Unlike the popular povidone iodine 10% and the effective Jatropha multifida L. latex, ozone has been used as an alternative wound healing therapy for a long time but the advantage is still controversial. The aim of this research is to compare the effect of ozone, Jatropha moultifida L. latex and povidone iodine 10% on the wound healing process. The experiment used a Random Complete Design with comparative characteristics. The animal models were 24 adult Swiss Webster female mice, divided into 4 groups (n=6). The thighs of the mice were shaved before an 8-mm slice on the skin was made. Group I had no treatment, group II was treated with povidone iodine 10% topically, group III with ozone and and group IV with Jatropha multifida L. latex. The treatment and the wound length measurements were carried out every day until all the wounds were healed. The result showed that the average time span of wound healing of each of groups I, II, III, and IV was subsequently 6.80 days, 6.88 days, 4.17 days, and 5.83 days. The time span of the healing process in the 3rd (ozone) group was very significantly different from that of the negative control group (p=0.001) and it was significantly different from that of Jatropha multifida L. latex group (p=0.0032). The time spans of the healing process of group II (povidone iodine 10%) and group IV (Jatropha multifida L. latex) were not significantly different from that of the negative control group (p=0.364). The conclusion is that ozone significantly accelerates the wound healing process more than Jatropha multifida L. latex and povidone iodine 10%.
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