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INDONESIA
Indonesian Journal of Medicine
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 96 Documents
Effect of Cardiac Rehabilitation on NT-Pro BNP, METS, and Quality of Life, in Patients with Coronary Artery Disease after Undergoing Percutaneous Coronary Intervention Rachma, Noer
Indonesian Journal of Medicine Vol 3, No 3 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Percutaneous coronary intervention (PCI) is one of the most effective therapies in patients with coronary artery disease (CAD) after the attack. Cardiac rehabilitation (CR) makes an important contribution to secondary prevention of cardiac events. The World Health Organization defines CR as the sum of activities required to influence favorably the underlying cause of the disease, as well as to ensure the best possible physical, mental and social conditions, so that they may, by their own efforts, preserve or resume when lost as normal a place as possible in the life of the community. This study aimed to estimate the effects of CR on NT-proBNP and METs among patients with CAD after PCI.Subjects and Method: This was a cohort study carried out at Dr. Moewardi Hospital, Surakarta, Central Java, from November to February 2018. A sample of 18 patients with CAD after PCI was selected for this study. The dependent variables were NT-proBNP, METs, and quality of life. The independent variable was CR. The three outcome variables were measured before and after CR. The data before and after CR were compared and tested by t-test.Results: NT-proBNP level in CAD patients after PCI (Mean= 97.17 ng/ml) was lower than before PCI (Mean= 1,629.4 ng/ml), and it was statistically significant. METS value in CAD patients after PCI (Mean= 8.31 ml/kg) was higher than before PCI (Mean= 6.41 ml/kg), and it was statistically significant. The quality of life also increased significantly.Conclusion: Cardiac rehabilitation is effective to lower NT-proBNP level, as well as to increase METS value and quality of life of CAD patients.Keywords: coronary artery disease, cardiac rehabilitation, NT-proBNP, METs, quality of lifeCorrespondence: Noer Rachma. Department of Physical Medicine and Rehabilitation, Dr. Moewardi Hospital, Surakarta, Central Java.Indonesian Journal of Medicine (2018), 3(3): 146-150https://doi.org/10.26911/theijmed.2018.03.03.04
Path Analysis: The Effect of Smoking on the Risk of Periodontal Disease Robbihi, Hilmiy Ila; Sulaeman, Endang Sutisna; Rahardjo, Setyo Sri
Indonesian Journal of Medicine Vol 3, No 2 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Periodontal diseases are prevalent both in developed and developing countries and affect about 20-50% of global population. Several risk factors such as smoking, poor oral hygiene, diabetes, medication, age, hereditary, and stress are related to periodontal diseases. The purpose of this study was to determine the effect of smoking on the risk of periodontal disease, using path analysis.Subjects and Method: A case-control study was carried out in Tasikmalaya community health center, West Java, from October to November 2018. A sample of 200 patients was selected by fixed disease sampling. The dependent variable was periodontal disease. The independent variables were age, knowledge on oral health, education, income, smoking behavior, oral and dental health behavior, plaque, and calculus. The data were obtained from medical record and questionnaire. The data were analyzed by path analysis.Results: The risk of periodontal disease directly increased by smoking behavior (b= 0.92; 95% CI= 0.09 to 1.75; p= 0.030), after controlling for the effect of calculus (b= 1.23; 95% CI= 0.40 to 2.07; p= 0.004) and age (b=1.63; 95% CI= 0.76 to 2.50; p<0.001). The risk of periodontal disease directly decreased by better knowledge on oral and dental health (b=-0.92; 95% CI= -1.72 to -0.12; p= 0.023) and high income (b= -1.47; 95% CI= -2.32 to -0.60; p<0.001). It was indirectly affected by plaque and education.Conclusion: The risk of periodontal disease directly increases by smoking behavior, after controlling for the effect of calculus and age. In addition, the risk of periodontal disease directly decreases by better knowledge on oral and dental health and high income. It is indirectly affected by plaque and education.Keywords: periodontal disease, smoking, factors, path analysisCorrespondence: Hilmiy Ila Robbihi. Masters Program in Public Health, Universitas Sebelas Maret, Surakarta, Jl. Ir. Sutami 36 A, Surakarta, Central Java 57126. Email: hilmiyilarobbihi@gmail.com. Mobile: +628975565050.Indonesian Journal of Medicine (2018), 3(2): 99-109https://doi.org/10.26911/theijmed.2018.03.02.06
The Effect of Coconut Water in Reducing Fatigue among Workers in North Sumatera Rajagukguk, Bona Rina Ria; Nurmaini, Nurmaini; Sudaryati, Etti
Indonesian Journal of Medicine Vol 3, No 3 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Fatigue can reduce working performance, worker motivation, and work produc­tivity. Fatigue due to exposure to heat pressure which causes excessive sweating must be overcome through the provision of fluids that are right for workers. Coconut water contains electrolytes, so it is very good to replace lost body fluids during activities throughout the day. The purpose of this study is to analyze differences in work fatigue with interventions giving 4 liters of drinking water and giving 1 liter of young coconut water (Cocos nucifera L.) accompanied by giving 3 liters of drinking water.Subjects and Method: This study is a quasi-experimental design with a research design of one group pre and post-test design. The study population was the production of cassava chips factory workers with a total sample of 20 people. The sampling technique is purposive sampling. The dependent variable is work fatigue while the independent variable is giving 4 liters of drinking water and giving 1 liter of young coconut water (Cocosnucifera L) accompanied by giving 3 liters of drinking water. The type of data collected is primary data in the form of work fatigue (in milliseconds) measured using the Reaction Timer. Bivariate analysis was conducted using the paired T-test.Results: Fatigue after giving 1 liter of young coconut water and 3 liters of drinking water was lower (mean = 118.00; p = 0.001) than the group given 4 liters of drinking water (mean 164.94; p= 0.001).Conclusion: Work fatigue in the group given 1 liter of young coconut water and 3 liters of drinking water was lower than the group given 4 liters of drinking water.Keywords: fatigue, young coconut water, drinking water, heat pressureCorrespondence: Bona Rina Ria Rajagukguk. Department of Occupational Health and Safety, Faculty of Public Health, Universitas Sumatera Utara, Medan, North Sumatera. Email: bonarinaria@gmail.com. Mobile: 081370185933.Indonesian Journal of Medicine (2018), 3(3): 173-179https://doi.org/10.26911/theijmed.2018.03.03.08
Procalcitonin as A Predictor of Left Ventricular Systolic Dysfunction in Sepsis Patients Wasyanto, Trisulo; Yasa, Ahmad; Murti, Bhisma
Indonesian Journal of Medicine Vol 3, No 3 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background:  Release of cytokines in sepsis can cause left heart failure and left ventricular sys­tolic dysfunction (LVSD). In sepsis, there is a releasing of Procalcitonin (PCT) and tumor necrosis factor-α (TNF-α) because of the stimulation of cytokine pro inflammation affected by activated NF-kB. This study aimed to examine PCT as a predictor of LVSD in sepsis, the value of Area Under the curve (AUC), sensitivity, specificity, cut off point, and a probability of PCT and TNF-α as a predictor of  LVSD, and then to identify the best diagnostic predictor of LVSD.Subjects and Method: This was a cross-sectional study. A sample of 71 sepsis patients aged >18 years old admitted to the intensive care unit (ICU) from November 2016 to March 2017was selected for this study. The dependent variable was left ventricle ejection fraction (LVEF). The independent variables were PCT and TNF-α. LVEF and diastolyc function were measured by transthoracic echocardiography. Data on PCT and TNF-α level were obtained from the medical record.Results: As many as 22 patients had mild sepsis (30.9%), 40 patients had severe sepsis (56.4%), and 9 patients had a septic shock (12.7%). The AUC value of PCT level was 0.81 (95% CI 0.71-0.91; p<0.001). The optimal cut-off point was ≥7.88 ng/mL and Diagnostic Odd Ratio (DOR) was 5.55. The AUC value of TNF-α level was 0.73 (95% CI 0.60-0.86; p= 0.002). Optimal cut off point was ≥7.36 pg/ml and DOR was 5.03. The multivariate analysis resulted that PCT was the best predictor of LVSD (AUC 0.70), and TNF-α (0.69). The combination of PCT + TNFα would increase diagnostic value with AUC 0.77.Conclusion:  PCT was a better predictor of LVSD than TNF-α. This finding is significant since it will enable clinicians to easily diagnose LVSD by measuring PCT. The combination of PCT and TNFα was the best efficient diagnostic predictor of LVSD.Keywords: Left Ventricular Systolic Dysfunction, predictor, PCT, TNF-α                                  Correspondence: Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Univer­sitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: trisulo.­wasyanto­@gmail.com.Indonesian Journal of Medicine (2018), 3(3): 139-145https://doi.org/10.26911/theijmed.2018.03.03.03 
Path Analysis on the Social, Economic, and Cultural Determinants of Male Contraceptive Use in Family Planning Village, Yogyakarta, Indonesia Kartikasari, Bettya; Nurhaeni, Ismi Dwi Astuti; Adriani, Rita Benya
Indonesian Journal of Medicine Vol 3, No 2 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: One of today's global problems is the rapid growth of population. Population growth can be controlled through contraceptive method utilization. However, contraceptive use among males in most developing countries, including Indonesia, remains low. This study aimed to determine the social, economic, and cultural factors affecting male contraceptive use in family planning village, Yogyakarta, Indonesia, using Theory of Planned Behavior (TPB) and path analysis.Subjects and Method: A case-control study was carried out in Yogyakarta, Indonesia. A sample of 200 men aged 15 to 49 years was selected for this study by fixed disease sampling. The dependent variable was male surgical contraceptive method use. The independent variables were age, knowledge, education, intention, attitude, perceived behavior control, subjective norm, social culture, access to health service, and health service quality. The data were collected by questionnaire and analyzed by path analysis.Results: Male surgical contraceptive method use was directly affected by older age (b = 1.50; 95% CI = 0.54 to 2.46; p= 0.002), better knowledge (b= 1.48; 95% CI= 0.48 to 2.49; p= 0.004), stronger intention (b= 1.10; 95% CI= 0.15 to 2.06; p= 0.24), more positive attitude (b= 1.33; 95% CI= 0.35 to 2.30; p= 0.008), stronger perceived behavior control (b= 1.21; 95% CI= 0.23 to 2.20; p= 0.016), better access to health service (b = 1.59; 95% CI = 0.58 to 2.59; p= 0.002), better health service quality (b= 1.17; 95% CI= 0.22 to 2.12; p = 0.016), and supportive subjective norm (b= 2.07; 95% CI= 1.12 to 3.01; p<0.001). It was also indirectly affected by subjective norm, social culture, education, education, and access to health service.Conclusion: Male surgical contraceptive method use is directly affected by age, knowledge, intention, attitude, perceived behavior control, access to health service, health service quality, and subjective norm. It is indirectly affected by subjective norm, social culture, education, education, and access to health service.Keywords: male, contraceptive method, use, determinants, path analysisCorrespondence: Bettya Kartikasari. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: bettyakartikasari21@gmail.com. Mobile: +6285817606484.Indonesian Journal of Medicine (2018), 3(2): 89-98https://doi.org/10.26911/theijmed.2018.03.02.05
Correlation between Hemoglobin Levels and Muscular Endurance in Soccer Athletes Octavia, Nur Afni Heryanti; Ichwan, Muhammad; Eyanoer, Putri Chairani
Indonesian Journal of Medicine Vol 3, No 3 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Muscular endurance is one of the important components of physical fitness in the sport of soccer player. Soccer athletes are required to contracting the muscle explosively as maximum as possible and must have high aerobic capability. This study aimed to determine the correlation between hemoglobin levels with muscular endurance in soccer athletes.Subjects and Method: This was an analytic observational study with a cross-sectional design. The population was soccer player athlete who was incorporated in soccer clubs and soccer schools at Medan, North Sumatera, Indonesia. A sample of 96 soccer athletes was selected for this study. The dependent variable was muscular endurance. The independent variables were hemoglobin levels. Hemoglobin level was measured by the cyanmethemoglobin method, and muscular endurance was measured by the push-up test. The data was analyzed using a Spearman test.Results: Hemoglobin levels were positively correlated with muscular endurance levels and it was statistically significant (r = 0.226; p<0.05).Conclusion: This study showed hemoglobin levels correlates with muscular endurance.Keywords: hemoglobin, muscular endurance, soccer  athletesCorrespondence: Nur Afni Heryanti Octavia. Masters Program in Biomedics, Faculty of Medicine, Universitas  Sumatera Utara. Email: nurafniheryantioctavia@gmail.com.Indonesian Journal of Medicine (2018), 3(3): 168-172https://doi.org/10.26911/theijmed.2018.03.03.07
The Effect of Toluene Exposure on Central Nervous Disorder among Printing Workers Marganda, Samuel; Ashar, Taufik; Nurmaini, Nurmaini
Indonesian Journal of Medicine Vol 3, No 3 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The use of toluene in printing dominates the use of metal chemicals. Toluene is used in 75% of printing work activities. Accumulation of toluene concentrations in printing can cause health problems to workers. The purpose of this study was to analyze the effect of toluene exposure on central nervous system disorders in printing industry workers.Subjects and Method: This study was cross-sectional in the printing industry in Medan, North Sumatra. The population consists of 50 people with consecutive sampling technique sampling. Data on subjective symptoms of central nervous system disorders were measured by the German version of the Q18 questionnaire. The data were analyzed using multiple logistic regression tests.Results: Subjective symptoms of central nervous system disorders increased with tenure ≥2 years (OR = 4.19; p = 0.018) and smoking (OR = 8.91; p = 0.001). Subjective symptoms of central nervous system disorders decreased with age ≤30 years (OR = 0.17; p = 0.004), female sex (OR = 0.50; p = 0.002).Conclusions: The most dominant variable affecting the subjective symptoms of central nervous system disorders is the smoking habit variable with a probability value of 0.92 or 92%.Keywords: subjective symptoms, central nervous system disorders, workers, a printing industryCorrespondence: Samuel Marganda. Department of Environmental Health, Faculty of Public Health, Universitas Sumatera Utara, Medan, North Sumatera. Email: samuelmarganda@yahoo.co.id. Mobile: 085362985340.Indonesian Journal of Medicine (2018), 3(3): 125-133https://doi.org/10.26911/theijmed.2018.03.03.01  
The Effect of Colchicine Administration on HsCRP Level and Mean Platelet Volume in Patients with Miocard Acute Infark Wasyanto, Trisulo; Yasa, Ahmad; Murti, Bhisma
Indonesian Journal of Medicine Vol 3, No 3 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Patients with coronary heart disease (CHD) who have received standard therapy to the fullest, are still at risk for further cardiovascular events. This is likely because the standard therapy fails to inhibit some inflammatory pathways and platelet aggregation which implies the disease. This study aimed to determine the effect of colchicine on reducing levels of high sensitive c-reactive protein (HsCRP) and mean platelet volume (MPV) in patients with Acute Myocardial Infarction (IMA) in the Intensive Cardiovascular Unit (ICVCU) Dr. Moewardi Hospital, Surakarta.Subjects and Method: Experimental study was conducted with pre and post design. The study was conducted from November 1 to December 31, 2016. A sample of 32 patients with Acute Myocardial Infarction was divided into two groups. The control group was given a placebo and the treatment group was given colchicine 0.5 mg orally for 5 days. Statistical analysis was done using two mean different tests with dependent t-test or Mann-Whitney and two mean analysis paired using independent t-test or Wilcoxon.Results: The HsCRP delta level in colchicine group (mean = 3.82; SD = 2.20) was higher than control group (mean = 0.57; SD = 3.12) and it was statistically significant (p<0.001). The delta MPV levels in colchicine group (mean = 2.01; SD = 1.16) were higher than control group (mean = 0.64; SD = 0.83) and it was statistically significant (p = 0.001).Conclusion: The administration of 0.5 mg colchicine by oral for 5 days was associated with levels of HsCRP and MPV among IMA patients. Keywords: Colchicine, HsCRP, MPV, Acute Myocardial InfarctionCorrespondence: Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta57126, Central Java, Indonesia. Email: trisulo.wasyanto@gmail.comIndonesian Journal of Medicine (2018), 162-167https://doi.org/10.26911/theijmed.2018.03.03.06
The Effect of Neoadjuvant Chemotherapy on HIF-1α Expression in Cervical Uterine Cancer Wiraswesty, Ika; Respati, Supriyadi Hari; Sulistyowati, Sri; Priyanto, Heru
Indonesian Journal of Medicine Vol 3, No 2 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Uterine cervical cancer is one of the main causes of female death related to cancer. Neoadjuvant chemotherapy aims to reduce tumor mass to allow radical surgery. HIF-1α is thought to have a key role in the development of cancer and the main target for chemoprevention.Objective: This study aims to prove the effect of neoadjuvant chemotherapy on HIF-1α expression in uterine cervical cancer as an assessment parameter for chemotherapy response. Subjects and methods: The study was carried out in the Department of Obstetrics and Gynecology and the Pathology Department of Anatomy Dr. Moewardi - Faculty of Medicine, Sebelas Maret University, Surakarta. Thirty (30) cervical cancer samples that met the inclusion and exclusion criteria were examined for HIF-1α expression before and after giving 3 times neoadjuvant chemotherapy. Examination using immunohistochemical methods. Data analysis using t-test.Results: Mean HIF-1α expression before administration of neoadjuvant chemotherapy 5.10± 1.174 cell/field, after administration of neoadjuvant chemotherapy 4.00±1.174 cell/field with p=0.001.Conclusion: Neoadjuvant chemotherapy has an effect on reducing HIF-1α expression in uterine cervical cancer.Keywords: neoadjuvant chemotherapy, HIF-1α, uterine cervical cancerCorrespondence: Sri Sulistyowati. Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret. Mobile: 08122968215. email: elis_spog@yahoo.co.id Indonesian Journal of Medicine (2018), 3(2): 119-124https://doi.org/10.26911/theijmed.2018.03.02.08
The Difference of Bovine Bone Graft and Iliac Crest Bone Graft Effect on Closure of Bone Defect in Alveolar Bone Graft in Dr. Moewardi Hospital and Panti Waluyo Hospitals, Surakarta Bahtiar, Ruzbih; Kurniasih, Dewi Haryanti; Alifianto, Untung
Indonesian Journal of Medicine Vol 3, No 3 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Cleft lip and palate (CLP) is a case of craniofacial congenital abnormalities that are often found by plastic surgeons. Successful management requires good surgical techniques, deep understanding of anatomical abnormalities and three-dimensional aspects of facial aesthetics. The Alveolar bone graft (ABG) aims to unite and stabilize Maxilla before definitive orthodontic action and restoration of dental care. The use of bone grafts in the surgical field is often done, aimed at maximizing the process of bone healing. Autogenous bone graft is the gold standard bone graft material because it contains all the properties needed in bone formation. The iliac crest bone graft (ICBG) is the most commonly used donor. Bromine bone graft (BBG) is increasingly being used as a substitute for autogenous bone graft. The purpose of this study was to determine the differences in the effect of the percentage of defect closure between CNG and ICBG on the closure of defects in ABG.Subjects and Method: The retrospective cohort study was conducted at Dr. Moewardi and Panti Waluyo Hospitals, Surakarta, Central Java, Indonesia, from February to April 2018. The dependent variable was bone defect closure. The independent variables were bovine bone and iliac crest bone grafts. The data were analyzed by Mann-Whitney.Results: Most patients after ABG surgery have a percentage of bone defect closure of 75-100% with bone resorption of 0-25% and include type I Bergland scale, where ICBG (66.7%) tends to be better than BBG (55.6%), but statistically not significant (p value = 0.678).Conclusion: There is no difference in the effect of the percentage of defect closure between CNG and ICBG on the closure of defects in ABG. ICBG tends to give a better percentage of defect closure than CNG, but it is not statistically significant.Keywords: Cleft lip and palate (CLP), Alveolar bone graft, bovine bone graft, Iliac crest bone graft, closure of bone defects.Correspondence: Ruzbih Bahtiar. Department of Surgery, Dr. Moewardi Hospital, Surakarta/Faculty of Medicine, Universitas Sebelas Maret.  Indonesian Journal of Medicine (2018), 3(3): 151-161https://doi.org/10.26911/theijmed.2018.03.03.05

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