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Farmasains : Jurnal Ilmiah Ilmu Kefarmasian
ISSN : 20866968     EISSN : 26219816     DOI : -
Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is an national journal published by Faculty of Pharmacy and Science University of Muhammadiyah Prof. DR. HAMKA. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is aimed at being a medium for research results dissemination and scientific paper exchanges on the pharmaceutical field among academics, practitioners, regulators, and public. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is issued two times annually, i.e., in April, and October.The Editor receives rigorous research manuscripts that have not been offered for publication elsewhere. Since its first issue published in 2010. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian has become a CrossRef Member since 2019. Therefore, all articles published by Farmasains: Jurnal Ilmiah Ilmu Kefarmasian will have unique DOI number with p-ISSN 2086-6968 dan e-ISSN 2621-9816
Articles 17 Documents
EVALUASI KETEPATAN PENGGUNAAN OBAT PASIEN IBU HAMIL DI DEPARTEMEN OBSTETRI DAN GINEKOLOGI RUMAH SAKIT “X” Abdushshofi, Muhammad Fikri; Elvina, Ridha; Hersunaryati, Yetti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

In the period of pregnancy, a woman requires drug therapy due to the disturbance suffered, whether related or unrelated to the pregnancy process. Drugs taken by pregnants  is noteworthy, because the drug is taken can affect the fetus. This study aimes to evaluate the accuracy of the indication, patient, and doses of drug use in pregnants in accordance with the guidelines used. The type of research is descriptive, data collection is do retrospectively. Sampling was done by purposive sampling in pregnants from the medical records of the Obstetric and Gynecology Department “X” Hospital Jakarta period from January to December, 2014. The results showed that meets the appropriate category indication as much as 99.30% and the category is not appropriate indication as much as  0.70%. Meets the appropriate category of patients as much as 99.30% and the category is not appropriate patients as much as 0.70%. Whereas, meet the appropriate category doses as much as 98.60% and the category is not appropriate doses of as much as 1.40%.
EVALUASI IMPLEMENTASI PELAYANAN KONSELING OBAT DI APOTEK KOTA YOGYAKARTA baroroh, farida; darmawan, endang
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Therefore, it is important to give counseling for patients and their family. This study is to evaluate the counseling service implementation at several pharmacy in Yogyakarta Indonesia. This study was a cross-sectional design. The result showed that the implementation counseling service at pharmacy was 59,00% of 96,00% patients who required counseling service. The several pharmacy patient were out-patient who responsible to their therapeutical management. There was 55,93% patients experienced that the room for counseling service was comfortable. So, the communication aspects of counseling service at pharmacy in Yogyakarta had been well conducted. Based on the communication technique, the pharmacist communicated with body language such as practicing how to use the drug in counseling services was 64.41%. In conlusion, the implementation counseling service at pharmacy in Yogyakarta Indonesia was 59,00% of 96,00% patients who required counseling service. A number of 94.83% of patients stated that pharmacists use an understandable language in counseling services. It can be concluded that although only 58.59% of respondents who had received counseling but the desire to get counseling services of pharmacy in Yogyakarta is very high, reaching 95.96% of respondents
OPTIMASI TABLET FLOATING TEOFILIN MENGGUNAKAN METODE DESAIN FAKTORIAL siswanto, agus; Hapsari, Indri; zulaikha, yusni ulfiani; rosmawati, eva
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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ABSTRACTTheophylline is a drug used in the management of asthma. It has relatively short half-life and narrow therapeutic index with 5-20 μg/mL serum concentration. Thus, Floating tablet formulations that can increase the bioavailability of the drug. The aims of this study were to determine the effect of the excipient (HPMC K4M CR and NaHCO3) to the quality of tablets and determine the optimum formula of theophylline floating tablet. A 22 randomized factorial design was used in development of theophylline floating tablet with HPMC K4M CR (A) and NaHCO3 (B) as independent variables.The flowability of mass tablet, floating character, and dissolution profile were chosen as dependent variables.The results showed that NaHCO3 was the most important factor on increasing flowability of mass tablet. HPMC K4M CR was the dominant factor in lowering the Flag time, improving integrity of the tablet, and decreasing the release of drug. The composition of HPMC K4M CR 40.00 mg and NaHCO3 35.39 mg produced the optimum formula of theophylline floating tablet with desirability value of 0.978.
GAMBARAN EFEK SAMPING ANTIPSIKOTIK PADA PASIEN SKIZOFRENIA RAWAT INAP DI RS. GRHASIA YOGYAKARTA jualeha, julaeha; ananda, vitarani; pradana, dimas
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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This study aimed to profile the use of antipsychotics, the prevalence of DRPs events, and to compare the prevalence of DRPs use of antipsychotics in patients with schizophrenia in Grhasia hospital. This study is an observational study with cross sectional descriptive. Patients who were included in this study were patients with schizophrenia in the period 2007-2009 Grhasia Hospital who met the inclusion criteria, number of patients who were taken in this research are as many as 300 patients with a stratified sampling method. Data collection was performed retrospectively through medical records included patient characteristics, drug use data, and side effect event. From the data were collected regarding the percentage of use of antipsychotics. The results showed that administration of combination klorpromazin and haloperidol, an antipsychotic of the most widely used for the treatment of schizophrenia with a percentage over the period 2007, 2008, and 2009 are 60%, 70%, and 47%. Percentage side effect event over the period 2007, 2008, and 2009 are 31%, 28 % dan 14 %.
UJI SITOTOKSIK EKSTRAK ETANOL 50% DAUN KITOLOD (Isotoma longiflora (L.) Presl.) TERHADAP SEL KANKER SERVIKS (Ca Ski Cell Line) SECARA IN- VITRO yanti, Aprilita rina
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Kitolod (Isotoma longiflora (L.) Presl.) Is a traditional medicinal plant which is efficacious as anticancer. Empirically kitolod had been used  by Indonesian people for the treatment of cancer, but this remains to be proven scientifically through research. The objective of this research was to determine the cytotoxic activity of 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) at a concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL against cervical cancer cells (Ca Ski Cell Line) in vitro assay using red natural methods.Results of Cytotoxic assay  shows that  IC50 values 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) in Ca Ski Cell Line  is  55.78 ug / mL. Ethanol extract  at  concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL have cytotoxic effecst against cervical cancer cells (Ca Ski Cell Line) and extract at a concentration of 125 ug / mL indicates the largest percentage of cell death.
ANALISIS PENGGUNAAN OBAT ANTI TUBERKULOSIS PADA PASIEN TUBERKULOSIS PARU KASUS BARU RAWAT JALAN DI RUMAH SAKIT ATMA JAYA Anwar, Yelfi; Ayuni, Fitri
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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ABSTRACT Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. The prevalence of pulmonary tuberculosis incident was included in the top 10 highest disease at Atma Jaya Hospital. Therefore, the study of the analysis of the use of anti-tuberculosis drugs in patients with new cases of lung rational at Atma Jaya Hospital indispensable. The purpose of this study was to determine the profile and analyze the rationality of the use of anti-tuberculosis drugs used in outpatients suffering from pulmonary tuberculosis new cases over the period July 2013 - June 2014.
FORMULATIONS GEL OF TUNA BONE COLLAGEN (Thunnus albacares) WITH HPMC AS A GELLING AGENT widayanti, ari; Fauziah, Desti Ayu; Radjab, Naniek Setiadi
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Tuna’s collagen may be applied to burns at 2%. To provide convenience in use it was made in drug form gel. HPMC is used as a gelling agent because it can form a gel that is clear and netral and has a viscosity that is stable in a long periode. This study aims to determine the effect of  increase in the concentration of HPMC as a gelling agent in the gel formula. at a concentration of 3%, 4%, 5%, 6%, 7%. The resulting gel is then evaluated by the organoleptic test, homogeneity test, pH test, viscosity test, centrifugation test, and freeze thaw test. Result of statistical analysis ANOVA one way to test the viscosity of the significant difference in each formula. Based on the result of this study concluded that the increased concentration of HPMC as a gelling agent can increase the viscosity of bone collagen gel tuna.
IDENTIFIKASI INTERAKSI OBAT-OBAT POTENSIAL PADA PASIEN GAGAL GINJAL KRONIK RSPAD GATOT SOEBROTO maifitrianti, maifitrianti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 2 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v3i2.3322

Abstract

Interaksi obat berhubungan dengan beberapa faktor seperti polifarmasi, usia, metabolisme hepatik dan penurunan fungsi ginjal. Polifarmasi sering kali ditemukan pada peresepan obat pasien gagal ginjal kronis. Penelitian tentang interaksi obat pada peresepan obat untuk pasien ini perlu dilakukan untuk mencegah kejadian yang tidak diharapkan akibat penggunaan obat. Tujuan dari penelitian ini adalah untuk mengidentifikasi interaksi obat-obat potensial pada pasien gagal ginjal kronik rawat inap di RSPAD Gatot Soebroto Jakarta periode Oktober – Desember 2015. Penelitian ini merupakan penelitian observasional dengan pendekatan deskriptif. Pengambilan data dilakukan secara retrospektif. Data diperoleh dari rekam medis. Sampel adalah pasien gagal ginjal kronik rawat inap di RSPAD Gatot Soebroto Ditkesad Jakarta periode Oktober – Desember Tahun 2015 yang mendapatkan minimal 2 obat dalam satu pola peresepan. Sampel yang memenuhi kriteria inklusi sebanyak 63 pasien dan ditemukan sebanyak 443 potensi interaksi obat. Interaksi obat dengan mekanisme farmakodinamik sebanyak 235 kasus (53,04%) dan farmakokinetik sebanyak 208 kasus (46,96%). Sebanyak 334 kasus (75,39%) merupakan interaksi obat dengan tingkat keparahan moderat. Interaksi obat seringkali dijumpai pada peresepan pasien gagal ginjal kronis yang dapat menyebaban kejadian yang tidak diharapkan jika tidak di deteksi sejak dini.
PENGHAMBATAN AKTIVITAS ENZIM α-GLUKOSIDASE DARI EKSTRAK AIR TANAMAN RARU (Vatica pauciflora) SECARA IN VITRO septiana, eris; winarti, wiwi; simanjuntak, partomuan
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 4 No 1 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v4i1.96

Abstract

Diabetes mellitus is a metabolic disorder that leading the blood sugar levels become higher than normal. In Indonesia, one of the plants that traditionally used to cure hyperglycemic is raru plant (Vatica pauciflora). The objectives of this research was to investigate α-glucosidase inhibitory activity from stem bark, root, and leaf of raru plant. Extraction of stem bark, root, and leaf was conducted with reflux at 70 °C by using water as a solvent. In vitro anti-diabetic activity was tested using the method of α-glucosidase inhibition. The results show that water extracts of raru’s stem bark, root, and leaf have α-glucosidase inhibitory activity. The stem bark water extract has the highest activity than leaf and root with IC50 values were 13.53, 16.96, and 41.91 ppm respectively. All extracts is categorized as active in inhibiting the activity of α-glucosidase enzyme by having IC50≤100 ppm. The results obtain in this research clearly indicate a promising potential as anti-diabetic properties of raru plant.
PENGARUH PENINGKATAN KONSENTRASI PEKTIN SEBAGAI GELLING AGENT TERHADAP SIFAT FISIK MARSHMALLOW ANTISARIAWAN EKSTRAK KENTAL DAUN SAGA (Abrus precatorius L.) elfiyani, rahmah; widayanti, ari; rahayu, budiarti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 2 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v3i2.3323

Abstract

Daun saga (Abrus precatorius L.) memiliki aktivitas antisariawan dan mengandung glisirizin. Glisirizin adalah senyawa saponin glikosida non hemolitik, golongan triterpenoid dan memiliki aktivitas anti-parasit. Penelitian ini bertujuan untuk mengetahui pengaruh peningkatan konsentrasi pektin sebagai bahan gel pada sifat fisik marshmallow. Ekstrak daun saga dibuat dalam marshmallow 4 formula, dengan variasi konsentrasi pektin 0,7%, 0,8%, 0,9% dan 1%. Evaluasi sifat fisik meliputi organoleptik, keseragaman berat, keseragaman ukuran, kadar air, dan tekstur. Data hasil uji kekerasan diperoleh pada 859,33; 710.03; 677.13; 506,36 gf, hasil uji kekompakan data 0.7375; 0,8247; 0,8780; 0,9327 gs, data hasil uji lambung 0,7255; 0,8142; 0,8530; 1,0236 gs. Data dianalisis menggunakan ANOVA satu arah diikuti dengan uji Tukey. Hasil penelitian menunjukkan bahwa konsentrasi pektin yang lebih tinggi akan meningkatkan daya tahan dan kekompakan serta mengurangi kekerasan marshmallow ekstrak daun saga kental.

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