Jurnal Medika Planta
Vol 1, No 1 (2010)

EFFECT OF ETHYL ACETATE AND BUTANOL FRACTIONS OF VELVET BEAN SEED (Mucuna Pruriens L.) TO IMPROVE LIPID PROFILE IN DYSLIPIDEMIC RATS


Ratnawati, Hana, Widowati, Wahyu, Chakravitha, Clarissa



Article Info

Publish Date
27 Jun 2013

Abstract

Introduction: Nowadays many people had dyslipidemic, affected by dietery habits and unhealthy lifestyle. High blood lipid can increase the risk of atherosclerosis and coronary heart disease (CHD). The CHD mortality rate are increasing and known as first leading cause of death in Indonesia. Objective: to find out the effect of ethyl acetate and butanol fractions of velvet bean seed (M. pruriens L.) to improve lipid profile in dyslipidemic rats. Methods: laboratory experimental prospective design, in vivo  preclinical test used dyslipidemic rats, which given ethyl acetate and butanol fractions in concentration at 15, 30, 60mg/kgBW/day, simvastatine 27mg/kgBW/day during ten days. The parameters used respectively are HDL, LDL, triglyceride, and total cholesterol level on dyslipidemic rats. Data were  analysed  with  Anava  and continued Post Hoc Duncan with level of significancy  95%. Results : Ethyl acetate fraction 15mg/kgBW/day significantly decreased total cholesterol level (56.667mg/dL) compared to positive control (70.667mg/dL), and ethyl acetate fraction 60mg/kgBW/day significantly decreased LDL level (7.333mg/dL) compared to positive control (14.333mg/dL), butanol fraction 60mg/kgBW/day significantly decreased  triglyceride level (65.667mg/dL) compared to positive control (112.333mg/dL) and significantly  increased HDL level (30.333g/dL) compared to positive control (24.333g/dL). Conclusion:  Ethyl acetate and butanol fractions of M. pruriens L. improve lipid profile such as decrease LDL, triglyceride, total cholesterol level and increase HDL level in dyslipidemic rats.


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