Indonesian Journal of Chemistry
Vol 16, No 2 (2016)

The Phenolic Compound from Kalanchoe blossfeldiana (Crassulaceae) Leaf and Its Antiplasmodial Activity against Plasmodium falciparum 3D7

Yun, Yenny Febriani (Unknown)
Hermanto, Faizal (Unknown)
Aisyah, Lilis Siti (Unknown)
Saputra, Tri Reksa (Unknown)
Hakim, Arif Rahman (Unknown)
Ningsih, Ade Kania (Unknown)
Herlina, Tati (Unknown)
Julaeha, Euis (Unknown)
Zainuddin, Achmad (Unknown)
Supratman, Unang (Unknown)



Article Info

Publish Date
13 Mar 2018

Abstract

Various species of Kalanchoe plants have been widely used as raw materials in traditional medicines. This study was the continuation of the researches on secondary metabolites from Indonesia Kalanchoe plants, focused on Kalanchoe blossfeldiana. Fresh K. blossfeldiana leaf was extracted with methanol at room temperature to obtain the concentrated extract. The concentrated methanol extract was dissolved in water and then partitioned successively with n-hexane and ethyl acetate. The methanol, n-hexane, ethyl acetate extracts were tested using antiplasmodial assay against Plasmodium falciparum 3D7. The IC50 of methanol, n-hexane, and ethyl acetate extract were 13.002; 2.807, and 11 nM, respectively. Ethyl acetate extract was separated by the combination of chromatography on silica and ODS. This process produced the yellow solid. The chemical structure of the compound was determined based on UV, IR, MS, 1H-NMR, and 13C-NMR analyses and the comparison of data obtained from the literature and identified as phenolic compound, namely 3,3,4,5,7-pentahydroxyflavone or quercetin (1), and displayed antiplasmodial activity with IC50 3.97x10-2 nM.

Copyrights © 2016






Journal Info

Abbrev

ijc

Publisher

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology ...