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Indonesian Journal of Obstetrics and Gynecology
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Articles
490
Articles
Endoglin Expression (CD105) in Ephithelial Ovarian Cancer

Jumsa, Rizkinov, Rambulangi, John, Arifuddin, Sharvianty, Miskad, Upik

Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Abstract Objective: Endoglin ( CD105 ) is one of the factors that play a role in vascular development , angiogenesis and vascular homeostasis. The aim of this research is to address the endoglin expression (CD105) in primary tumor and metastasis tumor (omentum) and their relation with clinicopathological factor: stadium, differentiation level, and histological epithelial ovarian cancer. Method: The research was performed at Public Service Hall of Dr. Wahidin Sudirohusodo Hospital and educational networking hospital of Obstetrics and Gynecology Departement of Medical Faculty Hasanuddin University Makassar. The research design is cross sectional with 55 samples consisting of 55 samples of primary tumor and 55 matastasis tumor. Imunohistochemistry examination was performed to all samples. Result:The results show a significant relation between endoglin (CD105) at omentum metastasis tumor and stadium and cell differentiation level of epithelial ovarian cancer. There is no significant relation between endoglin (CD105) expression at primary tumor of ovarian cancer and stadium and differentiation and type of histopathological cell. In addition, there is no significant relation between endoglin expression (CD105) at omentum metastasis tumor and type of histophatological cell of ovarian cancer. There is a significant correlation (strong category) between endoglin expression at omentum metastasis tumor and endoglin expression at primary tumor of epithelial ovarian cancer. Conclusion: Endoglin expression in ovarian cancer metastatic tumor to omentum is correlated to clinical stage and differentiation level of ovarian cancer. And endoglin is one of the pro angiogenic and pro metastasis factors. Keywords:epithelial ovarian cancer, endoglin expression, CD105, immunohistochemistry  

Malondialdehyde Levels in Preeclampsia before and after Delivery

Rumopa, Harold, Wagey, Freddy W., Suparman, Eddy

Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 Juli 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

  Objective: Determine differences plasma levels MDA in preeclampsiabefore and 2 hours after delivery.   Methods: This was an analytic cross-sectional study. Subjectconsists of 23 pregnancies with preeclampsia, where 23 bloodsamples taken before delivery and 23 were taken 2 hours afterdelivery. This study was conducted from August 2016 untilDecember 2016 at Department of Obstetrics and GynecologyFaculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D.Kandou Hospital Manado and satellite hospital. Samples weretaken from plasma and analysed using HPLC method at Prodiaclinical laboratory.   Results: In patients with severe preeclampsia before deliverywe found average value (1.4796  0.40819 nmol/ml), minimumvalue (1.03 nmol/ml) and maximal value (2.77 nmol/ml)and 2 hours after delivery with average value (1.2470 0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximumvalue (2.47 nmol/ml). by using Wilcoxon test, we foundthere were significant differences in plasma levels of MDA (p =0.000).   Conclusion: This significant difference suggests that decreasedplasma levels of MDA 2 hours after delivery and gives the sense thatthere is a relationship between oxidative stress of cells with severepreeclampsia before and shortly after delivery, that MDA is an indicatorof oxidative stress.   Keywords: malondialdehyde, oxidative stress, peroxidation lipid,preeclampsia

Secretory Leukocyte Protease Inhibitor in Preterm Labor and Pregnancy

Sutiono, Ferriyanto, Kaeng, Juneke J, Loho, Maria FT

Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 Juli 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

  Objective: To investigate the levels of secretory leukocyteprotease inhibitor (SLPI) in women with preterm labor andpregnancy.   Methods: SLPI level examination conducted to 32 samples ofpregnant women who meet the inclusion and exclusion criteria,consists of 16 preterm labor and 16 preterm pregnancy.Sample analysis carried out in Prodia Laboratory Jakarta. SLPIlevel examination used ELISA method. The obtained dataprocessed by SPSS software version 20.0 and discussed withexisting literature theory.   Results: Mean plasma SLPI level in patients with preterm laboris 30.319 ng/ml and median: 29.950 ng/ml with p value: 0.652,while the mean on preterm pregnancy is 45.975 ng/ml andmedian: 41.600 ng/ml with p value: 0.005.   Conclusion: There are significant differences of SLPI level betweenpreterm labor and preterm pregnancy. Keywords: preterm labor, preterm pregnancy, SLPI

Vaginal Delivery in Placental Abruption

Adjie, JM Seno, Ghazali, M Farid, Khusen, Denny

Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 Juli 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

    Objective: To describe the case of vaginal delivery in placental abruption.   Methods: A case report   Results: In the case of placental abruption, we could perform vaginal delivery.   Conclusion: The treatment of placental abruption can be vaginally or by cesarean section depending on the severity of disease, gestational age, and state of the mother and fetus. Keywords: IUFD, placental abruption, vaginal delivery

Fetal Biometry is a Prerequisite Part of Modern Antenatal Care

Salim, Azen

Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 Juli 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

N/A

Rectovaginal Examination, Transvaginal Ultrasonography, and Magnetic Resonance Imaging as Diagnostic Tools for Identifying Deep Infiltrating Endometriosis Nodules

Wirawan, Florencia, Marwali, Luky S, Muslim, Refni, Silalahi, Eva R, Bayuaji, Harjo S, Anindita, Astri

Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 Juli 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

    Objective: To investigate the comparison between rectovaginal examination (RVT), transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) as diagnostic tools for identifying various Deep Infiltrating Endometriosis (DIE).   Methods: Prospective longitudinal study was done involving 31 women referred for surgical management of DIE. Calculation of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of RVT, TVUS and MRI for DIE were recorded.   Results: The mean age was 35.1 years. DIE were present in 95.45% of women which commonly located at uterosacral ligaments (58.33%), followed by rectovaginal (16,67%), rectosigmoid- colon (16.67%) and bladder-ureter (8.3%). TVUS had the best accuracy (RVT 50.24%; TVUS 88.85%; MRI 75.77%) among other diagnostic tools for nodules located at uterosacral ligaments (RVT 52.63%; TVUS 87%; MRI 40%) and rectovaginal (RVT 76.75%; TVUS 93.34%; MRI 80%), but it poorly identified nodules located at rectosigmoid (RVT 20%; TVUS 65.56%; MRI 88.75%) and bladder-ureteral area (RVT 50.44%; TVUS 87.66%; MRI 93.55%). RVT had good PPV (88.89%) but bad NPV (32.01%) profile, made it worth to be a screening diagnostic tool.   Conclusion: RVT was a good screening diagnostic tools as it could be done easily but was weak in diagnosing anterior DIE. TVUS gave a better diagnosis rates on DIE located at sacrouterina ligaments and rectovaginal area whereas MRI did better on bowel DIE (rectosigmoid- colon area) and urological DIE (bladder-ureteral area).    Keywords: deep infiltrating endometriosis, magnetic resonance imaging, tranvaginal ultrasonography

Compatibility between Menstrual Pictogram Assessment and Haemoglobin Assessment in Abnormal Uterine Bleeding

Yulianti, Fitri, Manan, Heriyadi, Nurtjahyo, Awan, Husin, Syarif

Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 Juli 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To determine the amount of wasted blood and diagnosedAUB and determine amount of decrease in haemoglobinlevels by adjusting the examination of menstrual pictogramwith haemoglobin.Methods: Diagnostic test was conducted in the DepartmentObstetrics and Gynecology Dr. Mohammad Hoesin/Faculty ofMedicine Universitas Sriwijaya Palembang, start from January 2015through January 2017. Sample was obtained from 39 patients withabnormal uterine bleeding who meet the inclusion and exclusioncriteria. Frequency and distribution of data are described in tablesand cross analyze (cut-off point) to find cut points differencemenstrual pictogram and a decrease in haemoglobin levels usingROC curve. Accuracy is measured by the value of Kappa. Dataanalysis using SPSS version 21.Results: From 39 samples that obtained, majority characteristicsage > 35 years (59%), ideal BMI (59%) and multiparous(48.7%). From statistical analysis, there was significanceassociation between haemoglobin measurement toolsand menstrual pictogram (p = 0.063). Both measuring deviceshave compatibility in predicting the type of AUB (p = 0.047),with the degree of conformity is weak (Kappa = 0.232).Conclusion: Accuracy of menstrual pictogram examination andhaemoglobin has a weak degree of conformity, so menstrualpictogram examination can’t be used to determine a decrease inhaemoglobin levels. Menstrual pictogram menstruation only usedas an evaluation of therapeutic response.[Indones J Obstet Gynecol 2018; 6-3: 172-178]Keywords: abnormal uterine bleeding, haemoglobin, menstrual pictogram

Fetal Biometry Nomogram Based on Normal Population : an Observational Study

Wibawa, Aria, Rumondang, Amanda

Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 Juli 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

  Objective: To establish fetal biometry nomogram using percentilemethod based on normal population.   Methods: A descriptive retrospective study in order to establishfetal biometry nomogram using percentile method basedon normal population. Four fetal biometry measurement (BPD,HC, AC and FL) was collected from ultrasonography examinationresult in Fetomaternal Division Ultrasound Unit - AnggrekClinic and from medical record unit Dr. Cipto MangunkusumoGeneral Hospital, from January 2015 until April 2016. Databeing documented using case report form and being tabulatedusing Microsoft Excell 2011 Version 14.7.0 (161029). All datawere analyzed using SPSS 20.0 dan Matlab R2016a.   Results: There were 6169 pregnant women underwent fetalbiometry ultrasound within January 2015 - April 2016. Basedon inclusion criteria, 2798 (45%) were eligible as researchsample distributed from 12 until 42 wga. Due to evenly distributiondata, 2205 (78%) were distributed from 20 until 40 wgato develop fetal biometry nomogram. Most pregnant womenwere 28.9 years old (SD  5.74) in range of 21-30 (55%) yearsold. The youngest was 13 years old and the oldest was 45years old. Four fetal biometry were collected and distributedevenly using percentile method to establish fetal biometrynomogram. As for estimated fetal weight curve was developedby Hadlock C formula. Each biometry was calculated the 10th,50th and 90th centile curves according to gestational age. Thus,representing the fetal biometry and modified Hadlock C estimatedfetal weight nomogram based on normal population inJakarta.   Conclusion: Each biometry and modified Hadlock C estimated fetalweight were calculated in 10th, 50th and 90th centile curves accordingto gestational age represent fetal biometry nomogram based onnormal population in Jakarta. Keywords: biometry, estimated fetal weight formula, nomogram

Changes in Cortisol Levels before and after Supportive Psychotherapy in Patients with Comorbid Cervical Cancer Distress with Depression Type

Nuranna, Laila, Nuryanto, Kartiwa H, Andriansyah, Andriansyah, Elvira, Sylvia D, Sutrisna, Bambang

Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 Juli 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To prove the success of supportive psychotherapy thatwas provided as a distress therapy on advanced cervical cancer.Knowing the prevalence of distress type of depression in patientwith epithelial cervical cancer, proving the benefits of psychotherapysupportive for distress can decreasing cortisol level in cervicalcancer patient, can assess distress thermometer score, HAM-D17score and scoring incident predictors of distress with depressiontype.Methods: There were 32 subjects from 71 advanced cervical cancerpatients had mild-moderate depression. Then randomizationblocking was performed to determine a subject who entered thetreatment group (n = 16) who got supportive psychotherapy orcontrol group who got common psychotherapy (n = 16). All ofparticipants assessed the distress level with cortisol value, distressthermometer score, and HAM-D17 score before and after they gotsupportive psychotherapy.Results: After the intervention of psychotherapy in the treatmentgroup decreased HAM-D17 score, the average decline 7.53 (SB 3.34).The mean decreasing in the control group was 3.98 (SB 2.85). Thereis a significant difference in mean reduction in HAM-D17 scores ontreatment and control groups with p = 0.003 (p <0.005). There wasdecreasing blood cortisol level in the treatment group amounted to39.43, while the control group there was a drop of 1.59. The reductionof cortisol level in the treatment group and the control has a pvalue0.302. After got supportive psychotherapy, found a decreasingthe average value of the thermometer distress in the treatmentgroup 3.02 and the control group 2.51, with a p value more than0.492.Conclusion: There were 45% of cervical cancer patients in the clinicexperiencing distress disorder with depressive type. The bloodcortisol level could be decreased by giving supportive psychotherapywith a mean decrease of 39.43 nmol/l. There was a significantreduction in the level of depression (HAM-D17 score) of 7.53 pointsand distress thermometer impairment by 3 points after givensupportive psychotherapy. Obtained scoring predictors for theoccurrence of distress type of depression in patients with advancedcervical cancer with a sensitivity of 46.15% and a specificity of89.47%.[Indones J Obstet Gynecol 2018; 6-3: 179-187]Keywords: cervical cancer, cortisol, distress, distress thermometer,HAM-D17 score

Different Doses of Intraumbilical Oxytocin on the Third Stage of Labor

Islamy, Nurul, Bernolian, Nuswil, BasiR, Firmansyah, Theodorus, Theodorus

Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 Juli 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

  Objective: To compare the dose of oxytocin injected intraumbilicalltowards the duration of the third stage, blood loss volume, hemoglobinand hematocrit.   Methods: This study is a prospective randomised study with acontrol. The control group was given an intramuscular injection of10 IU oxytocin. The intervention of the three groups intraumbilicaloxytocin treatment dose of 10 IU, 20 IU and 30 IU diluted in 50 ml ofnormal saline solution and administered intraumbilically. Thesample selection by purposive sampling and the distribution groupbased on systematic random sampling (10 samples each). Data weretaken from the period April 2016-January 2017 with the inclusionand exclusion criteria. Data were analysed using Chi-square, T-test,ANOVA and Post hoc tests.   Results: Characteristics study for variables of age, occupation,parity, education, episiotomy and neonates weight showed homogeneouscharacteristics. The mean duration of the third stage forall groups was between 366.7  159.0 seconds and 440.1  244.99seconds. While the average number of postpartum haemorrhage forall group 61.894  226.3ml and 309.5  110.26 ml. There were nodifferences in the dose of oxytocin on the duration of the thirdstage (p> 0.05) and the amount of bleeding (p> 0.005). There was adifference of haemoglobin between intervention group of oxytocindose of 10 IU and 30 IU intraumbilical (p = 0.031). There was nodifference between the mean hematocrit levels between the groups(p> 0.005).   Conclusion: There were no differences in the dose of oxytocinintraumbilical towards the duration of the third stage, the amountof bleeding and hematocrit levels. The decrease of haemoglobingreater in 30 IU intraumbilical significantly. Keywords: duration of the third stage, haemoglobin and hematocrit,oxytocin intraumbilical, the amount of bleeding

Issues
All Issue Volume 6. No. 2 April 2018 Volume 6. No. 1. January 2018 Volume 6 No. 3 Juli 2018 Volume. 5, No. 4, October 2017 Volume. 5, No. 3, July 2017 Volume. 5, No. 2, April 2017 Volume. 5, No. 1, January 2017 Volume. 4, No.3, July 2016 Volume. 4, No. 2, April 2016 Volume. 4, No. 1, January 2016 Volume 4, No. 4, October 2016 Volume. 3, No. 4, October 2015 Volume. 3, No. 3, July 2015 Volume. 3, no. 2, April 2015 Volume. 3, No. 1, January 2015 Volume. 2, No. 4, October 2014 Volume. 2, No. 3, July 2014 Volume. 2, No. 2, April 2014 Volume. 2, No. 1, January 2014 Volume. 37, No. 2, April 2013 Volume. 37, No. 1, January 2013 Volume. 1, No. 4, October 2013 Volume. 1, No. 3, July 2013 Volume. 36, No. 4, October 2012 Volume. 36, No. 3, July 2012 Volume. 36, No. 2, April 2012 Volume. 36, No. 1, January 2012 Volume. 35, No. 4, October 2011 Volume. 35, No. 3, July 2011 Volume. 35, No. 2, April 2011 Volume. 35, No. 1, January 2011 Volume. 34. No. 2, April 2010 Volume. 34, No. 4, October 2010 Volume. 34, No. 3, July 2010 Volume. 34, No. 1, January 2010 Volume. 33. No. 4, October 2009 Volume. 33, No. 3, July 2009 Volume. 33, No. 2, April 2009 Volume. 33, No. 1, January 2009 Volume. 32, No. 4, October 2008 Volume. 32, No. 3, July 2008 Volume. 32, No. 2, April 2008 Volume. 32, No. 1, January 2008 Volume. 31, No. 4, October 2007 Volume. 31, No. 3, July 2007 Volume. 31, No. 2, April 2007 Volume. 31, No. 1, January 2007 Volume. 30, No. 4, October 2006 Volume. 30, No. 3, July 2006 Volume. 30, No. 2, April 2006 Volume. 30, No. 1, January 2006