Jurnal Kesehatan Reproduksi
ISSN : 2302836X     EISSN : 2621461X
urnal Kesehatan Reproduksi is a scientific journal published by Association of Women and Children Reproductive Health Enthusiasts and Experts/Ikatan Pemerhati Anak dan Kesehatan Reproduksi/IPAKESPRO) who works closely with the Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada. Jurnal Kesehatan Reproduksi first printed version was published in 2014 with ISSN 2302-836X. In 2016, we also have an online journal version with ISSN 2621-461X. Currently, we already use the Online Journal System, requiring all authors to submit their papers online. Afterwards, authors, editors and reviewers will be able to monitor the manuscript processing. This journal is published annually every April, August and December.
Articles 84 Documents
Interaksi Sosial dalam Kejadian Abortus Provokatus Kriminalis di Kabupaten Bulukumba Provinsi Sulawesi Selatan Ridwan, Rizal; Prawitasari, Shinta; Prawirodihardjo, Leo
JURNAL KESEHATAN REPRODUKSI Vol 3, No 3 (2016)
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Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.35956

Abstract

Background: Many factors influence the decision to commit abortions, among all are marital status and educational status which most are still in school, economic pressure, multiparity or contaception failure. The social interaction is a connection between t the people who perform abortion and their suggestive environment.Objective: to observe the social interaction that happend among the person who perform abortion and the surrounding society.Method: This research makes use of qualitative method to understand the motives behind abortion practice, through an indepth interview. The sample collection is performed on H. A. Sulthan Dg Radja Hospital and Daffiku Hospital Bulukumba.Result and Discussion: Subject who performed abortion was influenced by internal and external factors. The internal factors include anxiousness, financial worrisome to support the child and fear of embarrassing the family in an unmaried women. As for the external factor includes pressure from families and friends who insist on performing abortion and the help from traditional healer on performing abortion. These two factors are not independent, and between them there are interactions to materialize abortion practice.Conclussion: Social interaction between individuals and between individual and the environment are an important role against abortion in decision making to have an provocative abortion.Keywords: Social interaction, abortion, factors for abortion
Prestasi Belajar pada Remaja yang Mengalami Dismenorea Primer Fajarini, Yuniar Ika; Nurdiati, Detty Siti; Padmawati, Retna Siwi
JURNAL KESEHATAN REPRODUKSI Vol 5, No 1 (2018)
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Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.37972

Abstract

Background: Primary dysmenorrhea occurs in approximately 50% of teenage girls and cause serious disruptions in the quality of life and daily activities. Primary dysmenorrhea makes teenagers difficult to concentrate in school which will decrease their academic achievement.Objective: to investigate whether there is a correlation between Primary dysmenorrhea and academic achievement of students of SMP Islam Terpadu Pondok Pesantren Tahfidzul Qur’an (SMP IT PPTQ) Ibnu Abbas Klaten.Method: This study is a case-control study through a quantitative approach and was supported with qualitative data. The research sample is 68 teenage girls of SMP IT PPTQ Ibnu Abbas Klaten who fulfilled the inclusion criteria. The cases groups are female students with low learning achievement, while the control group was female students with high learning achievement. The samples were taken using simple random sampling. Researcher used a structured questionnaire, interview and secondary data to collect the data. The data analysis was using descriptive and inferential analysis including bivariate analysis using chi-square test and multivariate analysis using logistic regression with 95% confidence intervals (CI) and a significance level of p <0.05.Result and Discussion: The bivariate and multivariate analysis showed a significant correlation between primary dysmenorrhea and learning achievement. The possibility of finding girls with primary dysmenorrhea in the group of students who received a low learning achievement is 3 times larger than the group of students who received high learning achievement. Below-average intelligence is greater in the group of low-achieving students than the group of high-achieving students. There is a correlation between the variables of intelligence, stress level and frequency of dysmenorrhea and academic achievement. The variable of absences frequency not related to learning achievement.Conclusion: There is correlation between primary dysmenorrhea and learning achievement (p=0.026). This study indicates that women and their school should pay attention to their menstrual function and dysmenorrhea phenomenon.Keywords: learning achievement, primary dysmenorrhea, teenage, menstrual disorder
PERBANDINGAN RERATA EKSPRESI Bcl-2 DAN Bcl-XL PADA PREEKLAMSIA BERAT DAN KEHAMILAN NORMOTENSI Arianto, Budi; Hadiati, Diah Rumekti; Nurdiati, Detty Siti
JURNAL KESEHATAN REPRODUKSI Vol 2, No 2 (2015)
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Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.12639

Abstract

PERBANDINGAN RERATA EKSPRESI Bcl-2 DAN Bcl-XL PADAPREEKLAMSIA BERAT DAN KEHAMILAN NORMOTENSIBudi Arianto1, Diah Rumekti H2, Detty S Nurdiati3ABSTRACTBackground: The state of hypoxia in severe preeclampsia cause placental oxidative stress that can leadexcessive trophoblast apoptosis through the mitochondrial pathway. Apoptosis stimuli occurs throughmodulation of p53 and Bcl-2 family expression which has antiapoptosis and proapoptosis function.Antiapoptosis protein consist of Bcl-2 and Bcl-XL and is expressed lower in apoptosis.Objective: To compare the mean difference of the expression of antiapoptosis proteins Bcl-2 & Bcl-XL andidentify the type of protein that can be used as indicators of increased apoptosis.Method: A cross-sectional study which consisted of 43 severe preeclampsia pregnancies and 38 thirdtrimester normotensive pregnancies, recruited between October 2011 - March 2012. Observation ofprotein expression Bcl-2 and Bcl-XL used immunohistochemical techniques. Statistical analysis appliedindependent t test (P<0.05).Result and Discussion: There were significant differences (p<0.05)between the mean expression of Bcl-2protein in trophoblast tissue among severe preeclampsia group (1.03 ± 0.04) compared to normotensivegroup (1.10 ± 0.08). The mean expression of Bcl-XL protein in trophoblast tissue severe preeclampsiagroup (1.29 ± 0.12) compared to normotensive group (1.71 ± 0.14) were significantly difference (p<0.05).The mean difference in protein expression of Bcl-2 (0076; 95% CI 0.046 to 0.104) was lower than Bcl-XLprotein (0.42; 95% CI 0.47 to 0.36). The mean protein expression of Bcl-2 and Bcl-XL were lower in severepreeclampsia group compared with normotensive group, either in preterm or full-term gestation age withp value <0.05.Conclusion: The mean difference in protein expression of Bcl-2 and Bcl-XL is lower in severe preeclampsiapregnancies than normotensive pregnancies. The mean difference in protein expression of Bcl-2 is lowerthan Bcl-XL. Severe preeclampsia affects protein expression of Bcl-2 and Bcl-XL more than influence ofgestational age.Keywords: severe preeclampsia, trophoblast, Bcl-2 , Bcl-XL, apoptosis.ABSTRAKLatar belakang: Keadaan hipoksia pada preeklamsia berat akan menyebabkan stress oksidatif plasentayang dapat memicu terjadi peningkatan apoptosis trofoblas melalui jalur mitokondria. Stimulus apoptosisterjadi melalui modulasi ekspresi P53 dan ekspresi protein Bcl-2 family yang memiliki fungsi antiapoptosisdan proapoptosis. Protein antiapoptosis terdiri atas Bcl-2 dan Bcl-XL akan diekspresikan lebih rendah padakeadaan apoptosis.Tujuan: Untuk melihat perbedaan rerata ekspresi protein antiapoptosis Bcl-2 dan Bcl-XL dan mengidentifikasijenis protein yang dapat dijadikan indikator peningkatan apoptosis.Metode: Rancangan penelitian ini potong lintang dengan populasi penderita kehamilan preeklamsia beratdan normotensi yang dirawat di RSUP Sardjito antara bulan Oktober 2011 hingga Maret 2012. Didapatkansampel plasenta sebanyak 43 kehamilan preeklamsia berat dan 38 kehamilan normotensi. Pengamatanekspresi protein Bcl-2 dan Bcl-XL dengan teknik imunohistokimia. Analisis statistik menggunakanindependent t test (p<0.05).Hasil dan Pembahasan: Terdapat perbedaan yang bermakna (p<0,05) rerata ekspresi protein Bcl-2 padajaringan trofoblas kelompok kehamilan preeklamsia berat (1,03 ± 0,04) dibandingkan kelompok kehamilannormotensi (1,10 ± 0,08). Terdapat perbedaan yang bermakna (p<0.05) rerata ekspresi protein Bcl-xL padajaringan trofoblas kelompok kehamilan preeklamsia berat (1,29 ± 0,12) dibandingkan kelompok kehamilannormotensi (1,71 ± 0,14). Beda rerata ekspresi protein untuk Bcl-2 (0,076; CI 95% 0,046 – 0,104) lebihrendah dibandingkan beda rerata ekspresi protein Bcl-xL (0,42; CI 95% 0,47- 0,36). Rerata ekspresi proteinBcl-2 dan Bcl-XL lebih rendah pada kelompok preeklamsia berat dibandingkan dengan normotensi baikpada umur kehamilan preterm maupun aterm yang ditunjukkan dengan nilai p<0,05.Kesimpulan: Beda rerata ekspresi protein Bcl-2 dan Bcl-xL lebih rendah pada kehamilan preeklamsia beratdibandingkan kehamilan normotensi. Beda rerata ekspresi protein Bcl-2 lebih rendah dibandingkan bedarerata ekspresi protein Bcl-xl. Preeklamsia berat lebih berpengaruh terhadap ekspresi protein Bcl-2 danBcl-XL dibandingkan umur kehamilanKata Kunci: preeklamsia berat, trofoblas, protein Bcl-2, protein Bcl-xl, apoptosis1,2,3 Bagian Obstetri dan Ginekologi FK UGM/RSUP Dr. Sardjito, Yogyakarta
PERBANDINGAN LUARAN SEKSIO SESAREA DENGAN ANESTESI UMUM DAN SPINAL: PERUBAHAN KADAR HEMOGLOBIN, HEMATOKRIT IBU DAN SKOR APGAR BAYI Giantari, Ifrinda; Pranoto, Ibnu; Siswosudarmo, Risanto
JURNAL KESEHATAN REPRODUKSI Vol 1, No 1 (2014)
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Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.4912

Abstract

PERBANDINGAN LUARAN SEKSIO SESAREA DENGANANESTESI UMUM DAN SPINAL: PERUBAHAN KADARHEMOGLOBIN, HEMATOKRIT IBU DAN SKOR APGAR BAYIIfrinda Giantari, Ibnu Pranoto, Risanto SiswosudarmoABSTRACTBackground: Cesarean section is the most common surgical procedure in obstetrics. In 2008, nearly a third ofdeliveries was done by cesarean section. Two types of anestesi are used in cesarean section i.e., general andregional anestesi with their advantages and disadvantages. General anestesi is often used in emergency casesbut is often associated with greater risk of blood loss during surgery and depression of central nervous system ofthe newborn. Based on these facts, the decision of the type of anesthesia for cesarean section is still debated.Objective: To compare the effects between general and spinal anestesi in the alteration of maternal hemoglobinand hematocrit levels and the neonatal Apgar score.Method: This study was conducted at Setjonegoro Hospital Wonosobo, Banjarnegara, and Sardjito HospitalYogyakarta between September to December 2010. Patients undergoing cesarean section, who met inclusionand exclusion criteria were included in this study. Hemoglobin and hematocrit levels before and 6-12 hours aftersurgery were recorded, as well as the first minute Apgar score. Chi-square and t-test were used for statisticalanalysis.Results and Discussion: A total of 114 patients consisting of 59 cases for general anestesi and 55 for spinalgroups were recruited. They were comparable in terms ofmaternal age, age of gestation, parity, BMI and indicationof operation. Hemoglobin and hematocrit levels before surgery were also comparable.The decrease of hemoglobin level after operation in the group of general anesthesia was greater than in thespinal group (1,75 ± 1,09 mg/dL vs 1,00 ± 0,96 mg/d; p=0,00). The same was seen in the decrease of hematocritlevel (4,47 ± 2,77% vs 3,26 ± 3,04%, p=0,02). There were 28 cases of asphyxia in the group of general comparedto 22 cases in the group of spinal anestesi, but it was not statistically different (RR 1,16; 95% CI 0,81-1,65).Conclusion: The decreased level of hemoglobin and hematocrit after cesarean section in general anesthesia werehigher than spinal anesthesia group, although the difference was not clinically significant. There was no significantdifference in the incidence of asphyxia at first minute in both groups.Keywords: general anestesi, spinal anesthesia, cesarean section, hemoglobin, hematocrit, Apgar score   ABSTRAKLatar belakang: Seksio sesarea merupakan prosedur operatif obstetri yang paling sering dilakukan. Pada tahun2008, hampir sepertiga dari persalinan dilakukan dengan cara seksio sesarea. Dua jenis anestesi sering digunakanyakni anestesi umum dan spinal yang masing-masing mempunyai kelebihan dan kekurangannya. Anestesi umumsering digunakan pada kasus kedaruratan meskipun sering dikaitkan dengan risiko kehilangan darah yang lebihbesar dan penekanan pada susunan syaraf pusat bayi. Anestesi spinal sering dikaitkan dengan keadaan hipotensimaternal.Tujuan: Membandingkan penurunan kadar hemoglobin dan hematokrit ibu dan skor Apgar bayi pada seksiosesarea dengan anestesi umum dan spinal.Metode: Kohort prospektif.Penelitian dilakukan di RS Setjonegoro Wonosobo, RS Banjarnegara, dan RS Sardjitopada bulan September sampai Desember 2010. Pasien yang menjalani seksio sesarea dan memenuhi kriteriainklusi dan eksklusi dimasukkan dalam penelitian ini. Sampel penelitian diikuti sesuai dengan kelompok jenisanestesi. Kadar hemoglobin dan hematokrit sebelum operasi dan 6-12 jam sesudah operasi serta skor Apgar 1menit dicatat. X-square dan t-test dipakai untuk analisis data.Hasil dan Pembahasan: Sebanyak 114 kasus seksio sesarea memenuhi kriteria kelayakan, yang terdiri dari 59kasus kelompok anestesi umum dan 55 kasus anestesi spinal. Kedua kelompok komparabel dalam hal umur,umur kehamilan, paritas BMI dan indikasi operasi. Demikian juga kadar hemoglobin dan hematokrit sebelumoperasi, tidak menunjukkan perbedaan yang bermakna. Penurunan kadar hemoglobin setelah operasi padakelompok anestesi umum lebih besar dibanding kelompok spinal (1,75 ± 1,09 mg/dL vs 1,00 ± 0,96 mg/d;p=0,00), demikian juga penurunan kadar hematocrit (4,47 ± 2,77% vs 3,26 ± 3,04%, p=0,02). Pada penilaianmenit pertama terdapat 28 kasus asfiksia (skor Apgar < 6) pada kelompok anestesi umum dan 22 kasus padakelompok anestesi spinal (RR 1,16, 95%CI 0,81-1,65), tetapi tidak bermakna secara statistik (p=0,42).Kesimpulan: Terdapat penurunan kadar hemoglobin dan hematokrit ibu yang bermakna pada kelompok yangmenjalani seksio sesarea dengan anestesi umummeskipun secara klinis tidak bermakna. Tidak terdapat perbedaanbermakna secara statistik pada kejadian asfiksia pada menit pertama.Kata kunci: anestesi umum, anestesi spinal, seksio sesarea, hemoglobin, hematokrit, skor Apgar
Perbandingan hasil stimulasi ovarium dengan kombinasi klomifen sitrat gonadotropin dan klomifen sitrat pada inseminasi intra uteri Indriani, Farida; Widad, Shofwal; Sofoewan, Sulchan
JURNAL KESEHATAN REPRODUKSI Vol 3, No 2 (2016)
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Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.35939

Abstract

Background: Infertile couple with the cause of unexplained infertility and male factor can follow intrauterine insemination (IUI) program as a cheap and easy method for infertility therapy. Ovarian stimulation by combination of clomiphene citrate and gonadotropin and also clomiphene citrate alone was done as a superovulation mode to get higher number of mature follicle to gain higher pregnancy rate. Objective : To compare the amount of mature follicles and  endometrial thickness as an outcome of ovarian stimulation between combination drug of clomiphene citrate and gonadotrophin with clomiphene citrate alone.Methods: Observational retrospective cohort. Subject is one cycle intrauterine insemination stimulated either by combination CC gonadotrophin or CC alone, eligible in inclusion criteria and exclusion criteria. Statistic test used was independent t-test, chi-square and logistic regression.Location of study: Infertility Clinic of  Permata Hati, dr. Sardjito Hospital, Yogyakarta.Result: A total of 142 cycle from 98 couples followed IUI and stimulated by combination CC gonadotrophin (n=72) or CC alone (n=70). Multiple mature follicle number was different and statistically significant 77% vs 54%, RR 1,433 (IK95% 1,118-1,836), p=0,005, while endometrial thickness > 7mm was more frequent in combination group but not statistically different with percentage 81,9% vs 74,3%, RR 1,103 (CI95% 0,926-1,315), p=0,367.Conclusion: Ovarian stimulation by combination CC gonadotropin resulting of more multiple mature follicle number while  good endometrial thickness was more in combination group but not statistically significant.Keywords: ovarian stimulation, clomiphene citrate, gonadotrophin, multifollicular, endometrial thickness
Dampak Konseling Individu dan Konseling Berpasangan terhadap Penggunaan Kontrasepsi Pascasalin: Randomized Controlled Trials (RCT) Shintiana, Linda; Nurdiati, Detty Siti; Sumarni, Sumarni
JURNAL KESEHATAN REPRODUKSI Vol 4, No 3 (2017)
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Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.36478

Abstract

Background: The achievement of Contraceptive Prevalence Rate (CPR) is 57.9%, which indicates that the Family Planning has not run optimally one of which concerns the utilization of family planning counseling as an attempt to avoid an unplanned pregnancy. The postpartum period is a period appropriate in using contraception. Some studies suggest that the counseling given by health workers will increase the interest of potential acceptors of contraception.Objective:The objective of this research is to increase the utilization of postpartum contraception counseling.Method: This research used Randomised Controlled Trial (RCT) method to provide counseling to couples and individuals. The subject of this study were the final trimester pregnant women with Simple Random Sampling and technique then were randomized to determine the intervention and control groups. Bivariable analysis use statistical test Chi Square with CI 95 % and P value <0.05 and binomial logistic regression multivariable analysis.Result and Discussion:The proportion of postpartum contraceptive utilization in the intervention group compared with the control group was 86% the percentage difference. Variable wife age and information have a significant influence on the utilization of contraception postpartum.Conclusion:The use of counseling in pairs in pregnant women effectively increases the utilization of postpartum contraception. Keywords: Counseling, postpartum contraception
Accuracy of Risantos Formula Compared with Johnsons to Estimate Fetal Weight in Overweight Mothers Noviana, Fifi; Siswosudarmo, Risanto; Hadiati, Diah Rumekti
JURNAL KESEHATAN REPRODUKSI Vol 3, No 1 (2016)
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Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.13873

Abstract

Background: Estimated fetal weight (EFW) is becoming important because it is used as a guidence for determining mode of delivery. The use of estimated fetal weight based on fundal height has been widely used, but its use in overweight pregnant mothers was still limitted.Objective: To compare the accuracy of Risanto’s and Johnson’s formulas in estimating fetal weight based on fundal height in overweight mothers.Method: It was a cross-sectional study, conducted from March 2013 to July 2014 in Sardjito hospital and hospital networks. All pregnant mothers meeting the elligibility criteria were used as study subjects. Overweight mother was defined based on body mass index (BMI) and skinfold thickness on suprailiaca region. Fundal height (FH) was measured from the symphysis pubis to the midle of the upper border of the pregnant uterus. Accuracy of Risanto’s and Johnson’s formulas was dtermined by comparing the difference between EFW and actual infant birth weight (AIBW). Paired t-test was used for statistical analysis.Result and Discussion: There were 395 overweight pregnant mothers fulfilling the inclusion and exclusion criteria. The mean AIBW was 3060.3 ± 322.5 grams (ranged from 2360 to 3940 grams). The mean EFW using Risanto formula (R_EFW) was 3095.8 ± 320.3 grams (ranged from 2370 to 3870 grams ) while that of Johnson (J_EFW) was 3273,7 ± 378,1 grams (ranged from 2325 to 4185 grams). The mean difference between between AIBW and ∆R) EFW (was 109.85 grams while that of AIBW and J_EFW∆J) (was 198.41 grams ∆.RIt was clear that significantly smaller ∆J than with the mean difference minus 88.56 grams (95% CI -98.76 to -78.35; p value 0.000).Conclusion: The new Risanto’s formula was more accurate to estmate infant birth weight than Johnson’s in overweight mothers.Keywords: Risanto’s and Johnson’s Formulas, Estimated Fetal Weight, Overweight Mothers.
Peran Intervensi Grup Psikoterapi Suportif untuk Memperbaiki Keadaan Depresi pada Wanita Infertil di Klinik Permata Hati RSUP Dr. Sardjito Yogyakarta Dhestiana, Mega; Marchira, Carla; Siswishanto, Rukmono; Widad, Shofwal
JURNAL KESEHATAN REPRODUKSI Vol 3, No 3 (2016)
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Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.36037

Abstract

Background: Infertility is a worldwide problem, relates to a devastating condition that can destroy couples striving to have children. It can affect both men and women, and cause psychological related distress, depression, and low self- -esteem. Most interventions using directional, complete, and integrated approach have been focused on improving the quality of life of infertile men or women. Supportive psychotherapy is an example of such interventions.Objective: The study aimed to measure the effectiveness of supportive psychotherapy intervention in treating depression among infertile women.Method: A quasi experiment design using a pre and post- -test with a control group was employed in this study. Subjects were women (n=80) with infertility cases who sought for treatment at PermataHati Clinic Dr. Sardjito hospital. during the period from April to September 2014. A modified short supportive psychotherapywas to groups of patients over the course of four sessions. The sessions were managed by trained facilitatorscomprising psychiatrist and psychologist. Personal data and Beck Depression Inventory (BDI)were then used to assess the patients depression state.Result and Discussion: Findings indicated that 59.37% of the study subjects were found to have mild depression, whereas the other 40.63% had moderate depression. A significant change in BDI scores within the treatment group was found after intervention.Conclusion:Modified short supportive psychotherapy intervention can effectivelly reduce depression on infertile women.Keywords: modified short supportive psychotherapy, depression, infertile women
PERBANDINGAN COMPLETE RESPONSE PENDERITA KANKER OVARIUM STADIUM LANJUT YANG MENDAPAT REJIMEN PACLITAXEL-CARBOPLATIN DENGAN REJIMEN CYCLOPHOSPHAMIDE-ADRIAMYCIN-CISPLATIN SEBAGAI KEMOTERAPI LINI PERTAMA Sibuea, M.; Lutfi, M.; Hakimi, M.
JURNAL KESEHATAN REPRODUKSI Vol 2, No 2 (2015)
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Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.12645

Abstract

PERBANDINGAN COMPLETE RESPONSE PENDERITAKANKER OVARIUM STADIUM LANJUT YANG MENDAPATREJIMEN PACLITAXEL-CARBOPLATIN DENGAN REJIMENCYCLOPHOSPHAMIDE-ADRIAMYCIN-CISPLATIN SEBAGAIKEMOTERAPI LINI PERTAMAM. Sibuea1, M. Lutfi2, M. Hakimi3ABSTRACTBackground: Introduction of Platinum and Paclitaxel has increased survival rate in advanced epithelialovarian cancer. Several studies have been tried to establish the better combination with those anticancerdrugs.Objectives: Comparing complete response (CR) and progression-free survival (PFS) between Paclitaxel-Carboplatin and CAP as a first line treatment in advanced epithelial ovarian cancer.Method: This research used cohort retrospective study. Fifthy-three subjects with epithelial ovarian cancerFIGO stage III and IV were collected from Dr.Sardjito Hospital’s medical record analysis between January2009 and December 2013, and divided into two groups according to chemotherapy regimens. Completeresponse and progression-free survival were determined after cytoreductive surgery and total 6 coursesof chemotherapy.Result and Discussion: The frequency of complete response was similar, 61,5% in Paclitaxel Carboplatingroup as compared with 63% in CAP group (RR 0,977, 95% CI 0,642-1,487, p=1,000). Kaplan-Meier curvesshowed no difference in progression-free survival between the groups, with median PFS was 15 months(95% CI 13,228-16,772) on Paclitaxel-Carboplatin and 14 months on CAP (95% CI 7,686-20,314) (p logrank=0,741). Patients undergo optimal cytoreductive surgery attained more complete response (OR 8,274,95% CI 1,775-38,559, p=0,007) and had a longer PFS than the suboptimal group (17 vs 13 months, p logrank=0,046).Conclusion: Paclitaxel-Carboplatin was not superior compared with CAP regimen as first line chemotherapyin advanced epithelial ovarian cancer. Further evaluation of survival, toxicity profile, and quality of lifewere needed to determine superiority of Paclitaxel-Carboplatin compared with CAP. Optimal cytoreductivesurgery was an independent predictor for a better prognosis.Keywords: advanced ovarian cancer, chemotherapy, Paclitaxel-Carboplatin, CAPABSTRAKLatar belakang: Survival rate penderita kanker ovarium epitelial stadium lanjut meningkat sejakdiperkenalkannya Platinum dan Paclitaxel. Beberapa penelitian telah berusaha untuk menentukankombinasi yang lebih baik dari obat-obatan tersebut.Tujuan: Membandingkan complete response (CR) dan progression-free survival (PFS) antara Paclitaxel-Carboplatin dengan CAP sebagai terapi lini pertama pada kanker ovarium epitelial stadium lanjut.Metode: Penelitian ini menggunakan studi cohort retrospective. Lima puluh tiga subyek dengan kankerovarium epitelial stadium III-IV (FIGO) didapatkan dari analisis rekam medis RSUP Dr. Sardjito mulai Januari2009 hingga Desember 2013, yang terbagi menjadi dua kelompok berdasarkan jenis kemoterapi yang diterima. Complete response dan PFS ditentukan setelah pasien menjalani operasi sitoreduksi dan total 6 siklus kemoterapi.Hasil dan Pembahasan: Frekuensi CR kelompok Paclitaxel Carboplatin (61,4%) serupa dengan kelompokCAP (63%) (RR 0,977, 95% CI 0,642-1,487, p=1,000). Kurva Kaplan-Meier tidak menunjukkan perbedaanPFS di antara kedua kelompok, dengan median PFS Paclitaxel-Carboplatin 15 bulan (95% CI 13,228-16,772)dan CAP 14 bulan (95% CI 7,686-20,314) (p log-rank=0,741). Pasien dengan operasi sitoreduksi optimalmencapai CR lebih banyak (OR 8,274, 95% CI 1,775-38,559, p=0,007) dan median PFS lebih panjang dibandingkan dengan kelompok suboptimal (17 vs 13 bulan, p log-rank=0,046).Kesimpulan: Paclitaxel-Carboplatin tidak lebih superior dibandingkan dengan CAP sebagai kemoterapi linipertama pada kanker ovarium epitelial stadium lanjut. Namun, masih diperlukan pengukuran survival, profiltoksisitas, dan kualitas hidup guna menentukan keunggulan rejimen Paclitaxel-Carboplatin dibandingkan dengan CAP. Operasi sitoreduksi yang optimal merupakan prediktor independen dari prognosis yang lebih baik.Kata kunci: kanker ovarium stadium lanjut, kemoterapi, Paclitaxel-Carboplatin, CAP1,2,3 Bagian Obstetri dan Ginekologi FK UGM/RSUP Dr. Sardjito Yogyakarta
Pemberian Makanan Pralaktasi dengan Kelangsungan Hidup Bayi di Indonesia Dewi, Utami; Wilopo, Siswanto Agus; Wibowo, Tunjung
JURNAL KESEHATAN REPRODUKSI Vol 4, No 1 (2017)
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Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.35436

Abstract

Background: It is recommended for a mother to initiate to give early breastfeeding for a newborn as the first breast milk is known to be nutritious and contains antibody. The delay of breastfeeding shows that non breast milk-supplementary food is given. Based on BPS and Macro International data 65% of infants received pre-lacteal feeds besides breast milk in their three days of life.Objective: the known relationship between pre-lacteal feeds and infants’ survival in Indonesia.Method: This was an observational study with a cohort retrospective study design by using IDHS data year 2007. Samples were all infants (0-12 months, breastfed after birth) from mothers aged 15-49 years old as many as 2,886 mothers. The independent variable was pre-lacteal feeds after birth and the dependent variable was infants’ survival. The analyses used univariable, bivariable, and survival analysis with KaplanMeier, Log regression and Cox regression.Result and Discussion: Bivariable analysis using survival Kaplan-Meier showed that there was a significant relationship between pre-lacteal feeds after birth and infants’ survival. The survival of infants who received pre-lacteal feeds was greater than that of infants who did not receive pre-lacteal feeds (92%:89%). Multivariable analysis using Cox regression showed that the survival chance in infants who did not receive pre-lacteal feeds was 0.63 times lower than that in infants who received pre-lacteal feeds (HR 0.63; CI 95%=0.42-0.95).Conclusion: Pre-lacteal feeds showed a significant result with infant survival. Other factors affecting infant’s survival were mother’s age < 20 and ≥ 35 years, low economic status, and birth assistant with non professional.Keywords: infant’s survival, pre-lacteal feeds, infant