Indonesian Journal of Fundamental and Applied Chemistry
Vol 4, No 1 (2019): February 2019

Studies on the Controlled Release of Drugs from Magnetic Nanobiocomposites

Heinze, Thomas (Unknown)
Müller, Robert (Unknown)
Zhou, Mengbo (Unknown)
Rabel, Martin (Unknown)
Warncke, Paul (Unknown)
Fischer, Dagmar (Unknown)



Article Info

Publish Date
13 Feb 2019

Abstract

Magnetic nanocomposites are a class of smart materials that have attracted recent interest as drug delivery systems or as medical implants. In this study, meltable nanobiocomposites (NBC) composed of biocompatible dextran fatty acid ester and magnetic nanoparticles (MNPs) melting close to human body temperature were prepared and loaded with Rhodamine B (RhB) or green fluorescent protein (GFP) as model drugs to evaluate their potential use as drug delivery system. The release of the model drugs from the magnetic NBC investigated under the influence of a high frequent alternating magnetic field (AMF, 20 kA/m at 400 kHz) showed that on-demand release is realized applying the external AMF. The NBC showed a long-term stability (28 d) of the incorporated iron oxide particles after incubation in artificial body fluids. This work reveals the potential of the NBC as a drug carrier.

Copyrights © 2019






Journal Info

Abbrev

IJFAC

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science

Description

Indonesian Journal of Fundamental and Applied Chemistry (IJFAC) is an international research journal and invites contributions of original research articles as well as review articles in several areas of chemistry. The journal aims to publish refereed, high-quality research papers with significant ...