Jurnal Ilmiah Farmasi
Vol 6, No 1 (2009)

UJI IRITASI PRIMER LOTION EKSTRAK ETANOLIK DAUN KEMANGI (Ocimum basilicum Linn) PADA KELINCI JANTAN BERDASARKAN PARAMETER INDEKS IRITASI PRIMER

Arba Pramundita Ramadani (Unknown)
Ari Marstiyani (Unknown)



Article Info

Publish Date
15 Feb 2012

Abstract

ABSTRACTKemangi (Ocimum basilicum L.) is Lamiaceae family, consists of volatile oil, saponin,flavonoid, tanin, and polifenole. One of its functions is as an antioxidant. The antioxidantmechanism is blocking free radical oxidative bound with LDL (Low Density Lipoprotein) (Udupa,2006). This study explores kemangi as a lotion formulation on its primary iritation effect using malerabbits. Kemangi leaves are extracted with soxhletation method and formulated on lotion. Primaryirritation test is conducted by using patch test on 12 male rabbits. Rabbits are divided into 2 groups,with incision and without incision. Each of it got same treatments normal control aquadest, lotionbase control, and 4 tapering dose of kemangi leaves extract. Each treatment is done 6 times ondifferent rabbits, with incision and without incision group. The treatment is applied on rabbits backafter 3 stage shaving. For incision group, after 3 stages shaving the skin is scratched with minorincision on cell surface. Toxic symptom is observed during 24 hours and 72 hours after lotionapplication. The study result is analyzed qualitatively and quantitatively. Qualitative analysisshowed that any erythema found as reddish spot on the rabbits back skin, but no edema found.Primary irritation index as quantitative analysis showed 0,083 for normal control aquadest; 0,207 forlotion base control; 0,292 for 0,25g/inci2kemangi leaves extract; 0,416 for 0,5g/inci2kemangileaves extract; 0,582 for 1 g/inci2kemangi leaves extract; 0,642 for 2 g/inci2kemangi leaves extract.It means kemangi leaves extract have no primary irritation effect.Keywords: Kemangi, patch test, anti oxidant

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Journal Info

Abbrev

JIF

Publisher

Subject

Medicine & Pharmacology

Description

JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta ...