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Journal of Tropical Pharmacy and Chemistry
S4
Sinta Score
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090
Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: 2087-7099, ISSN-e: 2407-6090), The journal had been established in 2010, and online publication was begun in 2014. Since 2018, the journal has been published in English by Faculty of Pharmacy, Universitas Mulawarman (UNMUL) Samarinda, Indonesia in and only receives manuscripts in English.
Articles
165
Articles
Synthesis and Characterization of Methyl Amino Polystyrene as Resin Material of Chromatography

Herman, Herman, Anggraeni, Anni, Mutalib, Abdul, Bahti, Husein H.

Journal of Tropical Pharmacy and Chemistry Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

Ion-exchange chromatography has been widely used in various separation process and purification. Commercial ion-exchange resin mostly uses polystyrene as stationer phase. This study reviewed the synthesis of cation-exchange resin with polystyrene as starting material. Polystyrene must be activated in order to make one of aromatic carbon chains being able to be binding with acetamide n-hidroxymethyl electrophilic. Polystyrene activation was conducted through two stages, i.e. (1) the formation of amidomethyl polystyrene (AMDP), and followed with (2) elimination of acyl group. The activation of polystyrene generated white methylamino polystyrene (MAP) resin, of which its characterization used spectrophotometry UV, Fourier Transform-Infrared (FTIR), and density of MAP resin confirmed by pycnometer. The results showed that the characterization of FTIR and spectrophotometer UV for AMP exhibited forming amino propyl group at 3374.52 cm-1 with λmax 230 nm due to N–H bond; and the average of density of AMP resin sample was 1.7158 g/mL.

Antioxidant Assay of the Ethanolic Extract of Three Species of Rattan Fruits using DPPH Method

Salusu, Heriad Daud, Aryani, Farida, Budiarso, Edy, Kusuma, Irawan Wijaya, Arung, Enos Tangke, Zarta, Abdul Rasyid

Journal of Tropical Pharmacy and Chemistry Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

The bioactivity of some species of rattan fruit has been previously studied and it was found that it has potential antioxidant agents.  This study was conducted to determine the antioxidant content in three species of edible rattan fruit, namely Calamus manan Miq., Calamus ornatus Bl. and Calamus caesius Bl by using the DPPH method, whereby the test was carried out on the pericarp, flesh, and seeds of each fruit. The research findings revealed that phytochemical compounds, i.e. flavonoids, tannins, and triterpenoids are found almost in all parts of the fruit, while steroid is not found in any of the three species of the fruit. The antioxidant activity found in the fruit of C. caesius Bl is strong, meanwhile the antioxidant activity in the fruit of C. manan Miq only strong in its pericarp and seeds, but it is moderate in its flesh. The antioxidant activity found in the fruit of C. ornatus Bl. is strong in its pericarp and seeds, but it is moderate in its flesh. Therefore, these three species of rattan fruit are potential as antioxidant agents.

Antioxidant Activity of Ethanol Extract Combinations of Jeruk Purut Leaf (Citrus hystrix Dc.) and Jati Belanda Leaf (Guazuma ulmifolia L.)

Nadhira, Arina Nisyya, Maharani, Safira, Zatsyia, Fransisda Aulia, Trisharyanti, Ika, Kusumowati, Dian

Journal of Tropical Pharmacy and Chemistry Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

Ethanol extracts of Guazuma ulmifolia L. and Citrus hystrix Dc., have a strong antioxidant activity. The purpose of this research is to determine the antioxidant activity of ethanol extracts combination of Guazuma ulmifolia L. (jati belanda leaf) and Citrus hystrix Dc (jeruk purut leaf). Determination of antioxidant activity was done by DPPH method (1,1-diphenyl-2picrylhydrazil) using UV-Vis spectrophotometer with maximum wavelength 516.5 nm. The antioxidant activity of jeruk purut leaf is smaller than jati belanda leaf (IC50 48.70 mg/mL for jeruk purut leaf, IC50 35.92 mg/mL for jati belanda leaf). Antioxidant activity of the two extracts combination was lower than the antioxidants of each extract (without combination). The low antioxidant activity of both extract combination due to the antagonist activity as the interaction of the content of each extract so that the extract combination showing a weaker antioxidant activity. At the concentration of each different comparison of each extract combination volume shown no difference with P-value > 0.05 (P-value: 0.99).

Pharmaceutical Potential of 2’,4’-Dichloro-4-Hydroxy-3-Methoxychalcone Synthesized from Vaniline

Meilinda, Eka Rizky, Hajrah, Hajrah, Rahmadani, Agung, Rijai, Laode

Journal of Tropical Pharmacy and Chemistry Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

Chalcone is an intermediate compound as the main precursor for the biosynthesis of flavonoid in plants. Chalcone has been known to have variety of different pharmacological activities. The difference in chalcone activity is influenced by the differences of subtituents found in both aromatic rings on the chalcone stucture. This study performed the synthesis of 2',4'-dichloro-4-hydroxy-3-methoxychalcone compound from the raw material of 2,4-dichloro acetophenone and vanillin by Claisen-Schmidt reaction using conventional method by stirring. The yield of synthesized compound is 91.57% of purity. The synthesized compounds were characterized by structural elucidation methods using IR, MS, 1H-NMR and 13C-NMR. Toxicity and antioxidant activity tests were performed on the synthesized compound. Base on the test results obtained LC50 value of 20.04 ppm and IC50 26.10 ppm. It is better to describe the pharmaceutical potential of 2',4'-dichloro-4-hydroxy-3-methoxychalcone little bit further.

Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline

Khotimah, Nurul, Rahmadani, Agung, Rahmawati, Dewi, Ardana, Mirhansyah

Journal of Tropical Pharmacy and Chemistry Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

Pyrazoline is a five-ring heterocyclic compound having 3 carbon atoms and 2 nitrogen atoms known to have some biological activity. This study aims to synthesize 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) pyrazoline using 2’,4’-dichloro-4-hydroxy-3-methoxy chalcone and hydrazine. Synthesis was performed by reflux method at 80oC for 7 hours. The synthesis compounds were characterized by structural elucidation techniques. From the synthesis results obtained compound 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) Pyrazoline is pale yellow powder with 84%yield. The result of antioxidant activity test by 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that the compound had very strong antioxidant activity, Antibacterial test by diffusion method to use paper disk showed that the compound had antibacterial activity against Gram positive bacteria (S.aureus) and Gram negative bacteria (E.coli) and toxicity test by Brine Shrimp Lethality Test (BSLT) showed that the compound had toxicity.

α-Glucosidase Inhibitory Activity of In Vitro Combination of 96% Ethanolic Extract of Brotowali Stem (Tinospora cordifolia) and Cashew Apple (Anacardium occidentale L.)

Atmajani, Wanudya, Fatihati, Ahya Nafila, Shalihah, Afifah Mujahidah, Dian Kusumowati, Ika Trisharyanti

Journal of Tropical Pharmacy and Chemistry Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

Cashew tree (Anacardium occidentale L), contains flavonoid compound which plays a role in the medical treatment of Diabetes Mellitus because this compound has activity as an α-glucosidase inhibitor. Brotowali stem extract (Tinospora cordfolia) demonstrated α-glucosidase inhibitory (AGIS) activity. This research aimed to measure 96% ethanolic extract AGIS activity of brotowali-cashew apple combination (BJM). The research was conducted by using ELISA reader instrument at 405 nm for AGIS activity test. The IC50 was calculated from each sample. The IC50 of brotowali stem and cashew apple was 34,61 μg/ml and 109,32 μg/ml. Then, the combination of brotowali and cashew apple extract was mixed with each concentration of 0,5%. From 1:0, 1:2, 1:1,  2:1, and 0:1 BJM comparison resulted in AGIS power percentage averages of 84.05%, 69.51%, 70.92%, 68.10%, 40.37%. The results of this research indicated that brotowali stem has the potential as AGIS, while cashew apple has not any potential towards AGIS and that extract combination does not give synergic effect. Therefore, the use of a combination of brotowali-cashew apple extract is not as effective as the use of brotowali single extracts to inhibit the α-glucosidase enzyme

Antidiabetic Activities of Broccoli Extracts (Brassica oleracea L.var italica) on Mice Induced Streptozotocin-Nicotinamide

Lutfiyati, Heni, Yuliastuti, Fitriana, Hidayat, Imron Wahyu, Pribadi, Prasojo, Kamal, Sodiq

Journal of Tropical Pharmacy and Chemistry Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

Several plant species have been used for the treatment of diabetes. Research on plants that can be used to treat diabetes such as Cinnamomum cassia and Cinnamomum zeylanicum, Piper sarmentosum Roxb, Nelumbo nucifera, Ceiba petandra Memecylon malabaricum. Broccoli (Brassica oleracea L var italics) is a flower of vegetables like cabbage plants. Broccoli juice is made capable of direct and indirect effects on the reduction of blood LDL; the indirect effect is by repairing pancreatic beta cells and increasing insulin sensitivity. The purpose of this study was to determine whether broccoli has activity as antidiabetic. The subjects consisted of 15 mice induced with nicotinamide 70 mg/kg BW and Stz 150 mg/kg BW. Diabetic mice were divided into the positive control group (glibenclamide), negative control group (CMC Na) and three treatment groups. The test material is broccoli extract dose 75 mg / kg BW, 150 mg /kg BW and 300 mg/kg BW given peroral for 14 days. Anova test results showed that there was a significant difference in the average percentage of decreased blood glucose levels in all treatments. The result of Post Hock Tukey HSD test with a 95% confidence level showed a significant difference in the negative control group compared with positive control group and extract 300mg / kg BW. This shows that positive control group and extracts 300mg / kg body weight have an activity to decrease blood glucose level.

Front Cover, Editorial Information, Table of Content, Back Cover

Journal of Tropical Pharmacy and Chemistry Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

Front Cover, Editorial Information, Table of Content, Back Cover

Journal of Tropical Pharmacy and Chemistry Vol 2 No 5 (2014): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

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Front Cover, Editorial information, Table of Content, Back Cover

Journal of Tropical Pharmacy and Chemistry Vol 3 No 3 (2016): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

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