Journal of General-Procedural Dermatology & Venereology Indonesia
##issue.vol## 3, ##issue.no## 1 (2018): December 2018

Cumulative exposure to solar ultraviolet A & B increases apoptosis of peripheral blood cutaneous lymphocyte antigen (CLA)+ T-Lymphocytes in outdoor workers


Afif Nurul Hidayati ( Department of Dermatology and Venereology, Faculty of Medicine, Airlangga University/Dr. Soetomo General Hospital/Universitas Airlangga Hospital, Surabaya ) , Saut Sahat Pohan ( Department of Dermatology and Venereology, Faculty of Medicine, Airlangga University/Dr. Soetomo General Hospital/Universitas Airlangga Hospital, Surabaya ) , Widodo J. Pudjirahardjo ( Faculty of Public Health, Universitas Airlangga/Universitas Airlangga Hospital, Surabaya ) , Isaak Effendy ( Department of Dermatology and Allergology, Academic Teaching Hospital Bielefeld - Klinikum Bielefeld )



Article Info

Publish Date
31 Dec 2018

Abstract

  Background: Exposure to ultraviolet A & B (UVA-UVB) plays a role in the survival of human life, but it may cause negative effects, such as immunosuppression and skin cancer. The effect of solar UVA-UVB exposure on apoptosis (Bax/Bcl-2 ratio) of peripheral blood cutaneous lymphocyte antigen (CLA)+ T-lymphocyte; the immune competent cells in the skin, has not been investigated. Apoptosis of peripheral blood CLA+ Tlymphocyte affects its function; which serves as the skins resistance and is involved in infectious diseases, skin inflammation, and malignancies. This study observed the effect of solar UVA-UVB to apoptosis (Bax/Bcl2 ratio) of peripheral blood CLA+ T-lymphocytes. Methods: An observational cohort study of 37 male outdoor workers (caddies on the golf course) and 33 indoor workers in Surabaya, aged 20-45 years, with skin phototype IV/V. Measurement of solar UVA-UVB doses received by the subjects was conducted for 2, 4, and 8 weeks. Examination of Bax and Bcl-2 of peripheral blood CLA+ T-lymphocyte was conducted at the beginning of the study, after 4 and 8 weeks. Results: The average dose of solar UVA-UVB for 8 weeks received by outdoor workers was 12450.51±3948.81 (J/m2 ) and that by indoor workers was 1793.97±1518.46 (J/m2 ). Exposure to solar UVAUVB leads to the increase of apoptosis (Bax/Bcl-2 ratio) of peripheral blood CLA+ T-lymphocytes (p=0.003). Conclusion: Cumulative exposure to solar UVA-UVB radiation in high-dose or received within 8 weeks resulted in the increase in apoptosis of peripheral blood CLA+ T-lymphocytes. Keywords: solar UVA-UVB, CLA+ T Lymphocyte, Bax, Bcl-2, apoptotic.  


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Original Source : http://jgenprodvi.ui.ac.id/index.php/jdvi/article/view/103
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Journal Info

Abbrev

jdvi

Publisher

Subject

Medicine & Pharmacology

Description

The initiation of JDVI (Journal of General - Procedural Dermatology & Venereology Indonesia) was done by leading dermatologists and venereologists from Indonesia who aspired to contribute in the field of scientific publication and research. Knowledge and science continue to evolve in the field of ...