9) among Chinese Indonesian smokers were determined by allele-specific polymerase chain reaction (PCR) followed by electrophoresis method. The cigarette dependence was analyzed using the Fagerstrom Test for Nicotine Dependence (FTND) method.This study showed that there are CYP2A6 polymorphism genes among 30 smokers who participate in these study. The frequencies of the genotypes of CYP2A6 alleles were CYP2A6 *1/*1 (46.7%), CYP2A6 *1/*4 (16.7%), CYP2A6 *1/*7 (3.3%), CYP2A6 *1/*9 ( 10%), CYP2A6 *1/*4/*7 (6.7%), CYP2A6 *1/*4/*9 (10.0%), CYP2A6 *1/*7/*9 (3.3% ) and CYP2A6 *4/*7/* 9 (3.3%). The presence of inactive alleles can reduce the activity of the CYP2A6 enzyme in metabolizing nicotine, which can reduce the effects of cigarette dependence. The CYP2A6 gene, encodes the CYP2A6 enzyme, has a highly polymorphism. These ezyme have played a role in nicotine metabolism, one of the active compounds in cigarettes that causes of cigarette dependence. The active form of the CYP2A6 gene allele is * 1 allele and some inactive forms of the CYP2A6 gene allele are * 4, * 7 and * 9 alleles. The inactive alleles would reduce the activity of the CYP2A6 enzyme. The genotypes of CY2A6 gene (CYP2A6* 1, * 4, * 7 and * 9) among Chinese Indonesian smokers were determined by allele-specific polymerase chain reaction (PCR) followed by electrophoresis method. The cigarette dependence was analyzed using the Fagerstrom Test for Nicotine Dependence (FTND) method.This study showed that there are CYP2A6 polymorphism genes among 30 smokers who participate in these study. The frequencies of the genotypes of CYP2A6 alleles were CYP2A6 *1/*1 (46.7%), CYP2A6 *1/*4 (16.7%), CYP2A6 *1/*7 (3.3%), CYP2A6 *1/*9 ( 10%), CYP2A6 *1/*4/*7 (6.7%), CYP2A6 *1/*4/*9 (10.0%), CYP2A6 *1/*7/*9 (3.3% ) and CYP2A6 *4/*7/* 9 (3.3%). The presence of inactive alleles can reduce the activity of the CYP2A6 enzyme in metabolizing nicotine, which can reduce the effects of cigarette dependence. The CYP2A6 gene, encodes the CYP2A6 enzyme, has a highly polymorphism. These ezyme have played a role in nicotine metabolism, one of the active compounds in cigarettes that causes of cigarette dependence. The active form of the CYP2A6 gene allele is * 1 allele and some inactive forms of the CYP2A6 gene allele are * 4, * 7 and * 9 alleles. The inactive alleles would reduce the activity of the CYP2A6 enzyme. The genotypes of CY2A6 gene (CYP2A6* 1, * 4, * 7 and * 9) among Chinese Indonesian smokers were determined by allele-specific polymerase chain reaction (PCR) followed by electrophoresis method. The cigarette dependence was analyzed using the Fagerstrom Test for Nicotine Dependence (FTND) method.This study showed that there are CYP2A6 polymorphism genes among 30 smokers who participate in these study. The frequencies of the genotypes of CYP2A6 alleles were CYP2A6 *1/*1 (46.7%), CYP2A6 *1/*4 (16.7%), CYP2A6 *1/*7 (3.3%), CYP2A6 *1/*9 ( 10%), CYP2A6 *1/*4/*7 (6.7%), CYP2A6 *1/*4/*9 (10.0%), CYP2A6 *1/*7/*9 (3.3% ) and CYP2A6 *4/*7/* 9 (3.3%). The presence of inactive alleles can reduce the activity of the CYP2A6 enzyme in metabolizing nicotine, which can reduce the effects of cigarette dependence.

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