JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
JKKI, Vol 7, No 4, (2016)

Role of oxidative stress on acute ischaemic stroke


Setyopranoto, Ismail



Article Info

Publish Date
17 Oct 2016

Abstract

After the onset of a stroke, blood flows disrupted in areas affected by vascular occlusion limit the delivery of oxygen and metabolic substrates to neurons causing ATP reduction and energy depletion. The glucose and oxygen deficit that occurs after severe vascular occlusion is the origin of the mechanisms that lead to cell death and cerebral injury caused of oxidative stress. Oxidative stress constitutes mechanism of injury of many types of disease processes. On oxidative stress occurs on the increase in ROS and RNS. This paper will discuss about cerebral ischemia that causes activation of ROS and RNS, also the mechanisms that play a role in cell death after cerebral ischemia, for example the role of phospholipase, Haber-Weiss reaction, and lipid peroxidation. It is also described about anti-oxidants to fight free radicals, for examples glutathione peroxidase, catalase and superoxide dismutase.


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Original Source : http://journal.uii.ac.id/JKKI/article/view/6607
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Journal Info

Abbrev

JKKI

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

Description

Jurnal Kedokteran dan Kesehatan Indonesia is the English language based scientific periodical journal, managed by the Faculty of Medicine, Islamic University of Indonesia. It publishes one issue, three times a year. This journal is designed as a place of dissemination of information and scientific ...