Jurnal Gizi dan Pangan
Vol 2, No 2 (2007): Juli 2007

RESISTENSI INSULIN TERKAIT OBESITAS: MEKANISME ENDOKRIN DAN INTRINSIK SEL

Dewi, Mira (Unknown)



Article Info

Publish Date
02 Mar 2012

Abstract

The number of obese individuals worldwide has reached 2.1 billion and this will lead to explosion of obesity-related morbidity and mortality. Obese individuals will develop re­sistance to celluler action of insulin. The obesity related insulin resistance is the major risk factor of cardiovascular diseases and Type 2 Diabetes Mellitus, the disease which number has reached epidemic proportion. The association between obesity and insulin resistance seem to be cause and effect relation because studies on human and animal has indicated that the increase or decrease of body weight correlates with insulin sensitivity.  Among of many mechanisms proposed, the most often proposed mechanisms are endocrine and cell in­trinsik mechanism. The increase of fatty acid plasma concentration, dysregulation of adi­pokines and ectopic fat storage are proposed to be the endocrin mechanism that lead to obesity related insulin resistance while oxidative stress and mitochondria dysfunction are the cell intrinsic mechanisms that play role to the disease. Understanding the molecular mechanisms of obesity related insulin resistance will provide valuable information to search for interventions that help to prevent or treat Type 2 Diabetes Mellitus and cardiovascular diseases and its related pathologies. Keywords: Obesity, insulin resistance, fatty acid, adipokines, oxidative stress, mitochondria

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Journal Info

Abbrev

jgizipangan

Publisher

Subject

Health Professions

Description

Jurnal Gizi dan Pangan (Journal of Nutrition and Food) merupakan jurnal ilmiah yang memuat berbagai artikel hasil penelitian dan review (atas undangan) tentang gizi dan pangan, yang terkait dengan aspek biokimia, gizi klinik, gizi masyarakat, pangan fungsional, dan sosial ekonomi serta regulasi dan ...