Introduction: Nowadays many people had dyslipidemic, affected by dietery habits and unhealthy lifestyle. High blood lipid can increase the risk of atherosclerosis and coronary heart disease (CHD). The CHD mortality rate are increasing and known as first leading cause of death in Indonesia. Objective: to find out the effect of ethyl acetate and butanol fractions of velvet bean seed (M. pruriens L.) to improve lipid profile in dyslipidemic rats. Methods: laboratory experimental prospective design, in vivo preclinical test used dyslipidemic rats, which given ethyl acetate and butanol fractions in concentration at 15, 30, 60mg/kgBW/day, simvastatine 27mg/kgBW/day during ten days. The parameters used respectively are HDL, LDL, triglyceride, and total cholesterol level on dyslipidemic rats. Data were analysed with Anava and continued Post Hoc Duncan with level of significancy 95%. Results : Ethyl acetate fraction 15mg/kgBW/day significantly decreased total cholesterol level (56.667mg/dL) compared to positive control (70.667mg/dL), and ethyl acetate fraction 60mg/kgBW/day significantly decreased LDL level (7.333mg/dL) compared to positive control (14.333mg/dL), butanol fraction 60mg/kgBW/day significantly decreased triglyceride level (65.667mg/dL) compared to positive control (112.333mg/dL) and significantly increased HDL level (30.333g/dL) compared to positive control (24.333g/dL). Conclusion: Ethyl acetate and butanol fractions of M. pruriens L. improve lipid profile such as decrease LDL, triglyceride, total cholesterol level and increase HDL level in dyslipidemic rats.
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