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As-Syifaa Jurnal Farmasi
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Core Subject : Health,
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Articles 228 Documents
IDENTIFIKASI DAN PENETAPAN KADAR SILDENAFIL SITRAT PADA JAMU KUAT LELAKI YANG BEREDAR DI KOTA MAKASSAR Waris, Risda; Kadir, Abd.; Akbar, Chairil
Jurnal Ilmiah As-Syifaa Vol 5, No 1 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

A studies have been conducted identifying and determining the levels of sildenafil citrate in men vitality herbs that marketed in twon of makassar. This study aims to determine the presence of drugs chemicals substances (BKO) in men vitality herbs that is sildenafil citrate with TLC–Densitometry method. Herbal samples extracted using methanol solvent. Identification test by thin layer chromatography (TLC) using a mobiloe phase of chloroform – ethanol (9.5 : 0,5) indicates that the herbal sample were compared with comparator compounds contains sildenafil citrate. Assay done using a TLC-Densitometry at a maximum wavelength of 292 nm. The results showed levels of sildenafil citrate in men vitality herbs was 0,00827 g/100 g or 0,00827 % per capsule.Key Words : Identifying, Determining, Sildenafil Citrate, Men Vitality Herbs
FORMULASI YOGHURT SEBAGAI LOSIO PEMBERSIH WAJAH DENGAN MENGGUNAKAN VARIASI EMULGATOR Faradiba, Faradiba; Hasyim, Nursiah; Fitriyati, Andi
Jurnal Ilmiah As-Syifaa Vol 2, No 1 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

Yoghurt formulation as facial cleansing lotion has been done in which the emulsifier were nonionic (tween 60 and span 60), amine soap (triethanolamin and stearic acid), and detergent (sodium lauryl sulfate) respectively. The aim was to determine the most optimum stabilty formulation. The evaluation was carried out before and after accelerated condition in 5ºC and 35ºC respectively for 10 cycles.Organoleptic, creaming volume, emulsion type, dirpersed globul, viscosity, and yield value were observed. The result of organoleptik showed that there were no change in color and smell, creaming volume and dispersed globul before and after accelerated condition. Statystic analyses foward the viscosity in formula I was apparently indifferent mean while the second and the third formula were different in viscosity. statystic analyses foward the yield value in formula I was apparently indifferent and the second  was different mean while  the third formula very different in yield value. Formula I showed the most minimum alteration in rheogram . Of it the has taken that the most stable emulsion was nonionic emulsifier (tween 60 and span 60).Key Words : Facial cleansing lotion, Yoghurt, Emulgator
UJI EFEK ANTIINFLAMASI FRAKSI KLOROFORM DAUN JOHAR (Cassia siamea Lamk.) DENGAN METODE RAT HIND PAW EDEMA Amirah, Sitti; Herman, Hendra
Jurnal Ilmiah As-Syifaa Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

Johar (Cassia siamea Lamk.) leaves widely used as a traditional medicine. Johar leaves contain chemical compounds such us alkaloids, tannins, saponins, flavonoids, sitosterol and barakol which have effect of treatment for several diseases including inflammatory. This study aims to determine anti-inflammatory effect of chloroform fraction C.siamea leaves. This study was conducted using 15 Wistar rats were divided into 5 groups: control group who were given suspension of Na.CMC 1% w / v, the comparison group were given diclofenac sodium suspension 0.35 mg / kg, the test group dose of 75 mg / kg, the test group dose of 150 mg / kg and a test group of 300 mg / kg. Evaluation of anti-inflammatory activity was done by measured initial volume of the foot all test animal then given the drug orally according to dosage of its group. After 30 minutes, each group made inflammatory by induced karagen 1% 0.1 mL by intraplatar. Furthermore, inflammation’s degrees was measured every hour for 8 hours. The results obtained show that after 2 hours, inflammatory of the control group Na.CMC had increased much higher compared to the other groups. This is shows that Na.CMC doesn’t have effects anti-inflammation. The comparison group diclofenac sodium gave the best inhibitory effect that have been shown from an increase volume of feet smaller than the test group chloroform fraction of Johar leaves. While in chloroform fraction of Johar leaves test group, group with dosage 75 mg/kg gave an inhibitory effect better than the other test group dosage.
UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN SIRSAK (Annona muricata Linn.) TERHADAP MENCIT (Mus musculus) JANTAN YANG DIINDUKSI DENGAN KARAGEN Rahman, Safriani; Mustari, Mustari
Jurnal Ilmiah As-Syifaa Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

The research about aniinflammatory effect of Sirsak leaves (Annona muricata Linn.) ethanolic extract in male mice (Mus musculus) was conducted, the aim to assay the anti-inflammatory effect of Sirsak leaves done extract based on decrease in oedema volume of foot palm male mice. It was used 15 male mices that evaluated and divided into 5 groups that each group has 3 mices given extract in dose 0f 0,182 g/kgBB, 0,546 g/kgBB and 0,91 g/kgBB, one group as the compore which administered diclofenac sodium, one negative control group which administered 1% Na.CMC. induction carried out by injection 1% w/v carrageen 0,05 ml subcutan in the feet palm of mice. One hour later each group administered the teste preparation orally 1 ml/30 gBW. Group 1 to 3 the series dose of the extract 0,182 g/kgBB, 0,546 g/kgBB and 0,91 g/kgBB. Group 5 diclofenac sodium suspension. The measurement of oedema volume carried out prior and after administration of the tested preparation 0, 30, 60, 90, and 120 minutes. The data correlation between oedema versus time analysed value with use SPSS 20.Result indicated variaties with ethanolic Extract of Sirsak leaves have the effect antiinflamatory at dose 0,182 g/kgBB, 0,546 g/kgBB, dan 0,91 g/kgBB and not differ the reality by Natrium Diklofenak.Keywords : Inflamation, Anona muricata’s leaf, Carageen.
FORMULASI BUBUR INSTAN KOMBINASI TEMPE DAN RUMPUT LAUT SERTA EFEK SINERGISMENYA TERHADAP KOLESTEROL DARAH Syakri, Syamsuri; Djide, Natsir; Attamimi, Faisal
Jurnal Ilmiah As-Syifaa Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

Formulation  of Instant Porridge as the combination of Tempe and seaweed and its Synergism Effect Of Cholesterol level Blood. The aim of the research is to make instant porridge as the combination of tempe and seaweed which could be used as a food alternative and its influence on patients cholesterol and the determine  a suitable formulation in making instant porridge as the combination of tempe and seaweed. The absorption was measured by using photometer 5010 with a long unbroken wave 546 nm. The statictical analysis reveal that instant porridge as the combination of tempe and seaweed could decrease cholesterol in which decrease of cholesterol really  differs among formulation 1,2, and 3. The one in formulation 2 is 50%, and the one formulation  3 is 40%. The effect of synergism occurs in formulation 2, i.e 50% in which the comparison of tempe and seaweed is 50  : 50. Hedonic test by 10 respondents proves that all the respondents like instant porridge as the combination of tempe and seaweed about colour, aroma, taste, and texture. Key word : Instant Porridge, Formulation, Cholesterol, Seaweed, Tempe
UJI EFEK HIPOGLIKEMIK KOMBINASI EKSTRAK ETANOL DAUN SAMBILOTO (Andrographis paniculata Nees) dengan AKARBOSE pada TIKUS PUTIH (Rattus norvegicus) TERINDUKSI ALOKSAN sukmawati, sukmawati; Harsita, Muhammad Akbar; Kosman, Rachmat
Jurnal Ilmiah As-Syifaa Vol 8, No 2 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

Acarbose and sambiloto have the same mechanism of action in lowering blood glucose levels by inhibiting alfaglukosidase enzymes in the gut. This study aims to determine the hypoglycemic effect and combination effect from ethanol extract of  sambiloto leaves (Andrographis paniculata Nees) with acarbose in rat (Rattus norvegicus) induced alloxan. Twelve Wistar rats were divided into 4 groups; negative control, positive control, and two treatment groups (EEDS 59 mg/kgBW with Acarbose 2,05 mg/kgBB as combination I and  EEDS 234 mg/kgBW with Acarbose 2,05 mg/kgBB as combination II). Diabetes Mellitus  was induced by Aloksan Monohidrate dose 135 mg/kg BB  for three days. Level of blood glucose was measured with glukometer at 2, 4, 6 and 8 day.  Treatment with combinations of EEDS doses 59 and 234 mg/kgBW  and Acarbose 2,05 mg/kgBB for 7 days significantly decreased blood glucose  level (p<0,05) by 48,97 %, and 58,81 %  respectively. Keyword : Hypoglycemic; Andrographis paniculata Nees.; Blood glucose level; Acarbose; Combination
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN ARBENAN [Duchesnea indica (Jacks.) Focke] DENGAN METODE DPPH Nuraziza, Nuraziza; Dali, Seniwati; Waris, Risda
Jurnal Ilmiah As-Syifaa Vol 9, No 2 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

ABSTRACT            Arbenan [Duchesnea indica (Jacks.) Focke] is a plant belonging to Rosaceae family which server as an antioxidant, flavonoids. This research aimed to determine the antioxidant activity of ethanol extract of arbenan leaves using DPPH. The leaves were extracted using maceration method with a sample size of 300 gs dissolved using ethanol 70%, then obtained the viscous extract of 32,49 gs. The arrest of free radicals for each tested sample under the inhibition of DPPH. The tests were conducted at the 4 concentration series of 10, 20, 30, and 40 ppm by using methanol p.a by the addition of 0,5 mL with 3,5 mL DPPH of 30 ppm. Antioxidant activity absorbance was measured by a spectrophotometer at the wavelength of   515 nm and IC50 value was calculated based on the absorbance data. The calculations showed that the Arbenan leaves have a very strong antioxidant activity with IC50 value of 30,20 µg/mL. Keywords :  Antioxidant, Ethanol extract of arbenan leaves [Dunchesnea indica (Jacks) Focke], DPPH.
FORMULASI GEL MINYAK KAYU MANIS (Oleum Cinnamomi) SEBAGAI PEMBERSIH TANGAN MENGGUNAKAN VARIASI KONSENTRASI CARBOPOL Faradiba, Faradiba; Pakki, Ermina; Fardiyani, Fanny
Jurnal Ilmiah As-Syifaa Vol 1, No 2 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

As investigation has been done on cinnamomi oil gel formulation as hand clean use carbopol gel bases. The aim of the investigation was to select the most stable formula if cinnamomi oil through stability evaluation which done by organoleptic observation, viscosity and yield value determination. It was made three formula with several different concentration carbopol in this investigation that are 0,3 %, 0,4 % and     0,5 %. Of the  result organoleptic observation there was no alternation before and after stress condition. Result statistic analyse on viscosity data shown that there was an influence of gel formula to viscosity before and after stress condition. At formula I and III shown that there was a  very real influence between of  before and after stress condition, while at formula II shown that there was no real influence. Result statistic analyse on yield value data shown that there was an influence of gel formula to yield value before and after stress condition. At formula I shown that there was a  real influence between of  before and after stress condition, at formula III shown that there was a  very real influence between of  before and after stress condition, while at formula II shown that there was no real influence. The conclution was formula II have the most optimal stability  use concentration of carbopol 0,4 %.Key Words : Oleum Cinnamomi, Hand Clean, Carbopol
ANALISIS PENGARUH BERWUDHU TERHADAP PERUBAHAN TEKANAN DARAH SESAAT Ramadhan, Achmad Akbar; Rachman, Mochammad Erwin
Jurnal Ilmiah As-Syifaa Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

The ablution is a very important Islamic teachings as a condition of validity of prayers, besides ablution provide a very important benefit to human health. Objective: To determine the effect of berwudhu to changes in blood pressure on high school students shortly Global Mandiri Al - Ashri Makassar. Methods: This study used a survey method that uses the analytic approach of Cross Sectional. The samples used were mostly high school students Global Mandiri Al - Ashri Makassar as many as 50 people. Results : The results showed a mean systolic blood pressure was 123.56 mmHg before her ablutions, then after berwudhu 122.28 mmHg. Mean diastolic blood pressure before berwudhu was 64.08 mmHg , and 62.32 mmHg after her ablutions, with kemanaknaan p > 0.005 ( p = 0.270 ). Conclusion : There is a change in blood pressure just before and after her ablutions, although it is not significant.
UJI AKTIVITAS ANTIRADIKAL BEBAS EKSTRAK DIETIL ETER DAUN SIRSAK (Annona muricata Linn.) ASAL KOTA MAKASSAR DENGAN METODE DPPH Amirah, Sitti; Rahmawati, Rahmawati; Luspi, Andi Evi Wulandari
Jurnal Ilmiah As-Syifaa Vol 3, No 2 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

Has been on concerning test of activity radical scavenging of soursop leaves (Annonamuricata Linn.) extract of dietileter with DPPH method. This research aimed to know the level activity of free radical based on binding of DPPH free radicals of Soursop leaves (Annonamuricata Linn.).Extraction of soursop leaves (Annonamuricata Linn.) by macerate with methanol, methanol extract then is partition with dietileter.Than measured of quantitative by five concentration  50 ppm, 100 ppm, 200 ppm, 300 ppm and 400 ppm, the result of measured have done  with statistical method of regretion simple linier with average value of IC50 are 4980,4 ppm.  This potency explainextract activity is still very lowers than vitamin C and BHT with value of IC50 are 10,304 mg/ml dan 43,394 ppm.  Key Words :DPPH, Radical scavenging, Annonamuricata Linn. 

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