Journal of Tropical Pharmacy and Chemistry
Vol 3 No 1 (2015): Journal of Tropical Pharmacy and Chemistry

EFEK IMUNOSTIMULAN INFUS BUAH MAHKOTA DEWA (PHALERIA MACROCARPA (SCHEFF.) BOERL.) ASAL KAB. SIDRAB SULAWESI SELATAN TERHADAP SEKRESI ANTIBODI TIKUS PUTIH (RATTUS NORVEGICUS) JANTAN DENGAN TEKNIK HEMAGLUTINASI


Emelda, Andi, Rahman, Safriani, Hardianti, Hardianti



Article Info

Publish Date
30 Jun 2015

Abstract

Phaleria macrocarpa has chemical constituents that are flavonoids. Flavonoids may act as antioxidants and modulate the immune system. This study aimed to determine the effect of immunostimulatory infusion Phaleria macrocarpa using hemagglutination method. The animals were white rats (Rattus norvegicus) male. The animals were divided into 5 groups. Group I (control), group II (SDMD 5%), group III, IV and V are the groups given Phaleria macrocarpa infusion at the dose of 7.5 %, 15 % and 30 % respectively for 7 days. The animals were induced SDMD 5% intraperitoneally. Observations were made with a view the agglutination titer blood serum of the mice with SDMD. The results showed that infusion of Phaleria macrocarpaprovide the highest concentration at the 7.5% for titer antibody.   Keywords:  Phaleria macrocarpa, Imunostimulant, Immunoglobulin, Hemagglutination   ABSTRAK   Buah mahkota dewa mempunyai kandungan kimia yaitu flavanoid. Flavanoid dapat berfungsi sebaigai antioksidan dan memodulasi sistim imun. Penelitian ini bertujuan untuk menentukan efek imunostimulan infus buah mahkota dewa menggunakanmetode hemaglutinasi. Hewan uji yang digunakan pada penelitian ini adalah tikus putih (Rattus norvegicus) jantan. Hewan uji dibagi menjadi 5 kelompok. Kelompok kontrol, kelompok II (SDMD 5%), kelompok III, IV dan V adalah kelompok yang diberi infus buah mahkota dewa dengan dosis berturut-turut 7,5%, 15% dan 30% selama 7 hari.Hewan uji diinduksi dengan SDMD 5% secara intraperitonial. Pengamatan dilakukan dengan melihat titer aglutinasi serum darah tikus dengan SDMD. Hasil pengamatan menunjukkan bahwa infus buah mahkota memberikan titer antibodi tertinggi pada konsentrasi 7,5%.   Kata Kunci:   Imunostimulan, Mahkota Dewa, Imunoglobulin, Hemaglutinasi


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Original Source : https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/86
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Journal Info

Abbrev

jtpc

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Medicine & Pharmacology Public Health

Description

Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: ...