Journal of General-Procedural Dermatology & Venereology Indonesia
##issue.vol## 2, ##issue.no## 3 (2018): June 2018

Double-blind randomized trials once a week narrowband ultraviolet B (NB-UVB) phototherapy in vitiligo


Retno Dwi Utami ( Department of Dermatovenereology Dr. Moewardi General Hospital, Surakarta, Indonesia Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia ) , Mira Trisna Murti ( Department of Dermatovenereology Dr. Moewardi General Hospital, Surakarta, Indonesia Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia ) , Muhammad Risman ( Department of Dermatovenereology Dr. Moewardi General Hospital, Surakarta, Indonesia Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia ) , Arie Kusumawardhani ( Department of Dermatovenereology Dr. Moewardi General Hospital, Surakarta, Indonesia Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia )



Article Info

Publish Date
29 Jun 2018

Abstract

Background: Vitiligo is a skin pigmentation disorder, affecting approximately 1-2% population worldwide. Currently, there are wide varieties of treatment to achieve re-pigmentation, and phototherapy is one of the effective treatments. Narrowband ultraviolet B (NB-UVB) is administered twice a week according to the phototherapy protocol for vitiligo. Some vitiligo patients have difficulty following this schedule, leading to decrease of patient’s compliance. Therefore, we performed study comparing the efficacy of phototherapy frequency, once a week and twice a week NB-UVB in vitiligo. Methods: This preliminary study divided 10 patients into 2 groups of 5 patients each with randomized, double-blind method. Group A was scheduled for NB-UVB phototherapy twice a week while Group B was scheduled for once a week. All patients received topical desoxymetasone cream once daily. Re-pigmentation were compared using Vitiligo Area Scoring Index (VASI). VASI was graded as good (≥25%), moderate (10-24%), and poor (<10 %) responses. Evaluation for melanin index for each lesion was assessed by Mexameter® and cumulative doses of phototherapy were compared. Results: Thirty-seven lesions were treated on face and neck, trunk and extremities. Good responses were obtained in 14.29% group A patients and 13.04% group B patients. The mean of cumulative doses phototherapy in group A was 850 mJ/cm2, whereas group B was 800 mJ/cm2. There was no significant differences (p>0.05) between both groups in terms of re-pigmentation, cumulative doses of phototherapy, and melanin index. Conclusion: In vitiligo, once a week NB-UVB phototherapy appears to be as efficacious as twice a week treatment schedule.   Keywords: melanin index, narrowband ultraviolet B, phototherapy, vitiligo, vitiligo area scoring index


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Original Source : http://jgenprodvi.ui.ac.id/index.php/jdvi/article/view/93
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Journal Info

Abbrev

jdvi

Publisher

Subject

Medicine & Pharmacology

Description

The initiation of JDVI (Journal of General - Procedural Dermatology & Venereology Indonesia) was done by leading dermatologists and venereologists from Indonesia who aspired to contribute in the field of scientific publication and research. Knowledge and science continue to evolve in the field of ...