INDONESIAN JOURNAL OF PHARMACY
Vol 17 No 3, 2006

Three resveratrol’s oligomers from the stem bark of H. gregaria (dipterocarpaceae) and their toxicity and citotoxicity


., Sahidin ( Department of Chemistry, faculty of Mathematics and Natural Science Haluoleo University, Kendari, Southeast Sulawesi, Indonesia Natural Organic Chemistry Research Club, Chemistry Program Institut Teknologi Bandung ) , Hakim, Euis H. ( Natural Organic Chemistry Research Club, Chemistry Program Institut Teknologi Bandung ) , Syah, Yana M. ( Natural Organic Chemistry Research Club, Chemistry Program Institut Teknologi Bandung ) , Juliawaty, Lia D. ( Natural Organic Chemistry Research Club, Chemistry Program Institut Teknologi Bandung ) , Achmad, Sjamsul A. ( Natural Organic Chemistry Research Club, Chemistry Program Institut Teknologi Bandung ) , Latip, Jalifah ( School of Chemical Sciences & Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor D.E., Malaysia )



Article Info

Publish Date
01 Jul 2006

Abstract

Three resveratrol oligomers have been isolated from the stem bark of H. gregaria including a resveratrol trimer i.e. α-viniferin (1), and two resveratrol tetramers i.e. vaticanol B (2) and hopeaphenol (3). These structures were determined by spectroscopic evidence including UV, IR, 1H , 13C NMR and compared with that of the reported data in the literatures. Activities of the compounds were determined toward brine shrimp Artemia salina (toxicity) and murine leukemia P-388 cells (cytotoxicity). The compound 1 is the most active against A. salina (LC50 = 49,0 ± 5,8 μg/mL), and the compound 3 has very active level toward murine leukemia P-388 cells (LC50 = 5,7 ± 0,3 μM).Key words : Resveratrol oligomers, H. gregaria, toxicity, and cytotoxicity.


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Journal Info

Abbrev

3

Publisher

Subject

Medicine & Pharmacology

Description

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas ...