Journal of General-Procedural Dermatology & Venereology Indonesia
##issue.vol## 3, 1 (2018): December 2018

Elevated homeostatic model assessment of insulin resistance level increases the risk of acne

Stefani Nurhadi ( dermatology resident at medical faculty of Udayana University ) , IGAA Praharsini ( Dermato-Venereology Department Faculty of Medicine of Udayana University/ Sanglah Hospital, Denpasar ) , A. A. Gde Putra Wiraguna ( Dermato-Venereology Department Faculty of Medicine of Udayana University/ Sanglah Hospital, Denpasar )

Article Info

Publish Date
31 Dec 2018


Insulin resistance and carbohydrate diets are currently considered to be influential in acne aetiology. Insulin is a hormone that does not only regulate the concentration of blood glucose but also affects the production of sebum and through the Insulin Growth Factor-1 (IGF-1) receptor stimulates androgen synthesis which will increase the proliferation of keratinocytes of the pilosebaceous duct and the production of sebum in acne.   This is a cross sectional observational analytic study involving 38 acne patient and 38 non acne patients. This study aims to determine whether the increase in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) value is a risk factor for acne. HOMA-IR formula was used to determine insulin activity in basal state. High HOMA-IR values ​​are expressed from cut-off point ≥2. Sampling by consecutive sampling that meets inclusion and exclusion criteria. Fasting insulin and glucose levels is derived from venous blood examination.   The average age of acne subjects was 23.71 years (10 men and 28 women). The mean value of HOMA-IR in the acne group was higher (2.63 ± 0.29) than those in the non acne group (1.71 ± 0.26) and statistically significant (p value <0.001). The prevalence ratio was 31.58, meaning that patients with high HOMA-IR were 31.6 times more likely to have acne than patients with normal HOMA-IR values. These results were statistically significant with p value <0.001. The conclusion was elevated HOMA-IR is one of the factors that increase the risk of someone developing acne.

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Journal Info





Medicine & Pharmacology


The initiation of JDVI (Journal of General - Procedural Dermatology & Venereology Indonesia) was done by leading dermatologists and venereologists from Indonesia who aspired to contribute in the field of scientific publication and research. Knowledge and science continue to evolve in the field of ...