Jurnal Kedokteran Maranatha
Vol 7, No 2 (2008)

Potensi Antioksidan sebagai Antidiabetes


Widowati, Wahyu ( Universitas Kristen Maranatha )



Article Info

Publish Date
08 Dec 2010

Abstract

Diabetes mellitus (DM) is a syndrome  that is marked by elevated blood sugar level. DM is  categorized into two types:  type 1 DM is called insulin-dependent diabetes mellitus (IDDM) and type 2 DM is  called non-insulin-dependent diabetes mellitus (NIDDM). Glucose can be oxidized before or after bound with protein (glycated protein), producing Reactive Oxygen Species (ROS). Diabetic patients indicate lipid peroxide and Thiobarbituric Acid Reactive Subtances  (TBARS) plasma levels that are higher than normal individuals. The combination of glycation and glucose oxidation forms AGEs (Advanced Glycogen End-products). Glycated protein and AGEs modified protein can cause oxidative stress by  releasing  O2*- ,H2O2 and  carbonyl  toxic can damage protein. Many kinds of plants contain  active compounds that can inhibit carbohydrate hydrolysis and glucose absorption, regenerate β-cells so as to increase the release of insulin, inhibit aldose reductase and control the glucose level. Synthetic as well as natural antioxidant compounds from various plants can control glucose level and inhibit diabetic complications. Polyphenolic active compounds in  plants have antioxidant and hypoglycemic activities. To reduce the amount of type 1 DM patients it is necessary to change the life style, among others by consuming  enough vegetables and fruits as antioxidant sources.


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Original Source : http://majour.maranatha.edu/index.php/jurnal-kedokteran/article/view/116
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Journal Info

Abbrev

jurnal-kedokteran

Publisher

Subject

Medicine & Pharmacology

Description

Jurnal Fakultas Kedokteran - Universitas Kristen Maranatha ...