Indonesian Journal of Chemistry
Vol 8, No 2 (2008)

RESVERATROL DIMERS FROM STEM BARK OF Hopea gregaria AND THEIR CYTOTOXIC PROPERTIES

Sahidin, Sahidin (Unknown)
Hakim, Euis Holisotan (Unknown)
Syah, Yana Maolana (Unknown)
Juliawaty, Lia Dewi (Unknown)
Achmad, Sjamsul Arifin (Unknown)
Bin Din, Laily (Unknown)
Latip, Jalifah (Unknown)



Article Info

Publish Date
17 Jun 2010

Abstract

Six resveratrol dimers have been isolated from the stem bark of H. gregaria, ampelopsin A (1), balanocarpol (2), ε-viniferin (3), hopeafuran (4), heimiol A (5), and parviflorol (6). The structures of these compounds were determined based on spectroscopic evidence such as UV, IR, 1-D, 2-D NMR and comparison with the reported data. These compound inventions are strengthen conclusion that Hopea tends to produce resveratrol dimers. Biological activity of those compounds against murine leukemia P-388 cells showed that ε-viniferin (3) is the most active compound with IC50 value 5.1 ± 0.3 μg/mL.   Keywords: H. gregaria, resveratrol dimers, murine leukemia P-388 cells

Copyrights © 2008






Journal Info

Abbrev

ijc

Publisher

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology ...