Journal of General-Procedural Dermatology & Venereology Indonesia
##issue.vol## 2, ##issue.no## 3 (2018): June 2018

The comparison of skin irritation level between topical cajeput oil and telon oil: A pilot study


Sri Esa Ilona ( Departement of DermatoVenereology Dr. Moewardi General Hospital/ Medical Faculty of Sebelas Maret University Surakarta, Indonesia ) , Aris Cahyono ( Departement of DermatoVenereology Dr. Moewardi General Hospital/ Medical Faculty of Sebelas Maret University Surakarta, Indonesia ) , Endra Yustin Ellistasari ( Departement of DermatoVenereology Dr. Moewardi General Hospital/ Medical Faculty of Sebelas Maret University Surakarta, Indonesia ) , Muhammad Eko Irawanto ( Departement of DermatoVenereology Dr. Moewardi General Hospital/ Medical Faculty of Sebelas Maret University Surakarta, Indonesia ) , Harijono Kariosentono ( Departement of DermatoVenereology Dr. Moewardi General Hospital/ Medical Faculty of Sebelas Maret University Surakarta, Indonesia )



Article Info

Publish Date
29 Jun 2018

Abstract

Background: Cajuputi/Cajeput/Melalueca leucadendron oil is a type of essential oil, widely known and used by Indonesian for infants, children, and elderly. It is also included in telon oil compositions (±42%). Excessive application of cajeput oil and telon oil may lead to skin irritation.Methods: This randomized single-blind control trial was conducted with 10 subjects who met the inclusion criteria. Four areas with diameter of 10 mm each were made on the flexor surface of the upper arm. Area 1 was designated as negative control. Area 2 to 4 were pre-irritated with tape stripping for 40 ± 10 times using Nachitape®, followed by repeated open application test (ROAT) with cajeput oil, telon oil and alcohol (positive control). The skin irritation was examined in 15 minutes after each cycle by measuring transepidermal water loss (TEWL) using Tewameter® TM300 (Courage-Khazaka, Germany) and erythema using Mexameter® MDD4. Data were analyzed using One-way ANOVA with p<0.05 considered significance.Results: The average TEWL and erythema of cajeput oil (15.59; 345.42) were the highest compared to telon oil (12.63; 316.60), alcohol (13.87; 319.06) and negative control (7,48; 296.68).  All treatment groups had significant differences in TEWL (p<0.000) and erythema (p<0.002) when compared to the negative control. However, cajeput oil showed the largest difference.Conclusion: Cajeput oil caused the most irritation compared to alcohol and telon oil. Therefore, it should be used with caution.  Keywords: cajeput oil, essential oil, skin irritation, telon oil


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Original Source : http://jgenprodvi.ui.ac.id/index.php/jdvi/article/view/91
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Journal Info

Abbrev

jdvi

Publisher

Subject

Medicine & Pharmacology

Description

The initiation of JDVI (Journal of General - Procedural Dermatology & Venereology Indonesia) was done by leading dermatologists and venereologists from Indonesia who aspired to contribute in the field of scientific publication and research. Knowledge and science continue to evolve in the field of ...